The Use of Single-Cell Transcriptomics’ to Detect Cellular Transition through
Notch Signaling and Receptor Expression in Differentiated Kidney Collecting
Tubule Cells in Adult Mice: A Review
Molecular profiling is the screening of molecules to identify
deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and
protein. Over the last 45-years, gene sequencing has become a key
technology in many areas of biology and other sciences including medicine.
The advent of rapid DNA, RNA and protein sequencing
methods has greatly accelerated biological and medical research and discovery.
Its application to medicine continues to help further elucidate the biological
nature of disease processes and provides a better understanding of genetic diseases
by allowing for an ‘up close’ look at the genomic signature or fingerprint of diseases.
The advent of technology, such as transcriptomics, has
allowed for a better understanding and a more precise definition of disease.
This has shifted focus to specific pathways and the
genomic effects of disease processes. Transcriptomics has made
it possible to better predict prognosis and tailor care providers’ approach to treatment.
Molecular profiling has great potential. It has permitted targeted therapy to become the mainstay of
standard of care, in many cases, resulting in statistical differences in patient morbidity and mortality.
Nephrol Open J. 2019; 5(1): 15-18. doi: 10.17140/NPOJ-5-123