Meng-Tse Lee, PhD

Researcher
Department of Emergency Medicine
National Taiwan University Hospital
Number 7, Chung-Shan South Road
Taipei 100, Taiwan

Biography

Dr.Lee is a life scientist and epidemiologist in the Emergency Department of National Taiwan University Hospital (2,500-Bed Medical Center in Taiwan). At the emergency department of National Taiwan University hospital, he performed translational/multidisciplinary research using animal models, biobank data, clinical trial data, and nationwide claims data. He has published more than 40 SCI (Science citation index) articles.

Education

• (2014), Researcher, Emergency Department, National Taiwan University Hospital
• (2012), PhD in Biomedical Sciences, University of Massachusetts Medical School
• (2004), BS in Biochemistry, University of Wisconsin-Madison

Research Interest

His research interests include: Trauma research, Genetic epidemiology, Epidemiology of sepsis, Comparative effectiveness research.

Scientific Activities

Publications

1. Lee M-TG, Lee C-C, Lai C-C, et al. Preadmission statin use improves the outcome of less severe sepsis patients- a population-based propensity score matched cohort study. British Journal of Anaesthesia. 2017; 119: 645-654. doi: 10.1093/bja/aex294
2. Lee M-TG, Hsu T-C, Chen S-C, et al. Integrative genome-wide association studies of eQTL and GWAS data for gout disease susceptibility. Scientific Reports. 2019; 9(1). doi: 10.1038/s41598-019-41434-4
3. Lee M-TG, Lee C-C, Wang C-C, et al. Trends and outcomes of surgical treatment for colorectal cancer between 2004 and 2012- an analysis using national inpatient database. Scientific Reports. 2017; 7(1). doi: 10.1038/s41598-017-02224-y
4. Lee M-TG, Lin F-C, Chen S-T, et al. Web-based dashboard for the interactive visualization and analysis of national risk-standardized mortality rates of sepsis in the US. J Med Syst. 2020; 44(2): 54. doi: 10.1007/s10916-019-1509-9
5. Lee M-TG, Lee S-H, Chang S-S, et al. Comparative effectiveness of different oral antibiotics regimens for treatment of urinary tract infection in outpatients: An analysis of national representative claims database. Medicine (Baltimore). 2014; 93(28): e304. doi: 10.1097/MD.0000000000000304
6. Lee C-C, Lee M-TG, Chen Y-S, et al. Risk of aortic dissection and aortic aneurysm in patients taking oral fluoroquinolone therapy. JAMA. 2015; 175(11): 1839-1847. doi: 10.1001/jamainternmed.2015.5389
7. Lee C-C, Lee M-TG, Hsieh R, et al. Oral fluoroquinolone and the risk of aortic dissection. J Am Coll Cardiol. 2018; 72(12): 1369-1378. doi: 10.1016/j.jacc.2018.06.067
8. DiNitto JP, Delprato A, Lee M-TG, et al. Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. Mol Cell. 2007; 28(4): 569-583. doi: 10.1016/j.molcel.2007.09.017
9. Lee M-TG, Wang H-M, Ho J-A A, et al. Resuscitation using liposomal vasopressin in an animal model of uncontrolled hemorrhagic shock. PLoS One. 2015; 10(7): e0130655. doi: 10.1371/journal.pone.0130655
10. Lee M-TG, Lee C-C, Wang H-M, et al. Hypothermia increases tissue plasminogen activator expression and decreases post-operative intra-abdominal adhesion. PLoS ONE. 2016; 11(9): e0160627. doi: 10.1371/journal.pone.0160627
11. Yang Y-L, Lee M-TG, Lee C-C, et al. Pentoxifylline decreases post-operative intra-abdominal adhesion formation in an animal model. Peer J. 2018; 6: e5434. doi: 10.7717/peerj.5434
12. Lee M-TG, Mishra A, Lambright DG. Structural mechanisms for regulation of membrane traffic by rab GTPases. Traffic. 2009; 10: 1377-1389. doi: 10.1111/j.1600-0854.2009.00942.x
13. DiNitto JP, Lee M-TG, Malaby AW, Lambright DG. Specificity and membrane partitioning of Grsp1 signaling complexes with Grp1 family Arf exchange factors. Biochemistry. 2010; 49(29): 6083-6092. doi: 10.1021/bi1000454
14. Lee C-C, Lee M-TG, Chang S-S, et al. A comparison of vasopressin, terlipressin, and lactated ringers for resuscitation of uncontrolled hemorrhagic shock in an animal model. PLoS ONE. 2014; 9(4): e95821. doi: 10.1371/journal.pone.0095821
15. Lee M-TG, Lee S-H, Chang S-S, Chan Y-L, Hsu S-M, Lee C-C. Comparative treatment failure rates of respiratory fluoroquinolones or β-lactam + macrolide in the treatment of community-acquired pneumonia in adult outpatients: An analysis of national representative claims database. Medicine (Baltimore). 2015; 94(39): e1662. doi: 10.1097/MD.0000000000001662
16. Porta L, Lee M-TG, Hsu S-M, Hsu T-C, Tsaie T-Y, Lee C-C. Fluoroquinolone use and serious arrhythmias: A nationwide case-crossover study. Resuscitation. 2019; 139: 262-268. doi: 10.1016/j.resuscitation.2019.04.030
17. Lai C-C, Lee M-TG, Lee W-C, et al. Susceptible period for cardiovascular complications in patients recovering from sepsis. CMAJ. 2018; 190(36): E1062-E1069. doi: 10.1503/cmaj.171284
18. Lee M-TG, Lin H-Y, Lee S-H, et al. Risk of skin ulcerations associated with oral nicorandil therapy- a population-based study. Br J Dermatol. 2015; 173(2): 498-509. doi: 10.1111/bjd.13884
19. Lee C-C, Chang S-S, Lee S-H, Chen Y-S, Hsu S-M, Lee M-TG. Use of nicorandil is associated with increased risk for gastrointestinal ulceration and perforation- a nationally representative population-based study. Scientific Report. 2015; 5: 11495. doi: 10.1038/srep11495
20. Lee C-C, Lee M-TG, Hsu T-C, et al. A population-based cohort study on the drug specific effect of statins on sepsis outcome. Chest. 2017; 153: 805-815. doi: 10.1016/j.chest.2017.09.024
21. Lai C-C, Lee M-TG, Lee S-H, et al. Statin treatment is associated with a decreased risk of active tuberculosis: an analysis of a nationally representative cohort. Thorax. 2016; 71(7): 646-651. doi: 10.1136/thoraxjnl-2015-207052
22. Lee C-C, Lee M-TG, Lee W-C, et al. Preadmission use of calcium channel blocking agents is associated with improved outcomes in patients with sepsis – a population-based propensity score matched cohort study. Crit Care Med. 2017; 45(9): 1500-1508. doi: 10.1097/CCM.0000000000002550
23. Wu J-Y, Lee M-TG, Lee S-H, et al. Angiotensin converting enzyme inhibitors and active tuberculosis: A population-based study. Medicine (Baltimore). 2016; 95(19): e3579. doi: 10.1097/MD.0000000000003579
24. Lai C-C, Lee M-TG, Lee S-H, Lee S-H, Chang S-S, Lee C-C. Risk of incident active tuberculosis and use of corticosteroid. Int J Tuberc Lung Dis. 2015; 19(8): 936-942. doi: 10.5588/ijtld.15.0031
25. Yo C-H, Lee M-TG, Gi W-T, et al. Prognostic determinants of community-acquired bloodstream infection in type 2 diabetic patients in ED. Am J Emerg Med. 2014; 32(12): 1450-1454. doi: 10.1016/j.ajem.2014.08.071
26. Yo C-H, Lee M-TG, Hsein Y-C, Lee C-C. Risk factors and outcomes of afebrile bacteremia patients in an emergency department. Diagn Microbiol Infect Dis. 2016; 86(4): 455-459. doi: 10.1016/j.diagmicrobio.2016.08.020
27. Wu MH, Tsou PY, Wang YH, et al. Impact of post-sepsis cardiovascular complications on mortality in sepsis survivors: a population-based study. Crit Care. 2019; 23(1): 293. doi: 10.1186/s13054-019-2579-2
28. Hsieh YC, Tsou PY, Wang YH, et al. Risk factors for myocardial infarction and stroke among sepsis survivors: A competing risks analysis. J Intensive Care Med. 2020; 35(1): 34-41. doi: 10.1177/0885066619844936
29. Chiu C-C, Hsu S-M, Choi JJ, et al. Comparison of outcome and cost between the open, laparoscopic, and robotic surgical treatments for colon cancer: A propensity score-matched analysis using nationwide hospital record database. Surg Endosc. 2019; 33(11): 3757-3765. doi: 10.1007/s00464-019-06672-7
30. Yu CW, Chang SS, Lai CC, et al. Epidemiology of emergency department sepsis: A national cohort study between 2001 and 2012. Shock. 2019; 51(5): 619-624. doi: 10.1097/SHK.0000000000001219
31. Lee C-C, Yo C-H, Lee M-TG, et al. Adult sepsis – A nationwide study of trends and outcomes in a population of 23 million people. J Infect. 2017. 75(5): 409-419. doi: 10.1016/j.jinf.2017.08.012
32. Lee SH, Hsu TC, Lee M-TG, et al. Nationwide trend of sepsis: A comparison among octogenarians, elderly, and young adults. Crit Care Med. 2018; 46(6): 926-934. doi: 10.1097/CCM.0000000000003085
33. Hsu S-C, Chang S-S, Lee M-TG, et al. Risk of gastrointestinal perforation in patients taking oral fluoroquinolone therapy: An analysis of nationally representative cohort. PLoS One. 2017; 12(9): e0183813. doi: 10.1371/journal.pone.0183813
34. Tsou P-Y, Kurbedin J, Chen Y-S, et al. Accuracy of point-of-care focused echocardiography in predicting outcome of resuscitation in cardiac arrest patients: A systematic review and meta-analysis. Resuscitation. 2017; 114: 92-99. doi: 10.1016/j.resuscitation.2017.02.021
35. Chen Y-S, Gi W-T, Liao T-Y, et al. Using galectin-3 test to predict mortality in heart failure patients: A systematic review and meta-analysis. Biomark Med. 2016; 10(3): 329-342. doi: 10.2217/bmm.15.121
36. Wu C-W, Wu J-Y, Lee M-TG, et al. Risk of incident active tuberculosis disease in patients treated with non-steroidal anti-inflammatory drug: A population-based study. BMC Pulm Med. 2017; 17(1): 82. doi: 10.1186/s12890-017-0425-3
37. Chang S-S, Lai C-C, Lee M-TG, Lee C-C. Risk of spontaneous bacterial peritonitis associated with gastric acid suppression. Medicine (Baltimore). 2015; 94(22): e944. doi: 10.1097/MD.0000000000000944
38. Wu MC, Liao TY, Lee EM, et al. Administration of hypertonic solutions for hemorrhagic shock: A systematic review and meta-analysis of clinical trials. Anesth Analg. 2017; 125(5): 1549-1557. doi: 10.1213/ANE.0000000000002451
39. Wu C-W, Wu J-Y, Chen C-K, et al. Does procalcitonin, C-reactive protein, or interleukin-6 test have a role in the diagnosis of severe infection in patients with febrile neutropenia? A systematic review and meta-analysis. Support Care Cancer. 2015; 23 (10): 2863-2872. doi: 10.1007/s00520-015-2650-8
40. Lin K-H, Chang S-S, Yu C-W, et al. Usefulness of natriuretic peptide for the diagnosis of kawasaki disease- A systematic review and meta-analysis. BMJ Open. 2015; 5(4): e006703. doi: 10.1136/bmjopen-2014-006703