Advances in Food Technology and Nutritional Sciences

Open journal

ISSN 2377-8350

Giant Iatrogenic Lumbar Pseudomeningocele: A Case Report and Literature Review

Abolfazl Rahimizadeh*, Housain Soufiani, Shahrzad Rahimizadeh, Naser Asgari and Mahan Amirzadeh

Abolfazl Rahimizadeh, MD

Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran; Tel. +98 21 8895 2035; Fax. +98 21 8898 9690; E-mail:


Post-discectomy pseudomeningocele was reported first in 1947 by Swanson and Fincher.1 Three-years later in 1950, Winkler et al2 reported two additional cases of a pseudomeningocele after a lumbar discectomy. In 1968, Miller et al3 reported 10 new cases and classified pseudomeningoceles into congenital, iatrogenic and traumatic. Congenital pseudomeningoceles have been described in the patients with Marfan disease and neurofibromatosis mostly in the thoracic and lumbosacral regions respectively.4,5

Majority of the traumatic pseudomeningoceles develop subsequent to blunt traumatic events and are mostly seen in the cervical spine, but seldom in the lumbar region or with penetrating injuries.6,7,8

Iatrogenic pseudomeningoceles may occur in the lumbar, cervical or thoracic regions in decreasing frequency.9-13 In the lumbar region, they are mostly seen following the laminectomy for lumbar disc herniation or canal stenosis.

The cause of these cystic cerebrospinal fluid-containing lesions are incidental dural tears.9-13 The growth of the iatrogenic lumbar pseudomeningoceles is limited but in rare occasions it may continue to grow, till the pressure of the cyst’s contents and the surrounding tissues reach to equilibrium.9-13 Most of the pseudomeningoceles remain relatively minute (below 5 cm in size) and a small number will grow above 5 cm in size which are classified as large. Very rarely this pathologic sac may grow beyond 8 cm being classified as giant subtype.14-16

In 1963, Miller et al3 were the first to report 3 cases with giant iatrogenic pseudomeningocele and since then several cases with detailed information have been published so far.17-27 Herein, we present a middle age woman with giant pseudomeningocele which had developed after L4-L5 discectomy. With consideration of the previously published cases of giant pseudomeningocele with detailed information, the current case will be the 21st in the literature. The detailed information of 21 cases with iatrogenic giant lumbar pseudomeningoceles including the current case are presented separately (Table 1).

Table 1. Data on the Surgical Hardware Used in the Course of Surgical Treatment of Patients with Fracture-Dislocations of the PH


Year Age Sex Lumbar Procedure Clinical Picture


Miller et al3




Low lumbar laminectomy Low back and sciatic pain Good
Miller et al3




L5- S1 laminectomy S1 radiculopathy Good
Miller et al3




L4-L5 laminectomy Headache & LBP relieved by lying down Good
Rinaldi et al17 1969 50


L3-L4 hemilaminectomy Radiculopathy Good
Rinaldi et al17


42 F L5-S1 discectomy LBP, bilateral S1 radiculopathy Good
Rinaldi et al18




Subsequent to discectomy for recurrent L4-L5 disc LBP, Unilateral, radiculopathy Good
Schumacher et al19




L3-L4 hemilaminectomy+ discectomy Radiculopathy Good
Lee et al20




Right L4-L5 discectomy+ PLIF Persistent LBP, Right radiculopathy Good
Lee et al20




Right L4-L5 hemilaminectomy Palpable mass, L5 Paresthesia Good


Pavlou et al21




L4-L5 discectomy Weakness of dorsiflexion Good
Hamilton et al22




3 time surgery for L3-L4 spondylolisthesis Retroperitoneal mass on left ureter Good
Weng et al23




L4-L5 laminectomy discectomy Not described Good
Liu et al24 2011 40


L4-L5 laminectomy& Screw-rod fixation Radiculopthyy & Postural headache Good
Alvarez et al25




L4-L5 interlaminar-Laminectomy + discectomy LBP & radiculopathy Good
Alvarez et al25




L3-L4 & L4-L5 laminectomy LBP, Right leg radiculopathy Good
Eneke et al15




L4 &L5 laminectomy, L4-L5 discectomy LBP, Radiculopathy, N claudication Fair
Hamdan et al26




L5-S1 discectomy Episodes of black out while lying Good
Rahimizadeh et al14




L5-S1 interlaminar laminectomy+ discectomy LBP & left S1 radiculopathy Good
Rahimizadeh et al14




Multilevel laminectomy Neurogenic claudication Good




L4-L5Inter- laminectomy, discectomy LBP & subcutaneous lump Good
Current case




L4-L5Inter- laminectomy, discectomy LBP & Left L5 radiculopathy, Lump Good

A 49-year-old female who had undergone a lumbar laminectomy for a central L4-L5 disc herniation eight months earlier was referred to our facility after the appearance of a large subcutaneous midline lumbar mass which was associated with severe low back pain for a duration of 3-months (Figure 1). Neurological examination of motor and sensory nerves was normal. With the diagnosis of a pseudomeningocele, magnetic resonance imaging (MRI) was performed and displayed a very large pseudomeningocele at the site of the previous surgery. The pseudomeningocele was extended from L2 to S4, with a total length of 13 cm (Figure 2).

Figure 1. A Photograph of the Lumbar Region; Shows a Giant Subcutaneous Lump


Figure 2. (a) T2 Weighted Sagittal MRI, Shows a Giant Pseudomeningocele Extending from L2 to S4, (b) T2 Weighted Axial Images Showing the Narrow Stalk of the Pseudomeningocele (white arrows)



At surgery, the abnormally thick wall of the sac was widely opened. After evacuation of cerebrospinal fluid and at the depth of the cavity; a small breach with slow flow of cerebral spinal fluid (CSF) was found (Figure 3). The defect was subsequently enlarged and closed tightly with interrupted silk sutures. This was subsequently covered with free fat graft being reinforced with suturing of the lower part of the pseudomeningocele’s fibrotic wall. This was followed by a placement of a drain and closure of the wound in three layers. The pathological result of the wall of the pseudomeningocele was composed of connective tissue, mainly fibroblasts being aggregate with foamy macrophages (Figure 4). The patient recovered well-during the 4-days hospital stay and all her complaints had ceased at the time of the one month follow-up encounter. The patient had complete relief of her back pain and was doing well 5-months post-operatively. Successful excision and closure of the pseudomeningocele was confirmed in a MRI taken at six months follow-up (Figure 5).

Figure 3. (a) An Intraoperative Photograph Showing a Breach is Demonstrated at the Bottom of the Surgical Scene. (b) An Intraoperative Photograph showing a Pediatric Nasogastric Tube
Inserted intrathecal via the Breach Only to Show its Communication with Thecal Sac, so was Later Removed. (c) After Closure of the Breach, Reinforced with a Second Layer Composed of the Fibrotic Cyst’s Wall

An Intraoperative Photograph Showing a Breach is Demonstrated at the Bottom


Figure 4. Histopathologic Result of the Cyst’s Wall (a) Note an External Layer being Composed of Fibroblasts. This Layer is Aggregated with Foamy Macrophages. No Epithelial Lining is Seen. (b) Histopathologic Result of the Cyst’s Wall with Higher MagnificationORTOJ-6-121Fig4a


Figure 5. Post-Operative Sagittal and Axial Lumbar Spine MRI at 6-months Follow-up, (a & b) both T1 and T2-Weighted Sagittal and Axial Images after Excision of the Pseudomeningocele, the Small Hyperintense Mass is Probably Free Fat Graf




Lumbar pseudomeningoceles are uncommon complication of lumbar disc surgeries which develop as a consequence of an incidental or unrepairable dural tear. The true incidence of post-discectomy lumbar pseudomeningocele is difficult to ascertain because many remain asymptomatic.16 However, it is estimated to be between 0.1 and 2%.14,19

A small dural tear with concomitant arachnoid layer perforation results in a gradual extradural accumulation of the cerebrospinal fluids.14,16,28 According to one theory, the small dural tears leads to a higher probability of pseudomeningocele formation with respect to ball-valve mechanism.28,29 With subsequent reactive fibrosis, the fluid will be enveloped resulting in a cystic mass with false walls or pseudomeningoceles.16-27

Unnoticed dural tear with intact arachnoid and a ball valve mechanism will result in the development of a true cyst lined with arachnoid.29 This type of iatrogenic cyst is called true meningocele where surrounding connective tissue might reinforce the arachnoid capsule with time.14,16,28

Higher frequency of the pseudomeningoceles in the lumbar region in comparison to thoracic and cervical region is due to the relatively higher CSF pressure in the caudal thecal sac and the more frequency of lumbar disc surgeries.

The size of the lumbar pseudomeningoceles in majority remain minute, but in a small number of the cases, in a time frame which varies from a few months to a year after laminectomy, the pathology continue to grow till it reaches to an equilibrium. In rare occasions, a pseudomeningocele might grow beyond 8 cm.

Weng et al23 have attributed the giant size of a pseudomeningocele to high body mass index. However, we believe that intra-operative extensive dissection of the paravertebral muscles and fatty degeneration of these muscles might be the other predisposing factors.

Clinically, most of the lumbar pseudomeningoceles remain small and asymptomatic, this is in contrast to symptomatic ones which are relatively large. Large pseudomeningoceles might present a large subcutaneous lump. Nonetheless, in symptomatic cases, low back pain (LBP) which characteristically tends to be aggravated with straining and Valsalva maneuver is the most frequent clinical feature.30 If a rootlet is extruded through the breach and trapped within, radiculopathy may coexist.16,31-33 Such manifestation is clinically quite similar to a recurrent lumbar disc herniation.16,31-33 Rarely, in those with anterior dural breach, some rootlets might be trapped in corresponding collapsed intervertebral disc space.34 Occasionally, lower limbs motor dysfunction and incontinence and even cauda equina syndrome might occur.35 Headache as well as syncope and hypotension may be caused by compression of the subcutaneous lump of the pseudomeningocele. Positional headache has been also described in an iatrogenic lumbar pseudomeningocele.36 Positional syncope is another rare presentation of pseudomeningoceles which has been reported in a case report.

The patient’s symptom disappeared following the excision of the pseudomeningocele.37 Headache due to chronic subdural hematoma is another rare complication of the pseudomeningoceles.38 Clinical features of meningitis have been reported in an infected pseudomeningocele.39,40

An abdominal mass due to retroperitoneal growth of a pseudomeningocele is another rare presentation of the scenario.41 Hydronephrosis secondary to ureteral obstruction caused by a retroperitoneal growth of a giant pseudomeningocele has been reported in a rare case report.22

On plain radiographs, erosion of the surrounding bones might be seen in long standing cases.42 Ossification of the cyst’s wall is an infrequent scenario.43-47

The degree and extent of ossification can be best demonstrated in reconstructed computed tomography (CT) images.47

Computed tomography myelography can detect the small pseudomeningoceles, even in those tiny ones that grow intraosseously.48

Magnetic resonance imaging remains the most useful diagnostic tool for the demonstration of a pseudomeningocele and its short fistulous tract. A pseudomeningocele displays low signal intensity in T1-weighted and high signal intensity in T2-weighted MRI images.49 Furthermore, the measurement of the length of the pseudomeningoceles and their classification to minute, large and giant became possible with the aid of MRI.16-27 Generally, this specific CSF-containing mass is located posterior to the dural sac; although in rare instances it might grow into the intervertebral disc space and even progress into retroperitoneal space.22,50

Owing the high chances of spontaneous regression, conservative treatment is recommended for asymptomatic cases.51 Spontaneous regression may occur within 3-months to a few years following the diagnosis.51 According to Solomon et al51 healing of the dural defect with the gradual resorption of cerebrospinal fluid is the possible mechanism for the spontaneous resolution of pseudomeningoceles.16,52 Surgery for a symptomatic lumbar pseudomeningocele starts with widely opening the cyst and closure of the dural breach itself.14-20 For closure of the breach, both interrupted suture and titanium U shape clips can be used.14-16,52,53 In the case of a radiculopathy where entrapment of a rootlet is responsible; reduction of the rootlet into the thecal sac through the breach is the key to adequate treatment.16,31-33

Following the closure of the breach, lumbar myofascial flap was introduced by Misra et al.54 Myofascial flap which can be achieved with advancement of lumbar paravertebral muscles has been advocated in those with large dead space.


Incidental dural tears with CSF leakage during lumbar laminectomy should be properly addressed. Lumbar pseudomeningocele should be suspected in patients with a delayed reappearance of lower back pain or radiculopathy within a few months to several years after the initial laminectomy. Appropriate surgical intervention should be decided upon and undertaken once the diagnosis is reached. There remains no difference in the management of large and giant pseudomeningoceles.


The authors have received written informed consent from the patient.


The authors declare that they have no conflicts of interest.

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