Cancer Studies and Molecular Medicine

Open journal

ISSN 2377-1518

Bilateral Symmetric Thalamic Metastasis in a Patient with Small Cell Lung Cancer

Takeshi Saraya*, Chie Shimura, Sayuki Inaoka and Hajime Takizawa

Takeshi Saraya, MD, PhD

Department of Respiratory Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa Mitaka City, Tokyo 181-8611, Japan; Tel/Fax: +81(0)-422-44-0671; E-mail:


A 68-year old woman was referred to our hospital because of dry cough with persistent numbness in the extremities. Chest roentgenogram showed right hilar tumor with mediastinal lymphnode and brain magnetic resonance imaging (MRI) revealed multiple tiny nodules. After performing the transbronchial needle aspiration obtained from subcarinal lymphnode, she was diagnosed with small cell lung cancer (SCLC) accompanied by multiple brain metastasis (clinical stage IV: T4N3M1). After completion of four cycles of chemotherapy, the size of lung lesion was regressed together with complete resolution of brain lesions, and she discharged uneventfully. However, her numbness was remained. Four months later, she was hospitalized again for severe numbness in her trunk and extremities. Brain MRI (contrast-enhanced T1-weighted image) demonstrated new symmetric metastatic lesions in bilateral thalamus (Figure A and B) as well as left putamen. Another two months later, numbness exacerbated and spread from the top to toe with the growing of primary and bilateral thalamic metastatic lesions on computed tomography (CT) (Figure C and D). In spite of whole-brain irradiation, she had suffered from severe numbness, and died of obstructive pneumonia. To our knowledge, this is the first case of bilateral symmetric thalamic metastasis in SCLC with refractory numbness over the whole body.

Figure A and B. Brain MRI (contrast-enhanced T1-weighted image) Demonstrated New
Symmetric Metastatic Lesions in Bilateral Thalamus (arrow heads) as well as Left Putamen.

Brain MRI

Figure C and D. Head CT with Contrast-media Depicted that Bilateral Thalamic Metastatic Lesions are getting Larger in Size.

Head CT with Contrast-media Depicted that Bilateral Thalamic Metastatic Lesions are getting Larger in Size.


From Neck Pain to a Life-Threatening Condition: A Case Report

Floris Vandewoude* and Sören Verstraete


Chest X-ray Showed a Hazy Left Upper Lung Infiltrate

A Noteworthy Case of Myasthenic Crisis Induced by Levofloxacin

Ada Young*, Ramya Ramesh and Milind Awale


The Right Thigh Anterior Compartment was Swollen, and the Skin was Ulcerated due to the Traditional Cautery

Primary Skeletal Muscle Lymphoma: A Case Report and Literature Review

Solomon Bishaw*, Addisu Alemu and Abel Tefera