Wenbin Tan, MD, PhD
Assistant Project Scientist
Department of Surgery
Beckman Laser Institute and Medical Clinic
University of California
1002 Health Science Rd
Irvine, CA 92612, USA
• (2003-2008) PhD, Department of Neurobiology, UCLA
• (1997-2000) Master of Science in Biochemistry and Molecular Biology, Xiangya School of Medicine, Central South University, Changsha, Hunan, PR, China
• (1990-1995) Medical Degree, Xiangya School of Medicine, Central South University, Changsha, Hunan, PR, China
His current research is focused on two important questions about the treatment and pathogenesis of Port Wine Stain (PWS) birthmark: Whether combination of pulsed dye laser (PDL) and topical application of anti-angiogenetic agents render better therapeutic outcomes than PDL alone for PWS treatment and The molecular mechanism(s) of PWS pathogenesis.
1. Chen H, Tang L, Peng X, Luo Z, Luo S, Tan W. Effects of IFN-α combined with IL-6 on growth and expression of the genes related to cell-growth and apoptosis of bone marrow cells from patients with CGL. Chinese Journal of Hematology. 2000; 21(7): 341-344.
2. Luo J, Tan W, Tan Y, Cheng G. Cloning of the recombinant human hepatocyte growth factor gene. Bulletin of Hunan Medical University. 2000; 25(5): 425-427.
3. Tan W, Nie Y, Luo S, et al. Identification of novel regulatory elements of human stem cell factor gene in MCF Cell. Acta Biochimica et Biophysica Sinica. 2000; 32(6): 615-619.
4. Tan Y, Tan W, Peng X. Construction and identification of the fusion clone of the SCF 5flanking sequence and its full-length cDNA. Journal of Guangdong Medical College. 2001; 19(1): 6-9.
5. Nie Y, Tan W, Luo S, et al. Characterization of the AT rich region from –1190 to –853 of 5flanking sequence of human stem cell factor gene. Chinese Journal of Biochemistry and Molecular Biology. 2001; 17(3): 315-318.
6. Tan Y, Tan W, Peng X. Amplification and cloning of human stem cell factor full-length cDNA by RT-PCR. Guangdong Medicine. 2001; 22 (1): 16-19.
7. Tan W, Zhu M, Nie Y, et al. A method of DNA footprinting walking mapping. Progress in Biochemistry and Biophysics. 2001; 28(4): 551-555.
8. Tan W, Rouen S, Dremina YS, Dobrowsky RT. Nerve growth factor blocks the glucose-induced downregulation of Caveolin-1 expression in Schwann Cells via p75 neurotrophin receptor signaling. Journal of Biological Chemistry. 2003; 278(25): 23151-23162.
9. Shao XM, Tan W, Xiu J, Puskar N, Fonck C, Lester HA, Feldman JL. 4* nicotinic receptors in preBötzinger Complex mediate cholinergic/nicotinic modulation of respiratory rhythm. The Journal of Neuroscence. 2008; 28(2): 519-528. doi: 10.1523/JNEUROSCI.3666-07.2008
10. Tan W, Janczewski WA, Yang P, Shao XM, Callaway EM, Feldman JL. Silencing of preBötzinger Complex somatostatin-expressing neurons induces persistent apnea in adult awake rats. Nature Neuroscience. 2008; 11(5): 538-541. doi: 10.1038/nn.2104
11. Tan W, Pagliardini S, Yang P, Janczewski WA, Feldman JL. Projections of preBötzinger Complex neurons in adult rats. The Journal of Comparative Neurology. 2010; 518(10): 1862-1878. doi: 10.1002/cne.22308
12. Pagliardini S, Janczewski WA, Tan W, Dickson CT, Deisseroth K, Feldman JL. Active expiration induced by excitation of ventral medulla in adult anesthetized rats. The Journal of Neuroscence. 2011; 31(8): 2895-2905. doi: 10.1523/JNEUROSCI.5338-10.2011
13. Tan W, Sherman D, Turesson J, et al. Reelin demarcates a subset of preBötzinger Complex neurons in adult rat. The Journal of Comparative Neurology. 2012; 520(3): 606-619. doi: 10.1002/cne.22753
14. Tan W, Jia W, Sun W, Mihm MC, Stuart JS. Topical Rapamycin Suppresses the Angiogenesis Pathways Induced by Pulsed Dye Laser: Mechanisms of Inhibition of Regeneration and Revascularization of Photocoagulated Blood Vessels. Lasers in Surgery and Medicine. 2012; 44(10): 796-804. doi: 10.1002/lsm.22101
15. 25. Tan W, Chernova M, Gao L, et al. Sustained activation of c-Jun N-terminal and extracellular signal-regulated kinases in port-wine stain blood vessels. Journal of the American Academy Dermatology. 2014; 71: 964-968. doi: 10.1016/j.jaad.2014.07.025
16. Gao L, Nadora DM, Phan S, et al. Topical axitinib suppresses angiogenesis pathways induced by pulsed dye laser. British Journal of Dermatology. 2014; 669-676. doi: 10.1111/bjd.13439
17. Gao L, Nadora DM, Phan S, et al. Topical rapamycin systematically suppresses the early stages of pulsed dye laser-induced angiogenesis pathways. Lasers in Surgery and Medicine. 2014; 46: 679-688. doi: 10.1002/lsm.22296 </p >