Shibin Cheng, MD, PhD

Associate Professor
Department of Pediatrics
Women & Infants Hospital
Brown University
Providence, Rhode Island



• (2002) PhD in Neuroscience, Department of Neuroanatomy, Kagoshima University, Japan
• (1991) MS in Physiology, Sun Yat-sen University of Medical Sciences (SUMS), China
• (1988) MD, B.S. in Medicine, Wannan Medical College, China


(2013-Present) Assistant Professor of Pediatrics, Women & Infants Hospital, Brown University
• (2011-2013) Assistant Professor of Medicine (research), Division of Hematology & Oncology, Department of Medicine, Rhode Island Hospital and Brown University, RI
• (2009-2010) Visiting Scholar, Department of Pathology and Laboratory Medicine, Brown University, RI
• (2002-2003) Special Researcher, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
• (1993-1998) Lecturer, Department of Physiology, Sun Yat-sen University, PRC
• (1991-1993) Instructor, Department of Physiology, Sun Yat-sen University, PRC

Research Interest

His research interests include: Adverse Pregnancy Outcomes, G protein-Coupled Estrogen Receptor in Kidney, Neuroscience.

Scientific Activities


• Member of American Society of Reproductive Immunology (2013-present)
• Member of Society for Neuroscience, USA (2003-present)
• Member of Japan Neuroscience Society (1999-2003)
• Member of Japanese Association of Anatomists (1999-2002)


• (1992-19930) Teaching Excellence Award, Sun Yat-sen University of Medical Sciences (SUMS), China
• (1994) Research Achievement Award, SUMS, China
• (1995) Scientific Progress Award, Ministry of Health of People’s Republic of China
• (1999-2000) Travel Award, Kagoshima Prefecture International Communication Society, Japan
• (1999-2000) Scholarship, Ministry of Education, Science and Culture of Japan, Japan
• (2000) Travel Award, Kato Memorial Bioscience Foundation, Japan
• (2000-2001) Fellowship, Japan-China Medical Association, Japan
• (2000-2002) Publication Award, the Kodama Foundation for Research of Medical Science, Japan
• (2000-2002) Teaching Assistantship, Faculty of Medicine, Kagoshima University, Japan
• (2001-2003) Fellowship, Japan Society for the Promotion of Science, Japan
• (2001-2003) Research Award, Japan Society for the Promotion of Science (No. 200100115-14), Japan
• (2005) Travel Award, Neuroscience Center of Excellence, LSUHSC, USA
• (2005) Travel Award, Society of Neuroscience, USA
• (2006) Excellent Presentation Award, Neuroscience Center of Excellence, LSUHSC, USA
• (2007) Travel Award, International Herpes Simplex Virus Workshop, North Carolina, USA



1. Cheng SB, Dong J, Pang Y, et al. Anatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone. Mol Cell Endocrinol. 2014; 382(2): 950-959. doi: 10.1016/j.mce.2013.11.005
2. Kalkunte SS, Neubeck S, Norris WE, et al. Transthyretin is Dysregulated in Preeclampsia and Its Native Form Prevents the Onset of Disease in a Preclinical Mouse Model. Am J Pathol. 2013; 183 (5): 1425-1436. doi: 10.1016/j.ajpath.2013.07.022
3. Cheng SB, Filardo ED. Trans-Golgi network (TGN) as a regulatory node for beta1-adrenergic receptor down-modulation and recycling. J Biol Chem . 2012; 287(17): 14178-14191. doi: 10.1074/jbc.M111.323782
4. Cheng SB, Quinn J, Graeber CT, Filardo ED. Down-modulation of GPER/GPR30 from the cell surface occurs via a trans-Golgi-proteasome pathway. J Biol Chem. 2011; 286(25): 22441-22155. doi: 10.1074/jbc.M111.224071
5. Cheng SB, Ferland P, Bearer EL. Herpes simplex virus dances with amyloid precursor protein while exiting the cell. PLoS ONE. 2011; 6(3): e17966. doi: 10.1371/journal.pone.0017966
6. Cheng SB, Graeber CT, Quinn J, Filardo ED. Retrograde transport of the transmembrane estrogen receptor, G-protein-coupled-receptor-30 (GPR30/GPER) from the plasma membrane towards the nucleus. Steroids. 2011; 76(9): 892-896. doi: 10.1016/j.steroids.2011.02.018
7. Cheng SB, Stephanie A, Ren XQ, et al. Presynaptic targeting of alpha4beta2 nicotinic acetylcholine receptors is regulated by neurexin-1beta. J Biol Chem. 2009; 284(35): 23251-23219. doi: 10.1074/jbc.M109.017384
8. Ren XQ, Cheng SB, Treuil MW, et al. Structural determinants of 42 nicotinic acetylcholine receptor trafficking. J Neurosci. 2005; 25: 6676-6686. doi: 10.1523/JNEUROSCI.1079-05.2005
9. Cheng SB, Kuchiiwa S, Kawachi A, et al. Up-regulation of methionine-like enkephalin immunoreactivity by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin treatment in the forebrain of the Long-Evans rat. J Chem Neuroanat. 2003; 25: 73-82. doi: 10.1016/S0891-0618(02)00103-5
10. Cheng SB, Kuchiiwa S, Ga, H, Kuchiiwa T, Nakagawa S. Dioxin exposure down-regulates nitric oxide synthase and NADPH-d activities in the hypothalamus. Neurosci Lett. 2003; 345: 5-8. doi: 10.1016/S0304-3940(03)00347-1
11. Cheng SB, Kuchiiwa S, Gao H, Kuchiiwa T, Nakagawa S. Morphological study of orexin neurons in the hypothalamus of the Long-Evans rat, with special reference to co-expression of orexin and NADPH-diaphorase or nitric oxide synthase activities. Neurosci. Res. 2003; 46: 53-62. doi: 10.1016/S0168-0102(03)00026-9
12. Cheng SB, Kuchiiwa S, Nagatomo I, et al. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin pretreatment induces c-Fos expression in the forebrain of the Long-Evans rat. Brain Res. 2002; 931(2): 176-180.
13. Cheng SB, Kuchiiwa S, Kuchiiwa T, Nakagawa S. Effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin treatment on methionine-enkephalin immunoreactivity in the brain of the Long-Evans rat. Organohalogen Compounds. 2002; 57: 407-409.
14. Cheng SB, Kuchiiwa S, Kuchiiwa T, Nonaka S, Nakagawa S. Presence of neuronal nitric oxide synthase in autonomic and sensory ganglion neurons innervating the lacrimal glands of the cat: an immunofluorescent and retrograde tracer double-labeling study. J Chem Neuroanat. 2001; 22(3): 147-155. doi: 10.1016/S0891-0618(01)00125-9
15. Cheng SB, Kuchiiwa S, Kuchiiwa T, Nakagawa S. Three novel neuronal pathways to the lacrimal gland of the cat: an investigation with cholera toxin B subunit as a retrograde tracer. Brain Res. 2000; 873(1): 160-164. doi: 10.1016/S0006-8993(00)02536-1
16. Cheng SB, Hayakawa T, Kuchiiwa S, et al. Evidence for the collateral innervation of the esophagus and the heart from neurons in the compact formation of the ambiguus nucleus of the rat. Brain Res. 1999; 832: 171-174. doi: 10.1016/S0006-8993(99)01429-8
17. Kuchiiwa S, Cheng SB, Nagatomo I, et al. In utero and lactational exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin decreases serotonin-immunoreactivity in the raphe nuclei of mice. Neurosci Lett. 2002; 317(2): 73-76. doi: 10.1016/S0304-3940(01)02434-X
18. Kuchiiwa S, Cheng SB, Kuchiiwa T. Morphological distinction between the vasomotor neurons and the secretomotor neurons innervating the cat cranio-oro-facial regions. Neurosci Lett. 2000; 288(3): 219-222.
19. Kozako T, Kawachi A, Cheng SB, et al. Role of the vestibular nuclei in endothelin-1-induced barrel rotation in rats. Eur. J. Pharmacol. 2002; 454: 199-207. doi: 10.1016/S0014-2999(02)02498-6
20. Cheng SB, Lu G. Progress in the study of dorsal motor nucleus of the vagus nerve. Progress in Physiology Sciences. 1996; 27(1): 13-18.
21. Cheng SB, Lu G. General visceral function of the ambiguus nucleus. Bulletin of Physiology Guangdong. 1996; 3(2): 38-42.
22. Lu G, Wang Z., ChengS B, Huang W. Functional and morphological investigation on the regulation of gastric acid secretion. CAPS News Communication supplement. 1996; 15(1): 216-222.
23. Cheng SB, Lu G. Electron microscopic observation of connections between ependyma of medulla oblongata and neurons of rat. Guangdong Anatomical Bulletin . 1995; 17(1): 50-52.
24. Cheng SB, Lu G. Central localization of parasympathetic preganglionic neurons projecting to the different parts of rat stomach. ACTA ANATOMIVCA SIMICA. 1993; 24(1): 51-55.
25. Cheng SB, Luo T , Lu G. Central projection of vagal sensory fibers from the stomach in the rat: a light and electron microscopic study. ACAD J SUMS. 1993; 14(4): 252-255.
26. Cheng SB, Luo T, Lu G. Ultrastructure and connections of parasympathetic preganglionic nerve innervating the stomach in dorsal motor nucleus of the vagus. Chinese Journal of Neuroanatomy. 1992; 8(2): 225-228.
27. Zhang J, Cheng SB, Wang Z, Lu G. Effect of histamin on c-fos gene expression in the hypothalamus of the rat. ACAD J SUMS. 1998; 19(4): 319-320.
28. Wang X, Cheng SB, Lu G. Direct pathway between insular cortex and dorsal motor nucleus of the vagus nerve in the rat; a light and electron microscopic study. Acta Anatomical Sinica. 1994; 25(2): 128-131.
29. Liu Z, Liu N, Cheng SB. The G proteincoupled estrogen receptor (GPER-1): a novel regulator in the kidney.Nephrol Open J. 2015; 1(1): e4-e6.