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Volume 4, Issue 2
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Article in press

  • 2015, March

    research

    Microbial Safety of Foods in the SupplyOpen Access

    Mohamed T. Elkhishin, Ravi Gooneratne and Malik A. Hussain
    DOI: http://dx.doi.org/10.17140/AFTNSOJ-3-141
    Provisional PDF980.81 KB 980.81 KB
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  • 2015, December

    case report

    Squamous Metaplasia in Colorectal PolypsOpen Access

    Naziheh Assarzadegan* and Felipe J. Solano
    DOI: http://dx.doi.org/10.17140/PLMOJ-1-101
    Provisional PDF479.00 KB 479.00 KB
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  • 2016, January

    editorial

    Some Problems of Vaccination Campaigns in Developing CountriesOpen Access

    Chengjun Sun*
    DOI: http://dx.doi.org/10.17140/VROJ-1-e001
    Provisional PDF272.33 KB 272.33 KB
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  • 2016, February

    opinion

    Liquid Biopsies: Handle With CareOpen Access

    Deyali Chatterjee*
    DOI: http://dx.doi.org/10.17140/PLMOJ-1-102
    Provisional PDF312.45 KB 312.45 KB
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  • 2016, February

    mini review

    Leading Ebola Vaccine CandidatesOpen Access

    Vincent Pavot*
    DOI: http://dx.doi.org/10.17140/VROJ-1-101
    Provisional PDF364.53 KB 364.53 KB
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  • 2016, February

    mini review

    Mast Cells: The Key Players in Cardiac RemodellingOpen Access

    Amrit Pal Singh*, Harpal S. Buttar
    DOI: http://dx.doi.org/10.17140/PLMOJ-1-103
    Provisional PDF539.78 KB 539.78 KB
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  • 2016, February

    review

    Quality Improvement in Clinical Laboratories: A Six Sigma ConceptOpen Access

    Jawahar (Jay) Kalra* and Ashish Kopargaonkar
    DOI: http://dx.doi.org/10.17140/PLMOJ-1-104
    Provisional PDF496.92 KB 496.92 KB
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  • 2016, March

    editorial

    A Novel Application for a Rheumatologic MedicationOpen Access

    Charles F. Haller, Matthew B. Carroll*, Christopher Smith, Yolanda Moulds-Love, William Pomeroy and Bryan C. Ramsey
    DOI: http://dx.doi.org/10.17140/ORHOJ-1-e001
    Provisional PDF282.11 KB 282.11 KB
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  • 2016, April

    perspective article

    Perspective: Ultrastructural Origins of Bone FragilityOpen Access

    Jitin Samuel, Rohit Khanna and Xiaodu Wang*
    DOI: http://dx.doi.org/10.17140/ORHOJ-1-101
    Provisional PDF642.68 KB 642.68 KB
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  • 2016, April

    short communication

    The Use of Botulinum Toxin-A for Neck PainOpen Access

    Abdulrazzaq Alobaid*
    DOI: http://dx.doi.org/10.17140/ORHOJ-1-102
    Provisional PDF303.82 KB 303.82 KB
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  • 2016, April

    commentary

    C-C Chemokine Receptor Seven (CCR7): Coming of Age In VaccinesOpen Access

    Colin A. Bill, Olga B. Soto and Charlotte M. Vines*
    DOI: http://dx.doi.org/10.17140/VROJ-1-102
    Provisional PDF338.02 KB 338.02 KB
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  • 2016, April

    original research

    Herd Immunity Conferred By Hepatitis B Vaccination Increases the Protection Efficacy against Hepatitis B Virus InfectionOpen Access

    Yuting Wang, Ling-Ling Lu, Dongmei Wang and Chunfeng Qu*
    DOI: http://dx.doi.org/10.17140/VROJ-1-103
    Provisional PDF375.02 KB 375.02 KB
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  • 2016, April

    mini review

    Is Normal Knee Biomechanics Reproduced by Modern Total Knee Arthroplasty Designs? The Role of FluoroscopyOpen Access

    Pier Francesco Indelli*
    DOI: http://dx.doi.org/10.17140/ORHOJ-1-103
    Provisional PDF530.35 KB 530.35 KB
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  • 2016, June

    editorial

    Model Based vs. Rule Based Designs in Phase I Dose Finding Clinical TrialsOpen Access

    Yunfei Wang, DrPH; Jichuan Wang, PhD*
    DOI: http://dx.doi.org/10.17140/CTPOJ-1-e001
    Provisional PDF330.16 KB 330.16 KB
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  • 2016, July

    case report

    Gouty Arthritis of the Axial Skeleton: A Case ReportOpen Access

    Yuko Kobashi*, Yohei Munetomo, Akira Baba, Shinji Yamazoe and Takuji Mogami
    DOI: http://dx.doi.org/10.17140/ORHOJ-1-104
    Provisional PDF1.02 MB 1.02 MB
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  • 2016, July

    editorial

    Current Status of Human Immunodeficiency Virus VaccinesOpen Access

    Daniela Sosa, Rahul Dev Jayant*, Ajeet Kaushik and Madhavan Nair*
    DOI: http://dx.doi.org/10.17140/VROJ-1-e002
    Provisional PDF359.54 KB 359.54 KB
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  • 2016, July

    mini review

    Cultural Adaptation for Common Orthopedic Disorders Pathology and Presentations With Focus on Middle Eastern and Asian PatientsOpen Access

    Abdulrazzaq Alobaid*
    DOI: http://dx.doi.org/10.17140/ORHOJ-1-105
    Provisional PDF342.66 KB 342.66 KB
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  • 2016, September

    editorial

    Medical Error Disclosure: A Point of ViewOpen Access

    Jawahar (Jay) Kalra*
    DOI: http://dx.doi.org/10.17140/PLMOJ-1-e001
    Provisional PDF347.61 KB 347.61 KB
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  • 2016, September

    hypothesis

    Tumor Necrosis Factor Inhibitors May Improve Glycemic Control in Patients Rheumatoid Arthritis and Concomitant Type 2 Diabetes MellitusOpen Access

    Abhijeet Danve*, Shivtej Sehra, Divya jaykumar and Supriya Kulkarni
    DOI: http://dx.doi.org/10.17140/ORHOJ-1-106
    Provisional PDF319.93 KB 319.93 KB
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  • 2016, September

    case report

    A Rare Cause of Shoulder Pain: Ganglion Cyst of the Acromioclavicular JointOpen Access

    Hakan Sarman*, Metin Celik and Mehmet Murat Bala
    DOI: http://dx.doi.org/10.17140/ORHOJ-1-107
    Provisional PDF1.40 MB 1.40 MB
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  • 2016, September

    review

    Innovations in Microbial Biodiscovery, Targeting Silent Metabolism and New Chemical DiversityOpen Access

    Zeinab G. Khalil* and Robert J. Capon
    DOI: http://dx.doi.org/10.17140/VROJ-1-104
    Provisional PDF1.43 MB 1.43 MB
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  • 2016, September

    original research

    Dendritic Cell Maturation is a Critical Step in Dendritic Cell Vaccine Preparation for Cancer TherapyOpen Access

    Samad Farashi-Bonab and Nemat Khansari*
    DOI: http://dx.doi.org/10.17140/VROJ-1-105
    Provisional PDF961.51 KB 961.51 KB
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  • 2016, November

    original research

    The QuickDASH in the Assessment of Rheumatoid Arthritis Disease ActivityOpen Access

    Matthew B. Carroll*
    DOI: http://dx.doi.org/10.17140/ORHOJ-1-108
    Provisional PDF510.58 KB 510.58 KB
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  • 2016, November

    review

    Overview of Adult Immune ThrombocytopeniaOpen Access

    Leonard I. Boral*, Gregory P. Monohan and Valentina Moirangthem
    DOI: http://dx.doi.org/10.17140/PLMOJ-1-105
    Provisional PDF469.63 KB 469.63 KB
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  • 2016, November

    editorial

    Innovation of Wound and Burn Care Dressings from Traditional to Nonwoven Polymeric ScaffoldsOpen Access

    Sukhwinder K. Bhullar*, Harpal S. Buttar
    DOI: http://dx.doi.org/10.17140/PLMOJ-1-e002
    Provisional PDF510.32 KB 510.32 KB
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  • 2016, December

    case report

    Invasive Moderately-Differentiated Mucinous Adenocarcinoma Incidentally Identified in Perforated Acute Diverticulitis With Abscess FormationOpen Access

    Mahmoud L. Soliman, Sandra R. Cerda and Huihong Xu*
    DOI: http://dx.doi.org/10.17140/PLMOJ-1-106
    Provisional PDF2.31 MB 2.31 MB
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  • 2017, March

    original research

    Distribution and Conduct of Clinical Trials Involving Music Therapy: Registered Clinical Trials in the Lost 15 YearsOpen Access

    Keiko Yukawa, Hitoshi Fuji and Hajime Sato*
    DOI: http://dx.doi.org/10.17140/CTPOJ-1-101
    Provisional PDF491.29 KB 491.29 KB
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    Abstract [+]

    Objective: This study aimed to conduct an evaluation of music therapy clinical trials
    worldwide, to understand what trials have been conducted and to show the chronological
    changes. Additionally, we sought to clarify issues related to providing clinical trial registration
    information.
    Methods: We searched the International Clinical Trials Registry Platform (ICTRP) database for
    “music therapy,” and identified the disease target for each article found.
    Results: A total of 150 clinical trial studies were found in the ICTRP using the term “music
    therapy.” In these trials, music therapy was used for improvement of social functioning in
    schizophrenia and/or serious mental disorders, anxiety and depressive symptoms, and cancer
    symptoms. Twenty-five clinical trials were actively recruiting. Sixteen of the 25 trials were
    registered in the United States at ClinicalTrials.gov, of which 9 trials were conducted in the US.
    Seven trials were conducted in other countries such as Spain, Taiwan, and China.
    Conclusion: A search for music therapy clinical trials retrieved 150 trials from the ICTRP, and
    the number of clinical trial registrations has increased yearly. Music therapy is widely used in
    patients with various diseases, including Alzheimer’s disease, anxiety, and arthritic pain and
    has the potential to improve certain disease outcomes, but there is not enough evidence to
    substantiate its efficacy. It is important to enlighten researchers and pharmaceutical companies
    on the proper management of the quality of such clinical trial information, as this is an important
    issue.


  • 2017, May

    editorial

    Cell Derived Virus-Like Particles (VLP) in Future Vaccine DevelopmentOpen Access

    Pramila Walpita*
    DOI: http://dx.doi.org/10.17140/VROJ-1-e003
    Provisional PDF258.24 KB 258.24 KB
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  • 2017, May

    review

    Ebola Virus: Promising Vaccine CandidatesOpen Access

    Reema Sameem and Sajani Dias*
    DOI: http://dx.doi.org/10.17140/VROJ-1-106
    Provisional PDF385.19 KB 385.19 KB
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  • 2017, June

    editorial

    The Swan Song of a Pathologist: “Why Do I Love Thee, Pathology? Let Me Count the Ways….”Open Access

    Bhagirath Majmudar*
    DOI: http://dx.doi.org/10.17140/PLMOJ-1-e003
    Provisional PDF352.68 KB 352.68 KB
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  • 2017, June

    original research

    Fluorinated Lipids Conjugated to Peptide Antigens do not Induce Immune Responses Against Cervical CancerOpen Access

    Waleed M. Hussein, Saori Mukaida, Tzu-Yu Liu, Istvan Toth and Mariusz Skwarczynski*
    DOI: http://dx.doi.org/10.17140/VROJ-1-107
    Provisional PDF521.95 KB 521.95 KB
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  • 2017, August

    editorial

    Recent Advances in Adenovirus-Vectored Vaccines DevelopmentOpen Access

    Alexander N. Zakhartchouk*
    DOI: http://dx.doi.org/10.17140/VROJ-1-e004
    Provisional PDF310.46 KB 310.46 KB
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  • 2017, October

    editorial

    Hair Loss and Chemotherapy: An Overview about What You Need To KnowOpen Access

    Danúbia Sá-Caputo and Mario Bernardo-Filho*
    DOI: http://dx.doi.org/10.17140/TCOJ-1-e006
    Provisional PDF344.62 KB 344.62 KB
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  • 2017, October

    review

    Clinical Investigations on Medical Devices, after the New European Regulation (2017/745)Open Access

    Salvatore Bianco*, Alfredo Nunziata and Giacomo Pozzoli
    DOI: http://dx.doi.org/10.17140/CTPOJ-1-102
    Provisional PDF387.89 KB 387.89 KB
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  • 2017, October

    mini review

    Cluster Randomized Controlled Trials: A Quick Update on Concepts and TypesOpen Access

    Bolaji Emmanuel Egbewale*
    DOI: http://dx.doi.org/10.17140/CTPOJ-1-103
    Provisional PDF348.57 KB 348.57 KB
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  • 2017, November

    review

    Immunobiology of Anticancer Virotherapy With Newcastle Disease Virus in Cancer PatientsOpen Access

    Samad Farashi-Bonab and Nemat Khansari*
    DOI: http://dx.doi.org/10.17140/VROJ-1-108
    Provisional PDF438.63 KB 438.63 KB
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  • 2018, April

    editorial

    Education and Health System Collaboration are Indispensable in Vaccination CoverageOpen Access

    Chengjun Sun*
    DOI: https://dx.doi.org/10.17140/VROJ-1-e005
    Provisional PDF402.68 KB 402.68 KB
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  • 2018, May

    original research

    Training of Future Surgeons in Minimally Invasive Surgery Needs Intensification: A Multicentre StudyOpen Access

    Srinath Ranjit, Farhan Rashid, Sami Mansour, Khaleel Fareed, Neda Farhangmehr, Bruno Lorenzi and Alexandros Charalabopoulos*
    DOI: http://dx.doi.org/10.17140/SROJ-5-122
    Provisional PDF1.19 MB 1.19 MB
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  • 2018, May

    editorial

    The Case for Flu VaccinationOpen Access

    Olukayode A. Akinlaja*
    DOI: https://dx.doi.org/10.17140/VROJ-1-e006
    Provisional PDF270.56 KB 270.56 KB
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  • 2018, August

    review

    The Concept of Developing a Plasmodium vivax Malarial Vaccine with a Focus on its Pre-erythrocytic StageOpen Access

    Tuan Imaad Aarif, Sajani Dias*
    DOI: https://dx.doi.org/10.17140/VROJ-1-109
    Provisional PDF318.29 KB 318.29 KB
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  • 2018, August

    editorial

    New Ideas on Limitations to VO2max: Five Major Determinants for VO2maxOpen Access

    Masahiro Kohzuki*
    DOI: http://dx.doi.org/10.17140/PRRMOJ-5-e010
    Provisional PDF398.63 KB 398.63 KB
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  • 2018, September

    case report

    A Case Report on Vogt-Koyanagi-Harada Disease Seen at a Tertiary Hospital in the PhilippinesOpen Access

    Tathiana T. Marcelo*, Eleonore B. Iguban*
    DOI: http://dx.doi.org/10.17140/OOJ-3-116
    Provisional PDF338.25 KB 338.25 KB
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  • 2018, September

    editorial

    Don’t Shun the Shunt: Surgical Portosystemic Shunts in the Era of TIPS and Liver TransplantationOpen Access

    Her-HsinTsai*
    DOI: http://dx.doi.org/10.17140/LROJ-3-e004
    Provisional PDF260.48 KB 260.48 KB
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  • 2018, October

    review

    Dementia and Oral Health: Is There A Connection?Open Access

    Suellan Go Yao and James Burke Fine*
    DOI: http://dx.doi.org/10.17140/DOJ-5-140
    Provisional PDF387.93 KB 387.93 KB
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  • 2018, October

    systematic review

    Hair as a Specimen to Determine the Concentration of Cortisol Levels in Individuals that have Performed Physical ActivityOpen Access

    Alexandre Gonçalves de Meirelles*, Marcia Cristina Moura-Fernandes, Eloá Moreira-Marconi, Tânia Regina Lemos-Santos, Gefferson da Silva-Costa, Sérgio Oliveira De-Carvalho, Ivana de Cássia Araújo Ventura, Ygor Teixeira-Silva, Laisa Liane Paineiras-Domingos, Danúbia da Cunha de Sá-Caputo and Mario Bernardo-Filho
    DOI: http://dx.doi.org/10.17140/TCOJ-1-110
    Provisional PDF412.83 KB 412.83 KB
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  • 2019, January

    editorial

    Pediatric and Neonatal Malnutrition: A Collaborative, Family-Centered Approach Improves OutcomesOpen Access

    Dena L. Goldberg* and Holly A. Van Poots
    DOI: http://dx.doi.org/10.17140/PNNOJ-6-e008
    Provisional PDF315.00 KB 315.00 KB
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  • 2019, January

    review

    Glucocorticoid Induced Hypothalamic-Pituitary Axis Alterations Associated with Hypogonadotropic HypogonadismOpen Access

    Navid Mahabadi, Ashley Doucet, Andrew Lun Wong, and Vahid Mahabadi*
    DOI: http://dx.doi.org/10.17140/ORHOJ-1-109
    Provisional PDF428.78 KB 428.78 KB
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  • 2019, January

    original research

    Fractional CO2 Laser Treatment for Vaginal Rejuvenation in Post-Menopausal Indian WomenOpen Access

    Rahul Pillai* and Safal Rahim
    DOI: http://dx.doi.org/10.17140/TCOJ-1-111
    Provisional PDF403.86 KB 403.86 KB
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  • 2019, January

    original research

    Determinants of Canine Rabies in Morocco: How to Make Pertinent Deductions for Control?Open Access

    Mounir Khayli*, Youssef Lhor, Sami Derkaoui, Yassir Lezaar, Mehdi El Harrak, Latifa Sikly and Mohammed Bouslikhane
    DOI: https://dx.doi.org/10.17140/EPOJ-4-113
    Provisional PDF529.13 KB 529.13 KB
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  • 2019, January

    original research

    Alleviating Impact of Taurine on Renal Lipid Peroxidation and Oxidative Stress in Lambda-Cyhalothrin Exposed RatOpen Access

    Barun Chakroborty, Ananya Pradhan, Prasanta Maiti and Sujata Maiti Choudhury*
    DOI: https://dx.doi.org/10.17140/TFMOJ-4-126
    Provisional PDF609.21 KB 609.21 KB
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  • 2019, January

    original research

    Prevalaence of Anaemia among Preganant Women Attending 82 Division Nigerian Army Hospitals, EnuguOpen Access

    Chukwunonso Collins Ejiofor*, Rosemary Ujunwa Ozokono and Joshua Izuchukwu Ugwu
    DOI: https://dx.doi.org/10.17140/GOROJ-6-148
    Provisional PDF361.80 KB 361.80 KB
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  • 2019, February

    original research

    Compliance with Tobacco Control Policies and Global Youth Tobacco Survey: A Cross-Sectional Comparison between GYTS 2000 and 2015 in Maharashtra, IndiaOpen Access

    Mangesh S. Pednekar*, Prachi P. Kerkar, Sameer S. Narake, Dhirendra N. Sinha and Surendra S. Shastri
    DOI: https://dx.doi.org/10.17140/EPOJ-4-114
    Provisional PDF536.76 KB 536.76 KB
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  • 2019, February

    case report

    Actinic Lichen Nitidus with Dermoscopic Features, and Response to HydroxychloroquineOpen Access

    Smriti Shrestha* and Aditi Mishra
    DOI: http://dx.doi.org/10.17140/TCOJ-1-112
    Provisional PDF436.98 KB 436.98 KB
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  • 2019, February

    systematic review

    Poisonings in Singapore: A Poison Center PerspectiveOpen Access

    Ponampalam R*
    DOI: https://dx.doi.org/10.17140/TFMOJ-4-127
    Provisional PDF405.17 KB 405.17 KB
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  • 2019, February

    original research

    The Effectiveness of Transcutaneous Electrical Nerve Stimulation Versus Carbamazepine in Trigeminal Neuralgia: A Randomized Controlled TrialOpen Access

    Rebecca Millan-Guerrero*, Rebecca Isais-Millan, Gabriel Castillo-Varela, Gabriel Ceja-Espíritu and Martha Alicia Higareda Almaraz
    DOI: http://dx.doi.org/10.17140/CTPOJ-1-104
    Provisional PDF538.47 KB 538.47 KB
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  • 2019, February

    editorial

    Alternative Effective Management of the Musculoskeletal PainOpen Access

    Olena Plotkina* and Andrei Bourdeinyi
    DOI: https://dx.doi.org/10.17140/ORHOJ-1-e002
    Provisional PDF319.79 KB 319.79 KB
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  • 2019, February

    letter to the editor

    “The Moustache Sign”: A Common Morphological Characteristic in Cardiovascular Disease TreatmentOpen Access

    Vineet Bhatia*, Parneesh Arora, Anunay Gupta, Suman Bhandari and Upendra Kaul
    DOI: https://dx.doi.org/10.17140/HROJ-6-148
    Provisional PDF730.37 KB 730.37 KB
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  • 2019, February

    retrospective study

    Bilateral Staged Primary Total Knee Arthroplasty: Are Patients Less Pleased with their Second Side?Open Access

    Mehdi Suzangar*, Colin Esler, James Kennedy and Urjit Chatterji
    DOI: https://dx.doi.org/10.17140/ORTOJ-4-114
    Provisional PDF283.29 KB 283.29 KB
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  • 2019, March

    mini review

    Burden, Access, and Disparities in Kidney DiseaseOpen Access

    Deidra C. Crews*, Aminu K. Bello, Gamal Saadi and for the World Kidney Day Steering Committee**
    DOI: https://dx.doi.org/10.17140/NPOJ-5-121
    Provisional PDF466.89 KB 466.89 KB
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  • 2019, March

    review

    A Review of Vaccine Efficacy MeasuresOpen Access

    Sayan Dasgupta*
    DOI: https://dx.doi.org/10.17140/VROJ-1-110
    Provisional PDF379.93 KB 379.93 KB
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  • 2019, March

    retrospective study

    The Causes of Marginal Discrepancy of Fixed Dental Prostheses: A Cross-Sectional StudyOpen Access

    Asma Ismail, Yosra Gassara, Dalenda Hadyaoui and Mounir Cherif*
    DOI: https://dx.doi.org/10.17140/DOJ-5-141
    Provisional PDF466.01 KB 466.01 KB
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  • 2019, March

    editorial

    Challenges Facing Pediatric Dentistry Diplomates and the American Board of Pediatric Dentistry: Setting the Bar for Minimal Competency vs. ExcellenceOpen Access

    John E. Nathan*
    DOI: https://dx.doi.org/10.17140/PNNOJ-6-e009
    Provisional PDF248.71 KB 248.71 KB
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  • 2019, April

    editorial

    A Decision Support System is Needed for Rapid Triage of Chest Pain Patients Using High Sensitivity Troponin Testing-Based AlgorithmsOpen Access

    Chien-Chang Lee*, Cheng-Heng Liu, Sih-Shiang Huang and Cho-Han Chiang
    DOI: https://dx.doi.org/10.17140/EMOJ-5-e006
    Provisional PDF300.15 KB 300.15 KB
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  • 2019, April

    review

    Salmonella-based Anticancer Vaccines and their EfficacyOpen Access

    Samad Farashi-Bonab* and Nemat Khansari
    DOI: https://dx.doi.org/10.17140/VROJ-1-111
    Provisional PDF365.81 KB 365.81 KB
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  • 2019, April

    perspective

    Consensus Meeting on International Standards for Oral Whole Cell Killed Cholera Vaccines, 17-18 May 2018, Seoul, Republic of KoreaOpen Access

    Lina Odevall, Sjoerd Rijpkema, Dean Smith, Tong Wu, Firdausi Qadri, Jan Holmgren, Julia Lynch and Viliam Pavliak*
    DOI: https://dx.doi.org/10.17140/VROJ-1-112
    Provisional PDF474.29 KB 474.29 KB
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  • 2019, May

    letter to the editor

    Endoscopic Treatment of Refractory Variceal BleedOpen Access

    Shreyas Saligram*, Marina Roytman, Helen Wong and ThimmaiahTheethira
    DOI: http://dx.doi.org/10.17140/GOJ-4-128
    Provisional PDF339.36 KB 339.36 KB
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  • 2019, May

    brief research report

    A Cycle of Altered Proteasome and Reactive Oxygen Species Production in Renal Proximal Tubular CellsOpen Access

    Nirmala Parajuli*
    DOI: https://dx.doi.org/10.17140/TFMOJ-4-128
    Provisional PDF436.16 KB 436.16 KB
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  • 2019, May

    original research

    The Prognostic Value of PD-L1 Expression in Triple-Negative Breast Cancer: A Cohort Study and Systematic Literature ReviewOpen Access

    Daniel Schmolze, Carolyn E. Behrendt, Peter P. Lee and Sophia Apple*
    DOI: http://dx.doi.org/10.17140/PLMOJ-1-107
    Provisional PDF499.31 KB 499.31 KB
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  • 2019, June

    original research

    Changes on Electrocardiographic Patterns and Associated Factors among Chronic Obstructive Pulmonary Disease PatientsOpen Access

    Wondu Reta Demissie*, Samuel Tadessa, Elsah Tegene and Tewodros G. Mariam
    DOI: https://dx.doi.org/10.17140/HROJ-6-149
    Provisional PDF449.30 KB 449.30 KB
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  • 2019, June

    original research

    Antihyperglycemic Mechanisms of Allium sativum, Citrus sinensis and Persea americana Extracts: Effects on Inhibition of Digestive Enzymes, Glucose Adsorption and Absorption on Yeast Cells and Psoas MusclesOpen Access

    Boris Gabin Kingue Azantsa*, Guy Roussel Takuissu, Etienne Junior Tcheumeni, Martin Fonkoua, Edwige Ruth Kemadjou Dibacto, Judith Laure Ngondi and Julius Enyong Oben
    DOI: http://dx.doi.org/10.17140/DROJ-5-143
    Provisional PDF605.84 KB 605.84 KB
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    Abstract [+]

    Mechanisms by which some plants with antihyperglycemic effects reduce postprandial hyperglycemiaare not fully elucidated. This study was designed to investigate some action mechanisms of extracts from stem bark of Citrus sinensis, seeds of Persea americana and bulbs of Allium sativum including in vitro inhibition of α-amylase and invertase; glucophagic capacity, absorption capacity on yeast cells and psoas tissues.


  • 2019, June

    brief research report

    Compliance with Highly Active Antiretroviral Therapy (HAART) does not Prevent Human Papilloma Virus (HPV)- Related Cancers in Women Infected with Human Immunodeficiency Virus (HIV)Open Access

    Katherine Rogg and William R. Robinson*
    DOI: https://dx.doi.org/10.17140/GOROJ-6-149
    Provisional PDF358.08 KB 358.08 KB
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    Abstract [+]

    Introduction
    Cancer is one of the leading causes of death in people with human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS), due to behavioral choices and overlapping risk factors.

    Aim
    The purpose of this report is to determine the long-term incidence of human papilloma virus (HPV)-associated cancer in women with pre-invasive cervical neoplasia, and compliance with medication and cancer screening recommendations.

    Methods
    HIV-infected women diagnosed with pre-invasive cervical neoplasia and an HPV-associated malignancy between 1995-2008 were identified. Data collected includes: demographics, HIV treatment/response, malignancy treatment/response, other healthcare utilization, use of health navigators, and compliance.

    Results
    Seventy-one subjects were identified with HIV infection, cervical dysplasia, and at least ten years’ follow-up. 17/71 (24%) were identified with an HPV-related malignancy. The mean age of those diagnosed with HPV-related malignancy was 39-years. Malignancies included: Cervix-9, Vulva-7, Anal-4, Vagina-3, Uretha/Bladder-2, Oropharyngeal-3. Eight also had in-situ neoplasms: Cervix-4, Vulva-3, Oropharyngeal-1. Four subjects had 3 separate malignancies, and two others had 2 malignancies. Compliance with HAART correlated strongly with immunocompetence, response to therapy, use of patient navigators, and survival. Sixty out of saventy one (84.5%) subjects underwent screening mammography, 57/71 (80.3%) underwent colonoscopy, and 67/71 (94.3%) underwent pap smear testing. Compliance with screening compared favorably with the general population, and overall survival was similar.

    Discussion and Conclusion
    The long-term incidence and mortality from cancer in women with HIV and cervical dysplasia appears to be comparable to that seen in the general population, with the possible exception of oropharyngeal cancers. Compliance with cancer screening recommendations appears to be higher than in the general population. This suggests that structured primary care programs for HIV-infected women are effective in prevention/early diagnosis of cancer. Standardized screening programs for oropharyngeal cancers should be considered in this population.

    Keywords
    Human immunodeficiency virus (HIV); Cancer; Human papilloma virus(HPV); Women; AIDS;
    Highly active anti-retroviral therapy (HAART).


  • 2019, June

    original research

    Changes in Blood Bone Metabolism Markers with Oat Bran Consumption and Brisk Walking Exercise in Middle Age Hypercholesterolemic WomenOpen Access

    Foong Kiew Ooi*, Fakri Noor Fatin Nazieffa and Abidin Muhammad Amrun Haziq
    DOI: https://dx.doi.org/10.17140/SEMOJ-5-172
    Provisional PDF423.99 KB 423.99 KB
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    Abstract [+]

    Purpose
    To investigate the additional beneficial effects of combined oat bran consumption and brisk walking exercise compared to oat bran consumption alone on bone metabolism markers in 40 to 50 years-old hypercholesterolemic women.

    Methods
    Thirty-three hypercholesterolemic women participants aged 40 to 50-years-old were recruited and were assigned into three groups, with eleven participants per group (n=11): sedentary without oat bran consumption control (C), oat bran consumption alone (Ob), and combined oat bran consumption and brisk walking exercise (ObEx) groups. Participants in the ObEx group performed brisk walking exercise sessions 30 minutes per session, 3 sessions per week for 6 weeks. Participants in the Ob group and ObEx group consumed 18 g of oat bran powder, 7 days per week for 6 weeks. Participants’ anthropometry and blood bone metabolism markers were measured at pre- and post-tests.

    Results
    There were no significant main effects of time (p>0.05) in serum total calcium, serum phosphorus and serum C-terminal telopeptide of type 1 collagen (1CTP) (bone resorption marker) concentrations in all the groups. However, significantly (p<0.05) increase in serum alkaline phosphatase (bone formation marker) concentration was observed in Ob group and ObEx group respectively.

    Conclusion
    The present observations did not show large difference in the beneficial effects of combined oat bran consumption and brisk walking compared to oat bran consumption alone on bone metabolism markers. Future studies with longer duration may be needed to elicit greater effects of combined oat bran consumption and brisk walking than oat bran consumption alone on bone metabolism markers in middle age hypercholesterolemic women.

    Keywords
    Bone metabolism; Brisk walking; Hypercholesterolemic; Oat bran consumption; Middle age women.


  • 2019, June

    original research

    The Effectiveness of Inferior Turbinoplasty in Children with Nasal ObstructionOpen Access

    Balegh H. Abdelhak*, Ahmed A. Sadek, Rasha A. Abdel Moneim and Zein A. Saad
    DOI: https://dx.doi.org/10.17140/OTLOJ-5-155
    Provisional PDF366.88 KB 366.88 KB
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    Abstract [+]

    Objective
    To evaluate the effectiveness of medial flap inferior turbinoplasty for the treatment of nasal obstruction in children.

    Patients and Methods
    This study was conducted at the ear nose throat (ENT) Department at Minia University Hospital, Minia, Egypt which include 40 children with bilateral nasal obstruction due to bilateral hypertrophied inferior turbinates that did not respond to medical treatment for 3 successive months in the form of (systemic antihistamines, systemic and local decongestant drugs and local corticosteroid spray) who attended the ENT outpatient clinic. All patients were subjected to turbinate reduction through medial flap inferior turbinoplasty.

    Results
    Forty patients with bilateral hypertrophied inferior turbinates were assessed. Ninety days after surgery, 90% of patients transformed from severe or moderate degrees of nasal obstruction “pre-operatively” to mild degree or completely with no nasal obstruction; 80% of patients had grade I improvement in nasal obstruction and 14 patients had only grade II improvement; only
    10% of patients had crustation.

    Conclusion
    Medial flap inferior turbinoplasty is safe and effective in the treatment of nasal obstruction in children with almost no complications was recorded.

    Keywords
    Inferior turbinate hypertrophy; Inferior turbinoplasty; Nasal obstruction; Children.


  • 2019, June

    letter to the editor

    Coexistence of Tuberculosis and Metastatic Undifferentiated Carcinoma of Nasopharynx in Cervical Lymph NodeOpen Access

    Sameh Mezri*, Sameh Sayhi, Marwa Ben Amira, Issam Msakni, Besma Laabidi, Rania Ben M'hamed and Khemaies Akkeri
    DOI: https://dx.doi.org/10.17140/OTLOJ-5-156
    Provisional PDF588.41 KB 588.41 KB
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    Abstract [+]

    The coexistence of a head and neck cancer and a lymph node tuberculosis is rarely described. The problem is essentially diagnostic. We report the case of a patient with cervical lymphadenopathy and non suspect swelliing of nasopharynx. Histopathological study of lymph node reveled an association of a tubercular adenitis and a metastasis of a squamous cell carcinoma.


  • 2019, June

    original research

    Changes in Estimated Glomerular Filtration Rate, Biochemical and Hematological Profile of Workers in Spray Painting Industry: A Cross-Sectional StudyOpen Access

    Christopher E. Ekpenyong* and Nseobong N. Nkereuwem
    DOI: https://dx.doi.org/10.17140/NPOJ-5-122
    Provisional PDF480.31 KB 480.31 KB
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    Abstract [+]

    Introduction

    There is a global increase in occupational exposure to solvents, some of which are suspected to cause acute or chronic toxic nephropathies in humans. However, limited studies have been done to evaluate the systemic effects of exposure to some of the commonly used solvents such as paints.

    Aim

    The aim of the present study was to assess the effect of chronic exposure to paint fumes on renal and hepatic functions of industrial spray painters. Methodology In this cross-sectional study, 49 occupationally exposed male industrial spray painters who had served for greater than 5 years were evaluated for changes in renal, hepatic and hematological indices using standard instruments and results were compared with levels in the unexposed (sex and age-matched) participants.

    Results

    Significant changes in markers of renal, hepatic and hematological functions were observed in the exposed compared with unexposed participants including significant decrease in estimated glomerular filtration rate (eGFR) and serum levels of potassium (K+) and chloride (Cl-), and significant increases in serum levels of creatinine (Cr), sodium (Na+), urea (Ur) and uric acid (UA) in the exposed compared to levels in the unexposed group. Abnormal serum levels of hepatic enzymes (AST, ALT and ALP) and hematological indices (PCV, total-RBC, nuetrophils, basophils, monocytes and lymphocytes) were also observed in the exposed compared to levels in the unexposed participants.

    Conclusion

    Prolonged exposure to paint fumes may be associated with a significant risk for hepato-renal dysfunction and hematotoxicity. Preventive measures should include limiting exposure and using antioxidant medications.

    Keywords

    Spray painting; Toxicity; Workers; Kidney; Liver; Blood cells.
    Abbreviations ALT: Alanine transaminase; ALP: Alkaline phosphatase; AST: Aspartate transaminase; eGFR: Estimated glomerular fitration rate; C-G: Cockroft-Gault; MDRD: Modification of diet in renal disease; Na+/K+/ATPase: Sodium potassium adenosine triphosphatase; PH: Hydrogen Concentration; PCV: Packed cell volume; RBC: Red blood cells; ROS: Reactive oxygen species; UA: Uric acid; Ur: Urea.


  • 2019, July

    original research

    Loss of Pancreatic β-cell Secretory Function During Disease Progression in Type 2 Diabetes Mellitus – A Small Cross-Sectional StudyOpen Access

    George B. Kudolo*
    DOI: http://dx.doi.org/10.17140/POJ-3-109
    Provisional PDF517.96 KB 517.96 KB
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    Abstract [+]

    Introduction: Overt type 2 diabetes mellitus (T2DM) is a chronic progressive disease which is produced by the collusion of three metabolic defects-increased hepatic glucose production, impaired pancreatic β-cell insulin secretion and decreased insulin action. The measurement of plasma glucose 2 hours post-ingestion of 75 g of glucose during the oral glucose tolerance test (OGTT) may be used to classify individuals as normal glucose tolerant (NGT), impaired glucose tolerant, T2DM and T2DM with pancreatic β-cell failure.
    Objectives: This study was undertaken primarily to show the importance of assessing the pancreatic β-cell function especially during the care of the diabetic patient.
    Methods: A standard 75 g glucose tolerance test (OGTT) was administered to four groups of 8 subjects (4 male, 4 female). Blood was drawn every 15 minutes for 2 hours for the measurement of glucose, insulin and C-peptide and the measurement of the area under the curve (AUC(0→2)) over the 2-hour period.
    Results: American Diabetes Association (ADA) criteria were used to classify the subjects. The normal glucose tolerant (NGT), had 2 h glucose 111±11 mg/dL, those with impaired glucose tolerance (IGT) had 2 h glucose 160±13 mg/dL. The 2 h glucose for the T2DM group was 258±27 mg/dL and those for the T2DM-PE group was 260±42 mg/dL. The AUC(0→2) for NGT group were 254±40 mg/dL/h, 112±61 μU/mL/h and 10.2±4.6 ng/ml/h for glucose, insulin and C-peptide, respectively. The AUC(0→2) for the IGT group were 394±32 mg/dL/h, 160±48 μU/mL/h and 19.8±7.7 ng/ml/h for glucose, insulin and C-peptide, respectively. The AUC(0→2) for the T2DM group were 474±62 mg/dL/h, 194±40 μU/mL/h and 13.4±4.7 ng/mL/h for glucose and insulin, and C-peptide, respectively. The AUC(0→2) for the T2DM-PE group were 481±80 mg/dL/h, 51±29 μU/mL/h and 7.2±2.8 ng/mL/h for glucose, insulin and C-peptide, respectively. There was no significant difference between the diabetic groups with respect to the glucose AUC(0→2) but a significant difference existed in the insulin AUC(0→2), (p<0.0001) mirrored by the fasting plasma insulin levels (30±8 μU/mL vs 14+8 μU/mL, for T2DM and T2DM-PE, respectively, p<0.0005). Although there was about a 300% increase in fasting insulin between the IGT and T2DM groups, the corresponding fasting C-peptide levels were only about 15%. This is probably due to differences in hepatic and renal functions in those two groups, the processes that control insulin and C-peptide levels in the body. Conclusion: Although measurement of blood glucose appears adequate in the diagnosis of the diabetes, it seems that plasma insulin/C-peptide measurements could guide physicians in their choice of medications for the treatment of diabetic patients, especially when the pancreas begins to fail. To that end, larger studies are warranted to study the effects of hypoglycemic agents on hepatic insulin extraction and renal C-peptide excretion to ascertain the reliability of the plasma insulin and C-peptide levels. Keywords Type 2 diabetes mellitus; Pancreatic β-cells; Oral glucose tolerance test; Pancreatic exhaustion.


  • 2019, July

    original research

    Exploring the Everyday Lived Experience of African American People Living with HIV/AIDS (PLWH) in the Rural SouthOpen Access

    Jill E. Rowe*
    DOI: http://dx.doi.org/10.17140/HARTOJ-6-129
    Provisional PDF406.54 KB 406.54 KB
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    Abstract [+]

    Aims/Objectives

    Despite previous findings attesting to the syndemic nature of human immunodeficiency virus (HIV), chronic disease and mental illness coordination of these issues remains a significant barrier to initiating and maintaining the delivery of mental and physical health care to persons living with HIV (PLWH). These inequities are even greater when applied to rural settings, particularly in areas that are medically underserved. To date, there is scarce research regarding the lived experiences of African American PLWH
    in rural settings. Constructivist grounded theory was used to analyze this qualitative data set. These discourses provide a rich narrative regarding effective systems of care, the context in which these processes take place and related constraints or limitations of the current systems.

    Methods

    In-depth interviews with 24 African American PLWH both inside (N=20) and outside (N=4) of care in rural Northwestern Virginia were conducted. Rural African American PLWH were queried about their perceptions of the provision of HIV health care services, barriers to linkages to care, retention of PLWH in care, and recommendations for improving HIV health care services for rural PLWH.

    Results

    Participants offered insights on the linkages to health and mental health care consistent with the pattern recommended by the cascade of care (i.e. pre-screening, testing, refer to treatment, treatment and sustain treatment). Participants identified contextual factors, including traumatic events, medication (side effects), other chronic health issues, issues with the current health and mental health system, stigma, and lack of social support. We highlight PLWH’s recommendations for linking rural PLWH into care and sustaining that care.

    Conclusion

    We discuss the implications of these findings for programmatic development in the rural context.

    Keywords

    Rural African Americans living with HIV; Barriers to HIV health care; Rural South; HIV lived experience.


  • 2019, July

    case report

    Early Onset, But Late Diagnosis of a Rare DiseaseOpen Access

    Pamela Farah*, Pascale Daniel, Georges El Khoury, Rami El Rachkidi, and Aline Tohme
    DOI: http://dx.doi.org/10.17140/IMOJ-3-108
    Provisional PDF313.08 KB 313.08 KB
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    Abstract [+]

    One of the most common sphingolipidosis, Gaucher disease (GD) remains rare till date. A case report of a 56-year-old patient diagnosed with GD is presented herein. Her sister was known to have Gaucher disease. Her personal medical record consisted of splenectomy, anemia, recurrent infections, and bone lesions at a young age. Taking into consideration her personal and familial history, the clinical and paraclinical examinations, she was diagnosed with Gaucher disease which was confirmed with enzyme and gene testing. Upon introduction of specific enzyme replacement treatment for Gaucher patients,much evidence demonstrated the substantial improvement of hematological and visceral parameters. However, it has been observed that the bone tissue does not respond equally to the treatment.
    Learning Points
    • The physician should always investigate the splenomegaly of unknown etiology before deciding to do a splenectomy
    • Bone lesions in Gaucher disease are sometimes irreversible, hence the importance of early diagnosis of this rare disease
    Keywords
    Gaucher disease; Bone lesion; Splenomeagly.
    Acronyms
    GD: Gaucher disease; Hb: Hemoglobin; MRI: Magnetic resonance imaging; ERT: Enzyme replacement therapy.


  • 2019, July

    retrospective study

    Outcomes of Vocal Fold Immobility After Pediatric Cardiovascular SurgeryOpen Access

    Anatoli F. Karas, Aniruddha Patki, Marisa A. Ryan, Patrick A. Upchurch, Rose J. Eapen and Eileen M. Raynor*
    DOI: https://dx.doi.org/10.17140/OTLOJ-5-157
    Provisional PDF367.60 KB 367.60 KB
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    Abstract [+]

    Objectives
    Cardiovascular surgery is increasingly performed in children for congenital malformations of the heart and great vessels. Observed as vocal fold immobility, recurrent laryngeal nerve injury is a well-described complication. As overall outcomes improve and patients live longer, the sequelae of vocal fold immobility amplify insignificance. Families are often unaware of the longterm issues related to vocal fold immobility especially with regard to need for alternative alimentation routes. We report on the incidence of use of feeding tubes, the timing of vocal fold function return and need for additional aerodigestive interventions.
    Methods
    We reviewed 65 patients <2-years who underwent cardiovascular surgery at a tertiary center from 2008-2013 and were diagnosed post-operatively with vocal fold immobility by fiberoptic examination. Results Patent ductus arteriosus and hypoplastic left heart syndrome were the most common of the cardiovascular anomalies included. The majority (92%) had unilateral left immobility. Recovery of motion was observed in 29% ranging from 1-month to 3-years. Hypoplastic left heart syndrome had a significant negative correlation with recovery. Forty-six percent required gastrostomy tube placement either to supplement their oral intake or to completely meet their nutritional needs. Forty-eight percent required subsequent aerodigestive surgery including direct laryngoscopy/bronchoscopy (22%), tracheostomy (8%) and vocal fold injection (5%). Conclusion Counseling of families and primary care providers regarding the impact of pediatric vocal fold immobility after cardiac surgery should include the high potential requirement for supplemental alimentation as well as the need for feeding and speech therapy. Longitudinal otolaryngology and speech pathology care is imperative with vocal fold immobility since the majority of these patients do not experience functional recovery and may require further interventions over time. Keywords Vocal cord paralysis; Pediatric cardiovascular surgery; Pediatric aerodigestive disorders; Voice; Swallow; Gastrostomy.


  • 2019, July

    original research

    Physico-Chemical, Surface and Thermal Properties of Date Palm Pollen as a Novel Nutritive IngredientOpen Access

    Haifa Sebii*, Sirine Karra, Brahim Bchir, Abir M. Ghribi, Sabine M Danthine, Christophe Blecker, Hamadi Attia and Souhail Besbes
    DOI: https://dx.doi.org/10.17140/AFTNSOJ-5-160
    Provisional PDF645.88 KB 645.88 KB
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    Abstract [+]

    Background

    Date palm pollen (DPP) is a natural product well-known in folk medicine in the Arab world. It is used to improve the fertility of human beings and studies have tested this activity on rabbits and rats. In the region of Sfax from Tunisia, a huge quantity of DPP could be discarded. Taking into account of the richness of this typical product of different components and of the trend of producing food supplements that could be sold at medium price comparing with the existing product, DPP was analyzed on the basis of physical and chemical properties in order to promote its use as a techno-functional ingredient in the agri-food and pharmaceutical field.

    Results

    X-ray diffraction showed that DPP is characterized by an amorphous structure which leads to better techno-functional properties while stored in a water-air-tight container. Findings proved that DPP is capable to reduce the surface tension. Collected data from thermal analysis proved that DPP is thermally stable during storage and in different food systems.

    Conclusion

    The present study demonstrated that DPP could be used in the agri-food and pharmaceutical field. The obtained results help to define the suitable storage conditions of DPP and to predict its behavior when used as an ingredient. DPP can be used as a whole in food formulations or after extracting protein which is the main responsible agent for surfactant property. DPP proteins might be used as a food supplement in commercial sports nutrition products that can be sold at medium prices compared to some existing products.

    Keywords

    Date palm pollen; Physico-chemical; Morphology; Surface; Thermal.


  • 2019, July

    original research

    Why do HIV PrEP Patients Become Lost-to-Care and How Can We Improve PrEP Retention?Open Access

    Sahana Jayaraman*, Linden Lalley-Chareczko, Sarah Williams, Devon Clark, Caitlin Conyngham and Helen C. Koenig
    DOI: http://dx.doi.org/10.17140/HARTOJ-6-130
    Provisional PDF531.79 KB 531.79 KB
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    Abstract [+]

    Objectives

    To assess reasons for patients being lost-to-care (LTC) at an urban health center (Philadelphia, PA, USA) that provides access to oral tenofovir/emtricitabine(TDF/FTC) as pre- exposure prophylaxis(PrEP) to patients ages 13-30 years through a drop-in model of care.

    Methods

    Ninety-nine patients were identified as LTC based on not visiting a clinician in ≥4 months during the period April 2016-January 2017. Patients were contacted by phone/email to participate in a voluntary telephone survey regarding reasons for falling out of care. Results were analyzed descriptively.

    Results

    Of the 99 patients preliminarily identified as LTC, 19 completed the survey. Reason(s) for becoming LTC included: 47%(9) relocation, 11%(2) transportation difficulties to/from clinic, 26%(5) financial/insurance problems, 5%(1) perceived medication side effects, 16%(3) trouble remembering to attend appointments regularly, 5%(1) difficulty with daily medication adherence, and 0% social stigma. Furthermore, 21%(4) remain at high-risk of HIV/STI acquisition after becoming LTC. The main study limitations are selection bias and small sample size, where the small sample size did not allow for statistical significance.

    Conclusion

    While the major cause for becoming LTC was relocation, these findings suggest 37% of LTC incidences may be preventable with additional/up-front support. Because 21% of LTC patients remain at high-risk of HIV/STI acquisition, proactive re-engagement initiatives are potentially useful.

    Keywords

    HIV/AIDS; Pre-exposure prophylaxis; Retention and care; Socioeconomic factors; Adolescent Health; Lesbian/Gay/Bisexual/Transgender Persons.


  • 2019, July

    mini review

    Latest Results from Immunotherapy Clinical Trials in Triple Negative Breast CancerOpen Access

    Alexios Strimpakos*, Konstantinos Tsigaridas and Maria Avgoustidou
    DOI: http://dx.doi.org/10.17140/CTPOJ-1-105
    Provisional PDF469.61 KB 469.61 KB
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    Abstract [+]

    Cancer immunotherapy has evolved enormously in the recent years with better understanding of immune reactions, immune microenvironment and immunosurveillance. Breast cancer is characterized by large heterogeneity, a fact which rather complicated the development and the approval of novel therapeutic options in comparison to the majority of other solid tumors since each subtype has required a unique scientific approach and different targets and goals. Triple negative breast cancer (TNBC) is considered the most aggressive of the breast cancer subtypes with limited treatment options and worse outcome compared to others. This article summarizes some of the early clinical studies and the recently presented phase III clinical study of immunotherapy checkpoint inhibitors in this difficult setting.

    Keywords: Cancer; Immunotherapy; Triple negative breast cancer (TNBC); Breast cancer.


  • 2019, July

    review

    A Novel Hospital-Based Mass Casualty Decontamination Facility for Hazardous Material DisastersOpen Access

    Ponampalam R*
    DOI: https://dx.doi.org/10.17140/TFMOJ-4-129
    Provisional PDF496.54 KB 496.54 KB
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    Abstract [+]

    Since the Sarin incident in the subways of Tokyo in 1995, there has been an unprecedented increase in the use of chemical agents on civilian populations internationally. This scourge of chemical terrorism has been relentless worldwide and is likely to continue to be a public health issue that needs to be addressed by the relevant authorities as part of national disaster preparedness and response. One aspect of chemical disasters involves the need for mass decontamination of chemically-contaminated casualties from the scene. The traditional role of hazardous materials civil defence experts in providing such decontamination of victims in the pre-hospital setting is limited by many factors. The presence of congestion in densely populated areas in a highly built up environment of modern-day cities, compounds the timeliness of putting up cordons and crowd control and hence delays the prompt set up of such mobile decontamination facilities close to the incident site. The expected side effect is an almost instantaneous influx of contaminated casualties to the nearest hospital in such situations, which drives the need for public hospitals to be ultimately capable of performing mass casualty decontamination as part of hazardous materials disaster preparedness. This review presents an innovatively designed rapidly deployable hospital-based decontamination facility that has served a tertiary care hospital in Singapore for the last 2 decades in being prepared for managing mass casualties arriving from a chemical disaster in a timely manner.
    Keywords
    Decontamination; Chemical incident; Industrial disasters; Toxic industrial chemicals; Hazardous materials preparedness; Disaster contingency plans; Emergency preparedness.


  • 2019, July

    original research

    In Need of Care but Providers of Care: Grandparents Giving Fulltime Care to their Grandchildren in Rural UgandaOpen Access

    Neema Stella* and Nankwanga Annet
    DOI: http://dx.doi.org/10.17140/ANTPOJ-4-119
    Provisional PDF382.66 KB 382.66 KB
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    Abstract [+]

    Background

    In most African countries, the elderly face challenges that affect their health and wellbeing and are more pronounced because of the systemic factors of inadequate health care, food insecurity and the general care. Increasing population of the elderly persons in Uganda is raising concern than ever before. The purpose of this paper to ascertain care available to the rural elderly persons and their role as carers for their grandchildren and implications on their wellbeing.

    Methods

    This was a qualitative study conducted among the rural elderly aged 60 years and above in eight purposively selected district that included Lira, Nebbi, Kampala, Luwero, Pallisa, Jinja, Mbarara, and Ntungamo. The study sample consisted of 101 elderly person from whom in-depth interviews were conducted. Data was analysed using qualitative thematic content analysis.

    Results

    Rural elderly in Uganda face a lot of constraints that include access to healthcare and information, poor economic status, food insecurity and poor nutrition, and poor accommodation and housing conditions. Two broader themes emerged inductively from the analysis that include care available for the rural elderly and providing care to grandchildren. These themes generated several subthemes. Taking care of grandchildren crippled the elderly and reduced the economic benefits. That said some rural elderly were happy and felt fulfilled to care of the grandchildren despite the lack of resources.

    Conclusion

    The rural elderly in Uganda are living in doleful conditions with limited care and support. They need care but are the providers of care to the grandchildren. They are frails and may not afford to provide adequate care. They care for grandchildren many of whom are orphans and vulnerable yet they themselves need care. It is important the government and the community re-enforce this care not to put strain on elderly. The rural elderly unique challenges necessitates special targeting and mobilization of resources at the household, local, district and national levels.

    Keywords

    Grandparents; Care; Orphans; Grandchildren; Skip-generation; Uganda.


  • 2019, July

    opinion

    Neoantigen: A New Hope for Effective Cancer ImmunotherapyOpen Access

    Nemat Khansari*
    DOI: https://dx.doi.org/10.17140/VROJ-1-113
    Provisional PDF232.53 KB 232.53 KB
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  • 2019, July

    original research

    Uptake of the BI-RADS Ultrasound Characterization of Breast Masses: Perceptions among Staff at Mulago National Referral Hospital, UgandaOpen Access

    Alex Onono and Aloysius Gonzaga Mubuuke*
    DOI: https://dx.doi.org/10.17140/ROJ-3-123
    Provisional PDF370.34 KB 370.34 KB
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    Abstract [+]

    Introduction

    The Breast Imaging-Reporting and Data System (BI-RADS) is a classification system aimed at standardizing risk assessment during breast ultrasound to ensure patient safety. BI-RADS is currently used in Uganda so as to standardize breast ultrasound reporting and enhance patient management.

    Objective

    This study aimed at exploring staff perceptions towards the use of the BI-RADS ultrasound characterization of breast masses.

    Methodology

    It was an exploratory qualitative study that involved staff who perform breast ultrasound at Mulago Hospital in Uganda. Focus group discussions and individual interviews were conducted.

    Findings

    All staff used the BI-RADS system, however, some of them had a negative attitude towards BI-RADS. The three major themes that emerged were: standardization of breast ultrasound reporting for patient safety; need for more Continuous Professional Development (CPD) and challenges with the BI-RADS system.

    Conclusion

    The study demonstrated that the staff generally had positive perceptions and attitude of the BI-RADS system and felt that it was an efficient system for ensuring patient safety and further reduce mortality from breast cancer.

    Keywords

    Breast imaging-reporting and data system (BI-RADS); Breast; Ultrasound; Staff perceptions.


  • 2019, August

    review

    The Use of Single-Cell Transcriptomics’ to Detect Cellular Transition through Notch Signaling and Receptor Expression in Differentiated Kidney Collecting Tubule Cells in Adult Mice: A ReviewOpen Access

    Matthew A. Cornacchia*, Soroush Nomigolzar, Giovanni Charles, Himax Patel and Kenneth Luberice
    DOI: https://dx.doi.org/10.17140/NPOJ-5-123
    Provisional PDF361.59 KB 361.59 KB
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    Abstract [+]

    Transcriptomics has allowed for a better understanding of disease, and the sequencing of individual genes is becoming a leading approach to discovering novel germ lines. A newly defined cell type, described as transitional cells, was characterized based on their expression of key marker genes that define principle cells (PC) and intercalated cells (IC). Gene expression patterns suggested that a Notch signaling pathway was activated during the transition from IC to PC. An experimental model studying the transition in an inducible transgenic mouse demonstrated that Notch signaling and receptor expression is sufficient to drive cell transition in differentiated adult kidney collecting tubule. The identification of novel cell lines allows for a more accurate diagnosis of kidney disease and precise staging of disease. Molecular profiling and precision therapy will continue to revolutionize the field of medicine and warrants further exploration.

    Keywords

    Transcriptomics; Kidney disease; Principle cell; Intercalated cell; Notch signaling; Gene sequencing.

    Abbreviations

    PC: Principle cell; IC: Intercalated cell, DNA: Deoxyribonucleic acid; RNA: Ribonucleic acid; mRNA: Messenger ribonucleic acid.


  • 2019, August

    case report

    A Case of Pleomorphic Adenoma Metastasising to Contralateral Supraclavicular Lymph NodeOpen Access

    Esmail Abdulahi Ahmed*, Kamil Akdag, Onur Üstün, Ayça Başkadem Yılmazer, Pınar Özay Nayır, Zeynep Aydodu and Yavuz Uyar
    DOI: https://dx.doi.org/10.17140/OTLOJ-5-158
    Provisional PDF449.36 KB 449.36 KB
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    Abstract [+]

    Introduction

    Pleomorphic adenomas are the most common benign parotid tumours in all populations. Management always consists of a curative superficial parotidectomy. However, rare cases described, in which these histological benign tumors metastasize to distant sites. We present an example of a recurrent parotid pleomorphic adenoma with a contralateral supraclavicular lymph node metastasis after several surgical interventions.

    Case report

    In this case, we reported reported a case of 29-years male with extensive metastasis in submandibular, submental and also very rarely seen contralateral supraclavicular lymph node metastasis. Parotidectomy with preservation of facial nerve and radiotherapy was given to the patient since the lesions were very aggressive.

    Conclusion

    The patient had several surgical interventions, so it is essential to do meticulous resection in the first surgery to prevent local recurrence and distant metastasis.

    Keywords

    Pleomorphic adenoma; Metastasizing pleomorphic adenoma; Salivary gland benign neoplasia.


  • 2019, August

    original research

    Efficacy and Safety of Clarithromycin, Lenalidomide and Dexamethasone (Bird) Therapy for Japanese Patients with Relapsed or Refractory Multiple MyelomaOpen Access

    Hitoshi Hanamoto*, Aki Fujii, Mariko Fujita, Ko Fujimoto, Ryosuke Fujiwara and Kazuo Tsubaki
    DOI: http://dx.doi.org/10.17140/IMOJ-3-109
    Provisional PDF411.27 KB 411.27 KB
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    Abstract [+]

    Object

    It is difficult for the elderly, those with complications, and those who live in remote areas to visit the hospital, and as a result, there are limits on the drugs they are able to use. It is therefore effective to prescribe such patients oral medications that have few adverse effects and in regimens that require few hospital visits. Clarithromycin can induce cell death by autophagy and it has a direct antitumor effect. There have been reports of the outcomes of Lenalidomide and Dexamethasone therapy with Clarithromycin which is administered orally and is safe on multiple myeloma. However, in Japan, there have been few studies. Here, we report on Clarithromycin, Lenalidomide and Dexamethasone therapy in our hospital.

    Method

    We analyzed 7 patients with relapsed refractory or refractory multiple myeloma who were treated at this hospital between January 2012 and December 2014. The Clarithromycin, Lenalidomide and Dexamethasone therapy were administered in a 28-day cycle as follows: Clarithromycin 400 mg/day for 28-days, Lenalidomide 15 mg/day for 21-days, and Dexamethasone was administered in a dose of 20 mg once per week. The response criteria used were standard International Myeloma Working Group (IMWG) Uniform Response Criteria. and adverse events were graded according to the national cancer institute-common terminology criteria for adverse events (NCI-CTCAE) Ver. 4. Statistical analysis was performed using Easy R (EZR).

    Result

    The response to Clarithromycin, Lenalidomide and Dexamethasone therapy were selective catalytic reduction (sCR) in 2 patients, CR in 1 patient, per rectum (PR) in 3 patients, and standard deviation (SD) in 1 patient. Response rates of PR or better were observed in 86% of the patients. Duration of response was median 316-days (range, 160-522-days). Median oculus sinister (OS) period was 1,907 days. Median OS following discontinuation of the study was 1,385 days. Hematological adverse events were G1-2 anemia in 3 patients and G3-4 anemia in 1 patient. G1-2 thrombocytopenia was observed in 1 patient and G3-4 thrombocytopenia was observed in 1 patient. Leukopenia of G1-2 was observed in 6 patients but G3 was not observed. Non-hematological adverse events were G1-2 liver disorder in 6 patients, G1-2 skin rash in 3 patients, and G1-2 constipation in 2 patients. G4 adverse events were fainting and duodenal ulcer in 1 patient each.

    Conclusion

    Clarithromycin, Lenalidomide and Dexamethasone can be safely and effectively administered in the relapsed refractory multiple myeloma

    Keywords

    Multiple myeloma; Bird; Clarithromycin, lethal dose (Ld).


  • 2019, August

    original research

    Role of Sound Enhancer Device in TeleconsultationOpen Access

    Shijina Koliyath, Ravi Kumar Chittoria*, Vinayak Chavan, Abhinav Aggarwal, Saurabh Gupta, Chirra Likhitha Reddy, Padmalakshmi Bharathi Mohan and Imran Pathan
    DOI: http://dx.doi.org/10.17140/CTPOJ-1-106
    Provisional PDF329.78 KB 329.78 KB
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    Abstract [+]

    Aim

    To study the role of sound enhancer device in teleconsultation.

    Methods

    This study was conducted in the plastic surgery department in a tertiary care centre in the month of May-June 2019. A sound enhancer device was used with mobile phone for videoconferencing as form of teleconsultation by plastic surgery trainees in operation theatre and outpatient department. At the end of the study feedbacks were taken from the trainees.

    Results

    It was found that on using the sound enhancer device, the sound quality improved and it was helpful in the teleconsultation sessions using videoconferencing.

    Conclusion

    The use of sound enhancer is a simple, cost-effective, innovative method of using a simple technology to aid in utilisation of teleconsultation facilities in a very non-sophisticated way.

    Keywords

    Sound enhancer device; Teleconsultation; Telemedicine.


  • 2019, August

    case series

    Malignant Restenosis and Progression of Disease in Psoriatic Patients Undergoing Coronary Interventions: Is it the Koebner’s Phenomena to Blame?Open Access

    Vineet Bhatia*, Parneesh Arora, Vineet Relhan and Upendra Kaul
    DOI: https://dx.doi.org/10.17140/HROJ-6-150
    Provisional PDF275.33 KB 275.33 KB
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    Abstract [+]

    Severe psoriasis is associated with an enhanced risk of cardiovascular (CV) diseases. The potential impact of psoriasis on the prognosis following coronary revascularization (percutaneous coronary intervention (PCI) or surgical) is not well studied and sparse data available in literature points towards a grim long-term prognosis. The following two cases highlight this phenomenon. We also discuss the plausible reasons responsible for the poor prognosis and propose some possible mechanisms for the same.


  • 2019, August

    original research

    Ovine Network between Fatteners and Breeders in Middle Atlas of Morocco: Where to Act to Prevent the Spread of Epidemics?Open Access

    Lezaar Yassir*, Khayli Mounir, Caroline Coste, Renaud Lancelot and Bouslikhane Mohammed
    DOI: https://dx.doi.org/10.17140/EPOJ-4-115
    Provisional PDF892.17 KB 892.17 KB
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    Abstract [+]

    Objective

    This cartographic and analytical study, using the social network analysis method, aims to characterize sheep mobility from breeders producing lambs in the Middle Atlas Mountains to the fattening centers, passing through livestock markets in order to describe the exchange network, to identify the main mobility hubs and to secure the production of fattening lambs by improving the efficiency of the epidemiological surveillance system for “peste des petits ruminants” (PPR) in lambs producers of the Middle Atlas in Morocco.

    Design

    Descriptive cross-sectional study within the framework of active epidemiological surveillance. It was carried out at a regional level, for mapping the movements of sheep and to analyze the network of exchange relating to this species by the Social Network Analysis (SNA) method in the middle atlas massif and in the zone of sheep fatteners to guide epidemiological surveillance efforts. A total of 807 breeders producing lambs, sheep fatteners and traders were surveyed, including 54 fatteners in fattening workshops (sampling fraction of 48.6%), 150 breeders and traders in livestock markets of Middle Atlas and 603 producing lamb breeders of this massif (sampling fraction at the massif level of 6.64%).

    Results

    The study revealed a very strong commercial relationship between middle Atlas breeders and fattening zone breeders whose longrange outflows mainly converge towards urban consumption centers. The major strategic livestock markets of the middle Atlas proved to be key points in the articulation of the flows, as was the commune gathering the fatteners. Centrality indicators were used to identify the main trade hubs that contribute to the spread of diseases and to quantify their importance in the influence of sheep movement, while network cohesion parameters have shown that network is vulnerable to the spread of epidemics.

    Conclusion

    The results of this survey revealed the main commercial hubs at the Middle Atlas level and at the level of the province of fatteners, which represent a great risk of spreading sheep diseases over long distances rather quickly in event of an epizootic, but also representing the ability to control the spread through the control of the movement of animals at their level.

    Keywords

    Ovine network; Epizotic of (Peste des Petits Ruminants); Mapping; Social network analysis; Hub; Betweenness; Degree; Strong component; Cutpoint.


  • 2019, August

    original research

    Self-Adjuvanting Peptide Vaccines Against Cervical CancerOpen Access

    Hannah Hanh-Hong Truong, Waleed M. Hussein*, Tzu-Yu Liu, Zhongfan Jia, James W. Wells, Michael J. Monteiro, Mariusz Skwarczynski and Istvan Toth
    DOI: https://dx.doi.org/10.17140/VROJ-1-114
    Provisional PDF603.54 KB 603.54 KB
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    Abstract [+]

    Background

    Cervical cancer is a common cause of cancer-related deaths in women worldwide, with a fatality rate second only to breast cancer. Human papillomaviruses (HPVs) are the main causative agents of cervical cancer, and are therefore obvious targets for vaccine development. Although two prophylactic HPV vaccines have been commercialized, therapeutic vaccines against HPVs have not been developed yet. Current vaccine technologies emphasize the power of small particles in targeting immune cells, and particles of 20-50 nm have been reported to induce optimal immune responses against a variety of pathogens and cancers.

    Methods

    We synthesized new nanoparticle-based vaccines against cervical cancer by using antigenic 8Qmin peptide epitope derived from HPV-16 E7 protein, a hydrophilic poly-(L-glutamic acid) (PGA) linker, and an 8-arm poly (tert-butyl acrylate) dendrimer-based delivery system (D8).

    Results

    Four different peptides containing 8Qmin and PGA of different lengths were successfully synthesized with high yield and purity. These were then conjugated to alkyne-functionalized D8 by copper-catalyzed alkyne-azide cycloaddition “click” reaction. The conjugates self-assembled into nanoparticles, with decreased particle size corresponding to a greater number of Glu units. The four vaccine candidates were tested in C57 black 6 (C57BL/6) mice bearing well-established (7-day-old) tumors to examine their therapeutic effects.

    Conclusion

    Interestingly, only one conjugate delayed tumor growth, and montanide adjuvanted antigen, used as a positive control, failed to demonstrate any therapeutic effect.

    Keywords

    Peptide-based subunit vaccine; Human papillomavirus; Polyglutamic acid; Therapeutic cancer vaccine; Polymer-peptide conjugate; Self-adjuvanting; Cervical cancer.


  • 2019, August

    review

    Prothrombin Complex Concentrates in Post-traumatic Hemorrhage: A ReviewOpen Access

    Ozgur Karcioglu*, Ebru Yilmaz, Selman Yeniocak and Hakan Topacoglu
    DOI: http://dx.doi.org/10.17140/EMOJ-5-152
    Provisional PDF442.87 KB 442.87 KB
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    Abstract [+]

    Prothrombin complex concentrates (PCC) has long been used to reverse vitamin K antagonists (VKA)-induced coagulopathy rapidly and safely. However, its use in trauma-induced coagulopathy (TIC) in patients not using VKA drugs is yet to be elucidated. This article is a narrative review and analysis of the most recent literature to analyse consequences, and intended effects associated with this treatment modality in TIC. Utilization of PCC was addressed in the literature data found by searches of databases. The indications, efficacy and outcomes associated with the use of the product were reviewed in the articles. Some studies point out promising results with respect to PCC use to overcome the VKA-related coagulopathy in victims of trauma. PCC may be a viable option for resuscitation in emergency and critical care in the management of severe hemodynamic deterioration induced by trauma, despite contradictory findings in the literature.

    Keywords

    Blood coagulation factor; Trauma; Hemorrhagic shock; Exsanguinating hemorrhage.


  • 2019, September

    retrospective study

    Exploring the Association between Demographic Factors and Breast Cancer Diagnosis at a Holistic Breast Imaging Clinic in Cairo, EgyptOpen Access

    Hanan S. Gewefel*, Sophia Michelen, Bodour Salhia, Iman Ewais, Mona Fouad and Sejong Bae
    DOI: https://dx.doi.org/10.17140/ROJ-3-124
    Provisional PDF355.54 KB 355.54 KB
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    Abstract [+]

    Background

    Breast cancer is among the most common cancers affecting women worldwide, including Egypt. Age is a well-known determinant of breast cancer risk; however, more data is needed to better understand the importance of age on incidence of breast cancer in the Middle East. Being overweight or obese are also known risk factors—especially for post-menopausal women–however, these data are not available for women in developing countries.

    Purpose

    The purpose of this study was to qualitatively explore the association between age, breast density, and demographic factors of breast cancer patients, across a spectrum of radiological breast diagnoses at a large Breast Imaging Clinic in Cairo, Egypt.

    Materials and Methods

    We explored the association between age, demographic factors, and Breast cancer incidence among 6,711 women undergoing mammographic screening over a consecutive period of 6-years. Data was collected from March 2007 until March 2013 and extracted

    from an electronic data base system.

    Results

    A total of 6,711 participants were included in this study. The median age of all patients was 46.1. Mean body mass index (BMI) of 28.5, where 34% of the patients were overweight and 32.4% were obese. Older women were more likely to be obese compared to younger women (38.4% vs 18.1%, p<0.001). Older females were more likely to have less dense breasts (ACR: A) compared to younger females (18.1% vs 8.7%, p<0.001). Women older than 40 had a higher confirmed number of breast cancer diagnoses compared with the younger age group (10.7% vs 3.5%, p<0.001). Women with breast cancer were more obese (p<0.001), had denser breasts (p<0.001), were post-menopausal (p=0.002), and more likely to be Muslim (p=0.0021). In the multivariate analysis, aforementioned factors were significant predictors for confirmed diagnosis.

    Conclusion

    To our knowledge this is the largest study to examine the association of radiological breast assessments on breast cancer incidence, obesity and demographic factors in Egypt. Although data shows the global burden of breast cancer is shifting to the developing world and affecting younger women at alarming rates, our data demonstrated a very low occurrence of breast cancer in both age groups.

    Keywords

    Breast cancer; Breast radiological diagnoses; Phenotypic variations; Breast imaging-reporting and data system (BI-RADS).


  • 2019, September

    opinion

    Clinical Research: The Future of Medicine Stuck in the Digital PastOpen Access

    Elizabeth Del Mastro Benincasa*
    DOI: http://dx.doi.org/10.17140/CTPOJ-1-107
    Provisional PDF250.67 KB 250.67 KB
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  • 2019, September

    letter to the editor

    Call Me Anything but Thoughtless or Misguided in IBD ManagementOpen Access

    Nicholas V. Costrini*
    DOI: http://dx.doi.org/10.17140/GOJ-4-129
    Provisional PDF242.88 KB 242.88 KB
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  • 2019, September

    retrospective study

    Morbidity and Mortality Associated with Development of Hypogammaglobulinemia after RituximabOpen Access

    Hitoshi Hanamoto*, Aki Fujii, Mariko Fujita, Ko Fujimoto and Ryosuke Fujiwara
    DOI: http://dx.doi.org/10.17140/IMOJ-3-110
    Provisional PDF390.01 KB 390.01 KB
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    Abstract [+]

    Objective

    Low-levels of gamma globulin are associated with a risk of infection, and complications of hypogammaglobulinemia are often observed in hematologic malignancies. In chronic lymphocytic leukemia (CLL), IgG≤600 mg/dL is reportedly associated with higher risks of infection. The objective was to determine the risks of hypogammaglobulinemia and infection in malignant lymphomas for which rituximab that targets B-cells is used.

    Methods

    A retrospective analysis of data from medical records of patients with malignant lymphomas treated with rituximab-containing therapy at our hospital between April 2014 and March 2016 was performed to assess the risks of infections through an evaluation of IgG levels and hospitalizations for and deaths due to infections in patients hospitalized with infections during this period.

    Results

    From April 2014 to March 2016, 128 patients with malignant lymphomas received rituximab-containing therapy at our hospital, and 94 (61%) of these patients had IgG levels measured. These 94 patients were included in the analysis. The histological types were as follows: 30 had follicular lymphoma (FL), 17 had indolent non-Hodgkin’s lymphoma (iNHL), 42 had diffuse large B-cell lymphoma (DLBCL), and 5 had mantle cell lymphoma (MCL). The mean minimum immunoglobulin G (IgG) level in patients hospitalized for infection was 546 mg/dL and was 628 mg/dL in those not hospitalized (p=0.6). Although a significant difference was not observed, IgG levels tended to be low in hospitalized patients with infection. In addition, there were 4 patients with mean IgG levels that were 600 mg/dL or less in the 6-months immediately prior to hospitalization. Among these 2 died of infection.

    Conclusion

    Low-levels of gamma globulin are associated with a risk of mortality due to infections in malignant lymphomas.

    Keywords

    Hypogammaglobulinemia; Malignant lymphoma; Rituximab.

    Abbreviations

    CLL: Chronic lymphocytic leukemia; FL: Follicular lymphoma; iNHL: Indolent non-Hodgkin’s lymphoma; DLBCL: Diffuse large B-cell lymphoma; MCL: Mantle cell lymphoma; FN: Febrile neutropenia.


  • 2019, September

    review

    Do You Still Use Topical Antibiotics after Intravitreal Injections?Open Access

    Banu Turgut Öztürk*
    DOI: http://dx.doi.org/10.17140/OOJ-3-117
    Provisional PDF382.28 KB 382.28 KB
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    Abstract [+]

    Nowadays intravitreal drug injection is the most frequent treatment for retinal diseases. Despite widely use endophthalmitis is already most feared complication of every intravitreal injection in each patient. In clinical setting topical antibiotics have been widely used as a precaution to prevent endophthalmitis however recent published evidence showed it to be unnecessary. Furthermore repeated use of topical antibiotics might give rise to antibiotic resistance in conjunctival flora and thus more aggressive endophthalmitis. Strict asepsis has been awarded as the main rule for endophthalmitis prophylaxis intravitreal injection.

    Keywords

    Intravitreal injection; Steroid; Anti-vascular endothelial growth factor (VEGF); Topical antibiotic; Enodphthalmitis; Antibiotic resistance.


  • 2019, October

    original research

    The Relationship between Socioeconomic Status and Adherence to Antihypertensive Treatment Regimen in a Metropolitan Community Sample of Hypertensive African Americans in New YorkOpen Access

    Ednah Madu*, Kingsly Madu and William Jacobowitz
    DOI: https://dx.doi.org/10.17140/PHOJ-4-133
    Provisional PDF405.92 KB 405.92 KB
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    Abstract [+]

    Introduction

    Low socioeconomic status (SES) is one of the strongest predictors of morbidity and premature mortality worldwide, as well being associated with large increases in cardiovascular disease in both men and women. Uncontrolled hypertension contributes to cardiovascular disparity. Non-adherence to antihypertensive regimens worsens the cardiovascular burden and further widens the health disparity gap. A hierarchical multiple regression study of multiple factors impacting adherence among urban residents in a New York metropolitan region found socioeconomic factors as the strongest factors impacting adherence in this cardiovascular high-risk population..

    Methods

    Secondary analysis of data of a cross-sectional, correlation design study of a dissertation study, with each of the SES variables analyzed against adherence and self-efficacy variables.

    Results

    Overall, only three SES variables (years with the same provider, work status and income) were significantly related to adherence and/or self-efficacy. Years with the same provider was related to adherence with correlation of rs=0.16 (p=0.048), and to self-efficacy rs=2.0 (p=0.016). Work status was related to adherence with difference in adherence scores between retired and unemployed subjects (KS=38.6, p=0.013 with Bonferroni adjustment; means=3.7 and 3.3, respectively). Work status was not related to selfefficacy scores. Income level was significantly related to the self-efficacy scores, but not the adherence scores. Difference noted between earners<$10,000/year and >$80,000/year (KS=-44.2, p=0.037, with Bonferroni adjustment; means=3.06 and 3.51, respectively).

    Discussion

    Low socioeconomic status and non-adherence to antihypertensive regimens remain important factors which worsen cardiovascular health and widen health disparity health gaps. This is evident among the cardiovascular high-risk persons of African descent including those residing in the New York metropolitan regions. Self-efficacy is implicated as a mediating variable between income and adherence. The inverse relationship between fulltime work status and adherence was no longer noted. Further investigation on the associations between income, full time status and adherence among young, hypertensive Blacks/African Americans; as well as self-efficacy mediating effects on income and adherence is recommended.

    Keywords

    Socioeconomic status or poverty or low income; Adherence or compliance; Hypertension treatment or hypertension therapy; Blacks or African Americans.


  • 2019, October

    mini review

    Therapeutic Modalities: Best Practices to Protecting Patients from Harm During TreatmentOpen Access

    Benito J. Velasquez*
    DOI: https://dx.doi.org/10.17140/PHOJ-4-134
    Provisional PDF310.99 KB 310.99 KB
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    Abstract [+]

    Healthcare providers and clinicians such as athletic trainers and physical therapists utilize therapeutic modalities to administer treatment to patients in the clinical setting. It is the responsibility of these healthcare providers to ensure the safe use of therapeutic modalities during treatment sessions, as well as effective delivery of treatment. Thermal-heat, ultrasound, cryotherapy and electrostimulation treatments have the potential for causing harm to patients. Proper care and maintenance of modalities can minimize the risk to patients and avoid legal issues for physical therapists and athletic trainers. This article will explore some of the legal issues, case studies and reports as well as providing information on what healthcare providers can do to protect patients.

    Keywords

    Risk management; Negligence; Malpractice; Best practices; Injury prevention; Athletic Trainer; Physical Therapists; Accreditation.


  • 2019, October

    original research

    The Relationship between Pre-Season Testing Performance and Playing Time among NCAA Division II Men’s Soccer Athletes Over a Competitive Season: A Pilot AnalysisOpen Access

    Brandon L. Stone, Kelsey L. Minson, Emily C. Anderson, Robert G. Lockie and J. Jay Dawes*
    DOI: https://dx.doi.org/10.17140/SEMOJ-5-173
    Provisional PDF447.03 KB 447.03 KB
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    Abstract [+]

    Aim

    The purpose of this study was to investigate the relationships between pre-season testing performance and playing time within a Division II men’s soccer team over a competitive season.

    Methods

    Data was collected from pre-season athletic performance testing data for 13 male National Collegiate Athletic Association (NCAA) Division II men’s soccer players (age=20±1.5-years; height=180±6 cm; weight=75±7 kg), and was analyzed to determine if relationships existed between physical performance tests (countermovement jump height, peak anaerobic power in watts derived from jump height], change-of-direction performance (505-agility, modified T-test), linear speed (10 m and 30 m sprint intervals), and aerobic fitness (20 m multi-stage fitness test), and playing time over a collegiate season were provided by the University’s coaching staff and retrospectively analyzed.

    Results

    A Pearson’s moment correlations correlation revealed significant (p<0.05) moderate relationships between playing time and 10 m speed (r=-0.569) only.

    Discussion

    These results suggest that linear speed, in particular acceleration over short distance, could be a key characteristic that has some influence on playing time for Division II men’s soccer players.

    Conclusion

    Pre-season testing of soccer players is commonly used to assess athletic potential. Minimal research has investigated the associations between these tests and playing time over the course of a collegiate season.

    Keywords

    Aerobic capacity; Power; Speed; Agility; National Collegiate Athletic Association (NCAA).


  • 2019, October

    systematic review

    Complications Related to Implants Used in Anterior Bleb Forming Glaucoma Surgery: A Systematic Review of the LiteratureOpen Access

    Alejandra Salinas*, Fabián Rodríguez and Javier Bardavío
    DOI: http://dx.doi.org/10.17140/OOJ-3-118
    Provisional PDF499.75 KB 499.75 KB
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    Abstract [+]

    Purpose

    To make an account of published implant-related complications (IRC) by a systematic review of the literature.

    Methods

    A systematic search of Pubmed and Scopus databases and Google Scholar engine was performed with selection criteria to detect papers on IRC. We excluded unrelated papers and reviewed selected ones. We considered papers that did not explicitly state about occurrence or not occurrence of IRC as non-IRC reporting. Main outcome measures were the number of papers reporting on complications, IRC, and types of IRC.

    Results

    After the search, selection, and addition, we studied 109 papers. Incidence of IRC was 4.5%, half required explantation. While 26 implant studies found IRCs (23%), 13 case reports on surgical complications, 8 (61.5%) of them reported IRC. Frequent complications were conjunctival erosion, blockage of the tube, migration to anterior chamber or damage to surrounding tissues.

    Conclusion

    Most papers did not report on IRC. Length or nature of studies may skew finding IRC. The incidence of IRC was 4.5%. Hard and sharp implants carry a greater risk of IRC and explantation.

    Keywords

    Implant-related complications (IRC); Glaucoma surgery; Anterior bleb forming.


  • 2019, October

    original research

    A Study to Explore the Impact of Endometriosis in the United Kingdom: A Qualitative Content AnalysisOpen Access

    Babu Karavadra*, Paul Simpson, Edward Prosser-Snelling, Edward Mullins, Andrea Stöckl and Edward Morris
    DOI: https://dx.doi.org/10.17140/GOROJ-6-150
    Provisional PDF523.66 KB 523.66 KB
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    Abstract [+]

    Objective

    To gain insight into the areas that impact women with endometriosis.

    Design

    A qualitative content analysis of an online survey.

    Setting

    Online questionnaire via Endometriosis UK.

    Population

    Women diagnosed with endometriosis of any age range.

    Methods

    Free-text online questionnaire through Endometriosis UK completed by women. Results were analysed using NVivo version 9, qualitative analysis software. The software creates links between common words (codes), and these links allow data to be placed in nodes (called themes) which are then developed into categories. Content analysis was used to understand this data.

    Main outcome measures

    Impact of endometriosis on women’s lives.

    Results

    In total, 1872 questionnaires were returned but not everyone was able to identify ten separate features that affected them. As such, 1872 women provided at least one area that affected them, 1800 provided two areas, 1770 provided three areas and 1600 provided four areas. The results show that the main areas of concern for these women were pain (53%), heavy menstrual bleeding (11%), low mood (8%) and the perceived lack of understanding displayed by other people (7%). Other important factors were fertility concerns, impact on employment, problems with the medical team and uncertainty. These then impacted on their daily life whereby some women felt “guilty” for not ‘being a normal mother’. A key term that resonated was that endometriosis is an “invisible disease”.

    Conclusion

    This analysis provides us with insight into the complex psycho-social factors that interact with bio-physical symptoms. Further research is required in sub-population groups such as teenagers and ethnic minority women to explore any differences in impact and how care can be guided accordingly.

    Keywords

    Endometriosis; Impact; Qualitative methods; Quantitative methods; Online survey.


  • 2019, October

    original research

    Sirtuin Inhibitor as a Novel Cell Cycle Checkpoint and Regulator of the TP53-MDM2 Pathway in Uveal MelanomaOpen Access

    Zachary K. Goldsmith, Matthew W. McEwen, Mercy W. Kibe, Kelley Yuan, Hua Yang, Qing Zhang, Sumana R. Chintalapudi, Bradley T. Gao, Monica M. Jablonski, Benjamin King, Ryan P. Lee, Abigail Lepsch, Neel Patel, Xiang Di Wang, Hans E. Grossniklaus, Matthew W. Wilson*, Vanessa M. Morales-Tirado*
    DOI: http://dx.doi.org/10.17140/OOJ-3-119
    Provisional PDF1.06 MB 1.06 MB
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    Abstract [+]

    Purpose

    The liver is the most common site of uveal melanoma (UM) metastasis with approximately 50% of UM patients being affected. With no proven therapies that mitigate metastases the mortality rate is 85% within the first year after detection of the liver disease. In this study, we provide a mechanistic understanding of the de-regulation of the TP53-MDM2 pathway in UM, which plays a central role in tumor biology.

    Methods

    We investigated the TP53-MDM2 signaling pathway in the microenvironment of liver metastases taken from both a murine orthotopic xenograft and post-mortem metastatic UM human liver. These findings were studied in-depth using both primary and metastatic UM cell lines treated with the MDM2 antagonist Nutlin-3a and the sirtuin inhibitor and transcriptional activator of TP53, Tenovin-6.

    Results

    De-regulation of the TP53-MDM2 signaling pathway is specific to the liver microenvironment, providing a survival mechanism for UM metastases. Tenovin-6, not Nutlin-3a, reduced UM cell survival by increasing the percentage of cell death and reducing the percentage of proliferating cells. Tenovin-6 increased acetylation of p53, reduced ubiquitination of the protein, and acted as a cell cycle regulator.

    Conclusion

    Our findings suggest that in patients with metastatic UM de-regulation of TP53-MDM2 signaling pathway promotes growth of the liver metastases and provides pre-clinical information on the potential of targeting of the TP53-MDM2 signaling pathway via Tenovin-6.

    Keywords

    Uveal melanoma; Ocular tumors; Nutlin-3a; Tenovin-6; TP53; MDM2.


  • 2019, October

    case report

    Role of Bactiguard Infection Technology in Preventing Catheter-Associated Urinary Tract InfectionsOpen Access

    Shijina Koliyath, Ravi Kumar Chittoria*, Abhinav Aggarwal, Saurabh Gupta, Chirra Likhitha Reddy, Padmalakshmi Bharathi Mohan and Imran Pathan
    DOI: http://dx.doi.org/10.17140/CTPOJ-1-108
    Provisional PDF351.27 KB 351.27 KB
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    Abstract [+]

    To study the role of bactiguard infection technology (BIP) in preventing Catheter-associated urinary tract infections. This study was conducted in a tertiary care centre in the Department of Plastic Surgery, JIPMER, Pondicherry, India in the month of August 2019. The study subject was a 55-year-old gentleman with Fournier’s gangrene and type 2 diabetes mellitus (DM). The Foley’s catheter with BIP technology was used and its role in preventing urinary tract infections (UTI) was studied over a period of 10-days. During the period of the catheter use in our subject, patient did not develop features of urinary tract infections. BIP technology is claimed to be effective in preventing Catheter-associated urinary tract infections but further studies in more individuals is required to validate the same.

    Keywords

    Bactiguard infection technology (BIP); Catheter associated urinary tract infection (CAUTI); Biofilm.


  • 2019, October

    review

    Pulmonary Artery Hypertension in Children Living with Sickle Cell AnaemiaOpen Access

    Barakat A. Animasahun* and Moriam O. Lamina
    DOI: https://dx.doi.org/10.17140/HROJ-6-151
    Provisional PDF328.61 KB 328.61 KB
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    Abstract [+]

    Pulmonary artery hypertension (PAH) ultimately leads to straining of the right ventricle and increases the risk of heart failure in affected patients. Its clinical presentation is similar to that of many other diseases thus delaying the diagnosis until the disease is far advanced. It remains one of the leading causes of death in adults with sickle cell anaemia (SCA) worldwide. It confers a high risk of death with two-year mortality rates as high as 40-50% even at modest elevation of pulmonary artery pressure. Median survival age after detection of the disease is said to be 25.6-months. Early detection of elevated pulmonary artery pressure in childhood and appropriate intervention by optimization of anti-haemolytic therapy may prevent the progression of this complication. The current writes up is a review of literatures on pulmonary artery hypertension among children with sickle cell anaemia. This will give information which will aid early diagnosis and treatment of pulmonary artery hypertension among children with sickle cell anaemia. This will ultimately improve the quality of life of children with sickle cell anaemia and reduce morbidity and mortality from the disease in adults and children living with sickle cell anaemia.

    Keywords

    Sickle cell anaemia; Pulmonary artery hypertension; Children.


  • 2019, October

    opposite to the editorial

    Diagnosis and Cure: Intellectual Honesty is the Basis of All ScienceOpen Access

    Alfred Miller*
    DOI: http://dx.doi.org/10.17140/ORHOJ-1-110
    Provisional PDF271.12 KB 271.12 KB
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  • 2019, October

    commentary

    Remote Consent Clinical ResearchOpen Access

    Sriram Preethi*
    DOI: http://dx.doi.org/10.17140/CTPOJ-1-109
    Provisional PDF281.35 KB 281.35 KB
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    Abstract [+]

    Recruitment in clinical research trials can be challenging in trials that are time-sensitive and/or are rare disease and critical care trials. One of the hurdles for recruitment in these types of clinical trials is due to the consent process, and the need to have consent of the patient within a certain timeframe, or the patient unable to consent for themselves. This paper will discuss the usage of the utilization of remote consent options for these trials.

    Keywords

    Recruitment; e-consent; Remote consent; Clinical trials; Rare disease; Time-sensitive.


  • 2019, November

    original research

    Product Development and Quality Evaluation of Biscuit and Ready-to-Eat Snack from Cowpea-wheat Flour BlendsOpen Access

    Moges Yilma and Shimelis Admassu*
    DOI: https://dx.doi.org/10.17140/AFTNSOJ-5-161
    Provisional PDF1.02 MB 1.02 MB
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    Abstract [+]

    Aim

    The research was conducted with the aim to develop biscuit and ready-to-eat snack product from cowpea flour incorporated with wheat flour.

    Methods

    The wheat and cowpea flour blends were prepared in five blending ratios including B1 (90:10), B2 (40:60), B3 (65:35), B4 (78:22), and B5 (53:47); respectively. The D-optimal mixture design software was used for flour blend formulation. Biscuit and extrudate products from cowpea and wheat blends were analyzed. Quality characteristics parameter used for value-added products includes physical, functional, proximate, mineral and microbial quality. Furthermore, bioactive components and sensory quality evaluation were also investigated. The biscuit samples were prepared at a baking temperature of 205 °C for 10-minutes holding time. The extrudate samples were also manufactured at feed moisture (18 and 21%), barrel temperature (100, 110 and 120 °C) and screw speed (175 and 220 rpm).

    Results

    The result for crude protein analysis of biscuit (B3) and extrudate (Ex-3) samples was revealed that 15.972±0.125, and 15.915±0.251; respectively. The result for microbial quality analysis of biscuit (B3) and extrudate (Ex-3) samples was also shown as aerobic bacteria count of 44×10-5, 42×10-5 and yeast and mold (un-detected); respectively. The highest overall sensory evaluation of biscuit (B3) and extrudate (Ex-3) samples score were found 7.6 and 7.14; respectively.

    Conclusion

    Based on quality evaluation parameters, 35% cowpea flour with 65% of wheat flour blending ratio reveled sensor acceptable for biscuit production and manufacturing of ready-to-eat snack.

    Keywords

    Biscuit; Cowpea; D-optimal mixture; Extrudate products; Wheat.


  • 2019, November

    opinion

    Despite 50 Years of Knowledge of Actual Versus Perceived Risk, Public Fear Persists of Contaminated FoodsOpen Access

    Sweta Chakraborty*
    DOI: https://dx.doi.org/10.17140/SBRPOJ-4-118
    Provisional PDF222.43 KB 222.43 KB
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  • 2019, November

    case report

    Multiple Tumoral Calcinosis in a Hemodialysis PatientOpen Access

    Mrabat Samia*, Ennaciri Soufiane, Abdelhafid El Maarfi , Baybay Hanane, Bennani Mounia, Zakia Douhi, Elloudi Sara, Mernissi Fatima Zahra, Ahsaini Mustapha, Mellas Soufiane, El Ammari Jalaleddine, Tazi Med Fadl, Farih Moulay Hassan and Abdelmajid El Mrini
    DOI: https://dx.doi.org/10.17140/UAOJ-3-121
    Provisional PDF351.17 KB 351.17 KB
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    Abstract [+]

    Pseudotumoral calcinosis is a rare condition characterized by periarticular calcium deposition. It preferentially affects large joints such as the hip, shoulder and elbow. It is a severe complication of chronic renal failure. We report a case of secondary pseudotumoral calcinosis in a chronic hemodialysis patient.

    Keywords

    Tumoral calcinosis; Chronicrenal failure; Hemodialysis.


  • 2019, November

    opinion

    What IBD Physicians Can Learn from Major League Baseball ManagersOpen Access

    Nicholas V. Costrini*
    DOI: http://dx.doi.org/10.17140/GOJ-4-130
    Provisional PDF214.56 KB 214.56 KB
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  • 2019, November

    review

    The Evolving Field of Stereotactic Body Radiation Therapy in Pancreatic CancerOpen Access

    Maged Ghaly*, Emile Gogineni and Muhammad W. Saif
    DOI: http://dx.doi.org/10.17140/POJ-3-110
    Provisional PDF437.42 KB 437.42 KB
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    Abstract [+]

    Pancreatic cancer remains a devastating disease with dismal outcomes despite the development of novel chemotherapeutic regimens and radiation techniques. Stereotactic body radiation therapy (SBRT) offers an advantage both in image guidance and radiation dose delivery to direct ablative doses to tumors with acceptable toxicity compared to conventional techniques. Recent literature is clustered with data pertaining to SBRT in patients with resectable, borderline resectable and locally advanced pancreatic tumors. We here present a summary of the current data and highlight the limitations and potential for future growth. Further clinical study in the form of multi-institutional trials is warranted to establish the role of SBRT in combination with new chemotherapeutic agents as well as a non-invasive alternative to surgery.

    Keywords

    Pancreatic neoplasms; Pancreas cancer; Radiosurgery; Stereotactic; Stereotactic body radiation therapy (SBRT); Radiation; Radiotherapy.


  • 2019, November

    review

    Muscle Cell Function and the Effects of Hyperbaric Oxygen TherapyOpen Access

    Tammy Rossomando*
    DOI: https://dx.doi.org/10.17140/ORTOJ-4-115
    Provisional PDF260.09 KB 260.09 KB
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    Abstract [+]

    There are different processes via which a muscle cell can utilize oxygen to make energy that will sustain activity. The type of activity and duration of activity will determine what energy system is used to sustain the activity being done. Aerobic metabolism uses oxygen to sustain the energy demand. Oxygen is obtained from the air we breathe, and then transported to the cells though the myoglobin. Although ambient air only contains 21% oxygen, it is enough to sustain life and energy needs. But what if the muscle cell could instead receive 100% oxygen? The delivery method would be via hyperbaric oxygen therapy (HBO) which supplies oxygen at 100% concentration under a minimum of 1 atmospheric pressure. Atmospheric pressure will affect the outcomes of consuming 100% oxygen. Research supports positive findings on oxygen therapy under pressure and muscle cell recovery but much research still needs to be investigated. One research study revealed detrimental effects of 100% oxygen breathed in consistently for days resulting in comorbidities that did not exist prior to experiment. HBO can pose some risks but if it is applied in a controlled manner, HBO can be a safe option to enhance cellular recovery and cell function.

    Keywords

    Oxygen; Hyperbaric oxygen therapy; Muscle recovery; Muscle cells; Pure oxygen.


  • 2019, November

    review

    Circulating Tumor Cells: Beyond Isolation and DetectionOpen Access

    Michelle J. McNamara*
    DOI: http://dx.doi.org/10.17140/PLMOJ-1-108
    Provisional PDF466.90 KB 466.90 KB
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    Abstract [+]

    Circulating tumor cells (CTCs) are the precursors to metastases and increased numbers of CTCs in the peripheral circulation have been shown to correlate with decreased progression-free and overall survival. Although the current clinical utility has been focused on the prognostic significance, other clinical applications are being explored, such as determining if a patient is a candidate for treatment, determining the efficacy of treatment, evaluation for resistance to therapy, prediction of metastatic site, or as an early predictor of metastases. Current methodologies are based on quantifying CTCs and include technologies based on physical, immunological, and molecular techniques. However, these have limitations, of which most of them do not have the ability to perform morphological evaluation. Using morphological evaluation, CTCs in body fluids could be used for primary diagnosis in the setting of cancer of unknown primary (CUP) or in initial or early diagnostic scenarios. Additionally, cytological specimens have been shown to be useful for ancillary testing in patients when surgical resection specimens or biopsies are not available. Evaluation of CTCs should incorporate histological, immunehistochemical, and molecular characterization to enable clinicians to obtain the comprehensive diagnostic, prognostic and therapeutic information necessary to provide appropriate personalized care to cancer patients.

    Keywords

    Circulating tumor cell (CTC); Circulating; Tumor cell; Cancer; Isolation; Detection; Metastasis; Prognosis.

    Abbreviations

    CTC: Circulating tumor cell; RT-PCR: Reverse transcriptase-polymerase chain reaction; EMT: Epithelial-mesenchymal transition; MET: Mesenchymal-epithelial transition; TRAIL: Tumor necrosis factor-related apoptosis-inducing ligand; CEA: Carcinoembryonic antigen; CUP: Cancer of unknown primary; CAP: College of American Pathologists; AMP: Association for Molecular Pathology; ASCO: American Society of Clinical Oncology.


  • 2019, November

    editorial

    Challenges Ahead for Advanced Training Programs in Pediatric Dentistry in the Area of Sedation for Pediatric Dentists and the Commission on Dental AccreditationOpen Access

    John E. Nathan*
    DOI: https://dx.doi.org/10.17140/PNNOJ-6-e010
    Provisional PDF226.62 KB 226.62 KB
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  • 2019, November

    original research

    Robot Assisted Comprehensive Surgical Staging for Endometrial Cancer: A Validation StudyOpen Access

    Nitin A. Wadhwa*, Dennis Mauricio, Isabel Eisner, Ruchi K. Wadhwa and Pankaj Singhal
    DOI: https://dx.doi.org/10.17140/GOROJ-6-151
    Provisional PDF322.54 KB 322.54 KB
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    Abstract [+]

    Objective

    The study sought to evaluate the historical surgical-pathological trends in Gynecologic Oncology Group (GOG) 33 in a cohort of patients who underwent robot-assisted staging of uterine carcinomas.

    Materials and Methods

    This is a retrospective study from June 2016 through December 2018 at Catholic Health Services Hospitals in Long Island (CHSLI), NY, USA. All patients underwent robotic surgical staging with hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic lymphadenectomy. Fifty patients were included, and patients were separated into cohorts with endometrioid or non-endometrioid histology for analysis. Patients were staged using the International Federation of Gynecology and Obstetrics (FIGO) 2009 classification.

    Results

    For all patients undergoing surgical staging, the rate of pelvic and para-aortic nodal metastases occurred at 10% and 8%, respectively. Sixty percent of the grade 1 endometrioid tumors had less than 50% myometrial invasion. No patients had positive paraaortic lymph nodes in the absence of pelvic node involvement. High-risk histologies were associated with nodal disease thirteen percent of the time. A correlation between increasing depth of invasion and positive lymph nodes was demonstrated. Increasing grade of tumors was correlated with the frequency of nodal metastasis. Intraperitoneal spread was highly correlated to metastatic lymph nodes. Deep invasion was positively correlated with nodal disease.

    Conclusion

    The results of this study validate the trends previously known from GOG 33 in a population undergoing robot-assisted surgical staging for uterine carcinomas.

    Keywords

    Gynecologic Oncology Group (GOG) 33; Robotic; Surgery; Uterine cancer; Lymph nodes; Trends.


  • 2019, November

    commentary

    Mankind, Disease and Technology: A Cat, Mouse and Fiddle GameOpen Access

    Srinivasan Govindaraj*
    DOI: https://dx.doi.org/10.17140/PHOJ-4-135
    Provisional PDF218.92 KB 218.92 KB
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  • 2019, November

    original research

    Outpatient–Focused Advance Care Planning: Telehealth Consultation for Geriatric Primary Care PatientsOpen Access

    James S. Powers* and Lovely Abraham
    DOI: http://dx.doi.org/10.17140/PMHCOJ-5-133
    Provisional PDF302.86 KB 302.86 KB
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    Abstract [+]

    Introduction

    Documentation of advance care planning (ACP) in the electronic health record (EHR) is a quality measure promoted by both the Centers for Medicare and Medicaid Services (CMS) and the Department of Veterans Affairs (VA). There is no best practice model for promotion of ACP in primary care. Clinic prompts reminders from staff, and provision of forms and handouts modestly increase ACP completion. Targeted advance care planning and goals of care discussions for high-risk high-need older patients may help promote ACP in primary care.

    Methods

    High-risk, high-need geriatric patients were identified by the clinical assessment of need (CAN) risk calculator for a telehealth intervention by an advanced practice nurse trained in palliative care and embedded in the geriatric patient-aligned care team (Geri-PACT) and provided telehealth outreach for ACP and goals of care discussions.

    Outcomes

    At baseline the Geri-PACT panel had a 54% prevalence of ACP in the EHR. Completion of a life-sustaining treatment note (LST) increased from 39% to 74% following the telehealth intervention producing a total of 89% ACP documents in the EHR. Additionally, 9% of patients received goals of care discussions and a need for additional home and community-based services was identified for 12% of patients contacted. Outreach to three practices in an established physician referral and patient visit network which included 10 providers indicated that primary care providers desired to approach their own patients for ACP. These providers were educated and provided tools and information about CMS and VA ACP quality improvement directives.

    Conclusion

    A focused telehealth intervention performed by a nurse trained in palliative care and embedded in a geriatric patient-centered medical home was able to significantly increase ACP documentation in the EHR for elderly patients in the practice. Primary care providers place core importance on the value of the patient-clinician relationship and prefer to approach their own patients rather than rely on consultation for ACP. Education for primary care providers and provision of resources to perform ACP and goals of care discussions for their patients may be a worthwhile strategy to improve ACP completion and documentation in the EHR.

    Keywords

    Advance directives; Primary care; Telehealth.


  • 2019, November

    case study

    A Couple’s Personalized-Care Intervention for Weight-Loss and Diabetes based on DNA and Gut Biome Profiles: A Case StudyOpen Access

    Simitha Singh-Rambiritch*, Ranjan Sinha, Chandana Reddy, Alicia Nakamoto and Camel Irudayanathan,
    DOI: https://dx.doi.org/10.17140/OROJ-6-139
    Provisional PDF557.55 KB 557.55 KB
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    Abstract [+]

    Introduction

    The global prevalence of obesity has reached epidemic proportions. Given the negative strain that obesity and associated chronic diseases, such as type 2 diabetes, put on the healthcare system and the economy, disease management has begun evolving to help individuals change their behaviors. Obesity is often difficult to treat and even harder to maintain. Past studies have failed to show weight loss maintenance over long periods after interventions. To overcome the complexity of obesity, a multifaceted precision care treatment approach should be adopted.

    Aim

    The aim of this case study was to assess the health benefits and weight loss journey of a cohabiting Caucasian heterosexual married couple using the Digbi Health personalized obesity management program. A personalized integrative nutrition plan is created based on one’s genetic and gut microbiome obesity risk profile and incorporates daily digital tracking and lifestyle coaching. Never before has a program offered personalized data including genetic, gut microbiome and lifestyle coaching to help people understand the best plan to lose weight and keep it off long term.

    Method

    The male subject achieved a total change in weight loss of 15.94%, as well as a reduction in A1C and blood pressure levels and the female subject achieved a 13.65% change in weight loss over a period of four months. The couple have still been able to maintain their weight loss goals four months after completing the program, stating their individual and personalized approach gave them the tools long-term to maintain.

    Conclusion

    A supportive environment for cohabiting couples following a personalized weight loss program based on their genetic and gut microbiome profile may help with weight loss and long-term maintenance.

    Keywords

    Diabetes; Gut microbiome; Obesity; Diet; Physical exercise; Overweight; Body mass index (BMI); Couples; Hypertension.


  • 2019, December

    short communication

    Dealing with Violent Dangerous Patients: The Medicolegal PitfallsOpen Access

    Navin Naidoo*
    DOI: http://dx.doi.org/10.17140/EMOJ-5-153
    Provisional PDF298.85 KB 298.85 KB
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NOTE: The DOIs of the In-Press Articles will only function after the final publication of the articles and once they are uploaded to the Current Issues.
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Current Issue

  • 2015, March

    research

    Microbial Safety of Foods in the SupplyOpen Access

    Mohamed T. Elkhishin, Ravi Gooneratne and Malik A. Hussain
    DOI: http://dx.doi.org/10.17140/AFTNSOJ-3-141
    PDF980.81 KB 980.81 KB
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  • 2015, September

    editorial

    Hepatitis C UpdateOpen Access

    Omar Massoud*
    DOI: http://dx.doi.org/10.17140/LROJ-2-e003
    PDF297.12 KB 297.12 KB
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  • 2016, March

    editorial

    Cosmetology: Past, Presence and FutureOpen Access

    Varvaresou Athanasia*
    DOI: http://dx.doi.org/10.17140/TCOJ-1-e001
    PDF256.50 KB 256.50 KB
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  • 2016, March

    systematic review

    Is There Scientific Evidence that Panax Promotes Hair GrowthOpen Access

    Frederico EHFF*, Sá-Caputo DC, Dionello CF, Cardoso ALB, Morel DS, Maiworm A, Guimarães CAS, Santos R, Guedes-de-Aguiar EO, Gonçalves CR, Carvalho-Lima RP, Kutter CR, Machado-Rocha L, Pereira FG, Brandão-Sobrinho-Neto S, Jaña- Rosa A, Neves RF, Moreira-Marconi E, Paineiras-Domingos LL, Costa-Cavalcanti RG, Almeida-Farias C, Souza PL, Paoli S, Presta GA and Bernardo-Filho M
    DOI: http://dx.doi.org/10.17140/TCOJ-1-101
    PDF651.99 KB 651.99 KB
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  • 2016, April

    case report

    Bier Spots on the Face: The First Case ReportOpen Access

    Hamza Yildiz* and Huseyin Saman
    DOI: http://dx.doi.org/10.17140/TCOJ-1-102
    PDF950.96 KB 950.96 KB
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  • 2016, May

    original research

    Galdieria sulphuraria Relieves Oily and Seborrheic Skin By Inhibiting the 5-α Reductase Expression in Skin Cells and Reducing Sebum Production In VivoOpen Access

    M. Bimonte, A. De Lucia, A. Carola, A. Tito, S. Buono, A. L. Langellotti, V. Fogliano, G. Colucci and Fabio Apone*
    DOI: http://dx.doi.org/10.17140/TCOJ-1-103
    PDF601.97 KB 601.97 KB
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  • 2016, July

    original research

    Comparisons between Portosystemic Shunting Modalities in Patients with Liver Cirrhosis and Portal HypertensionOpen Access

    Firuz Gafurovich Nazyrov, Castro-Benitez C, Andrey Vasilyevich Devyatov, Azam Khasanovich Babadjanov*, Umid Ravshanovich Salimov and Laziz Lappasovich Mardonov
    DOI: http://dx.doi.org/10.17140/LROJ-2-109
    PDF1.48 MB 1.48 MB
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  • 2016, August

    editorial

    Genetic Therapy for Pancreatic Cancer: Is it the Future?Open Access

    Lorenzo Dioscorid
    DOI: http://dx.doi.org/10.17140/POJ-2-e005
    PDF288.89 KB 288.89 KB
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  • 2016, August

    letter to the editor

    A Simple Method for Breast De-epithelialization: The Monobloc MethodOpen Access

    Musa Kemal KELES, Ugur Horoz* and Hakan Cepni
    DOI: http://dx.doi.org/10.17140/TCOJ-1-104
    PDF3.82 MB 3.82 MB
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  • 2017, January

    mini review

    Iron and Copper Toxicity in Rat Liver: A Kinetic and Holistic OverviewOpen Access

    Rosario Musacco-Sebio, Christian Saporito-Magriñá, Juan M. Acosta, Alberto Boveris and Marisa G. Repetto*
    DOI: http://dx.doi.org/10.17140/LROJ-2-110
    PDF775.76 KB 775.76 KB
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  • 2017, January

    mini review

    Medical Micro-NeedlingOpen Access

    Ebtisam Elghblawi*
    DOI: http://dx.doi.org/10.17140/TCOJ-1-105
    PDF513.12 KB 513.12 KB
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  • 2017, January

    editorial

    Chemical Peels: A Must Have ArmamentariumOpen Access

    Rahul Pillai*
    DOI: http://dx.doi.org/10.17140/TCOJ-1-e002
    PDF269.93 KB 269.93 KB
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  • 2017, February

    editorial

    Mesotherapy Cocktails Can be the Secrecy for Youthful KeepingOpen Access

    Ebtisam Elghblawi*
    DOI: http://dx.doi.org/10.17140/TCOJ-1-e003
    PDF276.52 KB 276.52 KB
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  • 2017, February

    systematic review

    Could Hair Loss be a Relevant Symptom Associated with ChikungunyaOpen Access

    Danúbia Sá-Caputo, Laisa Liane Paineiras Domingos, Eliane O Guedes-Aguiar, Rafaelle P. Carvalho-Lima, Severo de Paoli, Danielle Soares Morel, Igor Bastos, Clailson H. A. Farias, Claudia F. Figueiredo, Glenda Dias, Eric H. F. Frederico and Mario Bernardo-Filho
    DOI: http://dx.doi.org/10.17140/TCOJ-1-106
    PDF672.49 KB 672.49 KB
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  • 2017, March

    original research

    Significance of Combined Emphysema in Idiopathic Pulmonary Fibrosis and Serum Surfactant Protein-D as a Prognostic FactorOpen Access

    Keiki Yokoo, Masanori Shiratori*, Kimiyuki Ikeda, Yasuaki Umeda, Mitsuo Otsuka, Hirotaka Nishikiori, Hirofumi Chiba, Hiroyuki Koba and Hiroki Takahashi
    DOI: http://dx.doi.org/10.17140/PRRMOJ-4-135
    PDF522.20 KB 522.20 KB
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  • 2017, March

    letter to the editor

    Plaque Psoriasis Formation and Body Hair (Re)Growth: A Common Pathway ActivationOpen Access

    Linda Lazzeri, Antonietta D’Errico and Francesca Prignano*
    DOI: http://dx.doi.org/10.17140/TCOJ-1-107
    PDF734.19 KB 734.19 KB
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  • 2017, March

    editorial

    Balloon Pulmonary Angioplasty (BPA) and Rehabilitation for Chronic Thromboembolic Pulmonary Hypertension (CTEPH)Open Access

    Masahiro Kohzuki*
    DOI: http://dx.doi.org/10.17140/PRRMOJ-4-e007
    PDF326.74 KB 326.74 KB
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  • 2017, April

    case report

    The Trans-Diaphragmatic Hydatid Cyst: An Unconventional Surgical StrategyOpen Access

    Hajar Hachim*, Mouna Alaoui, Mohamed Mountasser, Anass Mohammed Majbar, Farid Sabbah, Mohamed Raiss, Abdelmalek Hrora and Mohamed Ahallat
    DOI: http://dx.doi.org/10.17140/SROJ-4-119
    PDF2.40 MB 2.40 MB
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  • 2017, May

    editorial

    Essential Oils and Cosmetic AromatherapyOpen Access

    Saima Siddique*
    DOI: http://dx.doi.org/10.17140/TCOJ-1-e004
    PDF320.90 KB 320.90 KB
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  • 2017, May

    short communication

    Pediatric Acute Liver Failure: Current PerspectivesOpen Access

    José Colleti Jr., Rafael Teixeira Azevedo and Werther Brunow de Carvalho
    DOI: http://dx.doi.org/10.17140/LROJ-2-111
    PDF342.40 KB 342.40 KB
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  • 2017, May

    retrospective study

    Clinical Spectrum of Pediatric Optic Neuritis in Indian ChildrenOpen Access

    Digvijay Singh, Swati Phuljhele, Reena Sharma, Rohit Saxena, Pradeep Sharma and Vimla Menon
    DOI: http://dx.doi.org/10.17140/OOJ-2-109
    PDF1.20 MB 1.20 MB
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  • 2017, May

    editorial

    Nanocosmetics: The Good, the Bad and the BeautifulOpen Access

    Rinti Banerjee*
    DOI: http://dx.doi.org/10.17140/TCOJ-1-e005
    PDF315.91 KB 315.91 KB
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  • 2017, May

    case report

    Recurrent Acute Pancreatitis: Dangerous Etiology?Open Access

    Jesús Espinel Diez*, Maria Eugenia Pinedo Ramos, Vanesa Ojeda Marrero and Maria Guerra del Rio Lang-Lenton
    DOI: http://dx.doi.org/10.17140/POJ-2-108
    PDF417.89 KB 417.89 KB
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  • 2017, May

    observational study

    Topical Corticosteroid Misuse Among Females Attending at Dermatology Outpatient Department in EthiopiaOpen Access

    Feleke Tilahun Zewdu*, Awel Abdulkerim, Mahelet Dessie Nigatu, Getasew Mulatu Akenaw and Mastewal Misganaw Alemayehu
    DOI: http://dx.doi.org/10.17140/TCOJ-1-108
    PDF400.65 KB 400.65 KB
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  • 2017, May

    editorial

    Changing Ethics and the Hippocrates OathOpen Access

    Rakesh Bhargava*
    DOI: http://dx.doi.org/10.17140/ORTOJ-3-e003
    PDF259.29 KB 259.29 KB
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  • 2017, June

    brief research report

    The Effect of Intranasal Pressure on Intraocular PressureOpen Access

    Esra Türkseven Kumral, Burak Erden, Nimet Yeşim Erçalık, Elvan Alper Şengül, Çetin Akpolat, Erdi Özdemir, Tolgar Lütfi Kumral* and Ziya Saltürk
    DOI: http://dx.doi.org/10.17140/OOJ-2-110
    PDF433.64 KB 433.64 KB
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  • 2017, June

    original research

    Aesthetic Crowns for Restoring Anterior Primary IncisorsOpen Access

    Baydaa Ali Othman Al-Rawi*
    DOI: http://dx.doi.org/10.17140/TCOJ-1-109
    PDF823.32 KB 823.32 KB
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  • 2017, June

    original research

    Balloon Kyphoplasty: Cement Augmentation in Acute Osteoporotic Thoraco-Lumbar FracturesOpen Access

    Abdulrazzaq Alobaid*, Abdulaziz Al-Mutair, Islam Elsayed, Elsayed Mahgoub and Abdullah Al-Shatti
    DOI: http://dx.doi.org/10.17140/ORTOJ-3-111
    PDF1.28 MB 1.28 MB
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  • 2017, June

    mini review

    Family-Centered Care: A Philosophy to be DevelopedOpen Access

    Antonio Vázquez Sellán*, María Carmen Sellán Soto and María Luisa Díaz Martínez
    DOI: http://dx.doi.org/10.17140/PNNOJ-5-126
    PDF344.74 KB 344.74 KB
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  • 2017, June

    short communication

    Evidence-Based Practice in Irregular Cornea Patients’ Management With Contact LensesOpen Access

    Raúl Martín Herranz*
    DOI: http://dx.doi.org/10.17140/OOJ-2-111
    PDF471.26 KB 471.26 KB
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  • 2017, July

    case report

    Vitamin C Infusion for Gastric Acid Aspiration-Induced Acute Respiratory Distress Syndrome (ARDS)Open Access

    Christin Kim, Orlando Debesa, Patricia Nicolato, Bernard Fisher, Ramesh Natarajan and Alpha Alsbury Fowler, III*
    DOI: http://dx.doi.org/10.17140/PRRMOJ-4-136
    PDF2.00 MB 2.00 MB
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  • 2017, July

    case report

    Profile Teleradiography: A Diagnostic Means and a Prosthetic Construction Aid for the Removable ProsthesisOpen Access

    Sana Bekri*, Mohammed Bechir Annebi and Hiba Triki
    DOI: http://dx.doi.org/10.17140/DOJ-5-134
    PDF804.58 KB 804.58 KB
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  • 2017, July

    original research

    Ileal Interposition with Gastric Bipartition and a Weight-Adjusted Sleeve Gastrectomy: A New Model of Metabolic SurgeryOpen Access

    Tuğrul Demirel* and Surendra Ugale
    DOI: http://dx.doi.org/10.17140/SROJ-4-120
    PDF631.18 KB 631.18 KB
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  • 2017, August

    review

    Surgery in the Era of Molecular Medicine: Review of Gastroenteropanreatic Neuroendocrine TumoursOpen Access

    Kui Hin Liau*

    DOI: http://dx.doi.org/10.17140/SROJ-4-121
    PDF1.01 MB 1.01 MB
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  • 2017, August

    editorial

    Pancreatic Leaks and Fistulae: Pathophysiological PrinciplesOpen Access

    Massimiliano Mutignani, Lorenzo Dioscoridi*, Edoardo Forti, Francesco Pugliese, Marcello Cintolo, Giulia Bonato, Alberto Tringali and Stefanos Dokas
    DOI: http://dx.doi.org/10.17140/POJ-2-e006
    PDF301.31 KB 301.31 KB
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  • 2017, September

    editorial

    The Importance of Rehabilitation before and after Lung TransplantationOpen Access

    Masahiro Kohzuki*, Yosuke Izoe and Taku Harada
    DOI: http://dx.doi.org/10.17140/PRRMOJ-4-e008
    PDF308.78 KB 308.78 KB
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  • 2017, September

    editorial

    Traumatic Brain Injury: An UpdateOpen Access

    El Rasheid Zakaria* and Bellal Joseph
    DOI: http://dx.doi.org/10.17140/SROJ-4-e003
    PDF387.49 KB 387.49 KB
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  • 2017, September

    original research

    Efficacy and Safety of Lenalidomide Prednisolone Combination Treatment for Japanese Elderly Multiple Myeloma PatientsOpen Access

    Hitoshi Hanamoto, Aki Fujii, Mariko Fujita, Ryosuke Fujiwara, Katsuya Emoto, Keigo Sano, Shuji Minamoto and Hideo Yagi
    DOI: http://dx.doi.org/10.17140/IMOJ-2-106
    PDF569.82 KB 569.82 KB
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  • 2017, September

    editorial

    The Role of Pre-Assessment in Oesophageal Cancer SurgeryOpen Access

    Niven Akotia and Alexandros Charalabopoulos*
    DOI: http://dx.doi.org/10.17140/GOJ-3-e004
    PDF244.90 KB 244.90 KB
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  • 2017, September

    editorial

    Paraneoplastic Syndrome: What should Pulmonologists know?Open Access

    Takeshi Saraya*
    DOI: http://dx.doi.org/10.17140/PRRMOJ-4-e009
    PDF694.51 KB 694.51 KB
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  • 2017, September

    brief research

    Diagnosis of Pulmonary and Extra Pulmonary Tuberculosis: How Best is CBNAAT when Compared to Conventional Methods of TB Detection?Open Access

    Subhakar Kandi*, Vikasana Reddy and Sharath Burugina Nagaraja
    DOI: http://dx.doi.org/10.17140/PRRMOJ-4-137
    PDF347.38 KB 347.38 KB
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  • 2017, October

    editorial

    Dry Eye Post Surgery UpdateOpen Access

    Daniel H. Scorsetti*
    DOI: http://dx.doi.org/10.17140/OOJ-2-e007
    PDF317.74 KB 317.74 KB
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  • 2017, October

    mini review

    Insights into the Immune System and GlaucomaOpen Access

    Jennifer L. Kielczewski*
    DOI: http://dx.doi.org/10.17140/OOJ-2-112
    PDF671.59 KB 671.59 KB
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  • 2017, November

    review

    Do We Know the Optimal Oxygen Concentration for Resuscitating a Premature Newborn?Open Access

    Vasantha H.S. Kumar*
    DOI: http://dx.doi.org/10.17140/PNNOJ-5-127
    PDF368.56 KB 368.56 KB
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  • 2017, December

    mini review

    Visual Processing Disorder in ChildrenOpen Access

    Salai Dhavamathi Janarthanan*
    DOI: http://dx.doi.org/10.17140/OOJ-2-113
    PDF333.62 KB 333.62 KB
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  • 2017, December

    brief research report

    Writing Thank You Notes after Ophthalmology Residency Interviews?Open Access

    Kinley D. Beck, Debbie Schifanella, Kundandeep S. Nagi, Kent L. Anderson and Michael A. Singer*
    DOI: http://dx.doi.org/10.17140/OOJ-2-114
    PDF1.20 MB 1.20 MB
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  • 2017, December

    case report

    Case Report Using 4% Fucoidan Cream for Recurrent Oral Herpes Labialis: Patient Symptoms Markedly Improved in Terms of Time to Healing and Time to Loss of DiscomfortOpen Access

    Shuichi Tsubura* and Ayano Suzuki
    DOI: http://dx.doi.org/10.17140/DOJ-5-135
    PDF1.71 MB 1.71 MB
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  • 2017, December

    case study

    Baseline Visual Acuity of Women with Diabetic Macular Edema is Worse than Men: A Case-Control StudyOpen Access

    Abdullah Ozkaya*, Hande Mefkure Ozkaya, Hatice Nur Tarakcioglu, Mehmet Ozveren and Ali Demircan
    DOI: http://dx.doi.org/10.17140/OOJ-2-115
    PDF627.66 KB 627.66 KB
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  • 2017, December

    original research

    Toxicological Effects of Tobacco Compounds on the Expression of Genes Involved in Actinic CheilitisOpen Access

    Thiago Cavalcanti Leal, Luiz Carlos dos Santos, Ana Kelly Fernandes Duarte, Gabriel Cerqueira Braz da Silva, Jéssica Alves Gomes, Valdemir da Conceição, Wellington Danilo Soares and Carlos Alberto de Carvalho Fraga*
    DOI: http://dx.doi.org/10.17140/DOJ-5-136
    PDF757.93 KB 757.93 KB
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  • 2017, December

    review

    Oral Health for Infants: What Pediatricians and Pediatric NeoNatal Nursing Staff Need to KnowOpen Access

    John E. Nathan*
    DOI: http://dx.doi.org/10.17140/PNNOJ-5-128
    PDF1.66 MB 1.66 MB
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  • 2017, December

    original research

    Refusal of Venous Thromboembolism Prophylaxis and Incidence of Thrombosis in Patients with Cystic FibrosisOpen Access

    Taryn S. Murray, Nicole L. Metzger*, Melissa M. Chesson and Seth D. Walker
    DOI: http://dx.doi.org/10.17140/PRRMOJ-4-138
    PDF429.79 KB 429.79 KB
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  • 2018, January

    original research

    HIV-Related Health Status, Adherence, and Stress Coping Capacity among Men Living with HIV in JapanOpen Access

    Taisuke Togari*, Yoji Inoue, Sakurako Abe, Rikuya Hosokawa and Yousuke Takaku
    DOI: https://dx.doi.org/10.17140/HARTOJ-5-127
    PDF470.09 KB 470.09 KB
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  • 2018, February

    review

    Molecularly-Targeted Therapies in Gynecologic CancerOpen Access

    Kathryn Kennedy and William Robinson*
    DOI: http://dx.doi.org/10.17140/GOROJ-5-145
    PDF377.77 KB 377.77 KB
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  • 2018, February

    editorial

    Levamisole in MedicineOpen Access

    Fnu Nutan*
    DOI: http://dx.doi.org/10.17140/IMOJ-2-e001
    PDF273.79 KB 273.79 KB
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  • 2018, March

    editorial

    PD-1/PD-L1 Blockade: A New Promising Therapy for the Treatment of Pancreatic Cancer?Open Access

    Nicoletta Gagliano* and Michele Sommariva
    DOI: http://dx.doi.org/10.17140/POJ-2-e007
    PDF316.71 KB 316.71 KB
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  • 2018, March

    editorial

    What we do and do not know About Women and Kidney Diseases; Questions Unanswered and Answers Unquestioned: Reflection on World Kidney Day and International Woman’s DayOpen Access

    Giorgina B. Piccoli, Mona Alrukhaimi, Alkrukhami, Zhi-Hong Liu, Elena Zakharova, Adeera Levin* On behalf of the World Kidney Day Steering Committee
    DOI: http://dx.doi.org/10.17140/NPOJ-4-e011
    PDF571.69 KB 571.69 KB
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  • 2018, March

    case report

    Endoscopic Suturing of Esophageal StentOpen Access

    Dipti Sagar, Subramanyeswara Arekapudi, Sachdev Thomas, Helen Wong and Shreyas Saligram
    DOI: http://dx.doi.org/10.17140/GOJ-3-127
    PDF408.12 KB 408.12 KB
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  • 2018, April

    original research

    Prevalence of Undernutrition and Overweight or Obesity Among the Bengali Muslim Population of West Bengal, IndiaOpen Access

    Pushpa Lata Tigga, Sampriti Debnath, Mousumi Das, Nitish Mondal and Jaydip Sen*
    DOI: http://dx.doi.org/10.17140/ANTPOJ-3-115
    PDF468.98 KB 468.98 KB
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  • 2018, April

    review

    Non-Pharmacological Interventions in Refractory AnginaOpen Access

    Noman Ali* and Peysh Patel
    DOI: http://dx.doi.org/10.17140/HROJ-5-146
    PDF407.46 KB 407.46 KB
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  • 2018, April

    editorial

    The Elderly are Facing HIV/AIDS CrisisOpen Access

    Chengjun Sun*
    DOI: http://dx.doi.org/10.17140/HARTOJ-5-e011
    PDF265.17 KB 265.17 KB
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  • 2018, April

    editorial

    We Should be Optimistic about Mosquito-Borne Diseases ControlOpen Access

    Chengjun Sun*
    DOI: http://dx.doi.org/10.17140/EPOJ-3-e001
    PDF356.29 KB 356.29 KB
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  • 2018, April

    editorial

    HIV Infection on the Rise among Chinese College StudentsOpen Access

    Chengjun Sun*
    DOI: http://dx.doi.org/10.17140/HARTOJ-5-e012
    PDF256.59 KB 256.59 KB
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  • 2018, April

    original research

    Human Dopamine Transporter Function Following Exposure to Heavy Metals and PsychostimulantsOpen Access

    David R. Wallace* and Amber N. Hood
    DOI: http://dx.doi.org/10.17140/TFMOJ-3-124
    PDF746.32 KB 746.32 KB
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  • 2018, April

    mini review

    Understanding Headaches ClassificationOpen Access

    Erin K. Purdy-Payne* and Larry B. Mellick
    DOI: http://dx.doi.org/10.17140/EMOJ-4-146
    PDF457.31 KB 457.31 KB
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  • 2018, May

    original research

    Complications in the Combined and Consecutive Use of External and Internal Fixation of the Femur with Reference to Use of the Extracortical Clamp DeviceOpen Access

    Leonid N. Solomin*, Fanil K. Sabirov, Matthew Fletcher and Arvid B. Abolin
    DOI: http://dx.doi.org/10.17140/ORTOJ-3-112
    PDF410.17 KB 410.17 KB
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  • 2018, July

    research letter

    Antifungal Activity of Commercial Mouthrinses Against Candida AlbicansOpen Access

    Otto Lok Tao Lam* and Paul Wai Kei Tsang
    DOI: http://dx.doi.org/10.17140/DOJ-5-137
    PDF473.43 KB 473.43 KB
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  • 2018, July

    original research

    Frequency of Post-Instrumentation Symptoms Using Hand Files Versus Rotary ProtapersOpen Access

    Asaad Javaid Mirza*, Mohsin Nazir, Maaz Asad Javaid, Mohammad Khalid Shafiq and Rafique Moosa
    DOI: http://dx.doi.org/10.17140/DOJ-5-138
    PDF499.52 KB 499.52 KB
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  • 2018, July

    original research

    Doppler Indices of Uterine, Umbilical and Fetal Middle Cerebral Arteries Before and After Sildenafil Citrate and Transdermal Nitroglycerin in Cases Suffering from Intrauterine Growth RestrictionOpen Access

    Ahmed Mohammed El-Bheirey*, Nareman Mahmoud El-Hamamy, Mohamed Hassan El-Shafey and Hesham Mohamed El-Tokhy
    DOI: http://dx.doi.org/10.17140/GOROJ-5-146
    PDF448.26 KB 448.26 KB
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  • 2018, July

    case series

    Two Cases Report of Dysphagia Due to Diffuse Idiopathic Skeletal Hyperostosis (DISH)Open Access

    Abolfazl Rahimizadeh*, Housain Soufiani, Shaghayegh Rahimizadeh, and Mahan Amirzadeh
    DOI: http://dx.doi.org/10.17140/ORTOJ-3-113
    PDF678.77 KB 678.77 KB
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  • 2018, August

    short communication

    Replantation: Is the Glory Well Deserved?Open Access

    Pooja Kapoor, Harpreet Singh* and Jagvinder Singh Mann
    DOI: http://dx.doi.org/10.17140/DOJ-5-139
    PDF969.09 KB 969.09 KB
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  • 2018, August

    editorial

    The Urgency of Expanding Pre-Exposure Prophylaxis (PrEP) for Global HIV ReductionOpen Access

    Douglas A. Feldman*
    DOI: http://dx.doi.org/10.17140/ANTPOJ-3-e004
    PDF277.34 KB 277.34 KB
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  • 2018, August

    editorial

    Delayed Onset Post-ERCP Pancreatitis (DOPE-P)Open Access

    Vishal Khurana*
    DOI: http://dx.doi.org/10.17140/POJ-2-e008
    PDF266.83 KB 266.83 KB
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  • 2018, August

    original research

    Serum Urea and Creatinine Levels are Better Predictors of Mortality than Serum Potassium Levels in Chronic Digoxin ToxicityOpen Access

    Turgay Yılmaz Kilic*, Murat Yesilaras, Ibrahim Toker, Ozge Duman Atilla, Feriyde Caliskan and Selim Ekinci
    DOI: http://dx.doi.org/10.17140/EMOJ-4-147
    PDF356.67 KB 356.67 KB
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  • 2018, September

    editorial

    Cardiopulmonary Resuscitation: To Intubate or Not to IntubateOpen Access

    Chien-Chang Lee*, Jon Wolfshohl and Eric H Chou
    DOI: http://dx.doi.org/10.17140/EMOJ-4-e005
    PDF310.51 KB 310.51 KB
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  • 2018, September

    commentary

    Philosophy of Internal Medicine – Osler and Hinohara-ismOpen Access

    Hiroshi Bando*
    DOI: http://dx.doi.org/10.17140/IMOJ-2-107
    PDF269.32 KB 269.32 KB
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  • 2018, September

    original research

    Significant Reduction of Emergency Department Wait Time Correlates to Improvements in Patient Satisfaction and Yelp RatingsOpen Access

    Phillip A. Cohen, John Chon, Rachele Hwong, Ching-Che Chiu, Meng-Yin Wu*, Wen-Ta Chiu, Matthew Lin, Jonathan Wu
    DOI: http://dx.doi.org/10.17140/EMOJ-4-148
    PDF444.77 KB 444.77 KB
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  • 2018, October

    original research

    Trends of Pediatric Injuries Amongst 5-Year-Olds Presented in the Emergency Department: A Retrospective Cross-Sectional StudyOpen Access

    Anne Noor Sri Juwaneeta Jamaludin*, Jennifer Anne Oxley and Quek Kia Fatt
    DOI: http://dx.doi.org/10.17140/PNNOJ-5-129
    PDF398.68 KB 398.68 KB
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  • 2018, October

    original research

    Hyperuricemia as a Predictor of Perinatal Outcomes in Pregnancy Induced HypertensionOpen Access

    Shaimaa Sobhy Hamed Khalil*, Shahinaz Hamdy ElShourbagy, Said Mohamed Hamad and Essmat Hamdy Abo Zeid
    DOI: https://dx.doi.org/10.17140/GOROJ-5-147
    PDF363.47 KB 363.47 KB
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  • 2018, October

    systematic review

    Ageing: Postponing MorbidityOpen Access

    Richard Wiseman*
    DOI: https://dx.doi.org/10.17140/EPOJ-3-112
    PDF383.55 KB 383.55 KB
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  • 2018, October

    original research

    Comparison of Hispanics to Caucasians in Metabolic Evaluation of NephrolithiasisOpen Access

    Julie M. Riley, Jessica Ming, Frances Alba and Michael S. Davis*
    DOI: http://dx.doi.org/10.17140/UAOJ-3-116
    PDF280.78 KB 280.78 KB
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  • 2018, October

    original research

    In Vitro Cytotoxicity of Cyanuric Acid and Selected DerivativesOpen Access

    Tsvetelina Batsalova, Desislava Kolchakova and Balik Dzhambazov*
    DOI: http://dx.doi.org/10.17140/TFMOJ-3-125
    PDF731.50 KB 731.50 KB
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  • 2018, October

    short communication

    Reporting on X-ray Films by Radiographers will Always Remain Task-Specific and Limited In Scope: A Critical DiscourseOpen Access

    Aloysius Gonzaga Mubuuke*
    DOI: http://dx.doi.org/10.17140/ROJ-3-118
    PDF354.40 KB 354.40 KB
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  • 2018, November

    editorial

    β-cell Heterogeneity: The Key to β-cell Replacement TherapyOpen Access

    Ercument Dirice*
    DOI: http://dx.doi.org/10.17140/POJ-2-e009
    PDF296.78 KB 296.78 KB
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  • 2018, November

    review

    Fibroblast Growth Factor 23 as a Therapeutic TargetOpen Access

    Fan Li and Zhousheng Xiao*
    DOI: http://dx.doi.org/10.17140/NPOJ-4-118
    PDF327.30 KB 327.30 KB
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  • 2018, November

    editorial

    Three-Dimensional Printing-Generated Realistic Anatomy Models and Virtual Endoscopy-Enhanced Intravascular Assessment of PathologiesOpen Access

    Zhonghua Sun* and Sultan Aldosari
    DOI: http://dx.doi.org/10.17140/HROJ-5-e009
    PDF634.97 KB 634.97 KB
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  • 2018, November

    original research

    Study of Neck Circumference as a Measure of Obesity in South-Eastern Nigerian PopulationOpen Access

    Ukoha Ukoha, Ekezie Jervas*, Ukoha Chinwe Clarice, Obazie Ezuchwu, Okeke Chijioke Mmadueke and Miracle Oluebube Ebem
    DOI: http://dx.doi.org/10.17140/ANTPOJ-3-116
    PDF655.39 KB 655.39 KB
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  • 2018, November

    mini review

    Inhibiting the Inhibitors, PTP1B as a Therapeutic Target in Myocardial InfarctionOpen Access

    Lorna R. Fiedler*
    DOI: http://dx.doi.org/10.17140/HROJ-5-147
    PDF465.68 KB 465.68 KB
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  • 2018, November

    observational study

    Apathy, Ignorance or Natural Death? Present State of Museums in West Bengal, India and its Implication for Anthropological Study of Culture and PolicyOpen Access

    Sumahan Bandyopadhyay*
    DOI: http://dx.doi.org/10.17140/ANTPOJ-3-117
    PDF427.61 KB 427.61 KB
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  • 2018, November

    review

    The Concept of Composite Index of Anthropometric Failure (CIAF): Revisited and RevisedOpen Access

    Binoy Kumar Kuiti and Kaushik Bose*
    DOI: http://dx.doi.org/10.17140/ANTPOJ-3-118
    PDF389.30 KB 389.30 KB
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  • 2018, December

    case report

    Cranial and Spinal Subdural Hygroma Following Lumbar Epidural for Labour AnalgesiaOpen Access

    Elizabeth Thompson*, Nicholas Haden and David Hutchins
    DOI: http://dx.doi.org/10.17140/RPAOJ-4-121
    PDF322.01 KB 322.01 KB
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    Abstract [+]

    Intracranial hygroma is a rare and probably missed complication of epidural analgesia secondary to accidental dural breech. The patient presented had a presumed spinal cerebrospinal fluid leak with symptoms of intracranial hypotension. Unusually the patient had both an intracranial subdural hygroma and rarely reported extensive spinal intradural (extra-arachnoid) collection following a lumbar epidural, administered in labour. Given the potential for progression to symptomatic neurological deficits, anesthetists should consider subdural hygroma when encountering patients with features of intracranial hypotension, or altered neurology following epidural. Pathophysiology, imaging and management are discussed.

    Keywords

    Subdural hygroma; Epidural; Dural puncture.


  • 2018, December

    review

    Review of the REPRISE Trial: Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney DiseaseOpen Access

    Soroush Nomigolzar* and Himax Patel*
    DOI: http://dx.doi.org/10.17140/NPOJ-4-119
    PDF374.05 KB 374.05 KB
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  • 2018, December

    editorial

    Microgenderome: An Important Variable for Developing Therapeutic Strategies?Open Access

    Ravichandra Vemuri and Rohit Gundamaraju*
    DOI: http://dx.doi.org/10.17140/GOJ-3-e005
    PDF279.33 KB 279.33 KB
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  • 2018, December

    retrospective study

    Preventable Deaths among HIV-Positive Patients: A Real-Life Perspective from a Teaching Hospital in Northern MexicoOpen Access

    Andrea Ramirez Fontes, Juan Carlos Rodriguez Aldama, Luis Antonio Sanchez Lopez, Samantha Flores-Treviño, César Adan lmendarez-Sánchez and Adrian Camacho Ortiz*
    DOI: http://dx.doi.org/10.17140/HARTOJ-5-128
    PDF440.18 KB 440.18 KB
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  • 2018, December

    review

    Current Trends in Chronic Kidney DiseaseOpen Access

    Adel E. Berbari*, Najla Daouk and Majida Daouk
    DOI: http://dx.doi.org/10.17140/NPOJ-4-120
    PDF556.08 KB 556.08 KB
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  • 2018, December

    editorial

    Environmental Toxicants in Forensic EntomologyOpen Access

    Bashir M. Rezk*, Myles S. Masters, Geoffroy E. Sanga Pema, Wayne J.G. Hellstrom, Asim B. Abdel-Mageed and Suresh C. Sikka
    DOI: http://dx.doi.org/10.17140/TFMOJ-3-e008
    PDF272.54 KB 272.54 KB
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  • 2018, December

    review

    Caffeine, Bronchopulmonary Dysplasia and Neurodevelopmental Outcomes in Premature InfantsOpen Access

    Vasantha H.S. Kumar*
    DOI: http://dx.doi.org/10.17140/PNNOJ-5-130
    PDF420.36 KB 420.36 KB
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  • 2018, December

    retrospective study

    An Overview of Animal-Related InjuriesOpen Access

    Elif Ozturk, Bulut Demirel, Sema Avcı* and Ali Cihat Yıldırım
    DOI: http://dx.doi.org/10.17140/EMOJ-4-149
    PDF372.67 KB 372.67 KB
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  • 2019, January

    brief research report

    To Study the Effect of Myofascial Trigger Point Release in Upper Trapezius Muscle Causing Neck Disability in Patients with Chronic Periarthritis ShoulderOpen Access

    Michael Kaprail*, Shilpy Jetly, Avni Sarin and Paramdeep Kaur
    DOI: http://dx.doi.org/10.17140/SEMOJ-5-167
    PDF339.30 KB 339.30 KB
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  • 2019, January

    original research

    A Mixed Methods Evaluation of a Pilot Resilience Training Course on Stress ManagementOpen Access

    Shawn T. Mason*, Chun Wang, Raphaela O’ Day, Helen M.P. Scott, Jenn Lea, and Jennifer Turgiss
    DOI: https://dx.doi.org/10.17140/PHOJ-4-127
    PDF439.40 KB 439.40 KB
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  • 2019, January

    mini review

    Nonmedical Treatment (Voice Therapy) for Vocal Nodules in ChildrenOpen Access

    Neha Taneja*
    DOI: https://dx.doi.org/10.17140/OTLOJ-5-150
    PDF311.21 KB 311.21 KB
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  • 2019, January

    case report

    Palmoplantar Psoriasis Successfully Treated with Raw Natural Honey: A Case ReportOpen Access

    Lowlwa Al Meslamani, Badriya Al Lenjawi, Shawkia Al Majid, and Hashim Mohamed*
    DOI: http://dx.doi.org/10.17140/DRMTOJ-4-133
    PDF476.71 KB 476.71 KB
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  • 2019, January

    review

    Diagnostic Advances in Acute Viral Meningitis: Any Novelty for the Physician?Open Access

    Ozgur Karcioglu* and Ebru Yilmaz
    DOI: http://dx.doi.org/10.17140/EMOJ-4-150
    PDF436.63 KB 436.63 KB
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  • 2019, January

    case series

    Surgical Treatment of Laryngeal Haemangioma Laser CO2 Excision: Our Experience in Adult PatientsOpen Access

    Maria Cristina Cristi, Valeria Gambacorta, Arianna Di Stadio*, Simona Pindozzi, Luigi Tassi and Giampietro Ricci
    DOI: https://dx.doi.org/10.17140/OTLOJ-5-151
    PDF357.15 KB 357.15 KB
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  • 2019, January

    review

    Role of Exercise and Dietary Supplementation in Attenuation of Traumatic Brain Injury in American FootballOpen Access

    Kyle Rank, Giovanna Ramos, Cameron Addie, Tyler Neltner, Mike Fraser, Ludmila M. Cosio-Lima, Christopher Wirth, Debra Vinci and Youngil Lee*
    DOI: http://dx.doi.org/10.17140/SEMOJ-5-168
    PDF373.90 KB 373.90 KB
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  • 2019, January

    systematic review

    Long Working Hour Related Medical Errors and Patient Outcomes among Physicians: A Systematic ReviewOpen Access

    Wei-Yo Chao*, Shyr-Chyr Chen, Emma Geerdes, Jo-Ching Hsiung, Cheng-Han Li, Chien-Chang Lee, Haruna Tanoue and Mai Yamazaki
    DOI: http://dx.doi.org/10.17140/EMOJ-4-151
    PDF527.54 KB 527.54 KB
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  • 2019, January

    editorial

    Exploring Culturally Diverse Leadership Styles: A Mindset and Multicultural JourneyOpen Access

    Joseph E. Trimble* and Jean Lau Chin
    DOI: http://dx.doi.org/10.17140/SBRPOJ-4-e005
    PDF254.59 KB 254.59 KB
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  • 2019, January

    original research

    Repetitive Skin Focused Disorders May Express a Functional ConnectomeOpen Access

    Colleen M. Reisz*
    DOI: http://dx.doi.org/10.17140/SBRPOJ-4-114
    PDF516.34 KB 516.34 KB
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  • 2019, January

    systematic review

    Effects of Compression Garments on Skeletal Muscle Physiology, Performance and Recovery in Young Healthy Adults: A Systematic ReviewOpen Access

    Swarup Mukherjee* and Liew Yi Hui
    DOI: http://dx.doi.org/10.17140/SEMOJ-5-169
    PDF443.59 KB 443.59 KB
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  • 2019, January

    systematic review

    Enterprise Imaging: The Next Frontier in Healthcare Technology–A Liturature ReviewOpen Access

    Alex Liao* and Euclid Seeram
    DOI: http://dx.doi.org/10.17140/ROJ-3-119
    PDF404.20 KB 404.20 KB
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  • 2019, February

    editorial

    Review on Artificial Intelligence and Applications in HealthcareOpen Access

    Ravish Huchegowda*, Srinivas Huchegowda, Jyothi R. Jain, Manoj Parthasarathy, Tharika Shraddha, Nagalakshmi C. Sathyanarayanshetty, Bharat V. Poojary, Farhan Zameer, Chetan H Gowda, Naveen H. Gowda and Huskur N. Venkatesh
    DOI: http://dx.doi.org/10.17140/NOJ-6-e010
    PDF376.42 KB 376.42 KB
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  • 2019, February

    case study

    The Principles of Good Health Care in the U.S. in the 2020sOpen Access

    Andrew Targowski*
    DOI: https://dx.doi.org/10.17140/PHOJ-4-128
    PDF395.81 KB 395.81 KB
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  • 2019, February

    original research

    Combined Epley and Semont Maneuver in Benign Paroxysmal Positional VertigoOpen Access

    Nevzat Demirbilek*
    DOI: https://dx.doi.org/10.17140/OTLOJ-5-152
    PDF360.46 KB 360.46 KB
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  • 2019, February

    original research

    Reirradiation of Recurrent Tumors in Central Nervous System in Children and AdolescentsOpen Access

    Jose Alert*, Ivon Chon and Ramon Ropero
    DOI: https://dx.doi.org/10.17140/NOJ-6-129
    PDF407.63 KB 407.63 KB
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  • 2019, February

    brief research report

    To Study the Effects of Core Stability Exercise in Desk Job Patients with Mechanical Low Back PainOpen Access

    Michael Kaprail*, Paramdeep Kaur, Franky Valecha and Usha
    DOI: https://dx.doi.org/10.17140/SEMOJ-5-170
    PDF318.62 KB 318.62 KB
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  • 2019, March

    original research

    Nested, Place and Relational Multiple Social Identities among Latinx and White College Students in California, USAOpen Access

    Aghop Der-Karabetian*, Mark Lopez, Melissa Oseguera and Michelle Alfaro
    DOI: https://dx.doi.org/10.17140/SBRPOJ-4-115
    PDF376.77 KB 376.77 KB
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  • 2019, March

    review

    Application of Antioxidants in Food Processing Industry: Options to Improve the Extraction Yields and Market Value of Natural ProductsOpen Access

    Muluken Kebede, Shimelis Admassu*
    DOI: https://dx.doi.org/10.17140/AFTNSOJ-5-155
    PDF605.05 KB 605.05 KB
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  • 2019, March

    retrospective research

    Amygdala Basal Activity Differs in Hospitalized Pediatric Psychiatry Patients Compared to ControlOpen Access

    Byron Bernal*, David Bohannon, Jorge Gonzalez, Nolan Altman and Americo Padilla
    DOI: https://dx.doi.org/10.17140/ROJ-3-120
    PDF384.74 KB 384.74 KB
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  • 2019, March

    brief research report

    Evaluation of Different Varieties of Pea under Agro-Climatic Conditions of Gilgit-BaltistanOpen Access

    Muhammad Din, Faizullah Khan*, Abdul Karim, Tajuddin, and Saifullah
    DOI: https://dx.doi.org/10.17140/AFTNSOJ-5-156
    PDF350.35 KB 350.35 KB
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  • 2019, March

    illustration

    Fournier’s Gangrene in a Diabetic Young ManOpen Access

    Soufiane Ennaciri*, Mustapha Ahsaini, and Moulay Hassan Farih
    DOI: https://dx.doi.org/10.17140/UAOJ-3-117
    PDF192.05 KB 192.05 KB
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  • 2019, March

    systematic review

    MRI Brain Imaging in Assessment of Pediatric Head TraumaOpen Access

    Kathan Amin, Sharjeel Israr*, Dheeraj Reddy Gopireddy and Unni Udayasankar
    DOI: https://dx.doi.org/10.17140/ROJ-3-121
    PDF671.91 KB 671.91 KB
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  • 2019, March

    original research

    Gender Pay Gap: A Cross-Sectional Study of the Effect of Workplace Entitlement on Pay DifferencesOpen Access

    Ayisha Ayisha and Julie Aitken Schermer*
    DOI: https://dx.doi.org/10.17140/SBRPOJ-4-116
    PDF331.39 KB 331.39 KB
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  • 2019, March

    systematic review

    Importance of Simultaneous Treatment of Obesity and Diabetes Mellitus: A Sequelae to the Understanding of Diabesity-A ReviewOpen Access

    Kulvinder Kochar Kaur*, Gautam Allahbadia and Mandeep Singh
    DOI: https://dx.doi.org/10.17140/OROJ-6-136
    PDF767.01 KB 767.01 KB
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  • 2019, March

    mini review

    Vision in the Hearing-Impaired: Enhanced or Deprived?Open Access

    Jaikishan Jayakumar*
    DOI: https://dx.doi.org/10.17140/NOJ-6-130
    PDF329.07 KB 329.07 KB
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  • 2019, March

    editorial

    Re-evaluating the Optimal Exercise for the Critical Peri and Postmenopausal YearsOpen Access

    Ifigeneia Giannopoulou*
    DOI: https://dx.doi.org/10.17140/OROJ-6-e014
    PDF306.35 KB 306.35 KB
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  • 2019, April

    editorial

    Engaging African Americans in Breast Cancer Prevention Strategies: A Partnership Between a Community Cancer Center and the African American Community in DelawareOpen Access

    Jennifer Sims-Mourtada*, Zohra Ali-Khan Catts, Patricia Swanson and Nora Katurakes
    DOI: https://dx.doi.org/10.17140/CSMMOJ-5-e007
    PDF266.76 KB 266.76 KB
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  • 2019, April

    case report

    A Case of Junctional Epidermolysis Bullosa with Pyloric Atresia Due to Integrin β4 Gene MutationsOpen Access

    Nagisa Yoshihara, Hajime Nakano, Daisuke Sawamura, Asami Kamata, Hiroyuki Matsuzaki, Takashi Etoh and Shigaku Ikeda*
    DOI: https://dx.doi.org/10.17140/DRMTOJ-4-134
    PDF440.10 KB 440.10 KB
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  • 2019, April

    original research

    Evaluation of the Effects of Resonance Voice Therapy in Children with Vocal Fold NodulesOpen Access

    Ziya Saltürk*, Erdi Özdemir, Tolgar Lütfi Kumral, Güler Berkiten, Belgin Tutar, Yavuz Atar, Huseyin Sari and Yavuz Uyar
    DOI: https://dx.doi.org/10.17140/OTLOJ-5-153
    PDF358.56 KB 358.56 KB
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  • 2019, April

    retrospective study

    Increased Epulis Gravidarum Prevalence in Women with Both Nasal and Oral SymptomsOpen Access

    Maria Cristina Cristi, Valeria Gambacorta*, Alfredo Di Giovanni, Simona Pindozzi, Luigi Tassi, Paradiso Daniele and Giampietro Ricci
    DOI: https://dx.doi.org/10.17140/OTLOJ-5-154
    PDF335.72 KB 335.72 KB
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  • 2019, May

    original research

    Deep-Ultraviolet Raman Spectroscopy for Cancer Diagnostics: A Feasibility Study with Cell Lines and TissuesOpen Access

    Nicole M. Ralbovsky, Vladimir Egorov, Eugene Moskovets, Paromita Dey, Bijan K. Dey and Igor K. Lednev*
    DOI: http://dx.doi.org/10.17140/CSMMOJ-5-126
    PDF593.90 KB 593.90 KB
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  • 2019, May

    brief research report

    Lichen Planus Pigmentosus in North Africa: A Series of 17 CasesOpen Access

    Hakima Benchikhi*
    DOI: https://dx.doi.org/10.17140/DRMTOJ-4-135
    PDF504.69 KB 504.69 KB
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  • 2019, May

    book review

    IR Playbook – A Comprehensive Introduction to Interventional Radiology: A Book ReviewOpen Access

    Samuel Armstrong*
    DOI: https://dx.doi.org/10.17140/ROJ-3-122
    PDF172.57 KB 172.57 KB
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  • 2019, May

    case report

    Anesthetic Considerations in Bilateral Congenital Anophthalmia: A Rare Clinical EntityOpen Access

    Lalit Gupta* and Manisha Manohar
    DOI: http://dx.doi.org/10.17140/RPAOJ-4-122
    PDF317.55 KB 317.55 KB
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    Abstract [+]

    Congenital anomalies planned for ocular surgeries range from the rare to atypical to common. Many of this rare ophthalmopathy are associated with clinical syndromes and have important anesthetic implications. Not only is it important to know the syndrome we are dealing with, but it’s also the more important to understand the systems that are involved, the extent of involvement, potential anesthetic complications, right from the cerebrovascular, cardiovascular, endocrine, metabolic, neuromuscular, genitourinary systems to airway. Understanding these aspects becomes more important in rare clinical scenarios as it helps to plan the case, anticipate and treat the complications. Congenital anophthalmia is one of the rare conditions with an incidence of <3/1000 with microphthalmia reported in up to 11% of blind children, hence we report a rare case of bilateral congenital anophthalmia planned for excision of right ocular swelling.

    Keywords

    Ophthalmopathies; Congenital anophthalmia; Microophthalmia; Ocular surgery.


  • 2019, May

    case report

    Hardware Causing Hard Times: Use of the SuperNO2VA™ Nasal PAP Device to Address Airway Challenges Caused by Eroding Mandibular HardwareOpen Access

    Michael Marotta* and Geoffrey S. Kilgore, Jr
    DOI: http://dx.doi.org/10.17140/RPAOJ-4-123
    PDF361.87 KB 361.87 KB
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    Abstract [+]

    Background

    Maintenance of the airway and adequate ventilation are essential for the anesthetized patient and may be compromised in patients with pan-facial trauma, abnormal dentition, abnormal mandibular space, or presence of dental hardware. We present an unusual case of a patient with a lack of natural mandibular structure and exposed mechanical hardware with fistula complicating intubation and ventilation prior to surgery.

    Case Presentation

    A 35-year-old male with a history of a self-inflicted gunshot to the left submandibular region approximately 6 years prior was scheduled for urgent mandibular hardware removal, closure of left facial fistula, and removal of several teeth. Pre-oxygenation and ventilation were complicated by extruding hardware and eroded skin, causing interference with a conventional facemask seal. The patient was pre-oxygenated using the SuperNO2VA™ nasal mask with which an adequate seal was achieved without use of a nasal trumpet and with a modified grip. Tracheal intubation via oral video laryngoscopy was successful, and the case proceeded uneventfully.

    Conclusion

    Adequate ventilation and airway maintenance can be difficult to achieve in patients with abnormal facial structure or mandibular mechanical hardware using conventional methods. The SuperNO2VA™ nasal mask can address airway issues for these patients peri-operatively.

    Keywords

    Anesthesiology; Airway management; Difficult airway; Airway devices; Difficult intubation; Ventilation; Oxygenation; Facial trauma; Mask ventilation.


  • 2019, May

    case report

    Pneumocephalus Caused by an Epidural Ozone Injection for Treatment of Disc ProlapseOpen Access

    Surath Manimala Rao*, Laxmi Kotgire and B.V. Savitr Sastri
    DOI: http://dx.doi.org/10.17140/RPAOJ-4-124
    PDF319.44 KB 319.44 KB
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    Abstract [+]

    Pneumocephalus is a complication seen either after head trauma or post-neurosurgical procedure. It can be life-threatening if it turns into tension pneumocephalus. The presence of intracranial air indicates the presence of an open communication of cerebrospinal fluid. Air enters dura matter even without connection. Thin air flows upstream along the cerebrospinal fluid (CSF) pathway. Herein, we report a case of pneumocephalus in a 62-year-old female after epidural injection of Bupivacaine and Ozone for the treatment of a prolapsed disc. She was shifted to our hospital post-epidural injection for the management of severe headache. Though it is a rare complication, keeping this in mind will help to quickly diagnose, if need arises.

    Keywords

    Pneumocephalus; Head trauma; CT; Thunderclap headache.


  • 2019, May

    editorial

    Aging Inmates: Issues Surrounding Health Care, End-of-Life and Dying in PrisonOpen Access

    Deborah F. Farmer* and Cecile N. Yancu
    DOI: http://dx.doi.org/10.17140/PMHCOJ-5-e007
    PDF263.33 KB 263.33 KB
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  • 2019, May

    editorial

    An Avant-Garde National Home Hospice Service, IsraelOpen Access

    Ron Sabar, Glynis Katz and Michael Silbermann*
    DOI: http://dx.doi.org/10.17140/PMHCOJ-5-e008
    PDF321.50 KB 321.50 KB
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  • 2019, May

    original research

    Risk Assessment-Focused Interdisciplinary Outpatient Palliative Care Consultation for Elderly VeteransOpen Access

    James S. Powers*
    DOI: http://dx.doi.org/10.17140/PMHCOJ-5-130
    PDF351.39 KB 351.39 KB
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  • 2019, May

    editorial

    Multi-component Lifestyle Interventions for Diabetes and Associated Non-communicable Diseases: Considerations for Future ResearchOpen Access

    Ahmad Alkhatib*
    DOI: https://dx.doi.org/10.17140/OROJ-6-e015
    PDF265.83 KB 265.83 KB
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  • 2019, May

    original research

    Risk Behaviors for Proactive Health PromotionOpen Access

    Naiema Abdalla Wagialla*, Muna Hassan Mustafa, Amal Omer Bashir, Amani Elsayed Abdullah, Hind Amin Merghani, Eiman Mohamed Ibrahim Haj and Ahmed Mohammed Alamin Abdulmajid Abdulrahman
    DOI: https://dx.doi.org/10.17140/PHOJ-4-129
    PDF400.01 KB 400.01 KB
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  • 2019, May

    brief research report

    Demographic Characteristics and Management of Uninsured Patients with a History of MelanomaOpen Access

    Noura Ayoubi*, Abu-Sayeef Mirza, Mohammad Ayoubi and Justin Swanson
    DOI: https://dx.doi.org/10.17140/DRMTOJ-4-136
    PDF333.73 KB 333.73 KB
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  • 2019, May

    original research

    Epidemiological Profile of Hypertension, and Its Determinants Amongst Adult Patients in Cameroon: A Hospital-Based StudyOpen Access

    Christine Fernande Nyangono Biyegue*, Pierre Mintom Medjo, William Dakam, Marthe Edwige Banini, Yvette Noume and Marie Modestine Kana Sop
    DOI: https://dx.doi.org/10.17140/PHOJ-4-130
    PDF434.44 KB 434.44 KB
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  • 2019, May

    brief report

    U.S. Veteran Population Projections, 2015 through 2040: Implications for Health Planning and Monitoring Population Health OutcomesOpen Access

    Gregory Fant*
    DOI: https://dx.doi.org/10.17140/PHOJ-4-131
    PDF391.92 KB 391.92 KB
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  • 2019, May

    original research

    Lifestyle Pattern and Bone Mineral Density: A Preliminary StudyOpen Access

    Renu Tyagi*, Meenal Dhall, Mary Grace Tungdim, Peteneinuo Rülu and Satwanti Kapoor
    DOI: https://dx.doi.org/10.17140/PHOJ-4-132
    PDF354.93 KB 354.93 KB
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  • 2019, June

    original research

    A Pilot Study on the Effect of Massage on Stress among Female Japanese University StudentsOpen Access

    Emiko Katsurada*
    DOI: http://dx.doi.org/10.17140/WHOJ-5-129
    PDF312.87 KB 312.87 KB
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  • 2019, June

    original research

    Rationale Diagnostic Criteria of the Metabolic SyndromeOpen Access

    Makiko Nakade, Akemi Morita, Shaw Watanabe*, Naomi Aiba and Motohiko Miyachi.
    DOI: http://dx.doi.org/10.17140/DROJ-5-139
    PDF450.42 KB 450.42 KB
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  • 2019, June

    systematic review based hypothesis

    Fatty Acid Escape Hypothesis: The Pathway to Type-2 DiabetesOpen Access

    AbdulRahman Hamid Musleh Ali, Wesam Al-Kassas and Khawaja Husnain Haider*
    DOI: http://dx.doi.org/10.17140/DROJ-5-140
    PDF712.13 KB 712.13 KB
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  • 2019, June

    original research

    Hereditary Contribution Towards Development of Type 2 Diabetes Mellitus among Indian PopulationOpen Access

    Nilupher Feroz, Meenal Dhall* and Satwanti Kapoor.
    DOI: http://dx.doi.org/10.17140/DROJ-5-141
    PDF497.53 KB 497.53 KB
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  • 2019, June

    editorial

    Rice Function for Disease Prevention and Establishment of Medical Rice AssociationOpen Access

    Shaw Watanabe*.
    DOI: https://dx.doi.org/10.17140/DROJ-5-e013
    PDF351.99 KB 351.99 KB
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  • 2019, June

    editorial

    Latent Autoimmune Diabetes in Adults (LADA) in Recent Clinical PracticeOpen Access

    Hiroshi Bando*.
    DOI: http://dx.doi.org/10.17140/DROJ-5-e014
    PDF329.97 KB 329.97 KB
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  • 2019, June

    case report

    Effect of Music Therapy as an Adjunct in Management of Diabetic Foot UlcerOpen Access

    Shijina K, Ravi K. Chittoria*, Vinayak Chavan, Abhinav Aggarwal, Saurabh Gupta, Chirra L. Reddy, Padmalakshmi Bharathi Mohan, Imran Pathan and Praveen R.
    DOI: http://dx.doi.org/10.17140/DROJ-5-142
    PDF345.84 KB 345.84 KB
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  • 2019, June

    review

    Influence of Heat Treatment and Microfiltration on the Milk Proteins PropertiesOpen Access

    Silvani Verruck*, Saionara Sartor, Flávia Buss Marenda, Eulália Lopes da Silva Barros, Callebe Camelo-Silva, Maria Helena Machado Canella and Elane Schwinden Prudencio
    DOI: https://dx.doi.org/10.17140/AFTNSOJ-5-157
    PDF713.52 KB 713.52 KB
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    Abstract [+]

    Heat treatments are the established food technology for commercial processing of milk. However, degradation of valuable nutrients in milk (as proteins) and its sensory characteristics occur during these processes due to substantial heat exposure. The most important reactions that occur during milk heat treatment are the whey proteins denaturation, its interactions with the casein
    micelles and aggregation/dissociation of the casein micelles. Microfiltration represents an emerging food processing technology allowing gentle milk preservation at lower temperatures for similar, or better, nutritive value, microbial removal, and shelf stability. Thus, the aim of this work is to review the existing studies on the effects of microfiltration on milk proteins by comparing with the effects of heating treatments.


  • 2019, June

    brief report

    The Praxitype: An Improved Interpretation of Genotype-Phenotype VariationOpen Access

    Vincent M. Riccardi*
    DOI: https://dx.doi.org/10.17140/NOJ-6-131
    PDF336.22 KB 336.22 KB
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    Abstract [+]

    There is a need for an understanding of the genomic reality that realizes a connector between the genotype and the phenotype by addressing HOW the genotype actually manifests as the phenotype, as a function of the locus or the allele, mutated, variant or wildtype. That understanding is encompassed by the notion of the PRAXITYPE, which assembles and presents the available answers to the HOW!


  • 2019, June

    commentary

    Commission on Accreditation of Athletic Training Education (CAATE): Transition from Bachelor to the Entry-Level Master’s–A Changing Landscape for Athletic Training EducationOpen Access

    Benito J. Velasquez*
    DOI: https://dx.doi.org/10.17140/SEMOJ-5-171
    PDF268.39 KB 268.39 KB
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    Abstract [+]

    Athletic training education is undergoing many changes since the decision was made to move from the bachelor’s degree to the master’s degree for entry into the profession. Small colleges and universities are reviewing if they choose to transition from an existing undergraduate degree in athletic training to an entry-level Master’s degree; or starting a Master’s program from the ground up. This article will discuss some of the concerns such as student enrollment, CAATE Standards 11 and 41, and institutional resources including hiring of new faculty that need to be reviewed before taking the next step to transitioning or starting a new entry-level Master’s athletic training program. In addition, there will be discussion of the current status of master’s programs and their future.


  • 2019, June

    original research

    Demonstration of Technologies and Training of Growers for Handling and Value Addition of Fruits and Vegetables in Gilgit-BaltistanOpen Access

    Faizullah Khan*, Tariq Umar Khan, Muhammad Ayub, Rehmat Kabir and Tajuddin
    DOI: https://dx.doi.org/10.17140/AFTNSOJ-5-158
    PDF369.69 KB 369.69 KB
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    Abstract [+]

    The present activity was conducted to execute fruit handling, processing, preservation, dehydration and value addition trainings in Gilgit-Baltistan, to control wastages/losses of fruits and vegetable which is above 60% of total production.

    To prepare fruit pulp for fruit preservation using potassium metabisulphite (K2O5S2). To develop household level methods for development of value added products like fruit jam, tomato paste, mix vegetable pickle and dehydrated apricot.

    The research work for method development was carried out at Pakistan Council of Scientific & Industrial Research (PCSIR) Skardu, Gilgit-Baltistan, Pakistan. Methods were developed with recommended dosages of chemical preservatives. A total of two days training courses were conducted focusing fruit handling, processing, preservation, dehydration and value addition of fruits and vegetables at 4 different locations in 4 districts of Gilgit-Baltistan (Skardu, Diamer, Hunza and Shigar).

    The research work for method development was carried out at Pakistan Council of Scientific & Industrial Research (PCSIR) Skardu, Gilgit-Baltistan, Pakistan. Methods were developed with recommended dosages of chemical preservatives. A total of two days training courses were conducted focusing fruit handling, processing, preservation, dehydration and value addition of fruits and vegetables at 4 different locations in 4 districts of Gilgit-Baltistan (Skardu, Diamer, Hunza and Shigar).

    The basic objectives of training were to control wastages/losses of fruits, income generation of fruit growers through sale of fruit, value added products and to contribute to ensure food security issue in Gilgit-Baltistan.


  • 2019, June

    review

    Hysteroscopy Versus Laparoscopy in the Management of Isthmocele: A Review of the LiteratureOpen Access

    Mohammad Jaffal, Marco Mouanness*, Anastasia Salame, Maelle Saliba, Karine Azar and Georges Rameh*
    DOI: http://dx.doi.org/10.17140/WHOJ-5-130
    PDF446.74 KB 446.74 KB
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    Abstract [+]

    Objective
    Isthmocele is a pouch defect of the anterior uterine wall, detected at the site of the previous cesarean scar. It can be asymptomatic or cause abnormal uterine bleeding, pelvic discomfort and difficulty conceiving. The main objective of this review is to highlight the hysteroscopic and laparoscopic approaches in the management of this disorder.

    Main Findings
    During the hysteroscopic approach, the superior and inferior edges or just the superior edge of the defect are resected, removing the fibrotic tissue and allowing renewal of the continuous canal between the cervix and the uterine cavity. Whereas, the laparoscopic approach consists of direct visualization and removal of the defect followed by re-approximation of the myometrium. Both methods lead to significant improvement in symptoms and fertility.

    Conclusion
    While hysteroscopy is a quick non-morbid procedure that allows concurrent removal of other uterine pathology, laparoscopy is characterized by improved visualization and decreased risk of complications with defects less than 3mm as well as the possible correction of uterine retroversion. Definitely, randomized controlled trials are required in this field for better guidance of the diagnosis and management.

    Keywords
    Isthmocele; Uterine niche; Cesarean scar defect; Cesarean scar syndrome; Hysteroscopy; Laparoscopy.


  • 2019, July

    brief research report

    What Were They Thinking? Analytic and Cognitive Language in Instagram CaptionsOpen Access

    Sheila Brownlow*, Makenna Pate, Abigail Alger and Natalie Naturile
    DOI: https://dx.doi.org/10.17140/SBRPOJ-4-117
    PDF305.34 KB 305.34 KB
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    Abstract [+]

    Background
    We examined content and expression of Instagram captions of major celebrities who differed according to sex and status, with a focus on determining whether these variables influenced the use of analytic language and cognitive content.
    Method
    Instagram captions (n=942) were analyzed with the linguistic inquiry and word count (LIWC), which delineated percentage of language reflecting analytical thought and various cognitive mechanisms, such as causality and discrepancy.
    Results
    Men and low-status persons used more functional analytic language, demonstrating critical thought; in contrast, high-status celebrities showed more causality. Women more than men “qualified” their speech with discrepancy. These findings were not a function of sentence length.
    Conclusion
    Status increased the tendency to construct and explain, perhaps because higher status celebrities (particularly women) knew that they could hold followers’ attention with complex content. The tendency to write captions that were concrete was seen in those lower-status persons who may have perceived that followers would not wade through a lot of complicated thoughts. Thus, status contributes to the manner in captioning based, perhaps, on having a broader audience willing to read more complex language.
    Keywords
    Language use; Status; Instagram; Sex differences in linguistics.


  • 2019, July

    original research

    Contamination Status of Water, Fish and Vegetable Samples Collected from a Heavy Industrial Area and Possible Health Risk AssessmentOpen Access

    Yeasmin N. Jolly*, Ahsanul Kabir, Akter Shirin and A.M. Sarwaruddin Chowdhury
    DOI: https://dx.doi.org/10.17140/AFTNSOJ-5-159
    PDF579.08 KB 579.08 KB
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    Abstract [+]

    Aim
    The present study was conducted to extract information about heavy metal pollution in water of Karnaphuli river and to assess the risk to public health occurred from consumption of heavy metal contaminated foodstuff like fish and vegetables collected from the adjacent area of Karnaphuli river which receives a huge amount of industrial and domestic wastes from kalurghat heavy industrial area, Chittagong, Bangladesh.
    Methods
    Energy Dispersive X-ray Fluorescence (EDXRF) Spectrometer (Model: Epsilon 5) was used as major analytical technique for determining elemental concentration. For assessing toxicity level of analyzed foodstuffs and associate health risk problem some indices like metal pollution index (MPI), health risk index (HRI) and hazard index (HI) were also estimated.
    Results
    The mean value of physicochemical properties like pouvoir hydrogène (pH), electrical conductivity (EC), total dissolved solid (TDS), salinity of river water were found 6.8, 745.5 μS/cm, 458.2 mg/L, 747.4 μS respectively showing that those values are much lower than the Department of Environment (DoE) of Bangladesh suggestive value, indicating safe for irrigation but EC and salinity are higher than the DoE suggestive value for drinking water. In water, the mean concentration of heavy metals in Karnaphuli river was found in the sequence of Fe>K>Cr>Mn>Zn>Cu>As=Ni=Hg>Pb. Chromium, Manganese, Iron, Zinc, and Mercury concentrations are higher than World Health Organization (WHO) standard 2011, United States Environmental Protection Agency
    (USEPA) 2009 and Bangladesh Standard for drinking water but other elements are within the safe limit. All metal concentrations in water are below the Bangladesh Standard for Irrigation except Iron (Fe). The decreasing trend of heavy metals (mean) in all the vegetable was Fe>Zn>Cu>Cr>Ni>Pb>Co and for all fish was Fe>Mn>Zn>Cr>Ca>Se>Co>Cu>K. Metal pollution index (MPI) for fish and vegetable is high enough to cause any detrimental effect on human. Estimated daily intake (EDI) value for fish followed a decreasing sequence Fe>Mn>Zn>Cr>Cu>Ni=As>Pb and for vegetable samples Fe>Zn>Cu>Mn>Cr>Ni>Pb>As respectively. Health risk assessment (HRI), and hazard index (HI) value are less than one for fish but HI value is greater than one for most of the vegetable samples analysed.
    Conclusion
    From the overall study it can be concluded that the mean value of physicochemical parameters (pH, EC, TDS, salinity) in river water were much lower than the DoE of Bangladesh suggestive value, indicating safe for irrigation but not safe for drinking. Fishes are safer for human consumption than vegetables collected from that particular area and hence, suggested to consume those vegetables at lower amount in the diet to reduce any detrimental effect.
    Keywords
    Health risk index (HRI); Hazard index (HI); Metal pollution index (MPI); Toxic effect; Vegetables; Fishes.


  • 2019, July

    original research

    Music Therapy for Seniors at End-of-Life: Literature Review and a Preliminary Randomized Feasibility StudyOpen Access

    Kirsten Davis*, Joanne Davidson, Alison Fraser and Helena Daudt
    DOI: http://dx.doi.org/10.17140/PMHCOJ-5-131
    PDF433.75 KB 433.75 KB
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    Abstract [+]

    Background

    Music therapy (MT) is part of the care plan in many end-of-life (EOL) settings, though several authors remain cautious about its effectiveness to improve EOL symptoms and patient well-being.

    Objective

    Our primary goal was to design and test the feasibility of a clinical trial protocol that would address the main critiques of MT trials previously reported in the literature.

    Methods

    We conducted a literature review guided by the questions: (1) What is the set of indicators and tools that can be used to measure effectiveness of MT for seniors in palliative care and EOL settings? (2) What are the characteristics of a well-designed clinical trial protocol that can measure effectiveness of MT in palliative care and EOL settings and can be used for a future large scale study? Based on best practices from the review, we developed a clinical trial protocol and tested its feasibility.

    Results

    Ten participants were accrued. Approximately 25% of eligible participants chose to participate. The consent rate was 55% with 70% of participants completing all MT sessions. All participants completed more than 60% of questionnaires.

    Conclusion

    Although our protocol could not be considered feasible based on the parameters we originally set, we argue that our study provides enough data to make adjustments to our original trial protocol, which could lead to the collection of reliable evidence related to the effectiveness of MT for seniors at EOL. We recommend future studies to use block randomization and allocation concealment, focus on one primary outcome and conduct intention-to-treat analysis.

    Keywords

    Music Therapy (MT); End-of-Life (EOL); Seniors; Clinical trial; Palliative Performance Scale (PPS); Standardized Mini-Mental State Examination (SMMSE); Positive Affect and Negative Affect Schedule (PANAS); Spiritual Health Assessment (SHA).


  • 2019, July

    case report

    Transcatheter Arterial Embolization in Postpartum Hemorrhage: A Case ReportOpen Access

    Alka Chhabra*, Anil Bhiwal, Neha Pandey, Sitaram Barath and Sunanda Gupta
    DOI: http://dx.doi.org/10.17140/RPAOJ-4-125
    PDF763.34 KB 763.34 KB
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    Abstract [+]

    Background

    Postpartum haemorrhage is the leading cause of maternal mortality and morbidity. The significant impact of postpartum haemorrhage (PPH) on maternal mortality can be reduced if timely measures are implemented. Transcatheter arterial embolisation (TAE) is an alternative therapeutic strategy for PPH.

    Case report

    We report a case of postpartum haemorrhage which was managed by transcatheter arterial embolization in lieu of hysterectomy to preserve fertility and menstruation in a 27-year-old patient.

    Conclusion

    The critical role of obstetrician, anaesthesiologist and interventional radiologist as a team, improve the quality of care and patient safety.

    Keywords

    Postpartum hemorrhage (PPH); Peripartum hysterectomy; Transarterial embolisation.


  • 2019, August

    original research

    Preconception Care: Existing Knowledge in Karnataka, India and Need for an InterventionOpen Access

    Jancy Anna James, Linu Sara George* and Sweety Fernandes
    DOI: http://dx.doi.org/10.17140/WHOJ-5-131
    PDF263.99 KB 263.99 KB
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    Abstract [+]

    Background

    Preconception care improves pregnancy outcomes. The aim of preconception care is to identify situation in which the parents particularly mother or the fetus may be in any additional health risk, and to take steps to minimize the risk before pregnancy is possible. But the concept of preconception care is not as popular as in western countries comparing to India where the number of maternal and newborn morbidity and mortality is high.

    Objectives

    To assess the level of knowledge among married women on preconception care by structured knowledge questionnaire; determine the effectiveness of informational booklet in terms of gain in knowledge scores; find the association between pre-test knowledge score and selected variables like age, education, occupation, type of family and parity.

    Materials and methods

    The study was carried out among married women between the age group of 18-35 residing in a selected village of Udupi District, Karnataka, India. An evaluative approach with one group pre-test and post-test design was used. Frequency, percentage, paired t-test and Chi-square test were used to analyze the data.

    Results

    Majority (55%) of the women had poor knowledge and 45% women had average knowledge in pre-test. In the post-test 57% of women had good knowledge and 43% had average knowledge. Mean difference between the pre-test and post-test knowledge score was 7.92, p<0.001 which showed an improvement in knowledge scores among women. An association was found between educational status and knowledge among women which can be inferred that the level of knowledge is dependent on the level of education.

    Conclusion

    Majority of the married women had poor knowledge on preconception care and an informational booklet on preconception care is an effective intervention in improving the knowledge.

    Keywords

    Preconception care; Married women; Information booklet; Knowledge level.


  • 2019, August

    case report

    Incidentally Found Meckel’s Diverticulum Used in the Creation of an Orthotopic NeobladderOpen Access

    Shivam Priyadarshi* and Megha Priyadarshi
    DOI: https://dx.doi.org/10.17140/UAOJ-3-118
    PDF545.24 KB 545.24 KB
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    Abstract [+]

    An incidentally discovered Meckel’s diverticulum while performing radical cystoprostatectomy with neobladder for muscle invasive carcinoma bladder was utilized as the most dependent part of the pouch for anastomosis with the urethral stump leading to a simple tension free anastomosis with very good post-operative results.

    Keywords

    Meckel’s diverticulum; Ileal neobladder; Radical cystectomy; Carcinoma bladder.


  • 2019, August

    review

    Anticancer Natural Products: A ReviewOpen Access

    Ranwa A. Elrayess and Heba N. Gad El-Hak*
    DOI: http://dx.doi.org/10.17140/CSMMOJ-5-127
    PDF478.35 KB 478.35 KB
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    Abstract [+]

    Historically, natural products played a forceful role in human treatment ailments. Nowadays, natural products include a large part of current pharmaceutical agents, mostly in the field of cancer therapy. The main aim of this review is to provide a comprehensive summary of the most known natural product used as anticancer globally, including various other natural products. Many of these natural product appears to act through an anticancer mechanism. Overall, natural product research is a vigorous tool to discover novel biologically active components with unique mechanisms of action. Given the diversity of nature, it is sensible to indicate that chemical leads can be produced that are able to interact with most therapeutic targets. This review creates a solid foundation for further study these natural products with additional research and study.

    Keywords

    Anticancer; Natural product; Plant compounds; Marine flora; Microorganisms; Venom.


  • 2019, August

    review

    Stroke Prevention: Extra-Cranial Carotid Artery TherapyOpen Access

    Christopher J. White* and Jose David Tafur Soto
    DOI: https://dx.doi.org/10.17140/NOJ-6-132
    PDF501.11 KB 501.11 KB
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    Abstract [+]

    A patient-centered approach is reasonable in candidates for carotid revascularization. The patient and their physician should discuss the available treatment options, including revascularization (either carotid artery stenting (CAS) or carotid endarterectomy (CEA)) with their physician. There remains uncertainty regarding the value proposition for revascularization (either CEA or CAS) in asymptomatic patients as a strategy to prevent stroke. Investigation continues into characterizing high-risk carotid plaque subsets, but until that data is available, physicians and patients should continue to strive to achieve the best outcomes with the information that is currently available. The other consideration in asymptomatic patients is that there is a cumulative benefit to revascularization that is dependent on life expectancy. However, the magnitude of the benefit of revascularization, over the longer term in the setting of multifactorial medical therapy, including statins, is not known.

    Keywords

    Carotid endarterectomy; Carotid stent; Angioplasty; Embolic protection devices.