Waleed Hussein, PhD

School of Chemistry and Molecular Biosciences
The University of Queensland
St Lucia, QLD 4072
Australia

 

Biography

Dr. Hussein obtained his Master Degree in 2002 from the Faculty of Pharmacy at Helwan University in Cairo, Egypt. He took up a position as an Assistant Lecturer in the Organic Chemistry Department of Helwan University, and he later obtained an Egyptian government PhD scholarship to study abroad. Following his PhD in The University of Queensland, Australia, Dr. Hussein got a position as a Post-Doctoral Researcher in Ross McGeary group, co-supervising PhD and Honours students (2010-2012). In 2011, Dr. Hussein was appointed as a Lecturer in the Department of Pharmaceutical Organic Chemistry at Helwan University, Egypt. Currently Dr. Hussein is a Postdoctoral Fellow in Istvan Toth group at School of Chemistry and Molecular Biosciences in The University of Queensland, Australia.
Dr. Hussein works to develop synthetic peptide- and nanoparticle-based vaccines including the development of delivery platforms and safe synthetic adjuvants.
These vaccines target infectious diseases e.g. group A streptococcus, Mycobacterium Tuberculosis, and for the treatment of established tumors like those caused by human papilloma virus infection.
Dr. Hussein also investigates gene delivery with the aim of overcoming the hurdles of cell targeting and penetration, endosomal escape, and nuclear incorporation to develop effective gene therapies.

Research Interest

His research interests include: Synthetic organic chemistry, Biological chemistry and Medicinal chemistry.

Scientific Activities

AWARDS AND HONORS

• (2013) Awarded ECR Travel Fund from School of Chemistry and Molecular Biosciences, The University of Queensland, Australia, to attend the Drug Discovery & Therapy World Congress 2013 in Boston in June as an oral presenter
• (2006) Egyptian government support to obtain his PhD from The University of Queensland, Australia
• (2005) Best tutor for Organic Chemistry from Faculty of Pharmacy, Cairo, Egypt

Publications

1. Liu T, Hussein WM, Giddam A, et al. Polyacrylate-based delivery system for self-adjuvanting anticancer peptide vaccine. Journal of Medicinal Chemistry. 2015; 58: 888-896. doi: 10.1021/jm501514h
2. Ghaffar KA, Hussein WM, Khalil ZG, Capon RJ, Skwarczynski M, Toth I. Levofloxacin and Indolicidin for Combination Antimicrobial Therapy. Current Drug Delivery. 2015; 12: 108-114.
3. Liu, T, Giddam, A, Hussein WM, et al. Self-Adjuvanting Therapeutic Peptide-Based Vaccine Induce CD8+ Cytotoxic T Lymphocyte Responses in a Murine Human Papillomavirus Tumor Model Current Drug Delivery. 2015; 12: 3-8. doi: 10.2174/1567201811666141001155729
4. Hussein WM, McGeary RP. Use of ethyl (benzothiazol-2-ylsulfonyl) acetate for malonic ester-type syntheses of carboxylic acids and esters. Australian Journal of Chemistry. 2014; 67: 1222-1227. doi: 10.1071/CH14085
5. Christie MP, Simerska P, Jen FE-C, et al. A drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylation. Plos One. 2014; 9: e95024. doi: 10.1371/journal.pone.0095024
6. Hussein WM, Liu T, Skwarczynski M, Toth I. Toll-like receptor agonists: a patent review (2011-2013). Expert Opinion on Therapeutic Patents. 2014; 24: 453-470. doi: 10.1517/13543776.2014.880691
7. Skwarczynski M, Liu TY, Hussein WM, et al. Synthesis of therapeutic vaccine against cervical cancer. Pept. Sci. 2013, 50: 65-68.
8. Liu T, Hussein WM, Jia Z, et al. Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer. Biomacromolecules. 2013; 14: 2798-2806.
9. Hussein WM, Liu T, Toth I, Skwarczynski M. Microwave-Assisted Synthesis of Difficult Sequence-Containing Peptide Using the Isopeptide Method. Organic & Biomolecular Chemistry. 2013; 11: 2370-2376. doi: 10.1039/C3OB00030C
10. Hussein WM, Fatahala SS, Mohamed ZM, et al. Synthesis and Kinetic Testing of Tetrahydropyrimidine-2-thione and Pyrrole Derivatives as Inhibitors of the Metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. Chemical Biology & Drug Design. 2012; 80: 500-515. doi: 10.1111/j.1747-0285.2012.01440.x
11. Varamini P, Hussein WM, Mansfeld FM, Toth I. Synthesis, biological activity and structure–activity relationship of endomorphin-1/substance P derivatives. Bioorganic & Medicinal Chemistry. 2012; 20: 6335-6343. doi: 10.1016/j.bmc.2012.09.003
12. Liu T, Hussein WM, Toth I, Skwarczynski M. Advances in peptide-based human papillomavirus therapeutic vaccines. Current Topics in Medicinal Chemistry. 2012; 12; 1564-1575.
13. Wu FL, Hussein WM, Ross BP, McGeary RP. 2-Mercaptobenzothiazole and its Derivatives: Syntheses, Reactions and Applications. Current Organic Chemistry. 2012; 16: 1555-1580. doi: 10.2174/138527212800840964
14. Hussein WM, Ul Islam N, Guddat LW, Schenk G, McGeary RP. Penicillin inhibitors of purple acid phosphatase Faridoon. Bioorganic & Medicinal Chemistry Letters. 2012, 22, 2555-2559.
15. Hussein WM, Vella P, Islam NU, Ollis DL, Schenk G, McGeary RP. 3-Mercapto-1,2,4-triazoles and N-acylatedthiosemicarbazides as metallo-β-lactamase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2012; 22: 380-386. doi: 10.1016/j.bmcl.2011.10.116
16. Feder D, Hussein WM, Clayton DJ, et al. Identification of Purple Acid Phosphatase Inhibitors by Fragment-Based Screening: Promising New Leads for Osteoporosis Therapeutics. Chemical Biology & Drug Design. 2012; 80: 665-674. doi: 10.1111/cbdd.12001
17. Mohamed MS, Hussein WM, McGeary RP, Vella P, Schenk, G, Abd El-hameed RH. Synthesis and kinetic testing of new inhibitors for a metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa. European Journal of Medicinal Chemistry. 2011; 46: 6075-6082.
18. Mohd-Pahmi SH, Hussein WM, Schenk G, McGeary RP. Synthesis, modelling and kinetic assays of potent inhibitors of purple acid phosphatase. Bioorganic & Medicinal Chemistry Letters. 2011; 21: 3092-3094. doi: 10.1016/j.bmcl.2011.03.024
19. Vella, P, Hussein WM, Leung EWW, et al. The identification of new metallo-beta-lactamase inhibitor leads from fragment-based screening. Bioorganic & Medicinal Chemistry Letters. 2011; 21: 3282-3285. doi: 10.1016/j.bmcl.2011.04.027
20. Landsberg MJ, Ruggles JL, Hussein WM, McGeary RP, Gentle IR, Hankamer B. Molecular Packing of Functionalized Fluorinated Lipids in Langmuir Mono layers. Langmuir. 2010; 26: 18868-18873. doi: 10.1021/la103743e
21. Hussein WM, Ross BP, Landsberg MJ, Hankamer B, McGeary RP. Synthetic Approaches to Functionalized Lipids for Protein Monolayer Crystallizations. Current Organic Chemistry. 2009; 13: 1378-1405.
22. Hussein WM, Ross BP, Landsberg MJ, Levy D, Hankamer B, McGeary RP. Synthesis of Nickel-Chelating Fluorinated Lipids for Protein Monolayer Crystallizations. Journal of Organic Chemistry. 2009; 74: 1473-1479. doi: 10.1021/jo802651p
23. El-Azzouny AA, Maklad YA, Bartsch H, Zaghary WA, Ibrahim (Hussein) WM, Mohamed, MS. Synthesis and pharmacological evaluation of fenamate analogues: 1,3,4-oxadiazol-2-ones and 1,3,4-oxadiazole-2-thiones. Sci. Pharm. 2003; 71: 331-356.