Correlation of 18F-Fluorodeoxyglucose Glucose Uptake by Liver Cancer and Transcriptional Regulation of the Warburg Effects in ATT-MYC Mouse Model of Liver Cancer
Hepatocellular carcinoma (HCC) is a leading cause of cancer
death in the United States and considered the second leading
cause of cancer death in East Asia and sub-Saharan Africa and the
sixth most common in western countries.
The HCC occurred after chronic affection with hepatitis C, B, liver cirrhosis, Aflatoxin
B1 exposure, hemochromatosis, fatty liver disease, alpha-1 antitrypsin deficiency,
pesticides and chemical exposure.
The survival rate of HCC harboring patients is still low after using different
protocols of treatment in the presence or absence of cirrhosis to
the percentage of liver tumor tissue to non-tumor tissue based on
therapy by positron emission tomography/computed tomography imaging modalities.
The correlation of 18F-Fluorodeoxyglucose glucose uptake and large
volume of liver with tumor tissue in c-myc
transgenic mice treated with diethyl-nitrosamine was reported by
micro CT/PET imaging.
Genomics, radiogenomics or imaging, has new advanced tools in correlation
science of different imaging modality data with genomic data.
Radiogenomics science revealed detailed information about intratumor,
intertumoral and peritumor tissue.
The relationship of maximum standard glucose uptake with glucose
transporter 1 (GLUT1) expression and
the inverse correlation with glypican-3 (GPC3) expression was
seen in patients with harboring liver tumors.
Additionally, Li et al found that the 18F-FDG uptake of in hepatoma G2 (Hep G2)
cells-expressed GPC3 significantly lower than that of RH7777
cells which has not expressed GPC3.
Moreover, 18F-FDG uptake of the tumor to the non-tumor ratio
of the EGF transgenic model of liver cancer was recorded to be
dependent on lesion size and
correlated with the upregulation of gene expression of glucose
transporters and hexokinase isoenzymes.
Liver Res Open J. 2020; 3(1): 1-8. doi: 10.17140/LROJ-3-112