Yusheng Zhu, PhD, DABCC, FACB


Director of Clinical Chemistry & Toxicology
Director of Postdoctoral Clinical Chemistry Fellowship Program
and
Associate Professor of Pathology
Department of Pathology & Laboratory Medicine
Medical University of South Carolina
171 Ashley Ave MSC908 Suite 309
Charleston, SC 29425, USA

Biography

Dr. Zhu is an Associate Professor with tenure and Medical Director of Clinical Chemistry and Toxicology, Director of Postdoctoral Clinical Chemistry Fellowship Program at the Medical University of South Carolina. He is board certified by the American Board of Clinical Chemistry (ABCC) in Clinical Chemistry, Toxicological Chemistry, and Molecular Diagnostics and a Fellow of the National Academy of Clinical Biochemistry (NACB). He completed postdoctoral fellowship in biochemistry and molecular biology at the University of Georgia and clinical chemistry and pharmacogenetics at the University of Louisville. Yusheng is an invited reviewer of seven international medical journals. He has given many presentations at national and international conferences. He is interested in clinical and translational research and has received funding for research from NIH, AHA, and IVD industry. He has 96 publications including peer-reviewed papers, editorials, book chapters, and abstracts. He has received 31 awards from AACC, NACB, and other organization.

Research Interest

His research interest includes: Clinical and translational research in clinical chemistry, toxicology, point-of-care testing, hemoglobinopathy, pharmacogenetics, clinical application of mass spectrometry, and clinical trials of novel biomarkers.

Scientific Activities

HONORS AND AWARDS

• (2015) AACC Southeast Section Christopher Frings Travel Award (Student: Satya Narla, Mentor: Yusheng Zhu)
• (2015) AACC Southeast Section Gerald R. Cooper Travel Grant (Student: Jonathan Gullett, Mentor: Yusheng Zhu)
• (2014) AACC Southeast Section Gerald R. Cooper Travel Grant (Student: Satya Narla, Mentor: Yusheng Zhu)
• (2013) Distinguished Abstract Award: National Academy of Clinical Biochemistry (NACB): (Student: Zengliu Su, Mentor: Yusheng Zhu)
• (2012) AACC SYCL Domestic Travel Grant Award (Student: Zengliu Su, Mentor: Yusheng Zhu)
• (2012) AACC Student Travel Award (Student: Alina Sofronescu, Mentor: Yusheng Zhu)
• (2011) AACC Southeast Section Christopher Frings Travel Award (Student: Alina Sofronescu, Mentor: Yusheng Zhu)
• (2010) AACC Clinical Chemist Recognition Award
• (2009) Best Abstract of Interest to the Industry Division: AACC Annual Meeting
• (2009) Best Abstract Award: Clinical Laboratory and Analytical Sciences Annual Meeting
• (2008) Best Poster Award: Clinical Ligand Assay Society (CLAS) 34th International Annual Meeting
• (2008) Best Abstract of Interest to the Industry Division: AACC Annual Meeting
• (2008) Student Travel Award (Student: Deborah Spencer, Mentor: Yusheng Zhu): AACC Annual Meeting
• (2006) Distinguished Abstract Award: National Academy of Clinical Biochemistry (NACB)
• (2006) First Place Award: AACC Annual Meeting Student Oral Presentation
• (2006) Outstanding Research Award in Molecular Pathology or Pharmacogenomics: AACC Molecular Pathology Division
• (2006) Student Travel Awards: AACC
• (2006) Best Abstract Award: Clinical Ligand Assay Society (CLAS) International Annual Meeting
• (2006) Travel Award: The University of Louisville Research Committee
• (2006) Travel Award: University of Louisville School of Medicine, Department of Pathology and Laboratory Medicine
• (2005) Second Place Award: 2005 Research Louisville (Residents and Clinical Research Fellows category)
• (2005) Clinical Ligand Assay Society (CLAS) International Meeting Best Abstract Award
• (2005) AACC Ohio Valley Section Student Travel Award
• (2005) The University of Louisville School of Medicine, Department of Pathology and Laboratory Medicine Travel Award
• (2005The University of Louisville Research Committee Travel Award
• (2004) First Place Award: Research Louisville (Residents and Clinical Research Fellows category)
• (2004) First Place of Student Poster Contest at AACC Annual Meeting
• (2004) National Academy of Clinical Biochemistry (NACB) inaugural Distinguished Abstract Award
• (2004) AACC Molecular Pathology Division Outstanding Scientific Abstract Award
• (2004) AACC Annual Meeting Student Travel Award
• (2004) The University of Louisville Research Committee Travel Award
• (2004) The University of Louisville School of Medicine, Department of Pathology and Laboratory Medicine Travel Award
• (1997) Dongfang Scholarship sponsored by Daiichi Pharmaceutical Co., Ltd at Shanghai Medical University
• (1994) Guanghua Scholarship sponsored by Guanghua Foundation at Shanghai Medical University

Publications

1. Bohm NB, Hoover KC, Wahlquist AE, Zhu Y, Velez JCQ. A case-control study and case series of pseudohyperphosphatemia during exposure to liposomal Amphotericin B. Antimicrob Agents Chemother. 2015. doi: 10.1128/AAC.01306-15
2. Hermayer KL, Loftley AS, Reddy S, Narla SN,. Epps NA, Zhu Y. Challenges of Inpatient Blood Glucose Monitoring: Standards, Methods and Devices to Measure Blood Glucose. Curr Diab Rep. 2015, 15(3): 582-591. doi: 10.1007/s11892-015-0582-9
3. Tracy E, Andrews DM,. Constantin MA, Zhu Y. Differences Identified Between Serum and Urine Immunofixation Electrophoresis. Clin Chim Acta. 2015; 439: 68-70. doi: 10.1016/j.cca.2014.10.002
4. Su Z,. Stone RW, Zhu Y. Positive Propylene Glycol in a patient with Ethylene Glycol Poisoning. Clinical Chemistry . 2014, 60(4): 697-698.
5. Su Z, Narla SN, Zhu Y. 25-Hydroxyvitamin D: analysis and clinical application. Clin Chim Acta. 2014;433: 200-205. doi: 10.1016/j.cca.2014.03.022
6. Su Z, Slay BR, Carr R, Zhu Y. The recognition of 25-hydroxyvitamin D2 and D3 by a new binding protein based 25-hydroxyvitamin D Assay. Clin Chim Acta. 2013, 417: 62-66. doi: 10.1016/j.cca.2012.12.018
7. Su Z, Graybill WS, Zhu Y. Detection and monitoring of ovarian cancer. Clin Chim Acta. 2013, 415: 341-345. doi: 10.1016/j.cca.2012.10.058
8. Schmiedt M, Sofronescu A, Short B, Nahas Z, Zhu Y. Elevated prolactin concentration in a patient with bipolar disorder. Clinical Chemistry. 2013, 59(3): 473-477. doi: 10.1373/clinchem.2011.176925
9.Zhu Y, Marshall DT. Editorial: Prediction of Adverse Radiotherapeutic Effects in Prostate Cancer Patients Prior to Radiation. J Clin Exp Pathol. 2012, 2:e112. doi: 10.4172/2161-0681. 1000e112.
10.Sofronescu AG, Loebs T, Zhu Y. Effects of temperature and light on the stability of bilirubin in plasma samples. Clin Chim Acta. 2012, 413: 463-466. doi: 10.1016/j.cca.2011.10.036
11. Sofronescu Ag, Williams LM, Andrews DM, Zhu Y. Unexpected hemoglobin A1c results. Clinical Chemistry. 2011; 57:153-156. doi: 10.1373/clinchem.2010.155804
12. Spruill L, Constantin MA, Andrews DA, Zhu Y. Heterophilic antibody interference in a chemiluminescent immunometric erythropoietin assay. Clin Chim Acta. 2010; 411: 1156-1157. doi: 10.1016/j.cca.2010.04.018
13.Zhu Y, Williams LM, Horne BD. Disparity in estimated average glucose due to different hemoglobin A1c assays and hemoglobin S trait. Clin Chem Lab Med. 2010; 48(4):571-2. doi: 10.1515/CCLM.2010.083
14.Zhu Y, Williams LM. Falsely elevated hemoglobin A1c due to S-ß+-thalassemia interference in Bio-Rad VARIANT II TURBO HbA1c assay. Clin Chim Acta . 2009; 409: 18-20. doi: 10.1016/j.cca.2009.08.009
15. Spencer DV, Nolte FS, Zhu Y. Heterophilic Antibody Interference Causing False-Positive Rapid Human Immunodeficiency Virus Antibody Testing. Clin Chim Acta. 2009; 399(1-2): 121-122. doi: 10.1016/j.cca.2008.09.030
16.Shulian Wang, Jianmin Hu, Yusheng Zhu. Pharmacogenetics of Warfarin. Medical Journal of the Chinese Peoples Armed Police Forces. 2008; 19 (10): 944-946.
17.Zhu Y, Jenkins MM,. Brass DA, et al. Heterophilic antibody interference in an ultra sensitive three-site sandwich troponin I immunoassay. Clin Chim Acta. 2008; 395(1-2): 181-182. doi: 10.1016/j.cca.2008.04.027
18.Zhu Y, Shennan M, Reynolds KK, et al. Estimation of warfarin maintenance dose based on VKORC1 (-1639G>A) and CYP 2C9 genotypes. Clinical Chemistry. 2007; 53(7): 1199-205. doi: 10.1373/clinchem.2006.078139
19.Zhu Y, Hein DW, Doll MA, et al. Simultaneous determination of N-acetyltransferase-2 (NAT2) polymorphisms by allele-specific primer extension assay. Clinical Chemistry . 2006; 52(6):1033-9. doi: 10.1373/clinchem.2005.063198
20.Zhu Y, Valdes R.Jr, Simmons CQ, Jortani SA. Analysis of ligand binding by bioaffinity mass spectrometry. Clin Chim Acta. 2006; 371(1-2): 71-8. doi: 10.1016/j.cca.2006.02.023
21.Zhu Y, Elin J. Ethanol treatment of serum produces a spurious band on electrophoresis. Clin Chim Acta. 2006; 366(1-2): 341-343. doi: 10.1016/j.cca.2005.09.030
22.Zhu Y, Valdes R.Jr, Jortani SA. Application of bioaffinity SELDI-TOF mass spectrometry. Therapeutic Drug Monitoring. 2005; 27(6): 694-699.
23.Zhu Y, Tomlinson RL, Terns RM, Terns MP. Telomerase RNA accumulates in Cajal bodies in human cancer cells. Molecular Biology of the Cell. 2004; 15: 81-90. doi: 10.1091/mbc.E03-07-0525
24.Etheridge KT, Banik S R, Armbruster B N, et al. The nucleolar localization domain of the catalytic subunit of human telomerase. The Journal of Biological Chemistry. + 2002; 277 (27): 24764- doi: 10.1074/jbc.M201227200
25.Zhu Y, Lu Y, Lin G, Zhou X, Chen B. Expression of Bcl-2, Bcl-XL, Bax and Bak in acute leukemia cells and its clinical significance. The Journal of Fudan University (Medical Sciences). 2001; 28 (2): 113-118.
26.Zhu Y, Lu Y, Lin G, Zhan R, Yang Z, Lu Y-G. Relationship between expression of apoptosis-modulating proteins and multi-drug resistance in K562 / VCR cells. The Journal of Fudan University (Medical Sciences). 2001; 28 (1): 32-34.
27.Zhu Y. Application of telomerase detection in tumor diagnosis. Shanghai Journal of Medical Laboratory Sciences. 2000; 15 (5): 267-269.
28.ZhuY, Lu Y, Lin G, et al. Sensitivity to vincristine-induced apoptosis in K562 and K562/VCR cell lines. The Journal of Shanghai Medical University. 1999; 26(3): 191-193.
29.Zhu Y, Lu Y, Lin G, et al. Quantitative detection of apoptosis induced by vincristine in K562 and K562/VCR cell lines with ELISA. Shanghai Medical Journal. 1999; 22(2): 122-123.
30.Zhu Y. Antiapoptosis and multi-drug resistance (MDR) in tumor cells. Foreign Medicine: Clinical Biochemistry and Laboratory Medicine. 1999; 20(3): 101-102.
31.Zhu Y, Ni Z, Lu Y. Purification and characterization of human pancreatic and salivary amylases. Jiangxi Journal of Medical Laboratory Sciences. 1999; 17(1): 10-12.
32.Zhu Y. Current status of P-glycoprotein research. Foreign Medicine: Clinical Biochemistry and Laboratory Medicine. 1998; 19(4): 159-160.
33.Zhu Y. Cardiac troponin I: a sensitive and specific marker of myocardium injury. Chinese Journal of Laboratory Diagnostics. 1998; 2(2): 79-93.
34.Zhu Y, Bi X, Ni Z, Zhu J, Lu Y. Direct kinetic rate assay for α-amylase with 2-chloro-4-nitrophenyl-α-D-maltotrioside as substrate. Acta Academiae Medicinae Shanghai. 1997; 24(2): 141-143.
35.Zhu Y. Methods for determination of α-amylase isoenzymes. Foreign Medicine: Clinical Biochemistry and Laboratory Medicine. 1996; 17(4): 148-149.
36.Zhu Y. Substrates for α-amylase measurement. Shanghai Journal of Medical Laboratory Sciences. 1996; 11(4): 253-255.