1. Kochanek KD, Xu JQ, Murphy SL, Miniño AM, Kung HC. Deaths: final data for 2009. National vital statistics reports. 2011; 60(3).
2. AHA. Statistical Fact Sheet 2013, 2013. Available at: https:// my.americanheart.org/idc/groups/heart-public/@wcm/@sop/@ smd/documents/downloadable/ucm_319576.pdf Accessed March 29, 2015.
3. American Heart Association. 1997 Heart and Stroke Facts: Statistical Update. Dallas, Tex: American Heart Association; 1996.
4. Roger VL, Go AS, Lloyd-Jones DM, et al. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation. 2012; 125(1): e2-e220. doi: 10.1161/CIR.0b013e31823ac046
5. Huxley R, Barzi F, Woodward M. Excess risk of fatal coro nary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ. 2006; 332: 73-78. doi: 10.1136/bmj.38678.389583.7C
6. Kuhl H1. Hormonal contraception and substitution therapy: the importance of progestogen for cardiovascular diseases. Obstetrics Women. 1992; 52(11): 653-662. doi: 10.1055/s-2007- 1026140
7. Basili S1, Raparelli V, Proietti M, Tanzilli G, Franconi FJ. Impact of sex and gender on the efficacy of antiplatelet therapy: the female perspective. Atheroscler Thromb. 2015; 22(2): 109-125. doi: 10.5551/jat.24935
8. Ashley KE1, Geraci SA. Ischemic heart disease in women. South Med J. 2013; 106(7): 427-433. doi: 10.1097/smj.0b013e31829b9eab
9. Wood D, De Backer G, Faergeman O, et al. Together with members of the Task Force. Prevention of coronary heart disease in clinical practice. Recommendations of the second Joint Task Force of European and other Societies on coronary prevention. Eur Heart J. 1998; 19: 1434-1503. doi: 10.1053/euhj.1998.1243
10. Sesso HD, Lee IM, Gaziano JM, et al. Maternal and paternal history of myocardial infarction and risk of cardiovascular disease in men and women. Circulation. 2001; 104: 393-398. doi: 10.1161/hc2901.093115
11. Friedlander Y, Arbogast P, Schwartz SM, et al. Family history as a risk factor for early onset myocardial infarction in young women. Atherosclerosis. 2001; 156(1): 201-207. doi: 10.1016/ S0021-9150(00)00635-3
12. Bjartveit K, Tverdal A. Health consequences of smoking 1-4 cigarettes per day. Tob Control. 2005; 14(5): 315-320. doi: 10.1136/tc.2005.011932
13. Prescott E, Hippe M, Schnohr P, Hein HO, Vestbo J. Smoking and risk of myocardial infarction in women and men: longitudinal population study. BMJ. 1998; 316(7137): 1043-1047. doi: 10.1136/bmj.316.7137.1043
14. US. Department of Health and Human Services. Let’s Make the Next Generation Tobacco-Free: Your Guide to the 50th Anniversary Surgeon General’s Report on Smoking and Health. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014 Available at: http://www.surgeongeneral.gov/ library/reports/50-years-of-progress/consumer-guide.pdf Accessed March 5, 2014
15. Al-Delaimy WK, Stampfer MJ, Manson JE, Willett WC. Toenail nicotine levels as predictors of coronary heart disease among women. Am J Epidemiol. 2008; 167(11): 1342-1348. doi: 10.1093/aje/kwn061
16. Alcohol and Heart Health. AHA. website: http://www.heart. org/HEARTORG/GettingHealthy/NutritionCenter/HealthyEating/Alcohol-and-Heart-Health_UCM_305173_Article.jsp Accessed at: January 12,2015.
17. Chomistek AK, Manson JE, Stefanick ML, et al. Relationship of sedentary behaviour and physical activity to incident cardiovascular disease: results from the Women’s Health Initiative. J Am Coll Cardiol. 2013; 61(23): 2346-2354. doi: 10.1016/j. jacc.2013.03.031
18. Mosca L, Benjamin EJ, Berra K, et al. Effectiveness-based guidelines for the prevention of cardiovascular disease in women–2011 update: a guideline from the American heart association. Circulation. 2011; 123(11): 1243-1262. doi: 10.1161/ CIR.0b013e31820faaf8
19. Mazza A, Tikhonoff V, Schiavon L, Casiglia E. Triglycerides + high-density-lipoprotein-cholesterol dyslipidaemia, a coronary risk factor in elderly women: the cardiovascular study in the elderly. Intern Med J. 2005; 35(10): 604-610. doi: 10.1111/j.1445- 5994.2005.00940.x
20. Mozzafarian D, Benjamin EJ, Go AS, et al. Heart Disease and Stroke Statistics-2015 Update: a report from the American Heart Association. Circulation. 2015; e29-e322. doi: 10.1161/ CIR.0000000000000152
21. Wenger NK. Hypertension and other cardiovascular risk factors in women. Am J Hypertens. 1995; 8(12 Pt 2): 94s-99s. doi: 10.1016/0895-7061(95)99306-1
22. Wilkins K, Gee M, Campbell N. The difference in hypertension control between older men and women. Health Rep. 2012; 23(4): 33-40.
23. Chahal CA, Somers VK. Secondary hypertension: Obstructive sleep apnea. J Am Soc Hypertens. 2015; 9(3): 244-247. doi: 10.1016/j.jash.2015.02.001
24. Budhiraja R, Parthasarathy S, Quan SF. Endothelial dysfunction in obstructive sleep apnea. J Clin Sleep Med. 2007; 3(4): 409-415.
25. Kohler M1, Craig S, Nicoll D, Leeson P, Davies RJ, Stradling JR. Endothelial function and arterial stiffness in minimally symptomatic obstructive sleep apnea. Am J Respir Crit Care Med. 2008; 178(9): 984-988. doi: 10.1164/rccm.200805-717- OC
26. Won C, Guilleminault C. Gender differences in sleep disordered breathing: implications for therapy. Expert Rev Respir Med. 2015; 9(2): 221-231. doi: 10.1586/17476348.2015.1019478
27. Zhang J, Chen L, Delzell E, et al. The association between inflammatory markers, serum lipids and the risk of cardiovascular events in patients with rheumatoid arthritis. Ann Rheum Dis. 2014; 73; 1301-1308. doi: 10.1136/annrheumdis-2013-204715
28. Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation. 1983; 67(5): 968-977. doi: 10.1161/01. CIR.67.5.968
29. Page JH, Rexrode KM, Hu F, Albert CM, Chae CU, Manson JE. Waist-height ratio as a predictor of coronary heart disease among women. Epidemiology. 2009; 20(3): 361-366. doi: 10.1097/EDE.0b013e31819f38f1
30. Jensen MD, Ryan DH, Apovian CM, et al. American College of Cardiology/American Heart Association Task Force on Practice Guidelines; Obesity Society. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation. 2014; 129(25 Suppl 2): S102-S138. doi: 10.1161/01.cir.0000437739.71477.ee
31. National diabetes statics report 2014, 2014. Available at: http://www.cdc.gov/diabetes/pubs/statsreport14/national-diabetes-report-web.pdf Accessed November 12, 2013.
32. Roeters van Lennep JE, Westerveld HT, Erkelens DW, van der Wall EE. Risk factors for coronary heart disease: implications of gender. Cardiovasc Res. 2002; 53(3): 538-549. doi: 10.1016/S0008-6363(01)00388-1
33. Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C. American Heart Association; National Heart, Lung, and Blood Institute. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004; 109(3): 433-438. doi: 10.1161/01. CIR.0000111245.75752.C6
34. Carr MC. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab. 2003; 88(6): 2404-2411. doi: 10.1210/jc.2003-030242
35. Gami AS, Witt BJ, Howard DE, et al. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol. 2007; 49(4): 403-414. doi: 10.1016/j.jacc.2006.09.032
36. Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol. 2013; 6: 1-13. doi: 10.2147/CLEP.S37559
37. de Groot PC1, Dekkers OM, Romijn JA, Dieben SW, Helmerhorst FM. PCOS, coronary heart disease, stroke and the influence of obesity: a systematic review and meta-analysis. Hum Reprod Update. 2011; 17(4): 495-500. doi: 10.1093/humupd/dmr001
38. Low CA, Matthews KA, Kuller LH, Edmundowicz D. Psychosocial predictors of coronary artery calcification progression in postmenopausal women. Psychosom Med. 2011; 73(9): 789- 794. doi: 10.1097/PSY.0b013e318236b68a
39. Bose M, Oliván B, Laferrère B. Stress and obesity: the role of the hypothalamic-pituitary-adrenal axis in metabolic disease. Curr Opin Endocrinol Diabetes Obes. 2009; 16(5): 340-346. doi: 10.1097/MED.0b013e32832fa137
40. Williams SA, KasI SV, Heiat A, Abramson JL, Krumholz HM, Vaccarino V. Depression and risk of heart failure among the elderly: a prospective community- based study. Psychosomat Med. 2002; 64: 6-12. doi: 10.1097/00006842-200201000-00002
41. Drory Y, Kravetz S, Hirschberger G, Israel Study Group on First Acute Myocardial Infarction. Long-term mental health of women after a first acute myocardial infarction. Arch Phys Med Rehabil. 2003; 84: 1492-1498. doi: 10.1016/S0003-9993- (03)00316-2
42. Bellamy L, Casas JP, Hingorani AD, Williams DJ. Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ. 2007; 335(7627): 974. doi: 10.1136/bmj.39335.385301.BE
43. Grant PT, Oats JN, Beischer NA. The long-term follow-up of women with gestational diabetes. Aust N Z J Obstet Gynaecol. 1986; 26(1): 17-22. doi: 10.1111/j.1479-828X.1986.tb01521.x
44. Siddiqui N, Hladunewich M. Understanding the link between the placenta and future cardiovascular disease. Trends Cardiovasc Med. 2011; 21(7): 188-193. doi: 10.1016/j.tcm.2012.05.008
45. August P. Hypertension in women. Adv Chronic Kidney Dis. 2013; 20(5): 396-401. doi: 10.1053/j.ackd.2013.07.002
46. Eisenberger A, Westhoff C. Hormone replacement therapy and venous thromboembolism. J Steroid Biochem Mol Biol. 2014; 142: 76-82. doi: 10.1016/j.jsbmb.2013.08.016
47. Shifren JL, Gass ML. NAMS Recommendations for Clinical Care of Midlife Women Working Group. The North American Menopause Society recommendations for clinical care of midlife women. Menopause. 2014; 21(10): 1038-1062. doi: 10.1097/ GME.0000000000000319
48. The Women’s Health Initiative Steering Committee. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA. 2004; 291: 1701-1712. doi: 10.1001/ jama.291.14.1701
49. Manson JE, Hsia J, Johnson KC, et al. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med. 2003; 349(6): 523-534. doi: 10.1056/NEJMoa030808
50. Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013; 368(11): 987-998. doi: 10.1056/NEJMoa1209825
51. Laddu AA, Alderson L, Chaitman BR. Exercise Testing, Coronary Artery Disease. Cardiovascular Medicine. 2015; 181- 203. doi: 10.1007/978-1-4471-2828-1_8
52. Gulati M, Pandey DK, Arnsdorf MF, et al. Exercise capacity and the risk of death in women: the St James Women Take Heart Project. Circulation. 2003; 108(13): 1554-1559. doi: 10.1161/01. CIR.0000091080.57509.E9
53. Nishime EO, Cole CR, Blackstone EH, Pashkow FJ, Lauer MS. Heart rate recovery and treadmill exercise score as predictors of mortality in patients referred for exercise ECG. JAMA. 2000; 284(11): 1392-1398. doi: 10.1001/jama.284.11.1392
54. Chou R. High Value Care Task Force of the American College of Physicians. Cardiac screening with electrocardiography, stress echocardiography, or myocardial perfusion imaging: advice for high-value care from the American college of physicians. Ann Intern Med. 2015; 162(6): 438-447. doi: 10.7326/ M14-1225
55. Budoff MJ, Young R, Lopez, et al. Progression of coronary calcium and incident coronary heart disease events: MESA (Multi-Ethnic Study of Atherosclerosis). J. Am. Coll. Cardiol. 2013; 61: 1231-1239. doi: 10.1016/j.jacc.2012.12.035
56. Roberts ET, Horne A, Martin SS, et al. Cost-Effectiveness of Coronary Artery Calcium Testing for Coronary Heart and Cardiovascular Disease Risk Prediction to Guide Statin Allocation: The Multi-Ethnic Study of Atherosclerosis (MESA). PLoS One. 2015; 10(3): e0116377. doi: 10.1371/journal.pone.0116377
57. Zeb I, Budoff M. Coronary Artery Calcium Screening: Does it Perform Better than Other Cardiovascular Risk Stratification Tools?. Int. J. Mol. Sci. 2015; 16: 6606-6620. doi: 10.3390/ ijms16036606
58. Cushman M, Arnold AM, Psaty BM, et al. C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study. Circulation. 2005; 112(1): 25-31. doi: 10.1161/CIRCULATIONAHA.104.504159
59. Butler R, Morris AD, Belch JJ, Hill A, Struthers AD. Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension. Hypertension. 2000; 35: 746-751. doi: 10.1161/01.HYP.35.3.746
60. Zhang JW, He LJ, Cao SJ, Yang Q, Yang SW, Zhou YJ. Association of serum uric acid and coronary artery disease in premenopausal women. PLoS One. 2014; 9(9): e106130. doi: 10.1371/journal.pone.0106130
61. Koton S, Howard SC, Warlow CP, Murphy MF, Rothwell PM. Serum urate predicts long-term risk of acute coronary events in women after a transient ischemic attack and stroke. Cerebrovasc Dis. 2008; 26(5): 517-524. doi: 10.1159/000155990
62. Alderman M1, Aiyer KJ. Uric acid: role in cardiovascular disease and effects of losartan. Curr Med Res Opin. 2004; 20(3): 369-379. doi: 10.1185/030079904125002982
63. Grundy SM, Pasternak R, Greenland P, Smith S Jr, Fuster V. Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology. Circulation. 1999; 100(13): 1481-1492. doi: 10.1161/01.CIR.100.13.1481
64. Goff DC Jr, Lloyd-Jones DM, Bennett G, et al. American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014; 129(25 Suppl 2): S49-S73. doi: 10.1161/01.cir.0000437741.48606.98
65. Cook NR, Paynter NP, Eaton CB, et al. Comparison of the Framingham and Reynolds Risk scores for global cardiovascular risk prediction in the multiethnic Women’s Health Initiative. Circulation. 2012; 125(14): 1748-1756, S1-11. doi: 10.1161/ CIRCULATIONAHA.111.075929
66. DeFilippis AP, Young R, Carrubba CJ, et al. An analysis of calibration and discrimination among multiple cardiovascular risk scores in a modern multiethnic cohort. Ann Intern Med. 2015; 162(4): 266-275. doi: 10.7326/M14-1281
67. Chomistek AK, Chiuve SE, Eliassen AH, Mukamal KJ, Willett WC, Rimm EB. Healthy lifestyle in the primordial prevention of cardiovascular disease among young women. J Am Coll Cardiol. 2015; 65(1): 43-51. doi: 10.1016/j.jacc.2014.10.024
68. James PA, Oparil S, Carter BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014; 311(5): 507-520. doi: 10.1001/jama.2013.284427
69. Heart and Circulation. Using Aspirin for the Primary Prevention of Cardiovascular Disease – Provider Fact Sheet, 2009. Available at: http://www.ahrq.gov/professionals/clinicians-providers/resources/aspprovider.pdf Accessed April, 2009.
70. Internet Citation: Recommendation Summary. U.S. Pre ventive Services Task Force, 2009. Available at: http://www. uspreventiveservicestaskforce.org/Page/Topic/recommendation-summary/aspirin-for-the-prevention-of-cardiovascular-disease-preventive-medication Accessed March, 2009.
71. Wolff T1, Miller T, Ko S. Aspirin for the primary prevention of cardiovascular events: an update of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2009; 150(6): 405-410. doi: 10.7326/0003-4819-150-6-200903170-00009
72. Ridker PM, Danielson E, Fonseca FA, et al. JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008; 359(21): 2195-2207. doi: 10.1056/NEJMoa0807646
73. Howard-Alpe G1, Foëx P, Biccard B. Cardiovascular protection by anti-inflammatory statin therapy. Best Pract Res Clin Anaesthesiol. 2008; 22(1): 111-133. doi: 10.1016/j. bpa.2007.08.001
74. Gerstein HC, Miller ME, Byington RP, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008; 358(24): 2545-2559. doi: 10.1056/NEJMoa0802743
75. Christian RC, Dumesic DA, Behrenbeck T, Oberg AL, Sheedy PF 2nd, Fitzpatrick LA. Prevalence and predictors of coronary artery calcification in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2003; 88(6): 2562-2568. doi: 10.1210/jc.2003-030334
76. Zeller CB, Appenzeller S. Cardiovascular disease in systemic lupus erythematosus: the role of traditional and lupus related risk factors. Curr Cardiol Rev. 2008; 4: 116-122. doi: 10.2174/157340308784245775
77. Manzi S, Wasko MC, Manzi S. Inflammation-mediated rheumatic diseases and atherosclerosis. Ann Rheum Dis. 2000; 59(5): 321-325. doi: 10.1136/ard.59.5.321