Nasreen Najmunnisa, PhD


Research Assistant Professor
Division of Pulmonary Critical Care and Sleep Medicine
College of Medicine, University of Florida
1601 S W Archer Rd
Room: D-106.1 Malcom Randall VA Medical Center
Gainesville, FL, 32608, USA

Biography

Dr. Nasreen Najmunnisa is a Research Assistant Professor, Division of Pulmonary, Critical Care and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL.

Education
• (May 1987-Sept 1992), PhD (Physiology and Biochemistry) from Osmania University -Hyderabad, India.
• (Aug 1984-Dec 1986), MS (Zoology), First division with top 3% at Osmania University- Hyderabad, India.
• (June 1981-June 1984), BS. (Biology and Chemistry) First division with distinction, Osmania University – Hyderabad, India.

Research Experience
• (June 2010-Present), Research Assistant Professor, Division of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Florida, and Gainesville, FL, USA.
• (Oct. 2003-June 2010), Assistant Scientist, Division of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Florida, and Gainesville, FL, USA.
• (Nov. 1999-Oct 2003), Research Associate, Division of Pulmonary, Critical Care & Occupational Medicine, Indiana University School of Medicine, IUPUI, Indianapolis, IN, USA.
• (July 1996-Nov 1999), Post Doctoral Fellow, Division of Pulmonary, Critical Care & Occupational Medicine, Indiana University School of Medicine, IUPUI, Indianapolis, IN, USA.
• (Sept. 1990-Sept 1992), Senior Research Fellow, Osmania University -Hyderabad, India.
• (May 1987-Sept 1990), Junior Research Fellow, Osmania University -Hyderabad,India.

Research Interest

Her research interests include: Receptor EphA2/EphrinA1 signaling in thoracic malignancies NSCLC & malignant mesothelioma, Micro RNA regulation in thoracic malignancies, Epithelial cell injury and airway remodeling in COPD, Pleural mesothelial epithelial mesenchymal transition in lung fibrosis.

Scientific Activities

Scientific Honors & Awards
1. Received Best Abstract Award (First place), 2012 Department of Medicine, and University of Florida.
2. Awarded NIR (New Investigator Research Award) –Department of Health, Florida-2009-2012.
3. Excellence in Research Award – 2008, Department of Medicine, University of Florida.
4. Young Investigator Award-2003-2004, American Lung Association.
5. State Merit Scholarship Award -1988, Government of Andhra Pradesh, India.
6. Awarded Meena Pandeyal Gold Medal in Education-1987, Osmania University, and Hyderabad, India.

Membership in Scientific Societies
1. Member of American Thoracic Society
2. Member of American Federation for Medical Research.
3. Member of American Cancer Society

Research & Development – Subcommittees
• 2006-Present: Member, Subcommittee for Research Safety, North Florida/South Georgia Veterans Health Care System, Malcom Randall VAMC, and Gainesville, FL.
• 2007-Present: Member, Institutional Animal Care and Use Committee (IACUC) North Florida/South Georgia Veterans Health Care System, Malcom Randall VAMC, Gainesville, FL.
• 2007-Present: Member, Research Task Force, Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, Gainesville, FL.

Editorial Activities
1. American Journal of Cellular and Molecular Physiology
2. Cancer
3. Inflammation Research
4. Pharmacological Research
5. Molecular Medicine
6. Respirology
7. Cell Biology International
8. PLOS-one
9. American Journal of Cancer research
10. Journal of Nano-medicine

Mentoring & Training
• Hung-Yen Lee, PhD (Post-doctoral Associate) on research project “Gene Therapy for Lung Cancer/Malignant mesothelioma, Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (Jan, 2012 – present).
• Nazli, Khodayari PhD., (Post doctoral Associate) on research project “EphA2 Signaling in Tobacco Smoke Induced Bronchial Airway Epithelial Injury, Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (Jan, 2010 – Nov, 2012)
. • Bhagyalaxmi G. Sukka, PhD.,(Post doctoral Associate) on research project” Intra-Tumoral Gene Therapy for Lung Cancer, Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (Oct., 2010 – June 30th, 2013).
• Hung-Yen Lee, MS (Graduate Student) on research project “ Intra-Tumoral Gene Therapy for Lung Cancer, Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (Jan, 2010 – 2012).
• Zain Gowani, BS., (Under Graduate Student) on research project “Loss of Autophagic Control: The Precursor to Bronchiolitis Obliterans? Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (2009-2010).
• Zita, Burkhalter BA., (Laboratory technician) on research project “Suppressor of Cytokine Signaling-3 (SOCS-3) a biomarker for the efficacy of Advair in a murine model of COPD”.
• Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (2009 June 30th, 2013).
• Mark Vollenweider, M.D., Clinical Fellow, on the research project “Role of BIRC5 (Survivin) in Anchorage Independent Growth of Malignant Mesothelioma”. Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (2007-2009).
• Xaiohong Wang, BS., (Laboratory technician) on the research project “Role of receptor EphA2 and Ephrins in Malignant mesothelioma growth”. Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (2004-2009). • Shabnam, Ahmed, BS., (Under Graduate Student) on the research project “Role of receptor EphA2 in Bronchial Airway Epithelial permeability”. Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (2006-2007).
• Meryl J. Allapattu, BS.,(Under Graduate Student) Cyclical stretch of bronchial smooth muscle cells induces cyclin D1 expression and causes proliferation in p38 MAPK activation dependent manner.(2006-2007).
• Hung-Yen Lee, PhD (Post-doctoral Associate) on research project “Gene Therapy for Lung Cancer/Malignant mesothelioma, Division of Pulmonary Critical Care and Sleep Medicine, University of Florida, (Jan, 2012 – present).

Publications

1. Nasreen N, Hartman D, Mohammed K, Antony V. Talc Induces Pleural Mesothelial cell Expression of Proinflammatory Cytokines and Intercellular Adhesion Molecule-1 ICAM-1. Am J Respir Crit Care Med. 1998; 158: 971-978.
2. Mohammed K, Nasreen N, Ward M, Antony V. Macrophage Inflammatory Protein-1alpha: A C-C Chemokine in Parapneumonic Pleural Effusions. J Lab Clin Med. 1998; 1323: 202-209.
3. Mohammed K, Nasreen N, Ward M, Panadero F , Antony V. Mycobacterium Mediated Chemokine Expression in Pleural Mesothelial Cells: Role of C-C Chemokines in Tuberculous Pleurisy. J Infec. Dis. 1998; 178: 1450-1456. doi: 10.1086/314442
4. Nasreen N, Mohammed K, Ward M, Antony V. Mycobacterium-induced transmesothelial migration of monocytes into pleural space: role of intercellular adhesion molecule-1 in tuberculous pleurisy. J Infec. Dis. 1999; 180(5): 1616-1623. doi: 10.1086/315057
5. Mohammed K, Nasreen N, Ward M, Antony V. Helper T-cell type 1 and 2 Cytokines Regulate C-C Chemokine Expression in Mesothelial Cells. Amr J Respir Crit. Care Med. 1999; 159: 1653-1659. doi: 10.1164/ajrccm.159.5.9810011
6. Galffy G, Mohammed K, Ward M, Dowling P, Nasreen N, Antony V. Interleukin-8, an Autocrine Growth Factor for Malignant Mesothelioma. Cancer Research.1999; 59: 367-371.
7. Galffy G, Mohammed K, Nasreen N, Ward M, Antony V. Inhibition of interleukin-8 Reduces Malignant Pleural Mesothelioma Propagation in Nude Mouse Model. Interntl J Oncol. Res. 1999; 11: 187-194.
8. Nasreen N, Mohammed K, Dowling P,Ward M, Antony V. Talc Induces Apoptosis in Human Malignant Mesothelioma in vitro. Amr J Respir Crit Care Med. 2000; 161(2(1)): 595-610. doi: 10.1164/ajrccm.161.2.9904123
9. Nasreen N, Mohammed K, Ward M, Antony V. MCP-1 in pleural injury: CCR2 mediates haptotaxis of pleural mesothelial cells. Am J Physiol – Lung Cellu Mol Physiol. 2000; 278: L591-L598.
10. Mohammed K, Nasreen N, Ward M , Antony V. Induction of Acute Pleural Inflammation by Staphylococcus aureus: I. CD4+ T cells Play a Critical Role in Experimental Empyema. J infec Dis. 2000; 181: 1693-1699. doi: 10.1086/315422
11. Nasreen N, Mohammed K, Hardwick J, et al. Polar production of interleukin-8 by mesothelial cells promotes the transmesothelial migration of neutrophils: role of intercellular adhesion molecule-1. J Infec. Dis. 2000; 183(11): 1638-1645. doi: 10.1086/320700
12. Mohammed K, Nasreen N, Hardwick J, Logie C, Patterson C, Antony V. Bacterial Induction of Pleural Mesothelial Monolayer Barrier Dysfunction. Amr J Physiol-Lung Cellu Mol Physiol. 2001; 281(1): 119-125.
13. Lundien M, Mohammed K, Nasreen N, et al. Induction of MCP-1 Expression in Airway Epithelial Cells: Role of CCR2 Receptor in Airway Epithelial Injury. J Clin Immunol. 2002; 22(3): 144-152.
14. Nasreen N, Mohammed k, Hardwick J, et al. Low molecular weight hyaluronan induces malignant mesothelioma cell (MMC) proliferation and haptotaxis: Role of CD44 receptor in MMC proliferation and haptotaxis. Oncol. Res. 2002; 13(2): 71-78. doi: 10.3727/096504002108748105
15. Loghmani F, Mohammed K, Nasreen N, et al. Cytokines Mediate C-C (Monocyte Chemotactic Peptide) and C-X-C (Interleukin 8) Chemokine Expression in Human Pleural Fibroblasts. Inflammation.2002; 26(2): 73-82.
16. Sriram P, Mohammed K, Nasreen N, et al. Metastatic Ovarian Cancer Increases Pleural Permeability. Oncol Res An Internatl J. 2002; 13(2): 79-85.
17. Mohammed K, Nasreen N, Hardwick J, et al. Mycobacteria Induce Pleural Permeability by Down-Regulating Mesothelial Adherins Junction Proteins. Lung. 2003; 181(2): 57-66.
18. Nasreen N, Mohammed k, Sanders k, et al. Staphylococcus aureus Stimulated Pleural Mesothelial Cells (PMC) Modulate Polymorphonuclear Leukocyte (PMN) Apoptosis. Journal of Clinical Immunology. 2003; 23(1).
19. Sharma R, Mohammed K, Nasreen N, et al. Defensive role of Pleural Mesothelial Cell (PMC) Sialomucins in Tumor Metastasis. Chest. 2003; 124(2): 682-687. doi: 10.1378/chest.124.2.682
20. Nasreen N, Mohammed k, Sanders K, et al. Pleural Mesothelial cell (PMC) defence mechanisms against malignancy. Oncol. Res. An Internatl. J. 2004; 14(3): 155-161. doi: 10.3727/000000003771013053
21. Antony V, Nasreen N, Mohammed K, et al. Talc Pleurodesis. Pleural fluid bFGF predicts outcome of pleurodesis. Chest. 2004; 126(5(1)): 522-528.
22. Kilani MM, Mohammed K, Nasreen N, et al. Respiratory Syncytial Virus Causes Increased Bronchial Epithelial Permeability. Chest. 2004; 126(1): 186-191. doi: 10.1378/chest.126.1.186
23. Kilani MM, Mohammed KA, Nasreen N, Robert S, Tepper, Antony B. RSV Causes HIF-1alpha Stabilization via NO release in Primary Bronchial Epithelial Cells. Inflammation. 2004; 28(5): 245-251. doi: 10.1007/s10753-004-6047-y
24. Icaza G, Mohammed K, Nasreen,N, Horn R, et al. Th2 Cytokines IL-4 and IL-13 Down Regulate Paxillin Expression in Bronchial Airway Epithelial Cells. J Clin Immunol. 2004; 24(4): 426-434.
25. Nasreen N, Mohammed K, Antony V. Staphylococcus aureus Induces Differential Expression of C-fos, C-jun and Mediates Apoptosis in Pleural Mesothelial Cells. Lung. 2007; 185(6): 355-365.
26. Mohammed k, Nasreen N, Tepper R, Antony V. Cyclical stretch induces PlGF expression in bronchial airway epithelial cells via nitric oxide signaling . Am J Physiol. 2007; 292(2): L559-L566.
27. Brown S, Mohammed K, Sharma P, Nasreen N, Antony V, Moudgil B. Influence of Shape, Adhesion and Simulated Lung Mechanics on Amorphous Silica Nanoparticle Toxicity. Advanced Powder Technology.2007; 18(1): 69-79. doi: 10.1163/156855207779768214
28. Nasreen N, Mohammed K, Brown S, et al. Angiogenic balance in Malignant Pleural Effusions: Talc Mediates switch to angiostasis via Endostatin Induction in Pleural Mesothelial Cells Eur. Resp. Journal. 2007; 29(4): 761-769.
29. Scott C, Mohammed K, Nasreen N, et al. Influence of shape, adhesion and simulated lung mechanics on amorphous silica nanoparticle toxicity.Advanced Powder Technology.2007; 18(1): 69-79.
30. Lai Y, Mohammed K, Nasreen N, Baumuratov A, Bellew B, Antony B. Induction of cell cycle arrest and apoptosis by BCG infection in cultured human bronchial airway epithelial cells. Am J Physiol Cell and Mol. Physiol. 2007; 293(2): L393-L401. doi: 10.1152/ajplung.00392.2006
31. Nasreen N, Mohammed K, Antony V. Silencing the receptor EphA2 suppresses the growth and haptotaxis of malignant mesothelioma cells. Cancer. 2006; 107(10): 2425-2435. doi: 10.1002/cncr.22254
32. Nasreen, N, Mohammed K, Antony V. Receptor EphA2 activation with ephrinA1 suppresses growth of malignant mesothelioma (MM). Cancer Lett . 2007; 258(2): 215-222. doi: 10.1016/j.canlet.2007.09.005
33. Hussain T, Nasreen, N, Lai,Bellew B, Antony V, Mohammed K. Innate Immune Responses in Murine Pleural Mesothelial Cells: TLR2 -defensin-2 by Staphylococcal Peptidoglycan. J Am. J Physiol LCMB. 2008; 295(3): L461-L470.
34. Nasreen N, Mohammed k, Antony V . Tgf-beta1 induced epithelial-mesenchymal transition in PMC. Am J Physiol Lung Cell Mol. Physiol. 2009; 297(1): L115-L124.
35. Mohammed K, Wang X, Antony V, Nasreen N. Silencing receptor EphA2 Induces Apoptosis and attenuate tumor growth in Malignant Mesothelioma. Am j Cancer Research. 2011; 1(3): 419-431.
36. Mubarak K, Worboys A, Regev D, Nasreen N, et al. Parenchymal trafficking of pleural mesothelial cells in idiopathic pulmonary fibrosis:Potential role in pathogenesis. European Respiratory Journal. 2011.
37. Lee H, Mohammed K, Peruvemba S, Goldberg E, Nasreen N. Targeting Non Small Cell Lung Cancer with EphrinA1 Conjugated Albumin Microspheres. Journal of Pharmacology and pharmacology. 2011. doi: 10.1111/j.2042-7158.2011.01306.x
38. Khodayari N, Mohammed K, Goldberg E, Nasreen N. EphrinA1Inhibits Malignant Mesothelioma tumor growth via let-7 microRNA mediated repression of the RAS oncogene. Cancer Gene Ther. 2011. doi: 10.1038/cgt.2011.50
39. Nasreen N, Khodayar N, Zhang V, Antony V, Pate Vl, Mohammed K. Receptor EphA2 Regulates Barrier function in Tobacco Smoke Exposed Bronchial Airway Epithelial Cells. Cancer. 2012.
40. Nasreen N, Khodayar N, Mohammed K. Advances in Malignant Pleural Mesothelioma Therapy: targeting EphA2 a novel approach. . Am J Cancer Research. 2012; 2(2): 222-234.
41. Ganesh B, Mohammed K, Goldberg E, Nasreen N. Ephrin-A1 Inhibits NSCLC Tumor Growth via Induction of Cdx-2 a Tumor Suppressor Gene. BMC. Cancer. 2012; 12: 309. doi: 10.1186/1471-2407-12-309
42. Mubarak K, Worboys A, Regev D, et al. Parenchymal trafficking of pleural mesothelial cells in idiopathic pulmonary fibrosis. Eur Respir J. 2012; 39(1): 133-140. doi: 10.1183/09031936.00141010
43. Nasreen N, Khodayari N, Ganesh B, Peruvemba S, Mohammed K. Fluticasone Propionate and Salmeterol Combination Induces SOCS-3 Expression in Airway Epithelial Cells. International Journal of Immunopharmacology. 2012; 12(1): 217-222. doi: 10.1016/j.intimp.2011.11.014
44. Lee H, Mohammed K, Goldberg E, Nasreen N. Arginine-conjugated albumin microspheres inhibits proliferation and migration in lung cancer cells. Am J Cancer Res. 2013; 3(3): 266-277.
45. Lee HY, Mohammed KA, Kaye F, et al. Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer. Int J Nanomedicine. 2013; 8: 4481-4494. doi: 10.2147/IJN.S41782
46. Nasreen N, Gonzalves L, Peruvemba S, Mohammed K. Fluticasone furoate is more effective than mometasone furoate in restoring tobacco smoke inhibited SOCS-3 expression in airway epithelial cells Int. Immunopharmacol. 2014; 19(1): 153-160. doi: 10.1016/j.intimp.2013.12.029