Sho Kanzaki, MD, PhD

Assistant Professor
Department of Otorhinolaryngology, Head and Neck Surgery
Keio Univesity
School of Medicine
35 Shinanomachi Shinjuku, Tokyo160-8582
Japan

Biography

EDUCATIONAL BACKGROUND AND PROFESSIONAL EXPERIENCES

• (1994) Graduated Keio University medical school
• (1994) Department of Otolaryngology (MD)
• (1999) Special Otolaryngologist in Japan
• (1998-2002) Graduated student of Department of Otolaryngology in Keio University medical school (PhD)
• (1999-2001) Research Fellow in Kresge Hearing Research Institute of Michigan University (Yeoash Raphael laboratory)
• (2005-Present) Faculty member in Department of Keio University School of Medicine
• (2012-Present) Assistant professor, Department of Otorhinolaryngology, Head and Neck Surgery Keio University

Research Interest

His research interest includes: Otolaryngology specialist, Clinical otology and neurotology Otologic and Neurotologic research (middle ear surgery, cochlear implant and sensorineural hearing loss, Basic research drug and gene therapy, Bone metabolism of middle ear, Protection of cochlear damage, Clinical Allergy, Olfactory disorder.

Scientific Activities

HONORS AND AWARDS

• 1st Global otology research forum (GLORF) Award (Nov.13 2013, Antalya, Turkey) Kanzaki S, et al Novel in vivo imaging analysis of an inner ear (spiral ganglion) drug delivery system in mice.
• 25th Politzer society meeting (international otologic society meeting) award (2005 Seoul,Korea) Kanzaki S, Bone resorption of auditory ossicles in opg knockout mice
• Poster award of Annual Meeting American Academy of Otolaryngology Head and Neck Surgery. Hayashi K, Goto F, Kanzaki S, Ogawa K; The molecular mechanism of autophagy in auditory cells. & OTO Expo in Boston, MA,USA, 2010.9
• Medical Award of the Japan Medical Association (2014) • Tokyo medical association encouragement Award (2009)
• Japan foundation for aging and health Award (2005)
• Keio University School of Medicine, Sanshikai Award

MEMBERSHIPS

• Association in research in otolaryngology (ARO) active member
• Japanese otolaryngology society
• Japanese otology society,Japanese audiology society
• Japanese regeneration medicine, Japanese Allergy society

Publications

1. Tsuchihashi NA, Hayashi K, Dan K, et al. Autophagy through 4EBP1 and AMPK regulate oxidative stress-induced premature senescence in auditory cells. Oncotarget. 2015; 6(6): 3644-3645.
2. Watada Y, Yamashita D, Toyoda M, et al. Magnetic resonance monitoring of superparamagnetic iron oxide (SPIO)-labeled stem cells transplanted into the inner ear. Neurosci Res. 2015 Jun;95:21-6doi: 10.1016/j.neures.2015.01.010.
3. Hayashi K, Dan K, Goto F, et al. The autophagy pathway maintained signaling cross talk with the Keap1-Nrf2 system through p62 in auditory cells under oxidative stress. Cellular Signalling. 2015; 27(2): 382-393. doi: 10.1016/j.cellsig.2014.11.024.
4. Kanzaki S(CA),Sakagami M, Hosoi H, Murakami S, Ogawa K. High fibrinogen in peripheral blood correlates with poorer hearing recovery in idiopathic sudden sensorineural hearing loss. PLoS One. 2014; 9(8): e104680. doi: 10.1371/journal.pone.0104680
5. Hashiguchi K, Kanzaki S, Wakabayashi K, et al. Efficacy of fluticasone furoate nasal spray and levocetirizine in patients with Japanese cedar pollinosis subjected to an artificial exposure chamber. Journal of Drug Assessment. 2013; 2(1): 94-105. doi: 10.3109/21556660.2013.829070
6. Wasano K, Kanzaki S, Sakashita T, et al. A psychometric validation of the Japanese versions of new questionnaires on tinnitus (THI-12, TRS, TRSw, TSS, and TSSw). Acta Oto-laryngol. 2013; 133(5): 491-498. doi: 10.3109/00016489.2012.757799
7. Oishi N, Shinden S, Kanzaki S, Saito H, Inoue Y, Ogawa K. Effects of tinnitus retraining therapy involving monaural noise generators. European archives of oto-rhino-laryngology. 2013; 270(2): 443-448. doi: 10.1007/s00405-012-1951-5.
8. Kanzaki S(CA), Fujioka M, Yasuda A, et al. Novel In Vivo Imaging Analysis of an Inner Ear Drug Delivery System in Mice: Comparison of Inner Ear Drug Concentrations over Time after Transtympanic and Systemic Injections. PLoS One. 2012; 7: e48480. doi: 10.1371/journal.pone.0048480
9. Kanzaki S, Takada Y, Niida S, et al. Impaired vibration of auditory ossicles in osteopetrotic mice. Am J Pathol. 2011; 178(3): 1270-1278. doi: 10.1016/j.ajpath.2010.11.063
10. Kanzaki S, Takada Y, Ogawa K, Matsuo K. Bisphosphonate Therapy ameliorates hearing loss in mice lacking osteoprotegerin. J Bone Miner Res. 2009; 24(1): 43-49. doi: 10.1359/jbmr.080812
11. Kanzaki S, Ito M, Takada Y, Ogawa K, Matsuo K. Hearing loss and ossicles of osteoporosis in mice. Bone. 2006; 39(2): 414-419. doi: 10.1016/j.bone.2006.01.155
12. Oishi N, Shinden S, Kanzaki S, Saito H, Inoue Y, Ogawa K. Effects of tinnitus retraining therapy involving monaural noise generators. Eur Arch Otorhinolaryngol. 2012. doi: 10.1007/s00405-012-1951-5
13. Goto F, Saruta J, Kanzaki S, et al. Various levels of plasma brain-derived neurotrophic factor in patients with tinnitus. Neuroscience Letters. 2012; 510(2): 73-77 doi: 10.1016/j.neulet.2012.01.001
14. Wakabayashi K, Hashiguchi K, Kanzaki S, et al. Pranlukast dry syrup inhibits symptoms of Japanese cedar pollinosis in children using OHIO Chamber. Allergy Asthma Proc. 2012; 33(1): 102-109. doi: 10.2500/aap.2012.33.3517
15. Koike T, Sakamoto C, Hayashi K, Kanzaki S, Ogawa K. Effects of a perilymphatic fistula on the vibration of the basilar membrane. Hear Res. 2012; 283(1-2): 117-125. doi: 10.1016/j.heares.2011.10.006
16. Kanzaki S(CA), Saito H, Inoue Y, Ogawa K.A new device for delivering drugs into the inner ear: otoendoscope with microcatheter. Auris Nasus Larynx. 2012 Apr;39(2):208-11. doi: 10.1016/j.anl.2011.04.006.
17. Oishi N, Shinden S, Kanzaki S, Saito H, Inoue Y, Ogawa K. Influence of depressive symptoms, state anxiety, and pure-tone thresholds on the tinnitus handicap inventory in Japan. Int J Audiol. 2011; 50(7): 491-495. doi: 10.3109/14992027.2011.560904
18. Cui Y, Sun G, Yamashita D, et al. Acoustic overstimulation-induced apoptosis in fibrocytes of the cochlear spiral limbus of mice. Eur Arch Otorhinolaryngol. 2011;268(7):973-978. doi: 10.1007/s00405-011-1484-3
19. Kanzaki S(CA), Ogawa H, Masuda T, Ikeda M, Ogawa K. Multicenter analysis of the QOL of patients with seasonal allergic rhinitis. Acta otolaryngol. 2011; 131(3):290-297.
20. Minami SB, Shinden S, Okamoto Y, et al. Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus. Auris Nasus Larynx. 2011; 38(3):301-306. doi: 10.1001/jamaoto.2015.1219
21. Ide R, Harada T, Kanzaki S(CA), et al. Physical and Physiological Effects on Otoacoustic Emissions in Hypobaric Hypoxia. ORL. 2010; 72(4): 225-232. doi: 10.1159/000310352.
22. Wakabayashi K, Fujioka M, Kanzaki S, et al. Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea. Neuroscience Res. 2010; 66(4): 345-352. doi: 10.1016/j.neures.2009.12.008
23. Oishi N, Inoue Y, Saito H, Kanzaki S, Kanzaki J, Ogawa K. Long-term prognosis of low-frequency hearing loss and predictive factors for the 10-year outcome, Otolaryngol Head Neck Surgery. 2010; 142(4): 565-569. doi: 10.1016/j.otohns.2009.12.006
24. Oishi N, Kanzaki S, Kataoka C, et al. Acute-Onset Unilateral Psychogenic Hearing Loss in Adults Report of Six Cases and Diagnostic Pitfalls. ORL. 2009; 71(5): 279-283. doi: 10.1159/000251195
25. Oishi N, Kanzaki S, Shinden S, Saito H, Inoue Y, Ogawa K. Effects of selective serotonin reuptake inhibitor to treat tinnitus in patients stratified for the presence of depression or anxiety. Audiol Neurootol. 2009; 15(3): 187-193. doi: 10.1159/000251916.
26. Nagasao T, Miyamoto J, Tamaki T, Kanzaki S, Ogawa K. Inferior meatal antrostomy impairs dynamic stability of the orbital walls. Auris Nasus Larynx. 2009 ;36(4):431-437. doi: 10.1016/j.anl.2008.09.004.
27. Kanzaki J, Kanzaki S(CA), Ogawa K. Pathogenesis of hearing loss from the point of view of the long-term prognosis of steroid-dependent sensorineural hearing loss. Audiol Neurotol. 2009; 14(1): 26-34.
28. Taniguchi Y, Ohshiro T, Fujii S, et al. Cost-effectiveness of Different Treatment Modalities for Seasonal Allergic Rhinitis in Japan-Comparison of Laser Treatment with Subcutaneous Immunotherapy and Oral Medication. Laser Therapy. 2008;17 ( 4), 193-197. doi: 10.5978/islsm.12-OR-12
29. Ozawa H, Tomita T, Sakamoto K, et al. Mucoepidermoid carcinoma of the head and neck: clinical analysis of 43 patients. Jpn J Clin Oncol. 2008; 38(6): 414-418. doi: 10.1093/jjco/hyn045.
30. Masuda M, Tanaka K, Kanzaki S, et al. GFAP aggregates in the cochlear nerve increase the noise vulnerability of sensory cells in the organ of Corti in the murine model of Alexander disease. Neurosci Res. 2008; 62(1):15-24. doi: 10.1016/j.neures.2008.05.005
31. Yamashita D, Shiotani A, Kanzaki S, Nakagawa M, Ogawa K. Neuroprotective effects of T-817MA against noise-induced hearing loss. Neurosci Res. 2008;61(1):38-42. doi: 10.1016/j.neures.2008.01.009
32. Iizuka T, Kanzaki S, Mochizuki H, et al. In vivo delivery of adeno-associated virus was successfully and noninvasively transferred into the supporting cells of the neonatal mouse cochlea. Human Gene Ther. 2008; 19(4): 384-390. doi: 10.1089/hum.2007.167
33. Yamashita D, Minami SB, Kanzaki S, Ogawa K. Bcl-2 genes regulate noise-induced hearing loss. J Neurosci Res. 2008; 86(4): 920-928.
34. Kanzaki S(CA), Nameki H. Standardised method of selecting surgical approaches to benign parapharyngeal space tumours, based on pre-operative images. J Laryngol Otol. 2008; 122(6): 628-634. doi: 10.1017/S0022215107009875
35. Masuda M, Inoue Y, Tanosaki R, Kanzaki S, Ogawa K. Development of solitary plasmacytoma in the internal auditory canal and inner ear after allogeneic hematopoietic stem cell transplantation for plasma cell leukemia. Japanese Jap Clin Oncol. 2007;37(9):701-703.
36. Kanzaki S(CA), Shiotani A, Inoue M, Hasegawa M, Ogawa K. Sendai Virus Vector-Mediated Transgene Expression in the Cochlea in vivo. Audiol Neurotol. 2007;12:119-126. doi:
37. Kanzaki S, Beyer L, Karolyi I J, et al. Transgene correction maintains normal cochlear structure and function in 6 month old Myo15a mutant mice. Hear Res. 2006; 214(1-2): 37-44.
38. Kanzaki S, Beyer LA, Swiderski DL, et al. p27 kip1 deficiency causes organ of Corti pathology and hearing loss. Hear Res. 2006; 214(1-2): 28-36.
39. Fujioka M, Kanzaki S, Okano JH, Ogawa K, Okano H. Proinflammatory cytokines expression in noise-induced hearing loss. J Neurosci Res. 2006; 83(4): 575-583.
40. Masuda M, Nagashima R, Kanzaki S, Ogita K, Ogawa K. Nuclear factor-kappa B nuclear translocation in the cochlea of mice following acoustic overstimulation. Brain Res. 2006; 1068(1): 237-247.
41. Kawamoto K, Yagi M, Stover T, Kanzaki S, Raphael Y. Hearing and hair cells are protected by adenoviral gene therapy with TGF-b1 and GDNF. Mol Ther. 2003; 7(4): 484-492.
42. Ishimoto SI, Kawamoto K, Stover T, Kanzaki S, Yamasoba T, Raphael Y. A glucocorticoid reduces adverse effects of adenovirus vectors in the cochlea. Audiol Neurootol. 2003; 8(2):70-79.
43. Kanzaki S, Kawamoto K, Oh SH, et al. From gene identification to gene therapy. Audiol Neurootol. 2002; 7(3): 161-164. doi: 10.1159/000058303
44. Kanzaki S, Beyer LA, Canlon B, Meixner WM, Raphael Y. The Cytocaud: A hair Cell Pathology in the Waltzing Guinea Pig. Audiol Neurootol. 2002; 7(5): 289-297.
45. Kanzaki S, Ogawa K, Camper SA, Raphael Y. Transgene expression in neonatal mouse inner ear explants mediated by first and advanced generation adenovirus vectors. Hear Res. 2002;169 (1-2):112-120.
46. Kanzaki S, Stöver T, Kawamoto K, et al. GDNF and chronic electrical stimulation prevent VIII cranial nerve degeneration following denervation. J Comp Neurol. 2002; 454(3): 350-360. doi: 10.1002/cne.10480
47. Ishimoto S, Kawamoto K, Kanzaki S, Raphael Y. Gene transfer into supporting cells of the organ of Corti. Hear Res. 2002; 173(1-2): 187-197.
48. Kawamoto K, Oh SH, Kanzaki S, Brown N, Raphael Y. The functional and structural outcome of inner ear gene transfer via the vestibular and cochlear fluids in mice. Mol Ther . 2001; 4(6):575-585.
49. Stover T, Kawamoto K, Kanzaki S, Raphael Y. Untersuchungen zur Durchfuhrbarkeit eines Innenohr-Gentransfers nach Mittelohrapplikation eines adenoviralen Vektors. Germany. Laryngo-Rhino-Otologie. 2001; 80(8): 431-435.doi: 10.1055/s-2001-16433
50. Kawamoto K, Kanzaki S, Prieskorn D, Miller JM, Raphael Y. Gene-based therapy for inner ear disease. Noise and Health. 2001; 3(11): 37-47.
51. Yagi M, Kanzaki S, Kawamoto K, et al. Spiral ganglion neurons are protected from degeneration by GDNF gene therapy, JARO. 2000; 1(4): 315-325.