Trichology and Cosmetology

Open journal

ISSN 2377-1518

Bier Spots on the Face: The First Case Report

Hamza Yildiz* and Huseyin Saman

Corresponding Author

Hamza Yildiz, MD
Dermatologist, Department of Dermatology, Eskisehir Military Hospital, 26020, Eskisehir, Turkey; Tel. + 90 222 2204530/4220; Fax: + 90 222 2303433; E-mail:


Bier Spots (BS) are small, irregular, hipopigmented and transient macules. They are usually found on the arms and legs of young adults. These hypopigmented macules can be elicited by placing an affected the arms and legs in the dependent position. When the affected extremities are raised, the macules disappear.1


A 33-year-old man was referred to the outpatient clinic with a 4-year history of asymptomatic, white spots on his face. He had numerous, light colored spots over his face in a mottled pattern. Although the spots were asymptomatic, these spots bothered the patient cosmetically. Emotional stress does not aggravates his lesions. Hot weather aggravates his spots. He had no history of vascular disease and family history of such lesions. There were no associations with hyperhidrosis or acrocyanosis and nail or mucosal abnormalities. He has been a smoker for 15 years. He did not consume alcohol. He was diagnosed with alopecia areata six months ago. He was also diagnosed with epilepsy 31 years ago. He underwent epilepsy treatment. When he was two years old, he had started to use carbamazepine. He stopped to use carbamazepine when he was 18 years old. He was diagnosed with deep venous thrombosis in his left leg. He has been using coumadin for six months. He was diagnosed with insomnia three years ago.

Examination revealed hypopigmented macular lesions with irregular border and a background blanching erythema spread over the face, especially over his forehead. There were no similar skin lesions in any other body areas such as trunk, upper and lower extremities. Lesions appeared when his head was in a dependent position, in 10 seconds (Figure 1A). The lesions had disappeared in 10-15 seconds after he elevated his head (Figure 1B). Clinical examination was normal. Laboratory investigation, including blood count, serum biochemistry, erythrocyte sedimentation rate, rheumatoid factor revealed no abnormality. Electrocardiography and echocardiography were normal. Based on clinical findings, the patient was diagnosed with ‘Bier spot’.

Bier’s spots; Macule; Hypopigmentation

Figure 1: (A) White macules against a background of erythema on a 33-year-old man’s face in the dependent position. (B) The lesions disappeared, after the patients raised his head.


BS was first described in 1898. BS is more frequently in women than men.2 The etiology is unknown. BS is thought to be an exaggerated but physiological, vasoconstrictive response induced by venous stasis-associated hypoxia or, conversely, by a failure of the venoarteriolar reflex in dermal ascending arterioles in response to venous filling.3 To date, these white lesions have been given several names, including BS, exaggerated physiologic speckled mottling of the skin, physiologic anemic macules, nevus anemicus, speckled mottling of the limbs, constitutive speckled vascular mottling of the skin, and angiospastic macules.4

On the trunk, lower extremities, and upper extremities, including the palms were generalized, hypopigmented, 1-10 mm macules interspersed with blanching, erythematous macules. The lesions gave a reticulated, mottled appearance. The lesions were associated with dependency of the limbs. The spots almost disappeared completely with elevation of the limbs.1,4 In our case, BS was on his face. To the best of our knowledge, this is the first case report on the face. BS appeared when his head was in a dependent position, in 10 seconds and BS disappeared in 10-15 seconds after he elevated his head.

Some cases have been reported in association with miscellaneous disorders, such as insomnia, alopecia areata, varicosity, palmar hyperhidrosis, tachycardia, deep vein thrombosis during pregnancy, cryoglobulinemia, scleroderma, renal crisis, aortic hypoplasia, lichen planus, and Peutz-Jeghers syndrome.2,4 Our case was diagnosed with insomnia, alopecia areata, epilepsy, and deep venous thrombosis. The present case used carbamazepine for 16 years. It is important to be suspicious of systemic disease in patients with BS, because the spots are occasionally the first sign of such disease, but these spots are more often idiopathic.5

Fan et al reported that the BS in four generalized cases became more visible with emotional stress, but less visible after physical activity.4 BS of the our case does not become more visible with emotional stress, but hot weather aggravates his spots.

Because idiopathic BS is asymptomatic and possibly transient, no treatment is required.6 The present patient did not undergo treatment.


This is the first case report that presented BS on the face. While evaluating white macules on patients’ face, BS should be considered in the differential diagnosis.


The authors declare no competing interest.


No financial support was received for this paper.


The patient has provided written permission for publication of the case details.


Hamza Yildiz, MD1*; Huseyin Saman, MD2

1Department of Dermatology, Eskisehir Military Hospital, 26020, Eskisehir, Turkey
2Department of Dermatology, Isparta Military Hospital, 32020, Isparta, Turkey

Article History

Received: March 12th, 2016; Accepted: April 12th, 2016; Published: April 12th, 2016

Cite this Article

Yildiz H, Saman H. Bier spots on the face: The first case report. Trichol Cosmetol Open J. 2016; 1(1): 8-10. doi: 10.17140/TCOJ-1-102



Bier Spots are small, light, irregular, hypopigmented and transient macules, usually found on the upper and lower extremities of young adults, in which the intervening skin may seem ertyhematous but blanches with pressure so that these light macules disappear. This is a benign physiologic vascular anomaly of no clinical significance. We present, the case of a 33-year-old man with Bier spots on face associated with insomnia, alopecia areata, epilepsy, and deep venous thrombosis. To the best of our knowledge, this is the first case report that presented with Bier spots on the face.

1. Heller M. Diffuse Bier spots. Dermatol Online J. 2005; 11(4): 2. Web site. Accessed March 11, 2016.

2. Topal IO, Ulkumen PK, Duman H, Goncu OEK. Bier’s Spots in a young girl [In Turkish]. Okmeydanı Tıp Dergisi. 2015: 31(1): 52-53. doi: 10.5222 / otd.2015.052

3. Stinco G, Errichetti E, Patrone P. Hypopigmented macules of limbs in two sisters: Report on familial Bier spots. An Bras Dermatol. 2015: 90(5); 738-739. doi: 10.1590/abd1806- 4841.20153337

4. Fan YM, Yang YP, Li W, Li SF. Bier spot: six case reports. J Am Acad Dermatol. 2009: 61(3): e11-e12. doi: 10.1016/j. jaad.2009.03.009

5. Peyrot I, Boulinguez S, Sparsa A, Le Meur Y, Bonnetblanc JM, Bedane C. Bier’s white spots associated with scleroderma renal crisis. Clin Exp Dermatol. 2007; 32(2): 165-167. doi: 10.1111/j.1365-2230.2006.02298.x

6. Khera P, English JC 3rd. Physiologic anemic macules. Cutis. 2008; 81(6): 477-478. Web site. article/physiologic-anemic-macules/e71442eac88385ae13bfb5364ee90520.html?trendmd-shared=1. Accessed March 11, 2016.


Our Experience of Laparoscopic Living Donor

Our Experience of Laparoscopic Living Donor Nephrectomy

Shrenik J. Shah*, Tejanshu Shah, Kirtipal N. Visana, Abhishek Jha and Chirag Davara


Knowledge Attitude Hygiene Practices

Knowledge, Attitude, Hygiene Practices, and Enumeration of Salmonela from Raw Meat at Retailer Shops in Chelenko Town, Eastern Ethiopia

Bayan A. Mumed*, Mohammedkemal M. Ame, Fathi M. Sayaka, Hamza M. Yuya, Ahmed Adame, Mohammed Bedruddin, Megersa Abdulhamid, Mohammed Jemal and Abrahim Eliyas


The Real Deal: A Commentary and Examination of Xylazine Use and Unintended Consequences

Nelson J. Tiburcio* and Scarlett L. Baker


Physio-Chemical Analysis of Drinking Water

Physio-Chemical Analysis of Drinking Water in Populated Villages of District Skardu

Faizan Mustafa, Faizullah Khan, Tariq U. Khan, Shahid Masood, Muhammad Ashraf, Asma Saeed, Abdul Karim, Alim-un-Nisa, Ammarah Kanwal and Tajudin