Public Health

Open journal

ISSN 2472-3878

Hypertension Management in Primary Health Care Centres: Blood Pressure Control and Classes of Antihypertensive Medication, Khartoum State, 2018

Maha A. G. Magboul, Egbal A. B. A. Karaig* and Ibtisam A. Ali

Egbal A. B. A. Karaig, DRH, FFPH

Co-investigator, Fellowship in Community Medicine SMSB, Public Health Consultant, Planning Directorate, Federal Ministry of Health, Khartoum Sudan; E-mail: drigbal@gmail.com

BACKGROUND

Globally there are one billion hypertensive patients due to the prevalence of contributing modifiable risk factors. These factors, such as unhealthy diet, physical inactivity, tobacco and alcohol use, and hyperlipidemia–which are not yet well-addressed, will lead to an increasing number of patients. In the Eastern Mediterranean Region, the prevalence of hypertension averages 26% and it affects approximately 125 million individuals.1

Hypertension has the highest prevalence among the major non-communicable diseases (NCDs) in Sudan, represented a quarter of NCDs.2 Hypertension in Sudan is one of the ten leading diseases treated in outpatients of health facilities and also is one of the ten leading causes of death.3 Proper management of hypertension has been associated with about a 40% reduction in the risk of stroke and about a 15% reduction in the risk of myocardial infarction. Thus, by applying standard management of hypertension, we can reduce the major complications that lead to morbidity, disability and mortality.4

The goals for the management of hypertension are well-defined, effective therapies are widely available, and practice guidelines for hypertension have been disseminated extensively. Even with such advances, hypertension control rates are still low.5

World Health Organization (WHO) defined medication adherence as “the extent to which the medication-taking behavior of a patient corresponds with agreed recommendations from a health care provider”.6 It is important in achieving blood pressure control.7 Patients who were adherent to the regimen of their hypertension treatment were often significantly less likely to have elevated blood pressures.8 Unfortunately, poor adherence to medications is widespread especially in the treatment of chronic conditions such as hypertension leading to poor health outcomes and huge medical spending on drug-related morbidity. As reported by the WHO, adherence to medication in patients with chronic diseases averages only around 50% in developed countries. The situation is reported to be worse in developing countries due to poor accessibility to medications and health care services. The asymptomatic nature of the condition intensifies the problem of non-adherence in hypertension.6,9

The overall prevalence of hypertension in Sub-Saharan Africa (SSA) is estimated to be 30%, ranging from 16% at the age of 30-years to 44% at the age of 60.10 About 74.7 million individuals are currently hypertensive in SSA, and this number is expected to increase to 125.5 million individuals by the year 2025. In Sudan, the prevalence of hypertension in urban communities witnessed a dramatic increase from 7.5% in 1990 to 18.2% in 2012.11,12

In Sudan, delivery of care has been based on the primary health care (PHC) level which is the first contact of the community with the health system. A high percentage of the population use PHC, as it is more accessible and affordable and hence it has the drive to reach vulnerable populations. The PHC approach, with over 2078 PHC Centres and 380 rural hospitals, distributed all over Sudan supposed to deliver promotive, protective, curative, and rehabilitative services, but have never functioned as such as mentioned in the non-communicable diseases strategy 2010.13

PHC Centres are proposed to play an essential role in the provision of continuous, comprehensive care for hypertensive patients.

This study aimed to reveal the control status and treatment compliance among Sudanese hypertensive patients in Khartoum State, for possible public health application of the findings by the Ministry of Health (MOH) targeting at improving the management of hypertension at the PHC level.

MATERIALS AND METHODS

Study Design and Area

The study was a descriptive cross-sectional, health Centre’s based study. It was conducted in PHC Centres in Khartoum State in the three major localities; Khartoum, North Khartoum and Omdurman. There are consultants of family medicine in all these Centres. These Centres provided services in form of health education, regular follow-up for patients with chronic diseases, routine blood investigations. These services were provided covered with health insurance (HI), while the medicine included in the HI drug list was provided covered with 75% of the cost. Medicine not included in the HI drug list will be fully paid for by the patients. The study population included hypertensive patients who attended the selected PHC Centres State; it recruited all diagnosed Sudanese hypertensive patients whose age was more than 18-years.

Sample Size and Sampling

The sample size was calculated to be 384 using the formula n=Z2pq/e2, where Z=1.96 (which corresponds to the level of confidence); p=0.5 (estimated proportion of the population with controlled hypertension); Q=1-p=0.5; e=margin of error at 95th confidence interval (C.I) (0.05).

The total sample size was divided equally by the number of centres, and 64 patients were enrolled from each centre. The selection of the Centres was done purposively based on their geographical location, caseload and presence of a family physician as the care provider. Based on that six PHC centres were identified; [(2 in Khartoum (Omer Ibn-Alkhatab and GeraifGhareb Centre, 2 in Khartoum North (Alkhatmeiah and Alenghaz Centres) and 2 in Omdurman (AldawHagog and Wad Nobawie Centres)] The selection of the patients was done following a systematic selection of all diagnosed hypertensive patients who attended the outpatient clinic for follow-up during the study period, till reaching the sample size in each health centre.

Ethical Considerations

Ethical approval was obtained from the institutional review board (IRB) of the Sudan Medical Specialization Board (SMSB). Written consent was obtained from the administration of the six PHC Centres in the study area. Verbal consent was obtained from all participants through taking their agreement to participate after explaining to them the study objectives and benefits. The participants were informed of their rights that their participation in the study is completely voluntary and confidentially has been considered.

Data Collection Tools and Techniques

The study collected data by interviewing hypertensive patients and measuring their blood pressure (BP). The researcher assisted by twelve medical doctors – who have been trained by the researcher–collected the data using a structured pretested questionnaire developed by the researcher. The questionnaire followed the steps and recommendations of the Sudanese guideline in the management of hypertension. It covered the personal data, disease features, medication compliance and types. The medication compliance was assessed by asking the hypertensive patients about their practice concerning pills taking during the last month.

The BP was measured using a mercury sphygmomanometer; patients were relaxed and seated for five-minutes with uncrossed legs, back and arm supported. The researchers checked the right and left radial pulse, if they were the same then they used the left arm to measure the BP. If they were differed they measured the BP in both arms and took the highest reading. BP was used by placing the middle of the cuff on the upper arm at the level of the heart. One reading of BP was being taken for each patient, but if the BP reading as high as 160/100 the researchers gave the patient another five minutes for rest then measuring BP again and they took a second reading. The study variables included the demographic characteristics (age, gender, educational levels, occupation), disease features (hypertension duration, comorbidities, antihypertensive medications, medication compliance) as independent variables and hypertension control as the dependent variable.

Data Analysis

Data were analyzed by using a statistical package for the Social Science version 21.0. The researchers agreed on the level of 140/90 as the cutoff for the controlled hypertension. A Chi-square test was used to obtain the p value to test the association between the hypertension control and other variables.

RESULTS

Sample Coverage and Characteristics of the Study Population

In total, 384 hypertensive patients were interviewed, of them, 57% as females. The age of 47.7% of the studied population was more than 60-years, while only 5.7% were in the age group less than 40-years. A large percentage of the subjects were either primary educated or illiterate (32.6%, 19.8% respectively), whereas those having a post-university education were only (9.6%). Concerning their occupations, the majority were housewives (44%) (Table 1).

 

Table 1. Demographic Characteristics of the Hypertensive Patients Who Attended PHC. Khartoum State, Sudan, 2018
 

Hypertension Control

p value
Controlled (%)

Uncontrolled (%)

Gender
Male

71 (42.5%)

96 (57.5%)

0.266

Female

113 (52.1%)

104 (47.9%)

Age (Years)

<40

5 (22.7%) 17 (77.3%) 0.026
40–60 83 (46.4%)

96 (53.6%)

>60

96 (52.5%)

87 (47.5%)

Educational Levels
Illiterate

21 (27.6%)

55 (72.4%)

0.005

Primary

45 (36%)

80 (64%)

Secondary

34 (41.5%)

48 (58.5%)

University

51 (79.6%)

13 (20.4%)

Post-university

32 (86.5%)

5 (13.5%)

Occupation
Worker

27 (35.5%)

49 (64.5%)

0.061

Employee

64 (47.4%)

71 (52.6%)

Housewife

93 (55%)

76 (45%)

Student

0 (0%)

4 (100%)

 

Disease Features

Regarding the hypertension control status, more than half of the patients (52.1%) were uncontrolled, whereas the median of systolic blood pressure (SBP) was 135, about one-half (50.3%) of the patients had SBP less than 140. Moreover, the median of diastolic blood pressure (DBP) was 80, where 57% of the patients had DBP less than 90.

According to the hypertension duration, the majority (71%) of the patients had the disease for less than 10-years. More than half of the hypertensive patients had no comorbidities (52.9%). Diabetes was predominant (39.3%) among those who had comorbidities. The majority of the patients (92.7%) were adherent to the medication (Table 2).

 

Table 2. Clinical Characteristics and Drug Management of the Hypertensive Patients Attended PHC, Khartoum State, Sudan, 2018

Clinical Characteristics

Hypertension Control p Value
Controlled (%)

Uncontrolled (%)

Duration (Years) 
<5

68 (51.9%)

63 (48.1%)

0.036

5-10

62 (44%)

79 (56%)

>10

54 (48.2%)

58 (51.8%)

Comorbidities
Diabetes

73 (48.3%)

78 (51.7%)

0.159

Pervious stroke

4 (26.7%)

11 (73.3%)

0.000

CKD

5 (33.3%)

10 (66.7%)

0.046

None

102 (50.2%)

101 (49.8%)

0.215

Medication Adherence
Adherent

184 (51.7%)

172 (48.3%)

0.000

Non-adherent

0 (0%)

28 (100%)

Drugs
Mono-therapy

84 (37.7%)

139 (62.3%)

0.008

Combined therapy

100 (62.1%)

61 (37.9%)

 

Table 3 displayed the main reasons for non-adherence, where the majority mentioned ignorance of the importance of complying with the drug regimen, thus neglecting taking it regularly. In addition, 34% stated the financial problem as a reason for non-adherence, where they couldn’t pay for the cost of the drugs. Few of the study population mentioned that they dislike taking many pills during the day.

 

Table 3. Reasons of Non-Adherence among the Non-Adherent Hypertensive Patients (n=28) Attended PHC, Khartoum State, Sudan, 2018
 

N

%

Reasons of non-compliant
Financial problem

10

35.6

Dislike to take many pills during the day

6

21.4

Ignorance of the importance of drug compliance

12

43%

 

Concerning hypertension drug management, 58.1% of the studied patients used mono-therapy and the remaining used combined therapy. Calcium channel blocker (CCB) was found to be the common monotherapy used followed by Angiotensin covering enzyme inhibitor (ACEI) then Angiotensin receptor blocker (ARB) and beta-blocker are the least (27.6%, 16.7%, 12%, 1.8% respectively). On the other side the combination of ACEI and CCB was found to be the predominant used by 11.2% of the patients, then CCB and ARB in 9.1% and ACEI and beta-blocker in 5.2% of the patients. A triple combination of CCB, ARB and diuretics was used by 3.4% and ACEI, CCB and beta-blocker in 0.5% of the patients (Table 4).

 

Table 4. Distribution of Controlled and Uncontrolled Hypertensive Patients with the Types of Mono and Combined Therapy among Patients Attended PHC, Khartoum State, Sudan, 2018
 

Hypertension Control

p value
Controlled (%)

Uncontrolled (%)

Mono-therapy
Beta-Blocker

4 (57.1%)

3 (42.9%)

0.001

ACEI

25 (39.1%)

39 (60.9%)

ARB

36 (78.3%)

10 (21.7%)

CCB

55 (51.9%)

51 (48.1%)

Combined Therapy 
ACEI+Beta-Blocker

5 (45%)

11 (55%)

0.000

ACEI+CCB

18 (41.9%)

25 (58.1%)

ACEI+Diuretic

0 (0%)

13 (100%)

ACEI+ARB

0 (0%)

2 (100%)

Beta-Blocker+Diuretic

0 (0%)

6 (100%)

Beta-Blocker+CCB

4 (44.4%)

5 (55.6%)

Beta-Blocker+ARB

5 (41.7%)

7 (58.3%)

Diuretic+ARB

5 (100%)

0 (0%)

CCB+ARB

18 (51.4%)

17 (48.6%)

CCB+Diuretic

0 (0%)

1 (100%)

ACEI+CCB+Beta-Blocker

0 (0%)

2 (100%)

CCB+ARB+Diuretics

9 (69.2%)

4 (30.8%)

DISCUSSION

The study revealed that females were more affected by hypertension than males (57% vs. 44% respectively) with a ratio of 1.3:1 and about half of the hypertensive patients (47.7%) had aged more than 60-years, this is consistent with a study conducted by Eltagi et al14 in Khartoum, which showed a positive increase of hypertension with age, the prevalence reached 100% among those above 60-years and 51.7% among those in age group (46-60-years), also they found that the females were commonly affected by hypertension than males (53.5% vs. 46.5%). This is also in line with other studies where the risks of hypertension increase with age.15,16,17 This confirms that the prevalence of hypertension is affected by age and gender.

This study showed that diabetes was predominant in (39.3%) patients followed by previous stroke (3.9%) and chronic kidney disease (CKD) (3.9%). Also, Eltagi et al14 revealed that diabetes and kidneys’ problems were the main comorbidities in hypertensive patients. Also, the results showed that diabetic patients had five-four times more likely to have hypertension compared to those who have no history of diabetes OR 5.44 (95% CI 1.89-15.69, p=0.017).14 Also, Balla et al noticed that in Sudan among rural population diabetes and hypertension are closely interrelated.18 Another study that was carried out in Ethiopia revealed that self-reported diabetes was a significant predictor of hypertension.15

Also, the current study demonstrated that 52.1% of the patients were uncontrolled, this was lower than what was reported by Abdulmohsin et al19 which was 60%, and the Canada Heart Health Survey that found only 13% of Canadians with hypertension were adequately controlled,20 and higher than what reported by Al-Shammari et al21 which was 28.8%, and the international study conducted by Birtwhistle et al22 which revealed 20%. This result also was even higher than the US National Health and Nutrition Examination Survey (NHANES III) that 25% were uncontrolled.23 Also the percentage of uncontrolled hypertensive patients was more than what reported in Addis Ababa, Ethiopia (40.1%) and Gondar, Ethiopia (46.6%).24,25 These variations might be attributed to the differences in origins, geographical areas, physical activities, biological and genetic factors.

In medication adherence, the results showed that 92.7% of the studied hypertensive patients were adherent. These findings were consistent with the study conducted by Inkster et al26 reported a 91% level of adherence among hypertensive patients in primary care. However, the findings were much higher than those reported in the Ethiopian study (60.5%),27 and the United Arab Emirates (54.4%),28 this may be attributed to the presence of comorbidities and health education levels of the patients in the other studies, which may significantly affect medication adherence.

Though the Sudanese guidelines in the management of hypertension promote combination therapy, the present study revealed that 58.1% of the patients used monotherapy drugs, indicating that the medical practitioners still prescribing or otherwise adopting their prescription. The combination therapy drugs are more expensive and few of the patients don’t like to use more than one drug, stated by the non-adherent patients. The most frequent monotherapies were CCB and ACEI. These results went in the same line with Abdulaziz et al,29 who found that the majority of the subjects were on mono (70%) and the most frequent mono anti-hypertensive therapies were beta-blockers (34%) and ACEI (25%). In addition, CCB with ARB (9.1%) and ACEI with beta-Blocker (5.2%) were the frequent dual combined therapy.

The results of the present study showed that most controlled patients were found in older (52.5%) and middle-aged patients (46.4%), and most of younger age (77.3%) were found to be uncontrolled (p 0.026). These findings are consistent with the study of Solomon et al.27

Regarding the levels of education and the hypertension control, most post-university (86.5%) and university educated (79.6%) patients were found to be controlled, while illiterate (72.4%) and primary educated (64%) patients were found to be uncontrolled (p value=0.005). this indicated that A high-level of education was associated with better blood pressure control.30 In a study conducted on 184 patients with free access to care, Paulsen et al identified that patients with less than 10-years of education were less likely to achieve blood pressure control compared to those with more than 10-years levels of education.31 In the analysis of the NHANES1999-2004, Ostchega et al31 found that hypertensive patients with lower-levels of education and in the low socio-economic class were more likely to have uncontrolled blood pressure. Sandoval et al32 found that low education was associated with poor blood pressure control. Wong et al33 found that individuals with lower education backgrounds had 3.5 times higher uncontrolled BP than those with higher education.

According to the association between the hypertension control status and the clinical characteristics of the patients, duration of hypertension showed a significant relationship with control status; the patients with duration less than 5-years (51.9%) more tendered to be controlled and those had duration >10-years (51.8%) were uncontrolled patients (p value=0.036). additionally, the majority of patients without comorbidities (50.2%) were controlled.

Not surprisingly; all non-compliant patients were found to be uncontrolled. For no doubt, this indicated that; adherence to the medication is a key factor for controlling hypertension (p value=0.000), however, some of the adherent patients were still uncontrolled, this was mainly attributed to the presence of comorbidities which significantly affected the controlling of hypertension. (p=0.000). In addition, the use of monotherapy was another factor, where the study demonstrated that most of the patients who received monotherapy (62.3%) were uncontrolled, especially ACEI (60.9%), CCB (48.1%) and beta-blockers (42.9%) (p value=0.008) while most of the patients who received combined treatment (62%) were found to be controlled, especially those who used diuretic+ARB (100%), CCB+ARB+diuretic (69.2%) and CCB+ARB (51.4%).

Recent clinical trials have shown that effective BP control can be achieved in most hypertensive patients, by two or more antihypertensive drugs for most patients.34,35,36 As stated by Moser et al,37 30% to 60% of patients will be controlled with a single drug regimen, while two drugs in combination are likely to improve control rates by 80 to 85%; three or more drugs will provide control in 90 to 95% of patients.

In the association of controlled and uncontrolled hypertensive patients regarding the types of mono and combined therapy; the majority of the patients who used ACEI drug as monotherapy (60.9%) were uncontrolled and most of those used ARB (78.3%) were controlled (p=0.001). on the other side, all the patients who used ACEI+Diuretic, ACEI+ARB, Beta-Blocker+Diuretic, CCB+Diuretic and ACEI+CCB+Beta-Blocker in combination were uncontrolled, while all the patients who used Diuretic+ARB and most of the patients (62.9%) who used CCB+ARB+Diuretics in combination were controlled (p=0.000).

RECOMMENDATIONS

Information, education and culture materials are recommended for hypertensive patients to improve their adherence to medication and the control of their BP. The MOH has to avail the recommended types of antihypertensive medication in PHC Centres, maybe by including them in the HI drug list to overcome the financial problem as a reason for non-adherence. The MOH has to foster the protocols and guidelines for hypertension treatment, which is crucial to avoid the practice of doctors of prescribing a monotherapy and contraindicated combination of antihypertensive medication. Future research needs to disclose the noncompliance of doctors with Sudanese guidelines for the management of hypertension and the causes of uncontrolled hypertension among the younger age group of patients.

CONCLUSION

This study concluded that the high prevalence of uncontrolled hypertensive patients attending PHC was mainly attributed to use of monotherapy, presence of comorbidities and medication non-adherence. The latter is related to patients’ ignorance, financial constraints and dislike of using many drugs during the day. In addition, the use of combined therapy, the elderly and highly educated patients were factors for better control.

STRENGTH AND LIMITATIONS OF THE STUDY

In the centers, there were no specific day or examination room for hypertensive patients, so that the data collection took a long time. But what facilitates our data collection is the cooperation of the medical doctors and family physician.

CONSENT FOR PUBLICATION

Not applicable.

FUNDING

The study has been funded by the researcher own resources.

CONFLICTS OF INTEREST

The authors declare that they have no conflicts of interest.

1. World Health Organization (WHO). Report on the Regional Consultation on Hypertension Prevention and Control (Abu Dhabi, United Arab Emirates, 20-22 December 2003). 2004. Web site. https://apps.who.int/iris/handle/10665/255066. Accessed June 6, 2021.

2. Federal Ministry of Health. Sudan Household Health Survey (SHHS) 2010, chronic diseases results. 2010. Website. http://www.fmoh.gov.sd. Accessed September 26, 2016.

3. Federal Ministry of Health. Annual health statistical report 2008. 2008. Website. http://www.fmoh.gov.sd. Accessed September 26, 2016.

4. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, IzzoJL, et al. Seventh report of the Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. Hypertension. 2003; 42(6): 1206-1252. doi: 10.1161/01.HYP.0000107251.49515.c2

5. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. The seventh report of the Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure. JAMA. 2003; 289: 2560-272. doi: 10.1001/jama.289.19.2560

6. Sabaté E, World Health Organization (WHO). Adherence to long-term therapies: Evidence for action. Web site. http://apps.who.int/medicinedocs/en/d/Js4883e/6.1.3.html. Accessed July 7, 2012.

7. Fung V, Huang J, Brand R, Newhouse JP, Hsu J. Hypertension treatment in a medicare population: Adherence and systolic blood pressure control. Clin Ther. 2007; 29(5): 972-984. doi: 10.1016/j.clinthera.2007.05.010

8. Krousel-Wood M, Thomas S, Muntner P, Morisky D. Medication adherence: A key factor in achieving blood pressure control and good clinical outcomes in hypertensive patients. Curr Opin Cardiol. 2004; 19(4): 357-362. doi: 10.1097/01.hco.0000126978.03828.9e

9. Aziz AM, Ibrahim MI. Medication noncompliance – – a thriving problem. Med J Malaysia. 1999; 54(2): 192-199.

10. Ataklte F, Erqou S, Kaptoge S, Taye B, Echouffo-Tcheugui JB, Kengne AP. Burden of undiagnosed hypertension in sub-Saharan Africa: A systematic review and meta-analysis. Hypertension. 2015; 65: 291-298. doi: 10.1161/HYPERTENSIONAHA.114.04394

11. Ahmed ME. Blood pressure in a multiracial urban Sudanese community. J Hum Hypertens. 2012; 4: 621-624.

12. Sherif SM, Elbaghir KA, Homieda MM. Prevalence of hypertension in an urban community in Sudan. Khartoum Med J. 2012; 1: 72-74.

13. Nicholas DD, Heiby JR, Hatzell TA. The quality assurance project: Introducing quality improvement to primary health care in less developed countries. Qual Assur Health Care. 1991; 3(3): 147-165. doi: 10.1093/intqhc/3.3.147

14. Abdalla EAM, Elfadl LA, Eltayeb WAH. Epidemiology of hypertension among adults in Al-Azhary area in Khartoum-State Sudan: Community based study. International Journal of Pharmaceutical Science Invention. 2017; 6(1): 1-5.

15. Anteneh ZA, Yalew WA, Abitew DB. Prevalence and correlation of hypertension among adult population in Bahir Dar city, northwest Ethiopia: A community based cross sectional study. Int J Gen Med. 2015; 8: 175-185. doi: 10.2147/IJGM.S81513

16. Kingue S, Ngoe CN, Menanga AP, Jingi AM, Noubiap JJN, Fesuh B, et al. Prevalence and risk factors of hypertension in urban areas of cameroon: A nationwide population-based cross-sectional study. J Clin Hypertens (Greenwich). 2015; 17(10): 819-824. doi: 10.1111/jch.12604

17. Shitengea ST, Mabuza LH. A survey of risk factors associated with hypertension in the adult population of Kang, Kgalagadi North, Botswana. South African Family Practice. 2015; 57(3):177-182. doi: 10.1080/20786190.2014.976963

18. Balla SA, Abdalla AA, Elmukashfi TA, Ahmed HA. Hypertension among rural population in four states: Sudan 2012. Glob J Health Sci. 2014; 6(3): 206-212. doi: 10.5539/gjhs.v6n3p206

19. Al-Tuwijri AA, Al-Rukban MO. Hypertension control and co-morbidities in primary health care centers in Riyadh. Ann Saudi Med. 2006; 26(4): 266-271. doi: 10.5144/0256-4947.2006.266

20. Joffres MR, Hamet P, MacLean DR, L’italien GL, Fodor G. Distribution of blood pressure and hypertension in Canada and the United States. Am J Hypertens. 2001; 14: 1099-1105. doi: 10.1016/s0895-7061(01)02211-7

21. Al-Shammari SA, Nass M, Al-Maatouq MA, Al-Quaiz JM. Family practice in Saudi Arabia: Chronic morbidity and quality of care. Int J Qual Health Care. 1996; 8(4): 383-387. doi: 10.1093/intqhc/8.4.383

22. Birtwhistle RV, Godwin MS, Delva MD, Casson RI, Lam M, MacDonald SE, et al. Randomized equivalence trial comparing three month and six month follow up of patients with hypertension by family practitioners. BMJ. 2004; 328: 204. doi: 10.1136/bmj.37967.374063.EE

23. Burt VL, Cutler JA, Higgins M, Horan MJ, Labarthe D, Whelton P, et al. Trends in the prevalence, awareness, treatment, and control of hypertension in the adult US population. Data from the health examination surveys, 1960 to 1991. Hypertension. 1995; 26: 60-69. doi: 10.1161/01.hyp.26.1.60

24. Ambaw AD, Alemie GA, W/Yohannes SM, Mengesha ZB. Adherence to antihypertensive treatment and associated factors among patients on follow up at University of Gondar Hospital, Northwest Ethiopia. BMC Public Health. 2012; 12(1): 282. doi: 10.1186/1471-2458-12-282

25. Tesfaye A, Kumela K, Wolde M. Blood pressure control associates and antihypertensive pharmacotherapy patterns in tikur anbessa general specialized hospital chronic care department, Addis Ababa, Ethiopia. American Journal of Biomedical and Life Sciences. 2015; 3(3): 41-48. doi: 10.11648/j.ajbls.20150303.13

26. Inkster ME, Donnan PT, MacDonald TM, Sullivan FM, Fahey T. Adherence to antihypertensive medication and association with patient and practice factors. J Hum Hypertens. 2006; 20(4): 295-297. doi: 10.1038/sj.jhh.1001981

27. Asgedom SW, Gudina EK, Desse TA. Assessment of blood pressure control among hypertensive patients in Southwest Ethiopia. PLoS One. 2016; 11(11): e0166432. doi: 10.1371/journal.pone.0166432

28. Bader RJK, Koprulu F, Hassan NAGM, Ali AAA, Elnour AA. Predictors of adherence to antihypertensive medication in northern United Arab Emirates. East Mediterr Health J. 2015; 21(5): 309-318. doi: 10.26719/2015.21.5.309

29. Abdulaziz A, Ibrahim A, Ayman A, Samia K, Nisrin Z. Control and Management of Hypertension at a University Health Centre in Oman. Sultan Qaboosuni Med J. 2011; 8(2): 179-182.

30. Barrera L, Millett C, Blangiardo M, Pape UJ, Majeed A. Differences in the classification of hypertensive controlled patient in primary care: Cross sectional study. JRSM Short Reports. 2012; 3: 72. doi: 10.1258/shorts.2012.012008

31. Paulsen MS, Andersen M, Munck AP, Larsen PV, Hansen DG, Jacobsen IA, et al. Socio-economic status influences blood pressure control despite equal access to care. Fam Pract. 2012; 29(5): 503-510. doi: 10.1093/fampra/cmr130

32. Sandoval D, Bravo M, Koch E, Gatica S, Ahlers I, Henriquez O, et al. Overcoming barriers in the management of hypertension: the experience of the cardiovascular health program in chilean primary health care centers. Int J Hypertens. 2012; 2012: 405892. doi: 10.1155/2012/405892

33. Franklin SS, Jacobs MJ, Wong ND, L’Italien GJ, Lapuerta P. Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives: analysis based on National Health and Nutrition Examination Survey (NHANES) III. Hypertension. 2001; 37(3): 869-874. doi: 10.1161/01.hyp.37.3.869

34. Fox JC, Leight K, Sutradhar SC, Demopoulos LA, Gleim GW, Lewin AJ, et al. Te JNC 7 approach compared to conventional treatment in diabetic patients with hypertension: A double-blind trial of initial monotherapy vs. combination therapy. J Clin Hypertens (Greenwich). 2004; 6: 437-442. doi: 10.1111/j.1524-6175.2004.03488.x

35. Jamerson K, Bakris GL, Dahlof B, Pitt B, Velazquez E, Gupte J, et al. Exceptional early blood pressure control rates: The ACCOMPLISH trial. Blood Press. 2007; 16: 80-86. doi: 10.1080/08037050701395571

36. Neutel JM, Smith DH, Weber MA, Schofield L, Purkayastha D, Gatlin M. Efficacy of combination therapy for systolic blood pressure in patients with severe systolic hypertension: The Systolic Evaluation of Lotrel Efficacy and Comparative Terapies (SELECT) study. J Clin Hypertens (Greenwich). 2005; 7: 641-646. doi: 10.1111/j.1524-6175.2005.04615.x

37. Moser M, Pickering T, Sowers JR. Combination drug terapy in the management of hypertension: When, with what, and how? J Clin Hypertens (Greenwich). 2000; 2: 94-98. doi: 10.7573/dic.212531

LATEST ARTICLES

From Neck Pain to a Life-Threatening Condition: A Case Report

Floris Vandewoude* and Sören Verstraete

doi.

Chest X-ray Showed a Hazy Left Upper Lung Infiltrate

A Noteworthy Case of Myasthenic Crisis Induced by Levofloxacin

Ada Young*, Ramya Ramesh and Milind Awale

doi.

The Right Thigh Anterior Compartment was Swollen, and the Skin was Ulcerated due to the Traditional Cautery

Primary Skeletal Muscle Lymphoma: A Case Report and Literature Review

Solomon Bishaw*, Addisu Alemu and Abel Tefera

doi.

LATEST ARTICLES