Vinood B. Patel, PhD, PGCertHE, FHEA
Senior Lecturer in Clinical Biochemistry
Department of Biomedical Sciences
Faculty of Science & Technology
University of Westminster
115 New Cavendish Street
London, W1W 6UW, UK
Dr. Patel is currently a Senior Lecturer in Clinical Biochemistry at the University of Westminster and honorary fellow at Kings College London. He presently directs studies on metabolic pathways involved in liver disease, particularly related to mitochondrial energy regulation and cell death. Research is being undertaken to study the role of nutrients, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest identifying new biomarkers that can be used for diagnosis and prognosis of liver disease, understanding mitochondrial oxidative stress in Alzheimers disease and gastrointestinal dysfunction in autism. Dr. Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from Kings College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Dr. Patel is a nationally and internationally recognized liver researcher and was involved in several NIH funded biomedical grants related to alcoholic liver disease. Dr. Patel has edited biomedical books in the area of nutrition and health prevention, autism, biomarkers and has published over 150 articles.
He have over 20 years research experience understanding the pathological mechanisms in the development of liver disease, predominantly linked to acute and chronic alcohol consumption and more recently diet (saturated and unsaturated fatty acids). These areas are focused on the mitochondrial dysfunction, metabolic (lipid, protein, energy) dysregulation, cell death pathways and oxidative stress that arises in the liver. They are also interested in understanding the regulation of iron and hepcidin under physiological conditions under and iron overload. Other research interests include gastrointestinal markers of autism, treatment of alcoholic hepatitis and the identification of novel protein biomarkers for the detection of acute alcohol abuse. He have extensive experience with both in vivo and in vitro studies that involve dietary manipulation and more recently in clinical studies, involving children and alcoholic patients.
AWARDS AND GRANTS
• (2006) Awarded UoW PhD research scholarship
• (2007) Awarded UoW Cavendish PhD scholarship
• (2007) Wellcome Student Scholarship and Nuffield Foundation Scholarship
• (1997-2003) Supported by National Institute on Alcohol Abuse and Alcoholism (NIAAA)
PEER REVIEWED PUBLICATIONS
1. Preedy VR, Peters TJ, Patel VB, Miell JP. Chronic alcoholic myopathy: transcription and translational alterations. FASEB Journal. 1994; 8: 1146-1151.
2. Preedy VR, Why HJF, Paice AG, et al. Protein synthesis in the heart in vivo: its measurement and pathophysiological alterations. International Journal of Cardiology. 1995; 50: 95-106. doi: http://dx.doi.org/10.1016/0167-5273(95)93678-L
3. Patel VB, Siddiq T, Richardson PJ, Preedy VR. Protein synthesis in the hypertrophied heart of spontaneously hypertensive rats and the comparative effects of an ACE-inhibitor and a calcium channel antagonist. Cell Biochemistry and Function. 1995; 13: 111- 124.
4. Preedy VR, Patel VB, Why HJF, Corbett JM, Dunn MJ, Richardson PJ. Alcohol and the heart: biochemical alterations. Cardiovascular Research. 1996; 31: 139- 147. doi: http://dx.doi.org/10.1016/S0008-6363(95)00184-0 139-147
5. Patel VB, Rodrigues LM, Griffiths JR, Richardson PJ, Preedy VR. The acute and chronic effects of alcohol upon cardiac nucleotide status. Addiction Biology. 1996; 1: 171-180.
6. Patel VB, Why HJF, Richardson PJ, Preedy VR. The effects of alcohol on the heart. Adverse Drug Reactions and Toxicological Reviews. 1997; 16: 15-43.
7. Patel VB, Corbett JM Winrow V, et al. Protein profiling in cardiac tissue in response to the chronic effects of alcohol. Electrophoresis. 1997; 18: 2788-2794.
8. Patel VB, Siddiq T, Sherwood R, Richardson PJ, Preedy VR. Effects of the dihydropyridine calcium channel blocker amlodipine on ventricular and atrial protein synthesis in an aortic constriction model of hypertension and following chronic treatment in the left ventricle of SHR rats. International Journal of Cardiology. 1997; 58: 241-255. doi: http://dx.doi.org/10.1016/S0167-5273(96)02872-0
9. Preedy VR, Patel VB, Richardson PJ, Peters TJ. Alcohol and protein metabolism. Nutrition. 1999; 15: 604-608.
10. Reilly ME, Patel VB, Peters TJ, Preedy VR. In vivo rates of skeletal muscle protein synthesis in the rat are decreased in response to acute ethanol dosage but not ameliorated by a-tocopherol supplementation. Journal of Nutrition. 2000; 130: 3045-3049. doi: http://dx.doi.org/10.1053/meta.2003.50002
11. Mantle D, Patel VB, Why HJF, et al. Effects of lisinopril and amlodipine on anti-oxidant status in experimental hypertension. Clinica Chimica Acta. 2000; 299: 1-10. doi: 10.1016/S0009-8981(00)00270-9
12. Patel VB, Sandhu G, Dunn MJ, et al. A comparative study into the effect of chronic alcohol and hypertension on the myocardium of normotensive and hypertensive rats: An electrophoretic and biochemical study. Electrophoresis. 2000; 21: 2454-2462.
13. Patel VB, Richardson PJ, Preedy VR. Inability of propranolol to prevent alcohol induced reductions in cardiac protein synthesis in vivo. Clinica Chimica Acta. 2000; 300: 1- 12. doi: 10.1016/S0009-8981(00)00267-9
14. Patel VB Sandhu G, Dunn MJ, et al. Poor regression of myocardial hypertrophy following concomitant chronic alcohol ingestion and angiotensin converting enzyme (ACE) treatment. Life Sciences. 2000; 67: 1409-1421. doi: 10.1016/S0024-3205(00)00739-6
15. Patel VB, Siddiq T, Richardson PJ, Preedy VR. Alcohol-induced reductions in cardiac protein synthesis in vivo are not ameliorated by treatment with the dihydropyridine calcium channel blocker amlodipine. Alcoholism: Clinical and Experimental Research. 2000; 24: 727-732. doi: 10.1111/j.1530-0277.2000.tb02045.x
16. Patel VB, Richardson PJ, Preedy VR. Non-cardiac nucleic acid composition and protein synthesis rates in hypertension. Clinica Chimica Acta. 2000; 293: 167-179. doi: :10.1016/S0009-8981(99)00243-0
17. Bailey SM, Patel VB, Young AT, Asayama K, Cunningham CC. Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver. Alcoholism: Clinical and Experimental Research. 2001; 25: 726- 733.
18. Zima T, Tesar C, Mantle D, et al. Acute doxorubicin (adriamycin) dosage does not reduce protein synthesis in vivo, but decreases diaminopeptidase I and proline endopeptidase activities. Experimental and Molecular Pathology. 2001; 70: 154-161. doi: 10.1006/exmp.2000.2353
19. Patel VB, Cunningham CC, Hantgan RR. Physiochemical properties of rat liver mitochondrial ribosomes. Journal of Biological Chemistry. 2001; 276: 6739-6746. doi: 10.1074/jbc.M005781200
20. Siddiq T, Patel VB, Sherwood R, Richardson PJ, Preedy VR. In vivo protein synthetic rates of atrial, ventricular and pulmonary tissue proteins in aortic constriction, Goldblatt and bromoethylamine models of hypertension. Experimental and Molecular Pathology. 2001; 70: 19-30. doi: 10.1006/exmp.2000.2333
21. Hunter RJ, Patel VB, Baker AJ, Richardson PJ, Preedy VR. Cardiac changes in an animal model of acute and chronic liver disease. Journal of Nutrition. 2001; 131: 1513-1519.
22. Patel VB, Ajimal R, Sherwood RH, Sullivan A, Richardson PJ, Preedy VR. Cardioprotective effect of propranolol from alcohol induced heart muscle damage as assessed by the release of plasma cardiac troponin-T. Alcoholism: Clinical and Experimental Research. 2001; 25: 882-889. doi: 10.1111/j.1530-0277.2001.tb02294.x
23. Patel VB, Cunningham CC. Altered Hepatic Mitochondrial Ribosome Structure Following Chronic Ethanol Consumption. Archives of Biochemistry and Biophysics. 2002; 398: 41-50. doi: 10.1006/abbi.2001.2701
24. Hunter RJ, Patel VB, Baker AJ, Preedy VR. Liver dysfunction induced by galactosamine injection and bile duct ligation alters cardiac protein synthesis. Metabolism. 2004; 53: 964-968. doi: http://dx.doi.org/10.1016/j.metabol.2003.11.015
25. Patel VB, Worrall S, Emery PW, Preedy VR. Protein adduct species in muscle and liver of rats following acute ethanol administration. Alcohol and Alcoholism. 2005; 40: 485-493. doi: http://dx.doi.org/10.1093/alcalc/agh196
26. Patel VB, Spencer C, Cunningham CC. Post-translational modification of 3- hydroxy-3-methyl glutaryl Coenzyme A by 4-HNE following chronic ethanol consumption. Free Radical Biology & Medicine. 2007; 43: 1499-1507.
27. Everitt H, Patel VB, Tewfik I. Nutrition and alcoholic liver disease. Nutrition Bulletin. 2007; 32: 138-144.
28. Coles SJ, Easton P, Sharrod H, et al. SNitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and S-thiolation. Biochemistry. 2009; 48: 645-656.
29. Gyamfi D, Everitt HE, Tewfik I, Clemens DL, Patel VB. Hepatic mitochondrial dysfunction induced by fatty acids and ethanol. Free Radic Biol Med. 2012. doi: 10.1016/j.freeradbiomed.2012.09.024.
30. El Hindy M, Hezwani M, Corry D, et al. The branched-chain aminotransferase proteins: novel redox chaperones for protein disulfide isomerase-implications in Alzheimers disease. Antioxid Redox Signal. 2014, 20: 2497-2513.
31. Khalid Q, Bailey I, Patel VB. Non-Alcoholic fatty liver disease: the effect of bile acids and farnesoid x receptor agonists on pathophysiology and treatment. Liver Res Open J. 2015; 1(2): 32-40. doi: 10.17140/LROJ-1-106