Mohamad A. Mokadem, MD

Diplomate of the American Board of Obesity Medicine
Department of Internal Medicine
Division of Gastroenetrology and Hepatology
University of Iowa Health Care
200 Hawkins Drive, 4570 JCP
Iowa City, IA 52242, USA

Biography

Dr. Mokadem is native of Lebanon, one the smallest but most dynamic countries in the Middle East. He finished his undergraduate studies as well as his medical degree from the American university of Beirut (AUB) in 2003. He did his initial residency training in Internal Medicine at the AUB-Medical center where he also served as the Medical Chief Resident during 2006-2007. Then, he moved to the United States for advanced training where he did another residency in Internal Medicine at Indiana University in Indianapolis, IN followed by fellowship training in Gastroenterology and Hepatology at the UT Southwestern University (UTSW) in Dallas, TX. During that same period (extending between 2010 and 2014) he also finished post-doctoral fellowship training in obesity and metabolism with a focus on understanding the mechanism behind the beneficial effects of bariatric surgery at the Center for Hypothalamic Research at UTSW under the supervision and guidance of Joel Elmquist DVM, PhD and Vincent Aguirre M.D, Ph.D. Dr. Mokadem was involved in developing a surgical model for gastric bypass in mice to apply to genetic mouse models in order to better comprehend the molecular mechanism underlying that operation. He recently moved to the University of Iowa Health Care to start my career in clinical gastroenterology and my investigational quest to better understand the pathophysiology of obesity as well at the mechanism underlying the most effective therapy available for it at the moment, meaning bariatric surgery.

Research Interest

His research interests include: Studying the mechanism of body weight and metabolic regulation after bariatric surgery in rodents (specifically Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG)). We have developed a reproducible model of RYGB in mice that recapitulates the human effects of RYGB on body weight, body composition, food intake, fecal calories, glucose homeostasis, and lipid homeostasis. We are interested in looking at the outflow messages delivered from the re-arranged gut (post-surgery) into other parts of the body (including the brain, liver, pancreas and fat tissue) communicating the dynamic energy status of luminal tract and exerting changes to rest the host’s energy balance. These messages can be in a form of hormones (like GLP-1 P-YY, CCK etc…) or neuronal signals (like the afferent fibers of the Vagus nerve). This is, of course, important given the implications of understanding the RYGB mechanisms on developing less-invasive alternative therapies for weight loss, diabetes, and other related metabolic conditions.

Scientific Activities

PROFESSIONAL SOCIETIES:

• (2003-Present): American College of Physicians
• (2010-Present): American Gastroenterology Association
• (2010-Present): American Society for Gastrointestinal Endoscopy
• (2012-Present): The Obesity Society
• (2012-Present): The American Society for Metabolic and Bariatric Surgery

AWARDS AND HONORS:

• (2008-2009): ACP Research Abstract competition Award, Indiana Chapter
• (2008-2009): Winner of Test your Knowledge competition at ACP meeting, Indiana Chapter

Publications

1. Li H, Chan L, Bartuzi P, et al. Copper Metabolism Domain-containing 1 Represses Genes that Promote Inflammation and Protects Mice From Colitis and Colitis-associated Cancer. Gastroenterology. 2014. doi: 10.1053/j.gastro.2014.04.007
2. Mokadem M, Zechner JF, Margolskee RF, Drucker DJ, Aguirre V. Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency. Mol Metab. 2013; 3(2): 191-201. doi: 10.1016/j.molmet.2013.11.010
3. Barada K, Bitar A, Mokadem MA, Hashash JG, Green P. Celiac disease in Middle Eastern and North African countries: a new burden? World J Gastroenterol. 2010; 16(12): 1449-1457. doi: 10.3748/wjg.v16.i12.1449.
4. Khashab M, Mokadem M, DeWitt J, et al. Endoscopic ultrasound-guided fine-needle aspiration with or without flow cytometry for the diagnosis of primary pancreatic lymphoma – a case series. Endoscopy. 2010; 42(3): 228-231. doi: 10.1055/s-0029-1243859