Public Health

Open journal

ISSN 2472-3878

Pre-Travel Vaccinations and Malaria Prophylaxis for International Travelers

Androula Pavli and Helena C. Maltezou*

Helena C. Maltezou, MD, PhD

Department for Interventions in Health-Care Facilities, Hellenic Centre for Disease Control and Prevention, 3-5 Agrafon Street, Athens 15123, Greece, Tel. 30-210-5212-175; Fax: 0-210-5212-177; E-mail:


International travel has increased dramatically the past decades. The number of international arrivals is expected to reach 1.6 billion by the year 2020, with a significant increase noted in tropical and subtropical areas.1 International travels may pose health risks for the individual and contribute to the global spread of infectious diseases. Vaccine-preventable diseases constitute a non-negligible proportion of imported infectious diseases to developed countries.2,3 GeoSentinel Surveillance Network data demonstrated that vaccine-preventable diseases accounted for 3% of febrile episodes among 6957 travelers who reported fever as a chief reason for seeking care after travel at a GeoSentinel clinic during 1997-2006.4 In this GeoSentinel study, typhoid fever, hepatitis A, and influenza A were the most common vaccine-preventable diseases among febrile travelers after returning mainly from a travel to a tropical or subtropical area.4

Vaccinations are considered an important preventive measure of pre-travel preparation.5,6 In addition, pre-travel vaccinations most probably constitute the most common reason international travelers seek consultation for prior to their departure.5,6 Travel vaccines include a) routine vaccines which consist of vaccines incorporated in the national immunization programs, b) required vaccines which are necessary for entry into certain countries, and c) recommended vaccines whose recommendation depends on the risks of exposure at travel destination.

Malaria is endemic in over 100 tropical and subtropical countries worldwide, with an estimated annual global burden of 350-500 million infections and approximately 1 million deaths, 90% of which occur in sub-Saharan Africa only.7,8,9,10 The increasing international travel in association with the enormous influx of immigrants from malaria-endemic countries had a significant impact on imported malaria cases in developed countries the past decades.11,12,13 Although the number of malaria cases has decreased significantly over the past years,9 it is estimated that more than 10,000 international travelers who visit malaria-endemic areas acquire malaria every year; this figure may be higher due to under-reporting.12 In most of these cases, anti-malaria prophylaxis either was not prescribed or the patient did not adhere to prophylaxis. Occasionally, incorrect anti-malaria prophylaxis is prescribed.14

Risk assessment should be individualized on the basis of the epidemiological situation at destination, travel characteristics (e.g., areas visited, purpose and duration of travel), and traveler’s characteristics (e.g., age, medical and previous vaccination history).5,6 In addition, pre-travel consultation provides a timely opportunity for updating routine vaccinations.5,6,15,16 Travel medicine consultants should get updated information about the current epidemiology trends globally from public health authorities through internet, and be familiarized with the adverse events of vaccines and anti-malaria medications among others.

This is a short review of pre-travel advice in regards to vaccination and malaria prophylaxis for international travelers to developing countries. Different trends of pre-travel advice are taken under consideration.

Pre-travel Vaccinations

Vaccinations are key parts of travel preparation for the reduction of the risk of vaccine-preventable diseases for the traveler as well as the risk of their international spread. GeoSentinel data demonstrated that 1.5% of 37,542 ill returned travelers presenting to a GeoSentinel site had vaccine-preventable infections; only 29% of those attended for pre-travel consultation which emphasizes the potentially lost opportunity for intervention, given the high efficacy of almost all vaccines.2

Travel provides an opportunity for travelers to update their routine immunizations, which are incorporated in their national immunization programs including tetanus-diphtheria vaccine, measles-mumps-rubella (MMR), poliomyelitis, meningococcal and influenza vaccines.

Travel vaccines include hepatitis A, typhoid fever, cholera, meningococcal, yellow fever, rabies and Japanese encephalitis vaccines. Although there is a 10-50 fold decrease of hepatitis A incidence in travelers the last few years, the relative risk for travelers remains significant,17,18 and now-a-days hepatitis A remains one of the common vaccine-preventable diseases diagnosed among international travelers. Travelers, especially those visiting friends and relatives (VFRs), may also contribute to the importation of vaccine-preventable diseases in their countries of permanent residence and occasionally to the re-emergence of the onset of epidemics of vaccine-preventable diseases. Such a notable example is hepatitis A. All susceptible people aged over 1 year traveling for any purpose, frequency, duration to countries with high or intermediate hepatitis A endemicity especially if they are traveling to rural areas should be vaccinated before departure (2 doses scheme).6,19,20

Typhoid fever which is hyper-endemic in the Indian subcontinent is a common diagnosis among ill returning travelers accounting for 47.6% of all vaccine-preventable disease cases.2 Typhoid vaccination is recommended for travelers to developing countries according to the type of accommodation (local peoples’ homes), duration of travel (longer duration of travel) and eating behaviour (adventurous eater).6,19,20 The risk of cholera infection for most travelers is very low. It is indicated for humanitarian relief workers in disaster areas and refugee camps who may be at risk.19

Meningococcal vaccine is indicated for long-term travelers, and particularly for those living in close contact with the indigenous population and thus are at risk for meningococcal infection.6,19,20,21 Haji pilgrims, travelers to sub-Saharan Africa, especially to the meningitis belt, as well as international university students are at increased risk for meningococcal disease and should be vaccinated accordingly before departure.

Yellow fever (YF) vaccination is recommended for the prevention of travelers to areas where there is a risk of the disease. Under International Health Regulations (IHR, 2005), any country may require a YF vaccination certificate for travelers coming from areas with risk of yellow fever transmission, even if travelers are on transit through the country. Only a small number of African countries require proof of YF vaccination from all arriving travelers.19

Rabies is not a common travel related infection however the disease has potentially long latency and a fatal outcome. Pre-exposure rabies vaccination is recommended to long-term travelers, particularly to children and to those involved in extensive outdoor activities in rural areas, namely bicycling, hiking, camping, and backpacking even if they travel for short duration.6,19,20 Rabies vaccination is also recommended for specific occupations at risk (e.g., veterinarians).

The risk of Japanese encephalitis (JE) in persons from non-endemic countries traveling to Asia is considered low. However JE vaccination is indicated for travelers who stay for prolonged period of time in rural areas with active JEV transmission and expatriates.6,19,20,22

Malaria Prophylaxis

Malaria prophylaxis recommendations depend on a risk-benefit analysis, weighting the risk of the disease against the risk of possible side effects of the drug.23,24 There are only few evidence-based studies available regarding the risk of infection in travelers.25,26,27,28 Prescribing practices vary to a great extent between different countries. While in Europe ‚Äústand-by-medication‚ÄĚ is used for many malaria-endemic areas without high endemicity, in the USA a stand-by-medication strategy is not established.29,30,31

Destination is considered the main risk factor in regards to the risk assessment of malaria acquisition.32,33,34 According to the GeoSentinel surveillance network database, the risk for acquiring malaria per region visited was higher in sub-Saharan Africa followed by Oceania, South Asia, Central America, Southeast Asia and South America.35 Analysis of malaria imported into eight European countries from the Indian subcontinent, led to a consensus statement by the TropNet group recommending that non-selective prescription of prophylaxis for visitors to India, Pakistan, Bangladesh, and Sri Lanka should be dropped.31

Travelers VFRs are at higher risk for acquisition of malaria compared to non-VFRs,35,36,37,38 and according to GeoSentinel data that migrants VFRs were 4.5 times more likely to acquire malaria compared with tourist travelers, and this increase was even greater (8-fold) when travel destination was sub-Saharan Africa.39 VFRs typically demonstrate travel and behavioural patterns which render them at high risk for malaria exposure. Contributing factors include lack of provision of pre-travel services which are rarely sought by VFRs and misconceptions about possession of life-long immunity against malaria which make them less likely to receive or adhere to malaria prophylaxis recommendations. In addition, VFRs may face difficulties in accessing health-care services due to economic, cultural, language, or legal issues.35,36,37,38,39 Long-term travelers including expatriates are also at higher risk for acquisition of malaria due to longer exposure to areas where the disease is endemic and poor compliance to continuous malaria prophylaxis and personal protective measures.23,40 Travel-medicine consultants should be familiar with malaria prophylaxis, and especially with their side effects and contra-indications. Advice about mosquito protection should be provided. Travelers should be aware of the signs and symptoms of malaria and issues of self-medication should be discussed, on the basis of travel and travelers characteristics. Lastly, travelers traveling to or returning from malaria endemic areas should be advised that they should seek immediate medical attention in case they develop fever. If this is the case, their travel history should be reported to their healthcare professionals and the diagnosis of malaria should be verified or excluded through accurate tests.


Recommendations of vaccination and malaria prophylaxis should be based on selective and individualized risk assessment taking in consideration, not only the travel destination, but also the duration and purpose of travel, the area and specific place of stay, and the travelers activities. Public health authorities should increase awareness of travelers and health professionals for travel related health issues in order to prevent travel-associated vaccine-preventable diseases and malaria and promote safety both for the traveler as well as for the community.


The authors declare that they have no conflicts of interest.

1. United Nations World Tourism Organization. Annual Report. 2015. Web site. Accessed December 13, 2016.

2. Boggild AK, Castelli F, Gautret P, et al. Vaccine preventable diseases in returned international travelers: Results from the GeoSentinel Surveillance Network. Vaccine. 2010; 28(46): 7389-7395. doi: 10.1016/j.vaccine.2010.09.009

3. Centers for Disease Control and Prevention. Measles outbreaks. Web site. Accessed December 13, 2016.

4. Wilson ME, Weld LH, Boggild A, et al. Fever in returned travelers: Results from the GeoSentinel Surveillance Network. Clin Infect Dis. 2007; 44(12): 1560-1568. doi: 10.1086/518173

5. Lau S, Gherardin T. Travel vaccination. Aust Fam Physician. 2007; 36(5): 304-311. Web site. Accessed December 13, 2016.

6. Virk A, Jong EC. Adult immunizations. In: Keystone JS, Kozarsky PE, Freedman DO, Nothdurft HD, Connor BA, eds. Travel Medicine. Elsevier: Mosby, Spain; 2004: 87-123.

7. Reiter P. Global warming and malaria: Knowing the horse before hitching the cart. Malar J. 2008; 7(Suppl 1): S3. doi: 10.1186/1475-2875-7-S1-S3

8. Sachs J, Malaney P. The economic and social burden of malaria. Nature. 2002; 415(6872): 680-685. doi: 10.1038./415680a

9. World Health Organization. World Malaria Report. 2016. Web site. Accessed December 13, 2016.

10. Mali S, Steele S, Slutsker L, Arguin PM. Centers for Disease Control and Prevention (CDC). Malaria surveillance-United States, 2006. MMWR Surveill Summ. 2008; 57(SS05): 24-39.

11. Romi R, Sabatinelli G, Majori G. Malaria epidemiological situation in Italy and evaluation of malaria incidence in Italian travelers. J Travel Med. 2001; 8(1): 6-11. doi: 10.2310/7060.2001.5140

12. Malaria. International Travel and Health. Web site. Accessed December 13, 2016.

13. Ehrhardt S. Malaria. In: Maltezou HC, Gikas A, eds. Tropical and Emerging Infectious Diseases. Kerala, India: Research Signpost; 2010: 147-162.

14. Keystone JS, Steffen R, Kozarsky PE. Health advice for international traveler. In: Guerrant RL, Walker DH, Weller PF, eds. Tropical Infectious Diseases: Principles, Pathogens, and Practice. Philadelphia, USA: Churchill Livingstone Elsevier; 2006: 1400-1424. doi: 10.1645/0022-3395(2007)93[391:TIDPPP]2.0.CO;2

15. World Health Organization. International Travel and Health. Web site. Accessed December 13, 2016.

16. Centers for Disease Control and Prevention. Web site. Accessed December 13, 2016.

17. Steffen R. Changing travel-related global epidemiology of hepatitis A. Am J Med. 2005; 118 (Suppl 10A): S46-S49. doi: 10.1016/j.amjmed.2005.07.016

18. Mutsch M, Spicher VM, Gut C, Steffen R. Hepatitis A virus infections in travelers, 1988-2004. Clin Infect Dis. 2006; 42(4): 490-497. doi: 10.1086/499816

19. Liu SJ, Sharapov U, Klevens M. Patient awareness of need for hepatitis a vaccination (prophylaxis) before international travel. J Travel Med. 2015; 22(3): 174-178. doi: 10.1111/jtm.12186

20. Pavli A, Spilioti A, Lymperi I, Katerelos P, Maltezou HC. Vaccinations for international travellers travelling from Greece. Travel Med Infect Dis. 2013; 11(4): 225-230. doi: 10.1016/j.tmaid.2012.11.007

21. Pavli A, Katerelos P, Smeti P, Maltezou HC. Meningococcal vaccination for international travellers from Greece visiting developing countries. Travel Med Infect Dis. 2016; 14(3): 261-266. doi: 10.1016/j.tmaid.2016.03.001

22. Pavli A, Maltezou HC. Travel-acquired Japanese encephalitis and vaccination considerations. J Infect Dev Ctries. 2015; 9(9): 917-924. doi: 10.3855/jidc.5108

23. Pavli A, Smeti P, Spilioti A, Vakali A, Katerelos P, Maltezou HC. Descriptive analysis of malaria prophylaxis for travelers from Greece visiting malaria-endemic countries. Travel Med Infect Dis. 2011; 9(6): 284-288. doi: 10.1016/j.tmaid.2011.09.005

24. Schlagenhauf P, Petersen E. Malaria chemoprophylaxis: Strategies for risk groups. Clin Microbiol Rev. 2008; 21(3): 466-472. doi: 10.1128/CMR.00059-07

25. Phillips-Howard PA, Radalowicz A, Mitchell J, Bradley DJ. Risk of malaria in British residents returning from malarious areas. BMJ. 1990; 300(6723): 499503. doi: 10.1136/bmj.300.6723.499

26. Steffen R, Fuchs E, Schildknecht J, et al. Mefloquine compared with other malaria chemoprophylactic regimens in tourists visiting East Africa. Lancet. 1993; 341(8856): 1299-1303. doi: 10.1016/0140-6736(93)90814-w

27. Overbosch D, Schilthuis H, Bienzle U, et al. Malarone International Study Team. Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: Results from a randomized, double-blind study. Clin Infect Dis. 2001; 33(7): 1015-1021. doi: 10.1086/322694

28. Calleri G, Behrens RH, Bisoffi Z, et al. Variability in malaria prophylaxis prescribing across Europe: A Delphi method analysis. J Travel Med. 2008; 15(5): 294-301. doi: 10.1111/j.1708-8305.2008.00226.x

29. Freedman DO, Weld LH, Kozarsky PE, et al. Spectrum of disease and relation to place of exposure among ill returned travelers. N Engl J Med. 2006; 354(2): 119-130. doi: 10.1056/NEJMoa051331

30. Schlagenhauf P, Petersen E. Standby emergency treatment of malaria in travelers: Experience to date and new developments. Expert Rev Anti Infect Ther. 2012; 10(5): 537-546. doi: 10.1586/eri.12.42

31. Behrens RH, Bisoffi Z, Björkman A, et al. Malaria prophylaxis policy for travellers from Europe to the Indian Subcontinent. Malar J. 2006; 5: 7. doi: 10.1186/1475-2875-5-7

32. Gautret P, Schlagenhauf P, Gaudart J, et al. Multicenter Euro TravNet/GeoSentinel study of travel-related infectious diseases in Europe. Emerg Infect Dis. 2009; 15(11): 1783-1790. doi: 10.3201/eid1511.091147

33. Field V, Gautret P, Schlagenhauf P, et al. Travel and migration associated infectious diseases morbidity in Europe, 2008. BMC Infect Dis. 2010; 10: 330 doi: 10.1186/1471-2334-10-330

34. Fenner L, Weber R, Steffen R, Schlagenhauf P. Imported infectious disease and purpose of travel, Switzerland. Emerg Infect Dis. 2007; 13(2): 217-222. doi: 10.3201/eid1302.060847

35. Ericsson CD, Hatz C, Leder K, et al. Illness in travelers visiting friends and relatives: A review of the GeoSentinel Surveillance Network. Clin Infect Dis. 2006; 43(9): 1185-1193. doi: 10.1086/507893

36. Angell SY, Cetron MS. Health disparities among travelers visiting friends and relatives abroad. Ann Intern Med. 2005; 142(1): 67-72. doi: 10.7326/0003-4819-142-1-200501040-00013

37. Angell SY, Behrens RH. Risk assessment and disease prevention in travelers visiting friends and relatives. Infect Dis Clin North Am. 2005; 19(1): 49-65. doi: 10.1016/j.idc.2004.11.001

38. Pavli A, Katerelos P, Pierroutsakos P, Maltezou HC. Pre-travel counselling in Greece for travelers visiting friends and relatives. Travel Med Infect Dis. 2009; 7(5): 312-315. doi: 10.1016/j.tmaid.2009.07.002

39 Toovey S, Moerman F, van Gompel A. Special infectious disease risks of expatriates and long-term travelers in tropical countries. Part I: Malaria. J Travel Med. 2007; 14(1): 42-49. doi: 10.1111/j.1708-8305.2006.00091.x

40. Barnett ED, MacPherson DW, Stauffer WM, et al. The visiting friends or relatives traveler in the 21st century: Time for a new definition. J Travel Med. 2010; 17(3): 163-170. doi: 10.1111/j.1708-8305.2010.00411.x


From Neck Pain to a Life-Threatening Condition: A Case Report

Floris Vandewoude* and Sören Verstraete


Chest X-ray Showed a Hazy Left Upper Lung Infiltrate

A Noteworthy Case of Myasthenic Crisis Induced by Levofloxacin

Ada Young*, Ramya Ramesh and Milind Awale


The Right Thigh Anterior Compartment was Swollen, and the Skin was Ulcerated due to the Traditional Cautery

Primary Skeletal Muscle Lymphoma: A Case Report and Literature Review

Solomon Bishaw*, Addisu Alemu and Abel Tefera