Tatiana Goretsky (Zagranichnaya), PhD
Division of Digestive Diseases and Nutrition
Department of Internal Medicine
University of Kentucky
Lexington, KY 40506, USA
Dr. Goretsky received her MS degree from Lomonosov (Moscow State) University and Ph.D. from Russian Academy of Science. She worked as a postdoctoral researcher at the University of Chicago in and at Northwestern University. Currently she is working as a Assistant Professor in the Department of Internal Medicine, Division of Digestive Diseases and Nutrition of the University of Kentucky at Lexington. She has extensive experience in the biochemical analysis of both human and mouse intestinal crypt cell populations. She was studying a controversial role of nicotine in the origin and progression of ulcerative colitis and Chrons disease. She has interest in epigenetic regulation of β-catenin signaling.
Inflammation induced intestinal stem cells activation. β-catenin signaling and post-translation modifications. Origin and progression of the inflammatory bowel disease.
Her research interests include: Interrogate the role of β-Catenins post translation modifications in transcriptional activation of intestinal epithelial stem cells.
She is working to evaluate a role of TNF-induced PI3K (p85α) signaling in nuclear translocation of β-catenin in colitis and colon cancer.
1. Goretsky T, Dirisina R, Managlia E, Lee G, Katzman RB, Barrett TA. Mechanisms of TNF-induced crypt cell apoptosis in colitis. Am J of Path. 2012; 181(4): 1306-1315.
2. Dirisina R, Katzman RB, Goretsky T, et al. P53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis. Gastroenterology. 2011; 141(3): 1036-1045. doi: 10.1053/j.gastro.2011.05.032.
3. Brown JB, Cheresh P, Goretsky T, et al. Epithelial phosphatidylinositol-3-kinase signaling is required for beta-catenin activation and host defense against Citrobacterrodentium infection. Infect Immun. 2011; 79(5): 1863-1872. doi: 10.1128/IAI.01025-10
4. Lee G, Goretsky T, Managlia E, et al. Phosphoinositide 3-kinase signaling mediates β-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology. 2010; 139(3): 869-81, 881. e1-e9. doi: 10.1053/j.gastro.2010.05.037.
5. Tang Y, Clayburgh DR, Goretsky T, et al. Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation. Am J Pathol. 2010; 176(1): 158-167. doi: 10.2353/ajpath.2010.090548.
6. Brown JB, Lee G, Goretsky T, et al. Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis. Gastroenterology. 2010; 138(2): 595-605, 605.e1-605.e3. doi: 10.1053/j.gastro.2009.10.038.
ADDITIONAL PUBLICATIONS (IN CHRONOLOGICAL ORDER)
1. Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG. Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection. J Cell Physiol. 2008; 215(3): 715-724.
2. Birukova AA, Zagranichnaya T, Fu P, et al. Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation. Exp Cell Res. 2007; 313(11): 2504-2520. doi: 10.1016/j.yexcr.2007.03.036
3. Zagranichnaya T, Wu X, Villereal ML. Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. J Biol Chem. 2005; 280(33): 29559-29569.
4. Zagranichnaya T, Wu X, Danos A, Villereal ML. Gene expression profiles in HEK-293 cells with low or high store-operated calcium entry: can regulatory as well as regulated genes be identified? Physiol Genomics. 2005; 21(1): 14-33.
5. Villereal ML, Wu X, Zagranichnaya TK. A TRPC1/TRPC3-mediated increase in store-operated calcium entry is required for differentiation of H19-7 hippocampal cells. Faseb Journal. 2005; 19(4): A677-A677 Part 1 Suppl. S
6. Wu X, Zagranichnaya T, Gurda GT, Eves EM, Villereal ML. A TRPC1/TRPC3-mediated Increase in Store-operated Calcium Entry Is Required for Differentiation of H19-7 Hippocampal Neuronal Cells. J Biol Chem. 2004; 279: 43392 – 43402.
7. Babnigg G, Zagranichnaya T, Wu X, Villereal ML. Differential Tyrosine Phosphorylation of Plasma Membrane Ca2+-ATPase and Regulation of calcium pump activity by Carbacol and Bradykinin. J Biol Chem. 2003; 278(17): 14872-14882.
8. Villereal M, Zagranichnaya T, Wu X. Role of store-operated Ca2+ channels in regulating gene expression. Faseb Journal. 2003; 17(4): A45-A45 Part 1 Suppl. S.
9. Wu X, Babnigg G, Zagranichnaya T, Villereal ML. The role of human transient receptor potential protein 4(Htrp4) in thapsigargin-, carbachol- and diacylglycerol-stimulated calcium entry in HEK-293 cells. J Biol Chem. 2002; 277(16): 13597-13608.
10. Kulaeva ON, Zagranichnaya TK, Brovko FA, et al. New family of cytokinin receptors from Cereales. FEBS Letters. 1998; 423(2): 239-242.
11. Brovko FA, Zagranichnaya TK. Two methods to remove phenolic compounds from a plant extract. Plant Physiology and Biochemistry. 1998; 36: 10-16.
12. Zagranichnaya TK, Brovko FA, Shepelyakovskaya AO, Boziev KhM, Lipkin VM. Monoclonal antibodies to a 70-kD cytokinin-binding protein from etiolated maize seedlings. Russ J Plant Physiol. 1997; 44: 1-5.
13. Zagranichnaya TK, Brovko FA, Lipkin VM, Karavaiko NN, Selivankina SYu, Kulaeva ON. Monoclonal antibodies against new cytokinin-binding protein 70 kD from etiolated maize coleoptiles. J Plant Physiology and Biochemistry. 1996; (200).
14. Brovko FA, Zagranichnaya TK, Boziev KhM, et al. Isolation and characterization of a cytokinin-binding protein from etiolated maize seedlings. Russ J Plant Physiol. 1996; 43: 467-479.