Pamela Mary Ward, PhD


Associate Professor
Department of Pathology
Clinical Science Center
University of Southern California
2250 Alcazar Street, CSC 109P
Los Angeles, CA 90033, USA

Biography

EDUCATION AND PROFESSIONAL APPOINTMENTS

EDUCATION

1974 – HIGH SCHOOL A-LEVELS, NEWARKE GIRLS, LEICESTER, UK
1977 – B.SC HONS, ZOOLOGY, UNIVERSITY COLLEGE CARDIFF, WALES, UK
1981 – PHD, EXPERIMENTAL PATHOLOGY, UNIVERSITY COLLEGE CARDIFF, WALES, UK

POST-GRADUATE TRAINING

1980-1981 RESEARCH AFFILIATE, EXPERIMENTAL METASTASIS, L. LEONARD WEISS MD, PHD ROSWELL PARK CANCER INSTITUTE, NEW YORK STATE DEPT HEALTH, BUFFALO, NY

ACADEMIC APPOINTMENTS

1981-1985: CANCER RESEARCH SCIENTIST I – Research Affiliate, Experimental Metastasis, L. Leonard Weiss MD, PhD Roswell Park Cancer Institute, New York State Dept Health, Buffalo, NY
1985-1991: CANCER RESEARCH SCIENTIST II – Experimental Pathology, Roswell Park Cancer Institute Buffalo NY, USA
1991-1992: ASSOCIATE DIRECTOR – Molecular Diagnostics, Roswell Park Cancer Institute Buffalo NY, USA
1992-2000: LABORATORY DIRECTOR – Molecular Diagnostics, Roswell Park Cancer Institute Buffalo NY, USA
2000-2011: Technical Director & Non-Senate Faculty – Diagnostic Molecular Pathology, University of California, Irvine, Irvine CA, USA
2011 TO PRESENT: Associate Professor – Pathology, University of Southern California, Los Angeles CA, USA

Research Interest

His Research interest includes: Pathology, Advancing clinical molecular diagnostics

Scientific Activities

PROFESSIONAL SOCIETY MEMBERSHIPS

1997 to present – Association of Molecular Pathology, member

Publications

REFEREED JOURNAL ARTICLES

1. Weiss, L., and Ward, P.M. Arrest and retention of circulating cancer cells in the lungs of animals with defined metastatic disease. Cancer Res. 42: 1898-1903, 1982. PMID 7066901 Performed experimental work; co-authorship 50% contribution.
2. Weiss, L., Holmes, J.C., and Ward, P.M. Do metastases arise from pre-existing subpopulations of cancer cells? Br. J. Cancer 47:81-89, 1983. PMID 6571784 Performed experimental work and co-authorship, equal contribution with L.Weiss, 50%.
3. Weiss, L., Ward, P.M. and Holmes, J.C. Liver-to lung traffic of cancer cells. Int. J. Cancer 32:79-83, 1983. PMID 6862695 Performed experimental work and co-authorship, equal contribution with L. Weiss, 50%.
4. Weiss, L., and Ward, P.M. Cell detachment and metastasis. Cancer MetastasisReviews 2:111-127, 1983. PMID 6352010. Co-authorship 50% contribution.
5. Weiss, L., Ward, P.M., Harlos, J.P. and Holmes, J. C. Target organ patterns of tumors in mice following the arterial dissemination of B16 melanoma cells. Int. J. Cancer 33:825-830, 1984. PMID 6735524 Performed experimental work, co-authorship, equal contribution with L.Weiss, 50%.
6. Ward, P.M. and Weiss, L. The effect of single versus triple intravenous injections of B16 melanoma cells on the development of pulmonary tumors in mice. Int. J. Cancer 36:519-521, 1985. 4044060 Performed experimental work; co-authorship 50% contribution.
7. Weiss, L., Mayhew, E and Ward, P.M. Drug delivery to tumors: A problem requiring microscopic resolution. Anal. Quant. Cytol. Histol. 8:96-101, 1986. PMID 3730090 Performed experimental work and co-authorship, 33% contribution.
8. Weiss, L., Ward, P.M. and Harlos, J.P. The stability of kidney-induced selection of Lewis lung tumor cell populations and their metastasis-related behavior. Int. J. Cancer 38:207-213, 1986. PMID 3833261 Performed experimental work and co-authorship, equal contribution with L. Weiss, 50%.
9. Weiss, L. and Ward, P.M. Lymphogenous and hematogenous metastasis of Lewis lung carcinoma in the mouse. Int. J. Cancer 40:570-574, 1987. PMID 3666991 Performed experimental work; co-authorship 50% contribution.
10. Weiss, L. and Ward, P.M. Effects of metastatic cascades on metastatic patterns: studies on colon-26 carcinomas in mice. Int. J. Cancer 41:450-455, 1988. PMID 3346111 Performed experimental work; co-authorship 50% contribution.
11. Ward, P.M. and Weiss. L. The relationship between lymphogenous and hematogenous metastasis in rats bearing the MT-100-TC mammary carcinoma. Clin. Expl. Metastasis 7:253-264, 1989. PMID 2924446 Performed experimental work; co-authorship 50% contribution.
12. Weiss, L., and Ward, P.M. Effects of disseminative route in the liver- and lung-colonizing efficiencies of B16 melanoma and Colon-26 carcinoma in mice. Int. J. Cancer 44:1104-1107, 1989. PMID 2606578 Performed experimental work; co-authorship 50% contribution.
13. Ward, P.M., and Weiss, L. Metachronous seeding of lymph node metastasis in rats bearing the MT-100-TC mammary carcinoma: The effect of elective lymph node excision. Breast Cancer Res. Treat. 14:315-320, 1989. PMID 2611404 Performed experimental work; co-authorship 50% contribution.
14. Weiss, L., and Ward, P.M. Contributions of vascularized lymph-node metastasis to hematogenous metastasis in a rat mammary carcinoma. Int. J. Cancer 46:452-455, 1990. PMID 2394512 Performed experimental work; authorship 50% contribution.
15. Greenberg, S. J., Choi, Y., Ballow, M., Du, T-L., Ward, P.M., Rickert M. H., Frankel, S., Bernstein, SH. and Brecher, ML. Profile of immunoglobulin heavy chain variable gene repertoires and highly selective detection of malignant clonotypes in acute lymphoblastic leukemia. J. Leuk. Biol. 57 856-864, 1995. PMID 7790768 Performed all IgH southern blot analyses and interpretations.
16. Choi, Y., Greenberg, S.J, Du, T-L., Ward, P.M., Overturf, P., Brecher, M., and Ballow, M. Clonal evolution in B-lineage acute lymphoblastic leukemia by contemporaneous VH-VH gene replacements and VH-DJH gene rearrangements. Blood 87 2506-2512, 1996. PMID 8630417 Performed all IgH southern blot analyses and interpretations.
17. Sood R, Stewart CC, Aplan PD, Murai, H, Ward PM, Barcos M and Baer MR. Neutropenia associated with T-cell large granular lymphocyte proliferation: Long term repsonses to cyclosporine therapy. Blood 91 3372-3378, 1998. PMID 9558395 Performed all TCR southen blot analyses and interpretations.
18. Schmidt CJ, Domenico L, Ward P, Barcos MP and Stewart CC. Aberrant antigen expression detected by mulitparameter three color flow cytometry in intermediate and high grade B-cell lymphoma. Leuk. Lymph. 34 539-544, 1999. PMID 10492077 Performed IgH and TCR southern blot analyses and interpretations.
19. Khatri VP, Baiocchi RA, Peng R, Oberkircher AR, Dolce JM, Ward PM, Herzig GP and Caligiuri MA. Endogenous CD8+ T cell expansion during regression of monoclonal EBV- associated posttransplant lymphoproliferative disorder. J. Immunol. 163 500-506,1999. PMID 10384154 Performed IgH and TCR southern blot analyses and interpretations.
20. Tan DF, Wiseman S, Zhou Y, Li Q, Ward P, Slocum HK, Alrawi S, Loree T, Hicks W, Rigual N, Anderson G and Stoler D. Definition of a region of loss of heterozygosity at chromosome 11q23.3-25 in head and neck squamous cell carcinoma using laser capture microdissection technique. Diagn Mol Pathol 13 33-40, 2004. PMID 15163007 Provided expertise to optimize PCR reactions for LOH interpretation.
21. Kansal R, Sait SN, Block AW, Ward PM, Kelly FL, Cheney RT, Czuczman M, Brecher ML, Barcos M. Extra copies of chromosome 2 are a recurring aberration in ALK-negative lymphomas with anaplastic morphology.Mod Pathol. 18:235-43, 2005. PMID 15475980 Performed TCR southern blot analyes and interpretations; co-authorship 10% contribution.
22. Pettersson J, York V, Ward P, Green N and She RC. The value of a multiplexed gastrointestinal pathogen panel in two distinct patient populations. Diagn Microbiol Infect Dis 85:105-108, 2016. PMID 26906189 Joint project with USC Clinical Laboratories, Microbiology and LA County Public Health; implementation of assay, interpretation of results.
23.Wei CH, Pettersson J,Campan M,Chopra S, Naritoku W, Martin S and Ward PM. Gain of TP53 mutation in Imatinib treated SDH-deficient gastrointestinal stromal tumor and clinical utilization of targeted next-generation sequencing panel for therapeutic decision support. Appl Immunohistochem Mol Morphol. Dec 2016. PMID 28027118 Experimental design, interpretation of results; co-authorship 20% contribution.
24. Yang P, Hash S,Park K, Wong C, Doraisamy L, Pettersson J, Petti CA, Ward PM,Lee SH, Menon S, She RC. Application of nuclear magnetic resonance to detect toxigenic Clostridiumdifficile from stool specimens: a proof of concept. J Mol Diagn 19:230-235, 2017. PMID:28081922 Joint collaboration with USC Clinical Laboratories, Microbiology and Menon Biosensors, Inc; alpha testing implementation and results interpretation.