Wen-Hai Chou, PhD

Assistant Professor
Department of Biological Sciences
School of Biomedical Sciences
Kent State University
41, Cunningham Hall
Kent, Ohio 44242, USA



Dr. Chou received his PhD from Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, Texas, USA. He completed his postdoctoral training at UCSF and later promoted as an Assistant Adjunct Professor, Department of Neurology, UCSF. He is now an Assistant Professor, Department of Biological Sciences, School of Biomedical Sciences, Kent State University, Ohio, USA.
His current research interest focuses on the roles of PKC isozymes and lipocalin-2 in Stroke-reperfusion injury using mouse genetics, experimental stroke models, and Chemical-genetics approaches.

Research Interest

His research interests include: Stroke-reperfusion injury, PKC, Signal transduction, Neuroimmune interactions after stroke, Ischemia-induced Neuro degeneration.

Scientific Activities


• Elected as a Fellow of the American Heart Association (F.A.H.A.) for making major and productive Contributions in cardiovascular basic sciences, (2011)
• Farris Family Innovation Award, Kent State University, Kent, Ohio, (2011)
Certificate of Achievement from University of Texas Health Science Center at San Antonio, Texas, (2001)
• Certificate of Achievement from National Chung-Hsing University, Taichung, Taiwan, (2001)
• First-place poster award at the Annual Graduate Student Association Forum, University of Texas Health Science Center at San Antonio, Texas, (1998)
• Second-place outstanding research award at the Annual Retreat, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, Texas, (1998)
• Travel award for distinguish research from Institute of Biotechnology, University of Texas Health Science Center at San Antonio, Texas, (1997)


• Member of Society for Neuroscience, (1998-Present)
• Member of American Stroke Association, (2003-Present)
• Member of American Society for Cell Biology, (2008-2009)
• Member of New York Academy of Sciences, (1999- 2008)
• Member of Society of Chinese Bio scientists in America, (1997-2008)
• Member of Genetics Society of America, (1996-2001)


Refereed Journals

1. Szular J, Sehadova H, Gentile C, et al. Rhodopsin 5 and Rhodopsin 6 mediated clock synchronization in Drosophila melanogaster is independent of retinal Phospholipase C-ß signaling. Journal of Biological Rhythms. 2012; 27(1): 25-36. doi: 10.1177/0748730411431673
2. Chiang T, Messing RO, Chou WH. Mouse model of middle cerebral artery occlusion. Journal of Visualized Experiments. 2011; 48. doi: 10.3791/2761
3. Chou WH, Wang D, McMahon T, et al. GABAA receptor trafficking is regulated by PKC epsilon and the Nethylmaleimide- sensitive factor. Journal of Neuroscience. 2010; 30(42), 13955-13965. doi: 10.1523/JNEUROSCI.0270-10.2010
4. Birkholz DA, Chou WH, Phistry M, Britt SG. Disruption of photoreceptor patterning in the Drosophila Scutoid mutant. Fly. 2009; 3(4): 253-262.
5. Birkholz DA, Chou WH, Phistry M, Britt SG. rhomboid is essential for the differentiation of blue and green sensitive R8 photoreceptor cells in Drosophila. Journal of Neuroscience. 2009; 29(9): 2666-2675. doi: 10.1523/JNEUROSCI.5988-08.2009
6. Chou WH, Messing RO. Hypertensive encephalopathy and the blood-brain barrier: Is deltaPKC a gatekeeper?. Journal of Clinical Investigation. 2008; 118(1): 17-20.
7. Lesscher HMB, McMahon T, Lasek AW, et al. Amygdala PKC epsilon regulates corticotropin-releasing factor and anxietylike behavior. Genes, Brain and Behavior. 2008; 7(3): 323-333.
8. Qi ZH , Song M, Wallace MJ, et al. Protein kinase C epsilon regulates GABAA receptor sensitivity to ethanol and benzodiazepines through phosphorylation of γ2 subunits. Journal of Biological Chemistry. 2007; 282(45): 33052-33063. doi: 10.1074/jbc.M707233200
9. Allen JJ, Li M, Brinkworth CS, et al. A semi-synthetic epitope for kinase substrates. Nature Methods. 2007; 4(6): 511-516. doi: 10.1038/nmeth1048
10. Wallace MJ, Newton PM Oyasu M, et al. Acute functional tolerance to ethanol mediated by Protein Kinase C epsilon. Neur psycho pharmacology. 2007; 32(1): 127-136.
11. Chou WH, Messing,RO. Protein kinase C isozymes in stroke. Trends in Cardiovascular Medicine. 2005; 15(2): 47-51.
12. Chou WH, Cho DS, Zhang H, et al. Neutrophil protein kinase C delta as a mediator of stroke reperfusion injury. Journal of Clinical Investigation. 2004; 114(1): 49-56.
13. Knox BE, Salcedo E, Mathiesz K, et al. Heterologous Expression of Limulus Rhodopsin. Journal of Biological Chemistry. 2003; 278(42): 40493-40502.
14. Salcedo E, Huber A, Heinrich S, et al. Blue- and green-sensitive visual pigments of Drosophila: Ectopic expression and physiological characterization of the R8 photoreceptor cell-specific Rh5 and Rh6 rhodopsins. Journal of Neuro science. 1999; 19(24): 10716-10726.
15. Chou WH, Huber A, Bentrop J, et al. Patterning of the R7 and R8 photoreceptor cells: Evidence for induced and default cell-fate specification. Development. 1999; 126(4): 607-616.
16. Chang KH, Chen Y Chen TT, et al. A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein. Proceedings of the National Academy of Sciences. 1997; 94(17): 9040-9045.
17. Chou WH, Hall KJ, Wilson DB, et al. Identification of a novel Drosophila opsin reveals specific patterning of the R7 and R8 photoreceptor cells. Neuron. 1996; 17(6): 1101-1115.
18. Chou WH, Wang G, Kumar V, Weng YC. Lipocalin-2 in Stroke. Neuro Open J. 2015; 2(1): 38-41. doi: 10.17140/NOJ-2-109