Brain Mechanisms in Blood Glucose Mobilization and Absorption: The Role of the Left and the Right Frontal Regions in the Regulatory Control of Blood Glucose Levels
With the ravaging effects of glucose related diseases on the rise,
an increased understanding of the central mechanisms involved in glucose mobilization and
absorption, and the potential development of the metabolic syndrome, is becoming increasingly important.
Although, substantive efforts have been expended to better understand
the peripheral mechanisms involved with the systemic processing of glucose,
there remains a paucity of research dedicated to the central neural aspects largely
involved in the mobilization and absorption of blood glucose.
Despite this lack of research, the relationship between emotional
states of anger or fear and those oppositional processes associated with
quiescent states or digestive uptake have been clearly related to blood glucose levels.
Moreover, and perhaps most relevant here, is that the differential emotional
states just described have been established with origins in cerebral laterality
and with regulatory control mechanisms largely relegated to the frontal lobes and executive brain systems.
We have provided evidence with the potential to bridge this gap between
brain theory and research on peripheral mechanisms with specializations of the right brain for intense
emotional states and sympathetic drive7-10 and with somewhat oppositional specializations of
the left brain for quiescent states and perhaps parasympathetic drive.
Functional cerebral systems theory11-14 demonstrates the regulatory control over
sympathetic drive by the frontal lobe executive regions, where incremental blood pressure,
heart rate, sweating, cholesterol levels, and blood glucose levels may provide the biological
resources and reserves for the fight with elevance to insure success in meeting the potentially
coercive threat or challenge.
Diabetes Res Open J. 2017; 3(2): 17- 19. doi: 10.17140/DROJ-3-131