Motohiko Suzuki, MD, PhD


Associate Professor
Department of Otorhinolaryngology
Nagoya City University
Graduate school of medical sciences
Nagoya, Japan

Biography

PROFESSIONAL EXPERIENCES

• (2008-Present) Associate Professor, Department of Otorhinolaryngology, Nagoya City University, Nagoya, Japan
• (2005-2008) Post-doctoral fellow, Department of Surgery, Pathology, and Microbiology & Immunology, University of Western Ontario, London, Canada
• (2000- 2005) Assistant Professor, Department of Otorhinolaryngology, Nagoya City University, Nagoya, Japan
• (1998-2000) Doctor, Department of Otorhinolaryngology, Toyokawa Municipal Hospital, Toyokawa, Japan
• (1996- 1998) Doctor, Department of Otorhinolaryngology, Kainan Hospital, Aichi, Japan

Research Interest

His research interest includes: Allergic rhinitis, Sinusitis, Olfactory dysfunction, Sinonasal diseases, Sinonasal surgery.

Scientific Activities

AWARDS

• (2008) Travel Award, The Federation of Clinical Immunology Societies USA
• (2008) CSI (Canadian Society for Immunology)、Postdoctoral Fellows CSI Award Canada
• (2008) AAI (American Association of Immunologist)、AAI Abstract Award USA
• (2007) Travel Award, The Federation of Clinical Immunology Societies USA
• (2007) Rhinologic Society Award, Japan Rhinologic Society Japan
• (2006) Glaxo-SmithKline International Award, Japan Society of Immunology & Allergology in Otolaryngology Japan

Publications

1. Aoishi K, Takahashi H, Hato N, et al. Treatment of allergic rhinitis with intranasal infusion of botulinum toxin type A in mice. Life Sci. 2015. doi: 10.1016/j.lfs.2015.08.003
2. Nakayama M, Masuda A, Ando KB, et al. A Pilot Study on the Efficacy of Continuous Positive Airway Pressure (CPAP) on the Manifestations of Menieres Disease in Patients with Concomitant Obstructive Sleep Apnea Syndrome (OSAS). J Clin Sleep Med. 2015.
3. Yokota M, Suzuki M, Nakamura Y, Ozaki S, Murakami S. Cytokine modulation by IL-35 in mice with allergic rhinitis. Am J Rhinol Allergy. 2015 Jul-Aug;29(4):251-6. doi: 10.2500/ajra.2015.29.4188
4. Nakamura Y, Komori M, Yamakawa K, et al. Math1, retinoic acid, and TNF-α synergistically promote the differentiation of mucous cells in mouse middle ear epithelial cells in vitro. Pediatr Res. 2013; 74(3): 259-65. doi: 10.1038/pr.2013.103
5. Nakayama M, Koike S, Kuriyama S, et al. Seasonal variation in a clinical referral pediatric cohort at risk for obstructive sleep apnea. Int J Pediatr Otorhinolaryngol. 2013; 77(2): 266-269. doi: 10.1016/j.ijporl.2012.11.016
6. Nakamura Y, Suzuki M, Yokota M, et al. Optimal duration of macrolide treatment for chronic sinusitis after endoscopic sinus surgery. Auris Nasus Larynx. 2013; 40(4): 366-372. doi: 10.1016/j.anl.2012.09.009
7. Li R, Zheng X, Popov I, et al. Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis. J Transl Med. 2012; 10: 19. doi: 10.1186/1479-5876-10-19
8. Suzuki M, Nakamura Y, Nakayama M, et al. Modified transnasal endoscopic medial maxillectomy with medial shift of preserved inferior turbinate and nasolacrimal duct. Laryngoscope. 2011; 121(11): 2399-2401. doi: 10.1002/lary.22326
9. Nakayama M, Suzuki M, Inagaki A, et al. Impaired quality of sleep in Menieres disease patients. J Clin Sleep Med. 2010; 6(5): 445-449.
10. Zheng X, Suzuki M, Ichim TE, et al. Treatment of autoimmune arthritis using RNA interference-modulated dendritic cells. J Immunol. 2010; 184(11): 6457-6464. doi: 10.4049/jimmunol.0901717
11. Ozaki S, Toida K, Suzuki M, et al. Impaired olfactory function in mice with allergic rhinitis. Auris Nasus Larynx. 2010; 37(5): 575-583. doi: 10.1016/j.anl.2009.12.004
12. Suzuki M, Zheng X, Zhang X, et al. A novel allergen-specific therapy for allergy using CD40-silenced dendritic cells. J Allergy Clin Immunol. 2010;125(3):737-43. doi: 10.1016/j.jaci.2009.11.042
13. Zheng X, Suzuki M, Zhang X, et al. RNAi-mediated CD40-CD154 interruption promotes tolerance in autoimmune arthritis. Arthritis Res Ther. 2010; 12(1): R13. doi: 10.1186/ar2914
14. Inagaki A, Ugawa S, Safwat MM, et al. Reelin-disabled-1 signaling in the mature rat cochlear nucleus. Acta Otolaryngol Suppl. 2009; (562): 7-11.
15. Zheng X, Vladau C, Zhang X, et al. A novel in vivo siRNA delivery system specifically targeting dendritic cells and silencing CD40 genes for immunomodulation. Blood. 2009 Mar 19; 113(12): 2646-54. doi: 10.1182/blood-2008-04-151191
16. Zheng X, Zhang X, Feng B, et al. Gene silencing of complement C5a receptor using siRNA for preventing ischemia/reperfusion injury. Am J Pathol. 2008; 173(4): 973-80. doi: 10.2353/ajpath.2008.080103
17. Suzuki M, Zheng X, Zhang X, et al. Novel vaccination for allergy through gene silencing of CD40 using small interfering RNA. J Immunol. 2008; 180(12): 461-9. doi: 10.4049/jimmunol.180.12.8461
18. Zhang X, Li M, Lian D, et al. Generation of therapeutic dendritic cells and regulatory T cells for preventing allogeneic cardiac graft rejection. Clin Immunol. 2008; 127(3): 313-21. doi: 10.1016/j.clim.2008.01.013
19. Li M, Zhang X, Zheng X, et al. Tolerogenic dendritic cells transferring hyporesponsiveness and synergizing T regulatory cells in transplant tolerance. Int Immunol. 2008; 20(2): 285-293. doi: 10.1093/intimm/dxm142
20. Li M, Zhang X, Zheng X, et al. Immune modulation and tolerance induction by RelB-silenced dendritic cells through RNA interference. Journal of Immunology. 2007; 178: 5480-5487. doi: 10.4049/jimmunol.178.9.5480
21. Suzuki M, Matsumoto T, Ohta N, et al. Intranasal CpG DNA therapy during allergen exposure in allergic rhinitis. Otolaryngology-Head and Neck Surgery. 2007; 136: 246-251. doi: 10.1016/j.otohns.2006.09.009
22. Suzuki M, Ohta N, Min WP, et al. Immunotherapy with CpG DNA conjugated with T-cell epitope peptide of an allergenic Cry j 2 protein is useful for control of allergic conditions in mice. International Immunopharmacology. 2007; 7: 46-54. doi: 10.1016/j.intimp.2006.08.010
23. Suzuki M, Saito K, Toida K, et al. Identification of viruses in patients with postviral olfactory dysfunction. Laryngoscope. 2007; 117: 272-277. doi: 10.1097/01.mlg.0000249922.37381.1e
24. Popov I, Li M, Zheng X, et al. Prevention of rheumatoid arthritis by tolerogenic vaccination with antigen-specific immature dendritic cells. Arthritis Therapy and Research. 2006; 8 (5): R141 . doi: 10.1186/ar2031
25. Zhang X, Zheng X, Sun H, et al. Prevention of renal ischemia injury by silencing the expression of renal caspase 3 and caspase 8. Transplantation. 2006; 82: 1728-1732.
26. Zheng X, Zhang X, Sun H, et al. Synergistic protection of renal ischemia injury by combinations gene silencing of complement 3 and caspase 3 genes. Transplantation. 2006; 82: 1781-1786.
27. Sugiyama K, Hasegawa Y, Sugiyama N, et al. Smoking-induced Olfactory Dysfunction in Chronic Sinusitis and Assessment of Brief UPSIT and T&T Methods. American Journal of Rhinology. 2006; 20: 439-444. doi: 10.2500/ajr.2006.20.2924
28. Suzuki M, Itoh M, Ohta N, et al. Blocking of protease allergens with inhibitors reduces allergic responses in allergic rhinitis and other allergic diseases. Acta Oto-Laryngologica. 2006; 126: 746-751.
29. Mitsuya S, Kondo H, Suzuki M, et al. Modification of PEA olfactory test-a comparison study with UPSIT and T&T olfactometer. Nagoya Medical Journal, 2005; 47: 103-110.
30. Ohno N, Suzuki M, Matsumoto T, et al. Strain differences of the immunostimulatory effect of CpG in OVA-sensitized mice. Nagoya Medical Journal. 2005; 47: 111-122.
31. Takagi S, Nakamura Y, Suzuki M, et al. Epitope analysis of the Japanese cypress pollen major allergen, Cha o 1, recognized by a human T cell clone. Nagoya Medical Journal. 2002; 45: 121-132.
32. Nakamura Y, Takagi S, Suzuki M, et al. Survival of memory T cells specific for Japanese cypress pollen allergen is maintained by cross-stimulation of putative pectate lyases from other plants. Allergy. 2001; 56: 385-392. doi: 10.1034/j.1398-9995.2001.056005385.x
33. Suzuki M, Komiyama N, Itoh M, et al. Purification, characterization and molecular cloning of Cha o 1,a major allergen of Chmaecyparis obtusa(Japanese cypress) pollen. /i> Molecular Immunology.
1996; 33: 451-460.
34. Ito H, Baba S, Suzuki M, et al. Severe perennial allergic rhinitis treated with Nd:YAG laser, Acta Otolaryngol(Stockh). 1996; Suppl 525: 14-17.
35. Suzuki M, Ito M, Ito H, Baba S, et al. Antigenic analysis of Cryptomeria japonica and Chamaecyparis obtusa using anti−Cry j 1 monoclonal antibodies. Acta Otolaryngol(Stockh). 1996; Suppl 525: 85-89.
36. Kitao S, Ito H, Ito M, et al. Moth-related antigens contained in the house dust of the Japanese house. Acta Otolaryngol (Stockh). 1996; 525: 90-92.
37. Mamiya S, Ito H, Suzuki M, et al. Clinical evalution of histamine release test: A novel method for identifying allergens from the whole blood of allergic patients, Acta Otolaryngol (Stockh). 1996; Suppl 525: 93-97.
38. Ito H, Suzuki M, Mamiya S, et al. Study on changes in the level of serum IL-4 and soluble CD23 (sCD23) with immunotherapy in nasal allergy patients, Acta Otolaryngol(Stockh). 1996; Suppl 525: 98-104.
39. Suzuki M, Nagata S, Hiramatsu K, et al. Elevated levels of soluble FcεR II/CD23 and antibodies to Epstein-Barr virus in patients with Sjogren,s syndrome. Acta Otolaryngol(Stockh). 1996; Suppl 525: 108-112.
40. Ito H, Suzuki M, Nishimura J, et al. Analysis of the allergenic components of Hinoki cypress (Chamaecyparis obtusa) pollen by immunoblotting with the sera from patients with Japanese cedar pollinosis, Allergology International. 1996; 45: 181-186. doi: 10.2332/allergolint.45.181
41. Suzuki M, Itoh H, Sugiyama K, et al. Causative allergens of allergic rhinitis in Japan with special reference to silkworm moth allergen. Allergy. 1995; 50(1): 23-27. doi: 10.1111/j.1398-9995.1995.tb02479.x
42. Ito H, Nishimura J, Suzuki M, et al. Specific IgE to Japanese cypress (Chamaecyparis obtusa) in patients with nasal allergy. Annals of allergy, asthma & immunology. 1995; 74: 299-303.
43. Ito H, Nishimura J, Mamiya S, et al. A study of the change in the level of serum IgG4 antibody and soluble CD23(s-CD23) in nasal allergy patients with immunotherapy. Auris Nasus Larynx. 1993; 20, 185-196.