Mast Cells: The Key Players in Cardiac Remodelling

Abstract

The Mast Cells (MCs) are part of the immune system and they are actively involved 
in the inflammatory and allergic reactions. The MCs produce and release a wide variety of 
biologically active products, eg, histamine, Tumor necrosis factor-α (TNF-α), Transforming 
growth factor-β (TGF-β), interleukin and renin, which are involved in cardiac remodelling. 
MCs are considered culprits in various cardiovascular pathologies such as pressure and volume 
overload, ventricular dilatation, and heart failure. The deleterious role of MCs in failing heart 
and myocardial remodelling is being rigorously pursued in animal and human studies. The focus 
of this mini review is to highlight the detrimental effects of MCs in the cardiac remodelling 
process