A Randomized Clinical Trial Study of the Effects of Varicocelectomy on Sperm Clinical Analysis and DNA Fragmentation: A Preliminary Data
Varicocele is a disease characterized by abnormal dilatation of the testicular veins
within the pampiniform plexus due to difficult blood return in this region.
The prevalence of varicocele is 30 to 40% in infertile men, who frequently show
seminal changes and a high rate of sperm DNA Fragmentation Index,
one of the conditions responsible for failure of spermatogenesis.
Several studies have demonstrated that varicocelectomy may improve
the seminal parameters and even the quality of genetic material.
However, published papers are predominantly retrospective rather than prospective.
In this study, we show some effects of varicocelectomy on the seminal quality
and DFI rate of men who were submitted compared to men who did
not undergo the procedure, before and after nine months of the intervention.
A difference in DFI rate was detected between the varicocele and
the control group. In the varicocele group, no differences in DFI rate were
observed between patients submitted to varicocelectomy and patients who were not
submitted to the procedure, however, we could observe a sharp increase in the sperm
concentration of patients who underwent surgery compared with not submitted varicocelectomy.
These preliminary results emphasize that men with varicocele have a higher DFI rate.
Gynecol Obstet Res Open J. 2015; 2(1): 29-34. doi: 10.17140/GOROJ-2-107
