Olga M. Pulido, MD


Adjunct Professor
Department of Pathology and Laboratory Medicine
Medical School
Faculty of Health Sciences
University of Ottawa
Ottawa, Ontario, Canada


E-mail: opulido@uottawa.ca

Biography

EDUCATIONAL QUALIFICATIONS

• Medical Doctor (MD), Central University of Venezuela, Caracas, Venezuela
• Postgraduate Medical Training for Foreign Physicians, University of Miami, USA
• Licensed Physician and Surgeon, State of Illinois, USA
• Licensed Physician, College of Physicians of Nova Scotia, Canada
• Certificate from the Educational Council for Foreign Medical Graduates (ECFMG), USA
• F.L.E.X. Medical Licensing Examination, State of Illinois, USA
• Certificate for Foreign Physicians from the Medical Council of Canada
• Medical Residence: Laboratory Medicine and Anatomical Pathology, Queens University, ON, CA
• Medical Residence, Neuropathology, University of Western Ontario, CA
• Master of Science, Queens University, Kingston, Ontario, Canada
• Post-Doctoral Fellowship, Neuroscience, McMaster University, Hamilton, ON, CA
• Medical Specialist: Anatomical Pathology. American Board of Pathology, USA
• Fellow of the International Academy of Toxicologic Pathology (FIATP) http://www.iatpfellows.org

PROFESSIONAL EXPERIENCES

• Senior Medical Advisor, Specialist in Toxicologic Pathology and Head of Pathology, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch (HPFB), Health Canada (HC), (1992-2013)
• Medical Officer, Division of Endocrinology, Metabolism and Allergy, Bureau of Pharmaceutical Assessment, Therapeutic Program, HPFB, HC (1989-1992)
• Medical Advisor, Disability Assessment, Canada Pension Plan,( 1988-1989)
• Associate Professor, Department of Biomedical Sciences, Medical School, Faculty of Health Sciences, McMaster University, Hamilton, ON,CA, (1982-1988)
• Staff Physician, Armed Forces Hospital, Caracas Venezuela, (1967-1972)
• Staff Physician, Institute of Hygiene, and Ministry of Public Health, Caracas Venezuela (1967-1972)

Research Interest

Her research interest include: Pathology.

Scientific Activities

MEMBERSHIPS

• Canadian College of Family Physicians
• Canadian and Ontario Medical Association
• Provincial Medical Board of Nova Scotia, Canada
• Illinois Department of Professional Regulations, USA
• American Board of Medical Specialties, USA
• International Academy of Toxicologic Pathology, USA
• International Neurotoxicology Association (INA)
• Society of Toxicologic Pathologists, USA
• Whos Who

AWARDS

• Health Canada, Associate Deputy Minister Excellency Award for the contribution in the enhanced Food Allergens and Gluten Labeling Regulation (2010)
• Health Canada, Bureau of Chemical Safety Excellency Award for the contribution in Food Allergy and Celiac Disease (2009)
• Health Canada, Bureau of Chemical Safety Excellency Award for Development of Immunohistochemical Procedures and Applications to Toxicologic Pathology (2008)
• Mentor Post Doctoral Fellowship Program, Office of the Chief Scientist, HC, (2005-2007)
• Ontario Mental Health Foundation Research Fellowship (1978-1980
• American Embassy in Venezuela Scholarship 1971

Publications

1. Pulido OM. Letter to the Editor GHFBB; Response to Peña AS: What Is the Best Histopathological Classification for Celiac Disease? Does It Matter?. Gastroenterology and Hepatology From Bed to Bench 2016 9.1: 68–69.
2. Vieille SL, Pulido OM, Abbott M, Koerner TB, Godefroy S. Celiac disease and gluten-free oats: A Canadian position based on a literature review. Can J Gastroenterol Hepatol. 2015; 30: 17129.
3. Pulido OM. Marine Algal Toxins: Seafood Safety, Human Health and Beyond. Oceanography. 2014; 2: e111. doi:10.4172/2332-2632.1000e111 (by Invitation) doi: 10.4172/2332-2632.1000e111
4. Pulido OM. Chapter 8. Domoic Acid: Biological Effects and Health Implications. In Rossini, Gian Paolo, ed. Toxins and Biologically Active Compounds from Microalgae. Vol. 2. Biologicl Effects and Risk Management. Section 2. Impact of Toxic Microalgae and Microalgal Toxins on Biological Systems. CRC Press, 2014: 219-252 (by Invitation)
5. Pulido O, Zarkadas M, Dubois S, Macisaac K, et al. Clinical features and symptom recovery on a gluten-free diet in Canadian adults with celiac disease. Can J Gastroenterol. 2013; 27(8): 449-53. doi: 10.1155/2013/741740
6. Pulido OM, and Gill S. Chapter 35, Food and Toxicologic Pathology: An Introduction. In Haschek and Rousseauxs eds. Handbook of Toxicologic Pathology 3e, VOLUME II–Safety Assessment including Current and Emerging Issues in Toxicologic Pathology Part 3–Food and the Environment: Selected Toxic Agents. Elsevier, 2013: 1051-1073 (By invitation)
7. Gill S, Bowers W, Nakai J, et al. Effects of Environmentally Relevant Mixtures of Persistent Organic Pollutants on the Developmental Neurobiology in Rats. Toxicol Pathol. 2013; 41: 38-47. doi: 10.1177/0192623312451370
8. Zarkadas M, Dubois S, MacIsaac K, et al. Living With Celiac Disease and A Gluten-Free Diet: A Canadian Perspective. J Hum Nutr Diet. 2012; 28: 10-23. doi: 10.1111/j.1365-277X.2012.01288.x.
9. Gillespie Z, Pulido OM, and Vavasour E. Risk Assessment Approaches for Carcinogenic Food Contaminants. International Food Risk Analysis Journal. 2011; Volume 1, Issue 1. doi: 10.5722/10673
10. Pulido OM. Chapter 1. Immune-mediated adverse reactions to dietary proteins. In Allergen Management in the Food Industry, Editors: Joyce I. Boye and Samuel Godefroy; John Wiley & Sons Publishing Co. 2010: 3-32. (By invitation) doi: 10.1002/9780470644584.ch1
11. Pulido OM, Gillespie Z, and Godefroy SB. Chapter 4. The Canadian criteria for the establishment of new priority food allergens: evidences for the inclusion of mustard and insufficient evidences for garlic and onion as priority allergens in Canada. In Allergen Management in the Food Industry, Editors: Joyce I. Boye and Samuel Godefroy; John Wiley & Sons Publishing Co. 2010: 75-130. (By Invitation) doi: 10.1002/9780470644584.ch4
12. Pulido OM, Gillespie Z, Zarkadas M, et al. Chapter 6. Introduction of oats in the diet of individuals with Celiac disease. A systematic review. In Adv Food Nutr Res. 2009: 57: 235-85 (By invitation). doi: 10.1016/S1043-4526(09)57006-4.
13. Pulido OM. Domoic acid toxicologic pathology: a review. Marine Drugs. 2008; 6(2): 180-219. doi: 10.3390/md20080010.
14. Gill SS, Hou Y, Ghane T, Pulido OM. Regional susceptibility to domoic acid in primary astrocyte cells cultured from the brain stem and hippocampus. Marine Drugs. 2008; 6(1): 25-38. doi: 10.3390/md6010025
15. Gill S, Barker M, Pulido O. Neuroexcitatory targets in the female reproductive system of the nonhuman primate (Macaca fascicularis). Toxicol Pathol. 2008; 36(3): 478-84. doi: 10.1177/0192623308315663.
16. Chu I, Bowers WJ, Caldwell D, et al. Toxicological effects of in utero and lactational exposure of rats to a mixture of environmental contaminants detected in Canadian Arctic human populations. J Toxicol Environ Health A. 2008; 71(2): 93-108. doi: 10.1080/15287390701612811
17. Gill S, Veinot J, Kavanagh M, Pulido O. Human heart glutamate receptors–implications for toxicology, food safety, and drug discovery. Toxicol Pathol. 2007; 35(3): 411-7. doi: 10.1080/01926230701230361
18. Rashid M, Butzner D, Burrows V, et al. Consumption of pure oats by individuals with celiac disease: a position statement by the Canadian Celiac Association. Can J Gastroenterology. 2007; 21(10): 649-51.
19. Morton D, Kemp RK, Francke-Carroll S, et al. Best practices for reporting pathology interpretations within GLP toxicology studies. Toxicol Pathol. 2006; 34(6): 806-9. doi: 10.1080/01926230601034624
20. Chu I, Bowers WJ, Caldwell D, et al. Toxicological Effects of Gestational and Lactational Exposure to a Mixture of Persistent Organochlorines in Rats: Systemic Effects. Toxicol. Sci. 2005; 88: 645-655. doi: 10.1093/toxsci/kfi335
21. Gill S and Pulido OM. Distribution of Glutamate Receptors in Peripheral Tissues. In Glutamate Receptors in Peripheral Tissues, In: Gill S, Pulido O, eds. Kluwer Academic Plenum Press, NY, 2005: 3-26. doi: 10.1007/b111738
22. Pulido OM, Caldwell D, Murphy M, and Gill S. Chapter 15. Practical Considerations in Assessing Immunhistopathology in Rodents and Nonhuman Primates. In Investigative Immunotoxicology, Helen Tryphonas et al (Eds), Tylor & Francis International, CRC press, USA. 2005: 229.
23. Cooke GM, Tryphonas H, Pulido O, et al. In utero and postnatal oral (gavage) exposure of Sprague-Dawley rats to low doses of tributyltin chloride. Part 1: Toxicology, Histopathology and Clinical Chemistry. Food and Chemical Toxicology. 2004; 42(2): 211-20. doi: 10.1016/j.fct.2003.09.003
24. Tryphonas H, Cooke G, Caldwell D, et al. Oral (gavage), in utero and post-natal exposure of Sprague-Dawley rats to low doses of tributyltin chloride. Part II: Effects on the immune system. Food and Chemical Toxicology. 2004; 42(2): 221-35. doi: 10.1016/j.fct.2003.08.019
25. Bowers WJ, Nakai JS, Chu I, et al. Early developmental neurotoxicity of a PCB/organochlorine mixture in rodents after gestational and lactational exposure. Toxicol Sci. 2004; 77(1): 51-62. doi: 10.1093/toxsci/kfg248
26. Bowers WJ, Nakai JS, Chu I, et al. Neurobehavioral toxicity of in utero and lactational exposure to a chemical mixture based on blood levels in Canadian Arctic populations. Neurotoxicology and Teratology, 2003; 25: 395.
27. Gill S, Murphy M, Clausen J, et al. Neural Injury Biomarkers of Novel Shellfish Toxins, Spirolides. A pilot study using immunochemical and transcriptional Analysis. Neurotoxicology. 2003; 34: 593-604.
28. Mueller R, Gill S and Pulido OM. The monkey (Macaca fascicularis) heart neuralstructures and conducting system. An immunochemical study of selected neural biomarkers and glutamate receptors. Toxicologic Pathology. 2003; 31: 1-8. doi: 10.1080/01926230390183724
29. Wang GS, Karamchandani J, Pulido O, et al. Altered islet homeostasis before classic insulinitis in BB rats. Diabetes Metab. 2002; 28, 3S90–3S97.
30. Bondy G, Barker M, Cooke G, et al. In Synopsis of Research Conducted under the 2001-2002 Northern Contaminants Program. In Kalhok S, Ed. Indian and Northern Affairs Canada, Ottawa, 2002.
31. Pulido O. Ochratoxin hepatotoxicity. Moderators Report. In Registry of Toxicologic Pathology for Animals (RTPA). Armed Forces Institute of Pathology (AFIP), Washington, D.C., 2002.
32. Pulido O. Fumonisin B1 renal toxicity. Moderators Report. In Registry of Toxicologic Pathology for Animals (RTPA). Armed Forces Institute of Pathology (AFIP). Washington, D.C, 2002.
33. Pulido O. Retinal Degeneration in Rats and Dogs associated to the oral administration of ATP-sensitive potassium channel activators. Moderators Report. In Registry of Toxicologic Pathology for Animals (RTPA). Armed Forces Institute of Pathology (AFIP). Washington, D.C, 2002.
34. Pulido O. Myopathy related to the administration of HMG-CoA reductase inhibitor. Moderators Report. In Registry of Toxicologic Pathology for Animals (RTPA). Armed Forces Institute of Pathology (AFIP). Washington, D.C., 2002.
35. Pulido OM, Richard D, Quilliam M, et al. Toxicological Neuropathology from Domoic Acid to Spirolides. The Health Canada Experience. Can. J. Fisheries and Aquatic Sci. Proc. of the 7th Canadian Workshop on Harmful Marine Algae, 2001.
36. Bryce F, Iverson F, Andrews P, et al. Effects elicited by toxaphene in the cynomolgus (M. fascicularis) monkey. A pilot study. Food Chemical Toxicology. 2001; 39: 1243-1251. doi: 10.1016/S0278-6915(01)00068-0
37. Gill SS, Pulido OM. Glutamate receptors in peripheral tissues: current knowledge, future research, and implications for toxicology. Toxicol Pathol. 200; 29(2): 208-23. Review.
38. Gill S, Mueller R, McGuire P, and Pulido O. Potential target sites in peripheral tissues for excitatory neurotransmission and excitotoxicity. Toxicologic Pathology . 2000; 28: 277-284. doi: 10.1177/019262330002800207
39. Pulido O, Mueller R, Smyth P, Clausen J, and Gill S. Heart and brain glutamate receptors-a common mechanism for excitotoxicity? Brain Pathology. 2000; 10: 681.
40. Wang GS, Gruber H, Smyth P, et al. Hydrolysed casein diet protects diabetes-prone BB rats from developing diabetes by promoting islet neogenesis. Journal of Autoimmunity . 2000; 15: 407-416. doi: 10.1006/jaut.2000.0453
41. Sarwar G, LAbbe MR, Brooks SPJ, et al. Dietary Phytoestrogens: Safety, Nutritional Quality and Health Considerations. In ACS book entitled Quality Management of Nutraceuticals: edited by C-T. Ho and Q.Y. Zheng., 2000. doi: 10.1021/bk-2002-0803.ch017
42. Gill S, Pulido O, Mueller R, and McGuire P. Immunohistochemical characterization of metabotropic glutamate receptors in the rat heart. Brain Research Bulletin. 1999; 48: 143-146. doi: 10.3390/md8051637
43. Pulido O. Demonstration of glutamate receptors in body tissues and their relation to food safety and excitotoxicity. In Soc. for Neuroscience Press Book, Part II. 1999: 121. doi: 10.3390/md20080010
44. Gill S, Pulido O, Mueller R, and McGuire P. Molecular and immunochemical characterization of ionotropic glutamate receptors in the rat heart. Brain Research Bulletin; 1998; 46: 429-434. doi: 10.1016/S0361-9230(98)00012-4
45. Truelove J, Mueller R, Pulido O, et al. 30-Day Oral Toxicity of Domoic Acid in Cynomolgu Monkeys: Lack of Overt Toxicity at Doses Approaching the Acute Toxic Dose. Natural Toxins. 1997; 5: 111-114. doi: 10.1002/1522-7189(1997)5:3<111::AID-NT5>3.0.CO;2-6
46. Truelove J, Mueller R, Pulido O, and Iverson F. Subchronic toxicity Study of Domoic Acid in Rat. Food Chem. Tox. 1996; 34: 525. doi: 10.1016/0278-6915(96)81814-X
47. Niles LP, Pulido OM, and Pickering DS. Age-related changes in GABA and Benzodiazepine receptor binding in rat brain are influenced by sampling time. Prog. Neuropsychopharmacol. & Biol. Psychiat. 1988; 12: 337-344. doi: 10.1016/0278-5846(88)90053-X
48. Pulido O. Aging and a multicultural Society. In Proc. of Multicultural Health Workshop, Hamilton, Ontario, Pulido O, and Niles E. (Eds), Pine Crest. 1988.
49. Pulido O. Biology of Human Aging. In Monograph and Videotapes I-III, General Concepts in Gerontology and Theories of Aging. Brain E. (Ed). McMaster University, Hamilton, 1988.
50. Pulido O, and Clifford J. Age-associated changes in the circadian rhythm of retinal N-acetyl serotonin (NAS) and melatonin in rats with pigmented eyes. Exp. Gerontology. 1986; 21: 23-30.
51. Davis D, Majumdar B, Pulido O. Report and Recommendation on the Impact of Transculturalism on Health and Health Care. Proc. Transcultural Health Workshop, Faculty of Health Sciences, McMaster University. 1987.
52. Pulido OM, Clifford J, Brown C, and Cole S. Pineal and extra-pineal N-acetyl serotonin (NAS) and melatonin as function of age. International Workshop on the Pineal Gland during Development, Neuroendocrinology Lett. 1985; Vol. 7(4).
53. Niles LP, and Pulido OM. Age-related changes in GABA receptors. International Workshop on the Pineal Gland during Development, Neuroendocrinology Lett. 1985; Vol. 7(4).
54. Brown GM, Pulido O, Grota LJ, and Niles LP. N-acetyl-serotonin in the central nervous system. Prog. Neuropsycho-pharmacol and Biol. Psychiat. 1984; 8: 475-480. doi: 10.1016/0278-5846(84)90003-4
55. Brown GM, Niles LP, Pulido O, Ho A, and Grota LJ. Extrapineal melatonin and N-acetyl serotonin. PECS Proceedings, 1984.
56. Pulido O, Brown GM, and Grota LJ. B-adrenergic regulation of N-acetyl serotonin (NAS) synthesis in the rat cerebellum. Life Sciences. 1983; 33:1081. doi: 10.1016/0024-3205(83)90664-1
57. Pulido O, Brown GM, and Grota LJ. An Immunohistochemical method for the localization of N-acetyl serotonin (NAS) in the central nervous system. Description, validation and application of the technique. J. Histochem. Cytochem. 1983; 31: 1343.
58. Psarakis S, Pulido O, Brown GM, Grota LJ, and Smith GK. Identification and quantitation of N-acetyl serotonin in the developing hippocampus of the rat by immunohistology. Prog. Neuropsychopharmacol. and Biol. Psychiat. 1982; 6: 439. doi: 10.1016/S0278-5846(82)80124-3
59. Pulido O, Brown GM, and Grota LJ. Localization of N-acetyl serotonin (NAS) in the rat hindbrain by immunohistology. Prog. Neuropsychopharmacology 1981; 5: 573.
60. Pulido O, Brown GM, and Grota LJ. Immunohistological localization of N-acetyl serotonin in the rat brain. J. Histochem. and Cytochem. 1980; 28: 613.
61. Pulido OM, Bencosme SA, de ML, and de A. Intracellular B-cell serotonin and the dynamics of insulin release. Diabetologia 1978; 15: 197-204. doi: 10.1007/BF00421239
62. Pulido O, de A, de M, and Bencosme SA. Demonstration of a tryptaminergic mechanism in the rat B-cell. Experientia . 1977; 33: 268-270. doi: 10.1007/BF02124105
63. Gonzalez JE, Pulido O, and Rojas G. Accion del SH 90 000 C (d-norgestrel) sobre la estructura endometrial humana. In: II Latin American Meeting [Spanish] SH 90 000 C. México, 1970. Eds. Scharff, H.J.: Ruiz Albrecht F. Saladruck, Berlin. 1972: 104.
64. Potenza VL, Pulido O, and Rojas G. For effect of d-norgestrel on the structure of the human endometrium comparative under schug with the light and electronenmikroskop [German]. Medical releases Schering [German]. 1972; 1: 20.
65. Lejter M, Gonzalez JE, Pulido O, and Cardenas N. Rome is also the sin of Re [Chinese]. Arch. Come. Pueric there PEDT [French]. 1972; 2: 31.
66. Pulido O, and Contreras J. tubal pregnancy in patients with intrauterine spiral [Spanish]. Bol. Med. Hosp. Centr. FF. AA. (Caracas) 1971; 2: 7.