Vitamin C, E and Zinc Ameliorates Cadmium-Toxicity Induced Biochemical Changes in Male Albino Rats.
Environmental toxicants have become a major source of health hazards to humans, thereby negatively impacting the health and overall well-being of exposed individuals. Cadmium is a non-biodegradable heavy metallic which possesses a long half of lifestyles and comfortably accumulates inside the tissues in which it produces tissue toxicities main to tissue disorder.
Earlier reports suggest that heavy metals manifest their toxic effects by enhanced production of reactive oxygen species (ROS) production, a major cellular source of oxidative stress. ROS can damage every major cellular component, including membrane lipids, carbohydrates and deoxyribonucleic acid (DNA). The pathological consequence of such uncontrolled is wide spread tissue damage.
The data obtained in the present study also confirm that CD-intoxication causes a significant increase of lipid peroxidation concentration in liver tissue of rats. Since it causes lipid peroxidation in numerous tissues both in vivo and in vitro, 22 CD may induce oxidative stress by production of hydroxyl radicals,23 superoxide anions, nitric oxide and hydrogen peroxide. Cadmium exposure causes structural and functional damages to the cell membrane, significantly increasing permeability resulting in the leakage of hepatic enzymes into the blood.
Cadmium exposure results in hyperglycemia and is due to the toxic action of this metal on the secretory activity of the pancreas. Based on the present study results, it could be evident that CD has a harmful and stressful effect on hepatic, renal and hematological tissues. However, either individually or in combinations Vitamin C, E and Zinc had protective effects against CD-induced oxidative damage or stress.
Toxicol Forensic Med Open J. 2021; 6(1): 13-19. doi: 10.17140/TFMOJ-6-137
