Parenteral Diarrhea and Pediatric Urinary Tract Infections: A Systematic Review

Larry B. Mellick*, Sarathi Kalra and Edward Panacek

Parenteral Diarrhea and Pediatric Urinary Tract Infections: A Systematic Review.

It is important to recognize the association between non-infectious diarrhea and urinary tract infections to avoid delayed diagnosis and treatment of associated urinary tract infections or misdiagnosis of infectious diarrhea. We hypothesized that an association exists between the presence of diarrhea and culture-proven The purpose of this systematic review of the literature was to determine the reported frequency of associated UTI in cohort and case control studies of pediatric patients who had diarrhea.

After excluding 25 articles and adding 3 articles identified during manual review of article references,  Escherichia coli was the most common bacterial isolate from urine in all 9 studies that reported microbiology result. The stool and urine culture results (E. coli) were similar in 4 of the 6 studies that reported stool culture results. We excluded studies that examined particular diets such as breastfed or low-lactose or specific pediatric patient. We searched electronic databases (PubMed, Scopus, Google Scholar, and CINAHL) to identify articles about parenteral diarrhea and UTI using the following terms

The present systematic review confirmed an association between diarrhea and UTIs in 15.8% of infants and children up to age 5-years presenting with diarrhea, which is decidedly greater than the prevalence of UTI in febrile and afebrile young children.
Characteristics of studies and study patients were extracted manually including country, study type, patient age range, clinical history, presence of fever, urine sample method, number of patients in the study, number of patients who had UTI, microbiology results, and study level of evidence,8
quality, and limitations.

Pediatr Neonatal Nurs Open J
. 2022; 8(2): 38-42. doi: 10.17140/PNNOJ-8-137