Ravindra Kolhe, MD, PhD

Assistant Professor
Department of Pathology
Medical Director of Cytogenetics Laboratory
Laboratory Director of Georgia Esoteric & Molecular Labs
Medical College of Georgia at Augusta University
Augusta, GA, USA

Biography

Dr. Kolhe is an Assistant Professor in the Department of Pathology at the Georgia Regents University, Augusta GA. He is the CLIA laboratory director for the Georgia Esoteric and Molecular Labs and also serves as the Medical Director for the Cytogenetics Laboratory. He is a physician-scientist with expertise in basic mechanisms of tumor immunology, including tolerogenic DCs, Tregs, and the indoleamine 2,3-dioxygenase pathway. His work also lead to identification of mir-21 as a biomarker for early diagnosis of liver cancer. His laboratory is elucidating molecular mechanisms of acquired tolerance and immune suppression in tumor-bearing hosts, with a focus on the role of IDO-expressing DCs and IDO-activated Tregs in cancer. He haspublished numerous original research papers in leading journals, and presented his work at many national and international scientific meetings. He also serves on the editorial boards for journals in his field as well as acting as a reviewer of publications submitted to several scientific and clinical research journals.

Research Interest

His translational research is focused on the field of clinical molecular cytogenetics which has led to the identification of new leukomogenic regions in karyotypically normal adult leukemia patients.

Scientific Activities

HONORS AND AWARDS

•(2013) Best poster finalist, ASCP annual meeting, Chicago
•(2013) Best oral presentation finalist, ASCP annual meeting, Chicago
•(2013) Faculty Research Development Grant Award, Cancer center, Georgia Regents University
•(2012) Best scientific poster finalist, ASCP annual meeting, Boston
•(2012) Stephen C. Peiper M.D, award for excellence in resident research, Pathology, Georgia Regents University
•(2011) Resident Research Development Grant Award, Pathology, Georgia Regents University
•(1995-1999) National Book Scholarship awarded by Govt. of India to top 1% medical students for four straight years
•(1995-1999) State Merit Scholarship from State Government of Maharashtra, India over a course of 4 ½ years, awarding tuition-free medical education at MGMMCA India (1995-2000)
•(1995) State Merit Scholarship from State Government of Maharashtra, India for excellence in Mathematics, Physics, Biology and Chemistry

MEMBERSHIPS

• Member, United states and Canadian Academy of Pathology
• Member, American Society of Clinical Pathology
• Member, College of American Pathology
• Member, Association for Molecular Pathology
• Member, American society for Clinical Oncology
• Member, American College of Medical Genetics and Genomics
• Member, American College of Health care executives
• Member, Association of Pathology informatics
• Member, CLS Program Advisory Committee, GRU
• Member, Resident review committee, Pathology, GRU
• Member, MCG Clinical & Translation Sciences Advisory Committee, GRU
• Member, Search committee-Hematopathology Section Chief, GRU
• Member, Search committee-Clinical Pathology Section Chief, GRU
• Member, Search committee-Director of Microbiology/Immunology, GRU
• Member, Advisory Board- Microarray and NGS core Cancer Center, GRU
• Member, Advisory Board-Informatics core Cancer Center, GRU
• Pathology Liaison, LCME Medical Student Research Opportunities GRU

Publications

1. Krishan SB, Kolhe R, Black SM, Keller JR, Mivechi NF, Satyanarayana A. Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells. The FASEB Journal. 2015; fj-15.
2. Jalnapurkar S, Mangaonkar A, Mondal A, Burke J, Fulzule S, Kolhe R. miRNA in Pathophysiology of Peripartum Cardiomyopathy (PPCM): A Systemic Review. Journal of Clinical & Experimental Cardiology. 2015.
3. Rajnikumar S, Periyasamy-Thandavan S, Kolhe R, Fulzele S. MicroRNAs-141 and 200a regulate the SVCT2 transporter in bone marrow stromal cells. Molecular and Cellular Endocrinology. 2015. doi: 10.1016/j.mce.2015.01.007
4. Sangani R, Periyasamy-Thandavan S, Pathania R, et al. The crucial role of vitamin C and its transporter (SVCT2) in bone marrow stromal cell autophagy and apoptosis. Stem cell research. 2015; 15(2): 312-321. doi: 10.1016/j.scr.2015.06.002
5. Kolhe R, Mangaonkar A, Mansour J, et al. Utility and impact of early t (15; 17) identification by Fluorescence In Situ Hybridization (FISH) in clinical decision making for patients in Acute Promyelocytic Leukemia (APL). International Journal of Laboratory Hematology. 2015. doi: 10.1111/ijlh.12326
6. Kota V, Clemmons A, Chand A, et al. Congestive heart failure during induction with anthracycline-based therapy in patients with acute promyelocytic leukemia. JCSO. 2014; 12: 390-393.
7. Kolhe R, Reid MD, Lee JR, Cohen C, Ramalingam P. Immunohistochemical expression of PAX5 and TdT by Merkel cell carcinoma and pulmonary small cell carcinoma: a potential diagnostic pitfall but useful discriminatory marker. International journal of clinical and experimental pathology. 2013; 6(2): 142.
8. Kolhe R, Bollage R, Cook L. Lookbacks, Recalls, and Market Withdrawals. 2011.
9. Rekha R, Nalluri S, Kolhe R, et al. Treatment with panobinostat induces glucose-regulated protein 78 acetylation and endoplasmic reticulum stress in breast cancer cells. Molecular cancer therapeutics. 2010; 9(4): 942-952. doi: 10.1158/1535-7163.MCT-09-0988
10. Jianguang C, Fiskus W, Eaton K, et al. Cotreatment with BCL-2 antagonist sensitizes cutaneous T-cell lymphoma to lethal action of HDAC7-Nur77–based mechanism. Blood. 2009; 113(17): 4038-4048. doi: 10.1182/blood-2008-08-176024.
11. Warren F, Wang Y, Joshi R, et al. Cotreatment with vorinostat enhances activity of MK-0457 (VX-680) against acute and chronic myelogenous leukemia cells. Clinical Cancer Research. 2008; 14(19): 6106-6115. doi: 10.1158/1078-0432.CCR-08-0721
12. Warren F, Rao R, Fernandez P, et al. Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor–resistant acute myeloid leukemia cells. Blood. 2008; 112(7): 2896-2905. doi: 10.1182/blood-2007-10-116319
13. Shinohara Eric T, Kaminski JM, Segal DJ, et al. Active integration: new strategies for transgenesis. Transgenic research. 2007; 16(3): 333-339. doi: 10.1007/s11248-007-9077-z
14. Lakshmi P, Kolhe R, Gavini N. AT1-IR-beta association: A new mechanism for the inhibition of insulin receptor function in breast cancer. American Journal of Biochemistry and Biotechnology. 2008; 4(1): 24.