Effectiveness of 5-Pyrrolidone-2-Carboxylic Acid and Copper Sulphate (Pirometaxine) in Cold Dry Air Induced Rhinitis With or Without Viral Superinfection.
Exposure to cold dry air can determine rhinitis-like symptoms. 5-Pyrrolidone2-Carboxylic acid
and Copper Sulphate showed antiviral and osmoprotectant effect. Aim of this study is evaluation of effectiveness of 5-Pyrrolidone-2-Carboxylic acid and Copper Sulphate pentahydrate association in the treatment of cold dry air rhinitis with or without viral infection.
Fifty consecutive adult patients affected by cold dry air rhinitis with or without
viral/bacterial infection were enrolled in this prospective observational study and treated with pyroglutamic acid plus copper sulphate. All patients underwent an objective evaluation with optic fiber endoscopy and symptoms assessment at time of enrolment, after 3 and 7 days of treatment.
All symptoms scores decreased at 3 and 7 days with a mean Total Symptoms Score of 5.98±2.22
and 1.30±1.23, respectively. Twenty-seven patients reached a Total Symptoms Score of zero after 7 days.
Median number of days until healing was 6. Only 18% of cases had turbinate hypertrophy and 10%
nasal mucosa hyperaemia after 7 days. Main side effects were nasal itch in 4 cases and nasal burning in one case.
The association of 5-Pyrrolidone-2-carboxylic acid and copper sulphate represent a safe treatment for CDA-induced rhinitis with or without viral infection, with few side effects. Clinical importance of this
therapy will be better understood with further studies, comparing results to those observed in a control group.
Pulm Res Respir Med Open J. 2015; 2(3): 90-96. doi: 10.17140/PRRMOJ-2-115