This Special Edition of Psychology and Cognitive Sciences – Open Journal is entitled “Technology, Learning, and the Brain”. Information and digital technologies have reshaped teaching and learning in schools in addition to changing our students’ brains, but often not in ways anticipated by technology proponents. Technologies influence teaching and learning where schools have made significant use of assessment and instructional technologies to promote learning, whereas technologies for learners are somewhat limited in school contexts. Modern classrooms have experienced both advantages and disadvantages of innovative technologies and the benefits appear to far outweigh the obstacles. Newer technologies create newer challenges for teachers, but also open up potential new pathways for meaningful learning, innovative delivery models, and collaboration. Manuscripts from all disciplines of psychology, neuroscience, psychiatry, neurology, education, sociology, anthropology, and computer and information technology are invited to address this topic.