Radiation-Induced Parotid Mucoepidermoid Carcinoma: A Systematic Review

Omar Ramadan*

Radiation-Induced Parotid Mucoepidermoid Carcinoma: A Systematic Review.

Salivary gland tumors are uncommon tumors that
represent about 1% of head and neck tumors,
only 5% of which occur among children. Among epithelial
tumors of the salivary glands, mucoepidermoid carcinoma
is the most frequently observed histological type of cancer
occurring in both adults and children.

It is also the most common type of parotid gland malignancies.
Parotid gland MEC may be characterized by symptoms such as the formation of
a painless mass, facial weakness, referred otalgia, trismus and parenthesis. MEC can occur
either as a primary or secondary malignancy.

Long-term evaluation and
a high index of suspicion for second cancers are mandatory
for all patients had radiotherapy
previously. The secondary salivary MEC usually develop years
or even decades after treatment of the first neoplasm has been completed.

Since the survival of patients with cancer is
improving, particularly amongst children, awareness of the spectrum of possible second tumors
like parotid gland MEC is of increasing importance.

The purpose of our article is to review the literature investigating
the cases of parotid MEC induced by

Search criteria were input as “radiation induced parotid
tumors”, “radiation induced salivary gland tumors,” “radiation
induced parotid MEC,” and “radiation induced salivary gland

Abstracts were first reviewed to search for articles that
discussed cases of MEC induced by radiation occurring in the
parotid gland and full-text articles were subsequently selected
and reviewed for extraction of data. References of the included
studies were examined for additional cases.

Outcome measures extracted included: demographic
data, radiation dose for primary desease, latent time, primary
treatment modality, secondary parotid MEC treatment, follow-up, recurrence, metastasis.

Otolaryngol Open J. 2016; 3(1): 9-15. doi: 10.17140/OTLOJ-3-134