Nahum J. Duker, MD


Professor
Department of Pathology and Laboratory Medicine
Temple University School of Medicine
Philadelphia, PA 19140, USA


E-mail: granduke@temple.edu

Biography

Dr. Duker received his MD at the University of Illinois College of Medicine in 1966, and interned at Bellevue Hospital in New York. After two years in the United States Army, he served a Residency and Fellowship at New York University Medical Center. Since 1977 he has served on the Faculty of Temple University Medical School.

Research Interest

His research interests include: Experimental and Anatomic Pathology, with particular attention to the interactions between, DNA alterations, DNA repair, and the etiogenesis of human disease.

Scientific Activities

AWARDS AND HONORS

• (1983-1987) National Institutes of Health Research Career Development Award
• (1983) Award by Association for Radiation Research for Travel to the 7th International Congress of Radiation Research
• (1991) Award by American Society for Biochemistry and Molecular Biology for Travel to the 15th International Congress of Biochemistry
• (March 30, 1993) Chairman of Minisymposium DNA Damage and Repair, Federation of American Societies for Experimental Biology, 78th Annual Meeting, New Orleans, LA
• (July 16, 1998) Acres of Diamonds Award, Minorities Access to Research Careers Program, Temple University
• (1978-Present) Scientific Consultant, The Committee for the Scientific Investigation of the Claims of the Paranormal
• (1978-Present) Cancer Information Dissemination and Analysis Center

Publications

1. Teebor GW, Duker NJ, Ruacan SA, Zachary KJ. Inhibition of Thymine Dimer Excision by the Phorbol Ester, Phorbol Myristate Acetate. Biochem. Biophys. Res. Commun. 1973; 50: 66-70. doi: 10.1016/0006-291X(73)91064-4
2. Duker NJ, Teebor GW. Different Ultraviolet DNA Endonuclease Activity in Human Cells. Nature. 1975; 255: 82-84. doi: 10.1038/255082a0
3. Teebor GW, Duker NJ. Human Endonuclease Activity for DNA Apurinic Sites. Nature. 1975; 258: 544-547. doi: 10.1038/258544a0
4. Teebor GW, Duker NJ. Endonuclease Activity for DNA Apurinic Sites in Different Human Cell Lines. DNA-Repair and Late Effects. In: Altmann H, ed. Roetzer, Eisenstadt, Austria. 1976; 177-186.
5. Duker NJ, Teebor GW. Detection of Different Types of Damage in Alkylated DNA by means of Human Corrective Endonuclease (Correndonuclease). Proc. Natl. Acad. Sci. USA. 1976; 73: 2629-2633.
6. Teebor GW, Duker NJ, Becker FF. Normal Endonuclease Activities for Damaged DNA during Hepatocarcinogenesis. Biochim. Biophys. Acta. 1977; 477: 125-131. doi: 10.1016/0005-2787(77)90228-3
7. Brent TP, Teebor GW. Duker NJ. Analysis of DNA Lesions Determined by Susceptibility to Alkali, Apurinic Endonuclease or Other DNA Damage Specific Enzymes from Human Cells. In: Hanawalt PC, Friedberg EC, Fox CF, eds.DNA Repair Mechanisms. Academic Press, New York, San Francisco, London, 1978; 19-22.
8. Teebor GW, Goldstein MS, Frenkel K, Duker NJ, Brent TP. On the Nature of the Human Endonuclease Activity Directed Against Ultraviolet-Irradiated DNA. pp. 295-299, in DNA Repair Mechanisms. In: Hanawalt PC, Friedberg EC, Fox CF, eds. Academic Press, New York, San Francisco, London, 1978.
9. Duker NJ, Grant CL. Alterations in the Levels of Deoxyuridine Triphosphatase, Uracil-DNA Glycosylase and AP Endonuclease During the Cell Cycle. Exp. Cell Res. 1980; 125: 493-497.
10. Frenkel K, Goldstein MS, Duker NJ, Teebor GW. Identification of the cis-Thymine Glycol Moiety in Oxidized Deoxyribonucleic Acid. Biochemistry. 1981; 20: 750-754.
11. Duker NJ, Davies WA, Hart DM. Alteration of Uracil-DNA Glycosylase Activity by Uracil Dimers in DNA. Photochem. Photobiol. 1981; 34: 191-195. doi: 10.1111/j.1751-1097.1981.tb08985.x
12. Duker NJ, Hart DM, Grant CL. Stability of the DNA Apyrimidinic Site. Mutation Res. 1982; 103: 101-106. doi: 10.1016/0165-7992(82)90012-4
13. Duker NJ, Hart DM. Cleavage of DNA at Apyrimidinic Sites by Lysyl-Tryptophyl-alpha-Lysine. Biochem. Biophys. Res. Commun. 1982; 105: 1433-1439. doi: 10.1016/0006-291X(82)90948-2
14. Duker NJ, Jensen DE, Hart DM, Fishbein DE. Perturbations of Enzymic Uracil Excision due to Purine Damage in DNA. Proc. Natl. Acad. Sci. USA. 1982; 79: 4878-4882.
15. Lugo M, Peterson RO, Elfenbein IB, Stein BS, Duker NJ. Nephrogenic Metaplasia of the Ureter. Am. J. Clin. Pathol. 1983; 80: 92-97.
16. Weiss RB, Mineura K, Henderson EE, Duker NJ, deRiel JK. Enzymic Detection of Uracil in a Cloned and Sequenced Deoxyribonucleic Acid Segment. Biochemistry. 1983; 22: 4501-4507.
17. Duker NJ, Hart DM. Perturbations of Enzymic Uracil Excision due to Guanine Modifications in DNA. Cancer Res. 1984; 44: 602-604.
18. Chao TL, Duker NJ. Effects of 5-azacytosine in DNA on Enzymic Uracil Excision. Mutation Res. 1984; 140: 93-98.
19. Duker NJ. Perturbations of Enzymic Initiation of Excision Repair due to Guanine Modification in DNA. In: Waters MD, Sandhu SS, Lewtas J, Claxton L, Strauss G, Nesnow S, eds. Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV. Plenum Publishing Corporation, London and New York, 1985; 34-44.
20. Duker NJ, Merkel GM, Inhibition of Enzymic Incision of Thymine Dimers by Covalently Bound 2-[N-[(deoxyguanosin-8-yl)acetyl]amino] fluorene in Deoxyribonucleic Acid. Biochemistry. 1985; 24: 408-412.
21. Duker NJ, Jensen DE, Hart DM. Modifications of Circular DNA by Photoalkylation. Radiation Res. 1985; 103: 114-121.
22. Gallagher PE, Duker NJ. Detection of UV Purine Photoproducts in a Defined Sequence of Human DNA. Mol. Cell. Biol. 1986; 6: 707-709. doi: 10.1128/MCB.6.2.707
23. Duker NJ, Gallagher PE. Detection of DNA Damage in Human Cells and Tissues Using Sequencing Techniques. Exp. Mol. Pathol. 1986; 44: 117-131.
24. Duker NJ, Merkel GW. Inhibition of Enzymic Incision of Thymine Dimers by Covalently Bound Guanine Adducts of 4-nitroquinoline-1-oxide in DNA. Cancer Res. 1986; 46: 2374-2376.
25. Duker NJ, Chao TL, Resnick EM. Rates of Heat-Induced DNA Purine Alterations in Synthetic Polydeoxyribonucleotides. Chem.-Biol. Interact. 1986; 58: 241-251.
26. Weiss RB, Duker NJ. Photoalkylated DNA and Ultraviolet-Irradiated DNA are Incised at Cytosines by Endonuclease III. Nucleic Acids Res. 1986; 14: 6621-6631.
27. Duker NJ. Rates of Heat-Induced DNA Pyrimidine Alterations in Synthetic Polydeoxyribonucleotides. Chem.-Biol. Interact. 1986; 60: 265-273.
28. Weiss RB, Duker NJ. Endonucleolytic Incision of UVB-Irradiated DNA. Photochem. Photobiol. 1987; 45: 763-768. doi: 10.1111/j.1751-1097.1987.tb07879.x
29. Duker NJ, Gallagher PE. Purine Photoproducts. Photochem. Photobiol. 1988; 48: 35-39. doi: 10.1111/j.1751-1097.1988.tb02783.x
30. Gallagher PE, Weiss RB, Brent TP, Duker NJ. Wavelength Dependence of DNA Incision by a Human Ultraviolet Endonuclease. Photochem. Photobiol. 1989; 49: 363-367. doi: 10.1111/j.1751-1097.1989.tb04120.x
31. Weiss RB, Gallagher PE, Brent TP, Duker NJ. Cytosine Photoproduct-DNA Glycosylase in Escherichia coli and in Cultured Human Cells. Biochemistry. 1989; 28: 1488-1492.
32. Gallagher PE, Duker NJ. Formation of Purine Photoproducts in a Defined Human DNA Sequence. Photochem. Photobiol. 1989; 49: 599-605. doi: 10.1111/j.1751-1097.1989.tb08430.x
33. Gallagher PE, Weiss RB, Brent TP, Duker NJ. A Human Endonuclease Incises Ultraviolet-Irradiated DNA at Cytosines and Oxidized DNA at Thymines. Mol. Carcinogenesis. 1989; 2: 188-191.
34. Ganguly T, Duker NJ. Differential Cell Cycle Modulation of Human DNA Glycosylases Against Oxidized Pyrimidines. Mutation Res. 1990; 235: 137-146. doi: 10.1016/0921-8777(90)90067-F
35. Duker NJ, Weems KM. Excision of Cytosine Hydrates from Z-DNA. Nucleic Acids Res. 1990; 18: 2007-2010.
36. Ganguly T, Duker NJ. Glycosylases that Excise Modified DNA Pyrimidines in Young and Senescent Human WI-38 Fibroblasts. Mutation Res. 1990; 237: 107-115. doi: 10.1016/0921-8734(90)90016-K
37. Ganguly T, Weems, KM, Duker NJ. Ultraviolet-Induced Thymine Hydrates in DNA are Excised by Bacterial and Human DNA Glycosylase Activities. Biochemistry. 1990; 29: 7222-7228.
38. Duker NJ, Ganguly T. Enzymic Excision of Pyrimidine Hydrates from DNA. Trends Photochem. Photobiol. 1991; 2: 33-41.
39. Ganguly T, Duker NJ. Stability of DNA Thymine Hydrates. Nucleic Acids Res. 1991; 19: 3319-3323.
40. Duker NJ. Invited review of Bioorganic Photochemistry. Photochemistry and the Nucleic Acids. In: Morrison H, ed. Res. Commun. Chem. Pathol. Pharmacol. 1991; 1(72): 254-255.
41. Ganguly T, Duker NJ. Reduced 5-hydroxymethyluracil-DNA Glycosylase Activity in Werners Syndrome Cells. Mutation Res. 1992; 275: 87-96. doi: 10.1016/0921-8734(92)90012-E
42. Ganguly T, Duker NJ. Inhibition of DNA Polymerase Activity by Thymine Hydrates. Mutation Res. 1992; 293: 71-77. doi: 10.1016/0921-8777(92)90010-Z
43. Vairapandi M, Duker NJ. Enzymic Removal of 5-methylcytosine from DNA by a Human DNA-glycosylase. Nucleic Acids Res. 1993; 21: 5323-5327.
44. Vairapandi M, Duker NJ. Excision of Ultraviolet-Induced Photoproducts of 5-methylcytosine from DNA. Mutation Res. 1994; 315: 85-94. doi: 10.1016/0921-8777(94)90009-4
45. Duker NJ, Vairapandi M. Post-Methylational Modifications of DNA 5-methylcytosines. Life Science Advances-Biochemistry. 1995; 14: 1-7.
46. Krishnamachary N, Landau T, Sperling J, Vairapandi M, Duker NJ. Synthesis and Properties of DNA Purine Dehydrodimers: 8-8-bideoxyribonucleosides and 8-8-bideoxyribonucleotides. Redox Report. 1995; 1: 151-158.
47. Vairapandi M, Duker NJ. Partial Purification and Characterization of Human 5-methylcytosine-DNA Glycosylase. Oncogene. 1996; 13: 933-938.
48. Duker NJ. DNA Methylation and Neoplastic Development. The Cancer Journal. 1998; 11: 52-56.
49. Vairapandi M, Liebermann DA, Hoffman B, Duker NJ. Human DNA-Demethylating Activity: a Glycosylase Associated with RNA and PCNA. J. Cell. Biochem. 2000; 79: 249-260. doi: 10.1002/1097-4644(20001101)79:2<249::AID-JCB80>3.0.CO;2-Z
50. Duker NJ, Sperling J, Soprano KJ, Druin DP, Davis A, Ashworth R. ß-Amyloid Protein Induces the Formation of Purine Dimers in Cellular DNA. J. Cell. Biochem. 2001; 81: 393-400.
51. Duker NJ. Chromosomal Breakage Syndromes and Cancer. Am. J. Human Genet. (Semin. Med. Genet.). 2002; 115: 125-129. doi: 10.1002/ajmg.10688
52. Johnston J, Brady L, Simstein R, Duker NJ. Chronic Recurrent Gorham-Stout Syndrome with Cutaneous Involvement. Rare Tumors. 2010; 2: 109-111.
53. Bhavsar T, Wurzel J, Duker NJ. Myometrial Cavernous Hemangioma with Pulmonary Thromboembolism in a Post-partum Woman: a Case Report and Review of the Literature. J. Med. Case Reports. 2012; 6: 397-403. doi: 10.1186/1752-1947-6-397