A Case of Choroidal Metastasis from Small-Cell Lung Carcinoma

Manami Inoue, Takeshi Saraya*, Miku Oda, Masachika Fujiwara and Hajime Takizawa

A Case of Choroidal Metastasis from Small-Cell Lung Carcinoma.

A 74-year-old man visited to our hospital due to severe visual disturbance in his left eye for recent one month. Fundoscopy demonstrated the serous retinal detachment at the nose side of the left eye.
At the same time, chest X-ray demonstrated a mass measuring 4 cm in size at the left lower lung field and thoracic computed tomography depicted the mediastinal lymphadenopathies. On Hematoxylin-Eosin stain, both specimens
obtained from right B10 by transbronchial lung biopsy and subcarinal lymphnodes by endobronchial ultrasound-guided transbronchial needle aspiration demonstrated abundant atypical cells with high nuclear cytoplasmic ratio.
Those cells were positive for both CD and TTF-1, he was thus diagnosed with small cell lung carcinoma.

For further exploring the reason for loss of visual acuity, contrast enhanced head magnetic resonance imaging was
performed. The MRI on axial, coronal, and sagittal T1 weighted images demonstrated the enhanced crescent shaped tumor with non-enhanced soft tissue, which corresponded to retinal detachment and choroidal metastasis, respectively. Previous studies described that the incidence of ocular metastasis in patients with lung carcinoma ranged from 61 to 21%2 in post or antemortem examination. Choroid is the blood-rich tissue where the most preferable area in ocular metastasis. Physicians should be aware of the choroidal metastasis as the initial manifestation of lung carcinoma.

Cancer Stud Mol Med Open J. 2018; 4(1): 11-12. doi: 10.17140/CSMMOJ-4-124