Soundarapandian (Vijay) Vijayakumar, PhD
Department of Pediatrics
Adjunct Associate Research Scientist
Dr. Kumar served as the Assistant Professor of Pediatrics as well as of Pharmacology & Physiology at the University of Rochester. During his tenure at the University of Rochester, he developed an independent research project investigating the role of extracellular matrix in Polycystic Kidney Disease, and mentored undergraduate and high school research students. He has held research positions at the Columbia University in the City of New York as well as the University of Texas South-western Medical Center, Dallas, TX. As a young scientist, He has spent time at the University of Ulm, Germany and International Center for Theoretical Physics, Italy. He has published in several leading peer-reviewed journals such as the Journal of Cell Biology and Journal of Clinical Investigation, primarily on the role of hens in acid-base physiology.
He has extraordinary interest in STEM education and interdisciplinary thought. He has served as adjunct faculty at the Bryant & Stratton College, Henrietta and at the College of Mount Saint Vincent at Bronx, NY. He routinely participates in the First Lego League events primarily in the Judging area as well as in the NYC Science & Engineering Fair. He is devoted to making concepts easily understandable to students, active learning strategies and mentoring.
His research interests include structure of membrane proteins (CFTR, P450scc), Origin and evolution of life (primitive tRNA), Bioinformatics & genomics (P450scc, Polycystic Kidney Disease) as well as Developmental biology of the Kidney.
• The role of Microfibril-associated protein 4 in vascular morphogenesis and in the development of vascular diseases. Lund beck Foundation (Dec 2007-2009)
• Travel Grants from International Society for the study of Origins of Life, NASA and International Center for Theoretical Physics (1987-1995)
• Junior Research Fellowships from the Department of Science and Technology, India & University Grants Commission India (1986-1989)
• Best student of the College, RKM Vivekananda College, Chennai, India (1983)
MEMBERSHIP IN PROFESSIONAL SOCIETIES
• (2008-Present) Recessive PKD Core Center, Univ. of Alabama, Birmingham, AL 35294
• (2003-Present) American Society for Cell Biology, Bethesda, MD, USA
• (2003-Present) American Society of Nephrology, Washington DC, USA
• (1995-1997) Cystic Fibrosis Foundation. Bethesda, MD, USA
• (1988-1990) Society for Bio molecular Recognition
• (1991-1995) Biophysical Society
• (1987-2000) International Society for the Study of Origins of Life (ISSOL)
1. Vijayakumar S, Dang S, Marinkovich MP, et al. Aberrant Expression of Laminin-332 in ARPKD Contributes to Cystogenesis by Altering Principal Cell Proliferation. American Journal of Physiology. 2013. doi: 10.1152/ajprenal.00104.2013
2. Vijayakumar S, Peng H, Schwartz GJ. Galectin-3 Mediates Oligomerization of Secreted Hensin Using its Carbohydrate Recognition Domain. Am J Physiol. 2013; 305: F90-F99. doi: 10.1152/ajprenal.00498.2012
3. Peng H, Vijayakumar S, Schiene-Fischer C, et al. Secreted Cyclophilin A, A peptidyl prolyl cis/trans isomerase mediates matrix assembly of hensin, a protein implicated in epithelial differentiation. J Biol Chem. 2009; 10: 6465-6475. doi: 10.1074/jbc.M808964200
4. Vijayakumar S, Erdjument-Bromage H, Tempst P, Al-Awqati Q. Role of Integrins in Hensin Assembly and Function in Cultured Intercalated Cells. J Am Soc Neph. 2008; 19: 1079-1091. doi: 10.1681/ASN.2007070737
5. Vijayakumar S, Takito J, Gao X, Schwartz GJ, Al-Awqati Q. Differentiation of columnar epithelia: the hensin pathway. J Cell Sci. 2006; 119: 4797-4801. doi: 10.1242/jcs.03269
6. Schwaderer AL, Vijayakumar S, Al-Awqati Q, Schwartz GJ. Galectin-3 Expression is Induced in Renal -Intercalated Cells during Metabolic Acidosis. Am J Physiol Renal Physiol. 2006; 290.
7. Watanabe S, Tsuroka S, Vijayakumar S, Schwartz GJ. Cyclosporin produces Distal Renal Tubular Acidosis by blocking hensin polymerization. Am J Physiol. 2005; 288(1): F40-F47. doi: 10.1152/ajprenal.00218.2004
8. Al-Awqati Q, Vijayakumar S, Takito J. Terminal differentiation of epithelia. Biol Chem. 2003; 384: 1255-1258. doi: 10.1515/BC.2003.138
9. Al-Awqati Q, Vijayakumar S, Takito J. Terminal differentiation of epithelia from trophectoderm to the intercalated cell: the role of hensin. J Am Soc Nephrol. 2003; 14(1): S16-S21. doi: 10.1097/01.ASN.0000067633.19426.DD
10. Genter MB, Burman DM, Vijayakumar S, Ebert CL, Aronow BJ. Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa. Physiol Genomics . 2002; 12: 35-45. doi: 10.1152/physiolgenomics.00120.2002
11. Schwartz GJ, Tsuroko S, Vijayakumar S, Petrovic S, Milan A, Al-Awqati Q. Acid incubation reverses the polarity of intercalated cell transporters: An effect mediated by hensin. J. Clin. Inves. 2002; 102: 89-99. doi: 10.1172/JCI13292
12. Ma JF, Takito J, Vijayakumar S, Peehl DM, Olsson CA, Al-Awqati Q. Prostatic expression of hensin, a protein implicated in epithelial terminal differentiation. The Prostate. 2001; 49(1): 9-18. doi: 10.1002/pros.1113
13. Schwartz GJ, Kittelberger AM, Barnhart DA, Vijayakumar S. Carbonic anhydrase IV is expressed in H+-secreting cells of rabbit kidney. Am. J Physiol. 2000; 278: F894-F904.
14. Al-Awqati Q, Vijayakumar S, Takito J, Hikita C, Wiederholt YL. Phenotypic plasticity and terminal differentiation of the intercalated cell: the hensin pathway. Exp Nephrol. 2000; 8: 66-71. doi: 10.1159/000020650
15. Hikita C, Vijayakumar S, Takito J, Erdjument-Bromage H, Tempst P, Al-Awqati Q. Induction of terminal differentiation in epithelial cells requires polymerization of hensin by galectin-3. J Cell Biol. 2000; 151: 1235-1246. doi: 10.1083/jcb.151.6.1235
16. Vijayakumar S, Takito J, Hikita C, Al-Awqati Q. Hensin remodels the apical cytoskeleton and induces columnarization of intercalated epithelial cells: processes that resemble terminal differentiation. J. Cell. Biol. 1999; 144: 1057-1067. doi: 10.1083/jcb.144.5.1057
17. Hikita C, Takito J, Vijayakumar S, Al-Awqati Q. Only multimeric hensin located in the ECM induces apical endocytosis and reversal of polarity in intercalated cells. J. Biol. Chem. 1999; 274: 17671-17676. doi: 10.1074/jbc.274.25.17671
18. Takito J, Yan L, Ma J, et al. Hensin, the polarity reversal protein, is encoded by DMBT1, a gene frequently deleted in malignant gliomas. Am. J. Physiol. 1999; 277: F277-F289.
19. Al-Awqati Q, Vijayakumar S, Takito J, Hikita C, Yan L, Wiederholt T. Terminal differentiation in epithelia: the Hensin pathway in intercalated cells. Semin Nephrol. 1999; 19: 415-420.
20. Wigley WC, Vijayakumar S, Jones JD, Slaughter C, Thomas PJ. Transmembrane domain of Cystic fibrosis transmembrane conductance regulator: Design, characterization and secondary structure of synthetic peptides m1-m6. Biochemistry. 1998; 37: 844-853. doi: 10.1021/bi972293n
21. Al-Awqati Q, Vijayakumar S, Hikita C, Chen J, Takito J. Phenotypic plasticity in the intercalated cell: the hensin pathway. Am. J. Physiol.1998; 275: F183-F190
22. Chen J, Vijayakumar S, Li X, Al-Awqati Q. Kanadaptin is a protein that interacts with the kidney but not the erythroid form of Band 3. J. Biol. Chem. 1998; 273: 1038-1043. doi: 10.1074/jbc.273.2.1038 January 9, 1998 The
23. Vant hof W, Malik A, Vijayakumar S, Qiao J, van Adelsberg J, Al-Awqati Q. The effect of apical and basolateral lipids on the function of the Band 3 anion exchange protein. J. Cell. Biol. 1997; 139: 941-949. doi: 10.1083/jcb.139.4.941
24. Vijayakumar S, Salerno JC. Molecular modeling of the 3-D structure of cytochrome P-450scc. Biochim. Biophys. Acta. 1992; 1160: 281-286.
25. Vijayakumar S, Balasubramanian R. Origin of the discriminatory mechanism of proteinous aminoacids from the non-proteinous aminoacids by the protein synthesizing machinery. Origins of Life and Evolution of the Biosphere. 1989; 19: 370-372.