Panicos Shangaris, LRCP&SI, MBBCh, BAO, MSc(Dist)


Wellcome Trust Sparks Research Training Fellow in Maternal & Fetal Medicine
Prenatal Cell and Gene Therapy Group
UCL Institute for Womens Health
86-96 Chenies Mews
WC1E 6HX, London, UK

Biography

Panicos is a trainee in Obstetrics and Gynaecology and a PhD Candidate at UCL, in Prenatal Cell and Gene Therapy Group, under the supervision of Dr. Anna David and Professor Paolo De Coppi. He graduated from The Royal College of Surgeons in Ireland (RCSI) in 2005. He then moved to Manchester to complete his foundation years. He successfully applied and secured a job in the Obstetrics and Gynaecology training program at the London Deanery in 2007. In 2009, he took a year out of program, to undertake a masters degree at UCL, in Prenatal Genetics and Fetal Medicine. His research project was on “Cell proliferation in the uterine arteries of pregnant sheep, transduced with adenovirus VEGF-D”, under the supervision of Dr. Anna David. He was awarded, January 2011 with a CDRC/UCLH Charities Entry Level Fellowship and in June 2012, with a joint Wellcome Trust Sparks RTF to start a PhD on the project “Can we treat congenital blood disorders by transplantation of stem cells to the fetus?”.

Research Interest

His research interests include: Stem cell research, Fetal medicine in utero stem cell transplantation in utero gene therapy, Prenatal therapy and Fetal intervention.

Scientific Activities

AWARDS AND HONORS

AWARDS /GRANTS

• University College London, MSc in Prenatal Genetics and Fetal Medicine (Distinction with 90% in the research project) London, November (2010)
• Society of Gynaecologic Investigation (SGI) Award for Best Investigator Poster Presentation Orlando, Florida, March (2013)
• Society of Gynaecologic Investigation (SGI) SGI Presidents Presenter Awards. This award conveys a $1,000.00 research grant. The award was made possible by a grant from Pfizer, Florence, Italy March (2014)
• UCLs institute for Womens Health Best PhD/MD Poster Presentation, May (2014 International Fetal Medicine and Surgery Society (IFMSS): $1000 Travel Award & $1500 Vandenberghe-Storz Award for the best oral presentation by a trainee, Chatham, MA, USA, September (2014)
• June (2009) The A.G. Leventis Foundation Scholarship, £5,000 to cover the fees for the UCL Institute for Womens Health MSc Prenatal Genetics and Fetal Medicine, during the academic year (2009-2010)
• February (2011) UCLH Charities Clinical Research and Development Committee Entry-Level Fellowship: fund a PhD An in utero stem cell transplantation gene therapy approach for prenatal therapy of thalasseamia, £89417
• December (2011) Bogue Travel Fellowship, £1548, to visit Professor Ryans laboratory at UAB to study a humanized mouse model of thalassemia
• July (2012) Wellcome Trust, SPARKS Research Training Fellowship, March (2013-2015) to complete the project: Can we treat genetic blood disorders by transplantation of stem cells to the fetus?. £181,169

Publications

Original Publications

1. Pipino C, Panicos S, Elisa R, et al. Placenta as a Reservoir of Stem Cells: An Underutilized Resource? British Medical Bulletin. 2012; 105: 1-25. doi: 10.1093/bmb/lds033
2. Shaw SW, Blundell MP, Pipino C, et al. Sheep CD34+ Amniotic Fluid Cells Have Haematopoietic Potential and Engraft after Autologous in Utero Transplantation.Stem Cells (Dayton, Ohio). 2014. doi: 10.1002/stem.1839
3. Maghsoudlou P, Georgiades F, Tyraskis A, et al. Preservation of Micro-Architecture and Angiogenic Potential in a Pulmonary Acellular Matrix Obtained Using Intermittent Intra-Tracheal Flow of Detergent Enzymatic Treatment. Biomaterials. 2013; 34(28): 6638-6648. doi: 10.1016/j.biomaterials.2013.05.015
4. Mehta V, Abi-Nader KN, Shangaris P, et al. Local Over-Expression of VEGF-DΔNΔC in the Uterine Arteries of Pregnant Sheep Results in Long-Term Changes in Uterine Artery Contractility and Angiogenesis. PLOS One. 2014; 9(6): e100021. doi: 10.1371/journal.pone.0100021.
5. Pipino C, Mukherjee S, David AL, et al. Trisomy 21 Mid-Trimester Amniotic Fluid Induced Pluripotent Stem Cells Maintain Genetic Signatures During Reprogramming: Implications for Disease Modeling and Cryobanking. Cellular Reprogramming. 2014; 16(5): 1-14. doi: 10.1089/cell.2013.0091
6. Selo-Ojeme D, Rogers C, Mohanty A, et al. Is Induced Labour in the Nullipara Associated with More Maternal and Perinatal Morbidity? Archives of Gynecology and Obstetrics. 2011; 284(2): 337-341. doi: 10.1007/s00404-010-1671-2