Recent Tendency of Therapeutic Medical Agents for Diabetic Peripheral Neuropathic Pain

*Corresponding author: Hiroshi Bando*


Recently, elder patients tend to have neuropathic pain such as lower back and joints pain, stiff shoulders, besides diabetic neuropathy. Typical peripheral neuropathic pain includes diabetic peripheral neuropathic pain (DPNP), postherpetic neuralgia (PHN) and chronic pain due to herniated disc. Three analgesic agents are described. Pregabalin (LyricaÂź) has been prevalent worldwide. However, it has been provided for several diseases for off-label administration, which has been one of the clinical problems.Mirogabalin (TarligeÂź) has revealed efficacy for DPNP in a dose-dependent manner. Duloxetine hydrochloride (CymbaltaÂź) has efficacy for pain and also depression as serotonin and noradrenaline reuptake inhibitor (SNRI).


Neuropathic pain; Pregabalin; Mirogabalin; Duloxetine hydrochloride; Diabetic peripheral neuropathic pain (DPNP).


DPNP: Diabetic peripheral neuropathic pain; PHN: Postherpetic neuralgia; CRPS: Complex regional pain syndrome; FDA: Food and Drug Administration.