Philip L. Kong, PhD

Staff Scientist
Department of Vaccine and Infectious Disease
Fred Hutchinson Cancer Research Center
Seattle, WA, USA

Biography

EDUCATION

• Kennedy Institute of Rheumatology, Imperial College London, 2006-2011, Postdoctoral fellow
• Section of Immunobiology, Yale University School of Medicine, 1999-2005, PhD
• Department of Molecular Medicine, University of Auckland School of Medicine, 1997-1998, MSc
• School of Biological Sciences, University of Auckland, 1994-1996, BSc

Research Interest

His research interest includes: Immune cell functions in local tissue environment, Modulating the immune system to treat cancer, infectious diseases and autoimmunity.

Scientific Activities

MEMBERSHIPS

• Auckland Medical Research Foundation Summer Studentship (1996)
• University of Auckland Senior Scholarship (1997)
• Oral Presentation at Autoimmunity and Tolerance Keystone Symposium (2003)

Publications

1. Fraser J, Arcus V, Kong P, Baker E, Proft T. Superantigens – powerful modifiers of the immune system. Mol Med Today. 2000; 6: 125-132. doi: 10.1016/d1357-4310(99)1657-3
2. Lauvau G, Vijh, S, Kong P, et al. Priming of memory but not effector CD8 T cells by a killed bacterial vaccine. Science. 2001; 294: 1735-1739. doi: 10.1126/science.1064571
3. Mountjoy KG, Kong PL, Taylor JA, Willard DH, Wilkison WO. Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK293 cells. . Physiol Genomics. 2001; 5: 11-19.
4. Gutting BW, Bouzahzah F, Kong PL, Updyke LW, Amacher DE, Craft J. Oxazolone and diclofenac-induced popliteal lymph node assay reactions are attenuated in mice orally pretreated with the respective compound: potential role for the induction of regulatory mechanisms following enteric administration. Toxicol Appl Pharmacol 2003; 189: 120-133. doi: 10.1016/S0041-008X(03)00091-7
5. Kong PL, Odegard JM, Bouzahzah F, et al. Intrinsic T cell defects in systemic autoimmunity. Ann N Y Acad Sci. 2003; 987: 60-67. doi: 10.1111/j.1749-6632.2003.tb06033.x
6. Kong PL, Zhu T, Madaio MP, Craft J. Role of the H-2 haplotype in Fas-intact lupus-prone MRL mice: association with autoantibodies but not renal disease. Arthritis Rheum . 2003; 48: 2992-2995.
7. Kong PL, Morel L, Croker BP, Craft J. The centromeric region of chromosome 7 from MRL mice (Lmb3) is an epistatic modifier of Fas for autoimmune disease expression. J Immunol . 2004; 172: 2785-2794. doi: 10.4049/jimmunol.172.5.2785
8. Mizue Y, Ghani S, Leng L, et al. Role for macrophage migration inhibitory factor in asthma. Proc Natl Acad Sci U S A. 2005; 102: 14410-14415.
9. Drexler SK, Kong PL, Wales J, Foxwell BM. Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis. . Arthritis Res Ther. 2008; 10: 216. doi: 10.1186/ar2481
10. Drexler SK, Kong P, Inglis J, et al. SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis. . Arthritis Rheum. 2010; 62: 2249-2261. doi: 10.1002/art.27517
11. Drexler SK, Wales J, Andreakos E. Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR. Scand . J Immunol 2010; 71: 393-402. doi: 10.1111/j.1365-3083.2010.02392.x
12. Ripoll VM, Kong PL, Potter, PK. ENU-based phenotype-driven screening. Methods Mol Bio 2012; 844: 1-13. doi: 10.1007/978-1-61779-527-5_1
13. Ruhmann M, Piccinini AM, Kong PL, Midwood KS. Endogenous activation of adaptive immunity: tenascin-C drives interleulin-17 synthesis in murine arthritic joint disease. Arthtis Rheu. 2012; 64: 2179-2190. doi: 10.1002/art.34401
14. Alzabin S, Kong P, Medghalchi M, Palfreeman A, Willaims R, Sacre S. Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance. Arthritis Res Ther. . 2012; 14: R142-R152. doi: 10.1186/ar3875