Immunomodulatory Effects of Mesenchymal Stem Cells on T- and B-Cells in a Quiescent
State in a Chronic Experimental Model of Autoimmune Encephalomyelitis
MSC have been characterized by their multipotentiality and
their capacity for immunomodulation, thus raising great hopes in regenerative medicine.
They have the capacity to differentiate into mesodermal-derived
or into neural-like and glial-like cells they have been shown to have
immunoregulatory properties they secrete factors that may stimulate
endogenous neural stem cells in the CNS they can be safely injected autologously
without the need for immunosuppression they decrease the number of infiltrating inflammatory cells,
preserving axons and ameliorating demyelination, ameliorate neuroinflammation
and exert a neurotrophic action.
The effects of MSC on T- and antigen-presenting cells have been studied in depth.
Nevertheless, and contrary to their well-known effect on T-cells and antigen-presenting cells,
the effect of MSC on B-cells remains unclear.
The distribution of MSC in bone marrow and secondary lymphoid organs
allows an intimate interaction between both cell subsets, which contributes to normal
lymph node development as well as to the support of tumor B-cells in follicular lymphomas.
Therefore, the study of the effect of MSC on B-lymphocytes is necessary to increase our
insight into autoimmune processes such as MS. In addition to the demonstration
of the immunomodulatory effects of MSC on.
In the light of the foregoing data, we tested the therapeutic potential
of intravenously injected BM-MSC from healthy donors in a chronic EAE model.
We studied in vitro the immunomodulatory effects of MSC on the
B- and T-lymphocytes of both control and EAE animals and the
effects of intravenously administered MSC on EAE episodes.
Neuro Open J. 2017; 4(1): 38-49. doi: 10.17140/NOJ-4-128