Effects of Exposure to Cypermethrin on the Onset of Puberty and Ovarian Biomarkers in Female Prepubertal Rat: Attenuating Role of Zinc.
Cypermethrin treatment also produced oxidative stress in ovary by significant increase in malondialdehyde level, accompanied by a reduction in reduced glutathione and antioxidant enzymes. From the results, we may conclude that cypermethrin suppresses the female reproductive functions in rat by disrupting the estrous cycle and ovarian biomarkers by increasing oxidative stress and zinc attenuates the cypermethrin-induced toxicity.
In this study decrease in ovarian index in case of cypermethrin treated rats compared to control may be due to decreased number of ovarian germ cells. Rat is a spontaneously ovulating species
with estrous cycles and exhibits regular endocrine events. In this study, estrous cycle have been examined in the cypermethrin exposed female prepubertal rats as an indicator about the toxic
effects of cypermethrin on the female reproductive function involving the component roles of hypothalamus, pituitary, ovary and uterus. The reduction in ovarian and uterine indices that may
be due to reduced anabolic role of estradiol on the weight of the ovary and uterus
This decrease may also be due to other toxic effects of cypermethrin another systems of the animal (Table 2). In case of female prepubertal rats, exposure to cypermethrin remarkably delayed the onset of puberty as evidenced by the age of vaginal opening and appearance of first estrous (Table 1). The delay in the age of vaginal opening and appearance of first estrous may be related with the decline in the ovarian steroid genesis process.
Toxicol Forensic Med Open J. 2016; 1(1): 32-41. doi: 10.17140/TFMOJ-1-106
