The Related Factors and Clinical Predictive Value of Left Atrial Spontaneous Echo Contrast in Patient with Nonvalvular Chronic Atrial Fibrillation.
Atrial fibrillation is the most common predisposing factor in the formation of LASEC, which is mainly related to a low left atrium blood flow velocity, blood stasis, the left atrium dysfunction and enlarged left atrium.
Numerous clinical and animal experiments show that the formation of SEC was usual accompanied by thrombus and thrombogenesis almost corresponded with blood stasis. PTS is a pathological process about blood coagulation fibrinolytic system involved in many factors and it is prone to cause hematological change to have a high risk for thromboembolism which increases blood coagulation, and tiny thrombosis that can increase the occurrence of thromboembolism has formed virtually with no positive presence by imageological examination.
However, currently, there is no uniform diagnostic criteria for PTS. D-dimer, as a maker of fibrin that has a procedure of product and degradation reflected PTS by someone, which has already reflected a slightly pathological change in blood coagulation fibrinolytic system, is quite sensitive and specificity.
Hypertension was the most important risk factor in Nonvalvular atrial fibrillation patients,
and the chronic hypertension impairs myocardial contractility, then the increased left ventricular diastolic pressure overload leads to elevation of the left atrial pressure, which causes decompensated LA enlargement, thus bloodstream slows down to result in blood stasis, sequentially Red Blood Cell (RBC) makes conglutination and aggregation to form local hypercoagulable state.
In addition, fresh LA thrombus is easy to fall off or dissolve by fibrinolysin without visualized place or size by ultrasonic probe, therefore, LASEC could get a long-time existence to have a higher prediction of stroke, and it also prompts clinicists to take anticoagulation therapy to prevent thrombogenesis.
Heart Res Open J. 2015; 2(1): 46-50. doi: 10.17140/HROJ-2-108