Massimo Collino, PhD

Associate Professor of Pharmacology and Toxicology
Department of Drug Science and Technology
University of Turin
Corso Raffaello 33
10125 Torino, Italy

 

Biography

EDUCATION

• (1998) Bachelor Degree in Pharmaceutical Chemistry and Technology at the University of Turin, Faculty of Pharmacy summa cum laude
• (31/12/2003) PhD in Pharmacology and Toxicology
• (2003-2004) Visiting Scientist at The William Harvey Research Institute, Centre for Experimental Medicine, Nephrology & Critical Care, Barts and The London, Queen Marys School of Medicine and Dentistry, London (UK)
• (2002-2014) Assistant Professor of Pharmacology and Toxicology, Dept. Drug Science and Technology, University of Turin (Italy)

Research Interest

His research interests include: Pathophysiology and the pharmacological therapy of diet-induced insulin resistance and the related cardiovascular risk factors, mainly organ-related ischemic events. Specifically, investigation of the pharmacological potential of selective ligands of the enzyme GSK-3beta, nuclear receptors PPAR and erythropoietin derivatives in in vivo models of ischemic diseases (myocardial infarction, stroke, acute kidney injury), Shock (hemorrhagic and endotoxic shock) and diet-induced (mainly sugar-induced) dysmetabolism. Most recent research activity has been focused on the validation of the NLRP3 inflammasome, a multiprotein complex leading to the processing and secretion of the proinflammatory cytokines interleukin-(IL-)1beta and IL-18, as pharmacological target for cardiometabolic diseases.

Scientific Activities

MEMBERSHIPS

• World Journal of Diabetes (ISSN 1948-9358; DOI: 10.4239)
• World Journal of Pharmacology (ISSN 2220-3192; DOI: 10.5497)
• Journal of Diabetes & Metabolism (ISSN:2155-6156)

Publications

PUBLICATIONS IN INTERNATIONAL JOURNALS

1. Dianzani C, Lombardi G, Collino M, Ferrara C, Cassone MC, Fantozzi R. Priming effects of substance P on calcium changes evoked by interleukin-8 in human neutrophils. J Leukoc Biol. 2001; 69: 1013-1018.
2. Dianzani C, Collino M, Lombardi G, Garbarino G, Fantozzi R. Substance P increases neutrophil adhesion to human umbilical vein endothelial cells. Br J Pharmacol. 2003; 139: 1103-1110.
3. Collin M, Rossi A, Cuzzocrea S, et al. Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton. J. Leukoc. Biol. 2004; 76: 961-970.
4. Collino M, Patel NS, Lawrence KM, et al. The selective PPARγ antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion.Kidney Int. 2005; 68: 529-536.
5. Collino M, Aragno M, Mastrocola R, et al. Modulation of the oxidative stress and inflammatory response by peroxisome proliferator-activated receptor-γ agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. Eur. J. Pharmacol. 2006; 530: 70-80.
6. Gallicchio M, Rosa AC, Benetti E, Collino M, Dianzani C, Fantozzi R. Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells. Brit. J. Pharmacol. 2006; 147: 681-689.
7. Dianzani C, Collino M, Gallicchio M, et al. Evaluation of in vitro anti-inflammatory activity of some 2-alkyl-4,6-dimethoxy-1,3,5- triazines. J. Pharm.Pharmacol. 2006; 58: 219-226.
8. Dianzani C, Collino M, Gallicchio M, Di Braccio M, Roma G, Fantozzi R. Effects of anti-inflammatory [1,2,4]triazolo[4,3-a] [1,8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study. J. Inflamm. 2006; 3: 4-15.
9. Collino M, Aragno M, Mastrocola R, et al. Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: effects of the PPAR-alpha agonist WY14643. Free Radic Biol Med. 2006; 41: 579-589.
10. Patel NS, Cuzzocrea S, Collino M, et al. The role of cycloxygenase-2 in the rodent kidney following ischaemia/reperfusion injury in vivo. Eur J Pharmacol. 2007; 562: 148-154.
11. Gallicchio M, Rosa AC, Dianzani C, et al. Celecoxib decreases expression of the adhesion molecules ICAM-1 and VCAM-1 in a colon cancer cell line (HT29). Br J Pharmacol. 2008; 153(5): 870-878.
12. Dianzani C, Brucato L, Gallicchio M, Rosa AC, Collino M, Fantozzi R. Celecoxib modulates adhesion of HT29 colon cancer cells to vascular endothelial cells by inhibiting ICAM-1 and VCAM- 1 expression. Br J Pharmacol. 2008; 153: 1153-1161.
13. Murch O, Abdelrahman M, Collino M, et al. Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat. Crit Care Med. 2008; 36: 550-559. doi: 10.1097/01.CCM.0B013E3181620D2F.
14. Collino M, Thiemermann C, Mastrocola R, et al. Treatment with the glycogen synthase kinase-3β inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus.Shock. 2008; 30: 299-307. doi: 10.1097/SHK.0b013e318164e762.
15. Collino M, Patel NS, Thiemermann C. PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury. Therapeutic Advances in Cardiovascular Disease. 2008; 2: 179-197. doi: 10.1177/1753944708090924.
16. Tripatara P, Patel NS, Collino M, et al. Generation of Endogenous Hydrogen Sulfide by Cystathionine Gamma-Lyase limits the Renal Injury and Dysfunction caused by Ischemia/Reperfusion. Lab Invest. 2008; 88: 1038-1048. doi: 10.1038/labinvest.2008.73.
17. Sivarajah A, Collino M, Yasin M, et al. Anti-apoptotic and anti-inflammatory effects of hydrogen sulphide in a rat model of regional myocardial ischaemia and reperfusion. Shock. 2009; 31: 267-274. doi: 10.1097/SHK.0b013e318180ff89.
18. Collino M, Aragno M, Castiglia S, et al. Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta. Diabetes. 2009; 58: 235-242. doi: 10.2337/db08-0691.
19. Miglio G, Rosa AC, Rattazzi L, Collino M, Lombardi G, Fantozzi R. PPARgamma stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss.Neurochem Int. 2009; 55: 496-504. doi: 10.1016/j.neuint.2009.05.001.
20. Aragno M, Tomasinelli CE, , Vercellinatto I, et al. SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats. Free Radic Biol Med. 2009; 47: 1067-1074. doi: 10.1016/j.freeradbiomed.2009.07.016.
21. Collino M, Castiglia S, Manoni M, et al. Effects of a semisynthetic N-,O-sulfated glycosaminoglycan K5 polysaccharide derivative in a rat model of cerebral ischemia/reperfusion injury. Thromb Haemost. 2009; 102: 837-845. doi: 10.1160/TH09-01-0012.
22. Kapoor A, Collino M, Castiglia S, Fantozzi R, Thiemermann C. Shock. 2010; 34: 117-124. doi: 10.1097/SHK.0b013e3181cd86d6.
23. Collino M, Aragno M, Castiglia S, et al. Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation. Br J Pharmacol. 2010; 160: 1892-1902. doi: 10.1111/j.1476-5381.2010.00671.x.
24. Kapoor A, Shintani Y, Collino M, et al. Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock. American Journal of Respiratory and Critical Care Medicine. 2010; 182:1506-1515. doi: 10.1164/rccm.201002-0240OC.
25. Lovell MJ, Yasin M, Lee KL, et al. Bone marrow mononuclear cells reduce myocardial reperfusion injury by activating the PI3K/Akt survival pathway. Atherosclerosis. 2010; 213: 67-76 doi: 10.1016/j.atherosclerosis.2010.07.045.
26. Miglio G, Rosa AC, Rattazzi L, et al. The subtypes of peroxisome proliferator-activated receptors expressed by human podocytes and their role in decreasing podocyte injury. Br J Pharmacol. 2011;162: 111-125. doi: 10.1111/j.1476-5381.2010.01032.x.
27. Collino M, Benetti E, Miglio G, et al. Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats. Free Radic Biol Med. 2011; 50: 345-353. doi: 10.1016/j.freeradbiomed.2010.10.710.
28. Patel NS, Nandra KK, Brines M, et al. A non-erythropoietic peptide that mimicks the 3D structure of erythropoietin reduces organ injury/dysfunction and inflammation in experimental hemorrhagic shock. Mol Med. 2011. doi: 10.2119/molmed.2011.00053.
29. Benetti E, Patel NS, Collino M. The Role of PPARβ/δ in the Management of Metabolic Syndrome and its Associated Cardiovascular Complications. Endocr Metab Immune Disord Drug Targets. 2011; 11: 273-284.
30. Collino M. High dietary fructose intake: Sweet or bitter life? . World J Diabetes. 2011; 2:77-81. doi: 10.4239/wjd.v2.i6.77.
31. Patel NS, Collino M, Yaqoob MM, Thiemermann C. Erythropoietin in the intensive care unit:beyond treatment of anemia. Ann Intensive Care. 2011; 1: 40. doi: 10.1186/2110-5820-1-40.
32. Rosa AC, Rattazzi L, Miglio G, Collino M, Fantozzi R. Angiotensin II induces tumor necrosis factor-α expression and release from cultured human podocytes. Inflamm Res. 2012; 61: 311-317. doi: 10.1007/s00011-011-0412-8.
33. Nandra KK, Takahashi K, Collino M, et al. Acute treatment with bone marrow-derived mononuclear cells attenuates the organ injury/dysfunction induced by hemorrhagic shock in the rat. Shock. 2012; 37: 592-598. doi: 10.1097/SHK.0b013e31824e4c0d.
34. Patel NS, Kerr-Peterson HL, Brines M, et al. Delayed Administration of Pyroglutamate Helix B Surface Peptide (pHBSP), a Novel Nonerythropoietic Analog of Erythropoietin, Attenuates Acute Kidney Injury. Mol Med. 2012; 18: 719-727. doi: 10.2119/molmed.2012.00093.
35. Collino M, Pini A, Mastroianni R, et al. The non-anticoagulant heparin-like K5 polysaccharide derivative K5-N,OSepi attenuates myocardial ischaemia/reperfusion injury. J Cell Mol Med. 2012; 16: 2196-2207. doi: 10.1111/j.1582-4934.2012.01530.x.
36. Bertinaria M, Rolando B, Giorgis M, et al. Carnosine analogues containing NO-donor substructures: synthesis, physicochemical characterization and preliminary pharmacological profile. Eur J Med Chem. 2012; 54: 103-112. doi: 10.1016/j.ejmech.2012.04.032.
37. Rosa AC, Grange C, Pini A, et al. Overexpression of histamine H4 receptors in the kidney of diabetic rats.Inflamm Res. 2013; 62: 357-365. doi: 10.1007/s00011-012-0587-7.
38. Collino M, Benetti E, Rogazzo M, et al. (2012). Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR agonism correlates with impaired NLRP3 inflammasome activation. Biochem Pharmacol.2013; 85: 257-264. doi: 10.1016/j.bcp.2012.10.014.
39. Nandra KK, Collino M, Rogazzo M, Fantozzi R, Patel NS, Thiemermann C. Pharmacological preconditioning with erythropoietin attenuates the organ injury and dysfunction induced in a rat model of hemorrhagic shock. Dis Model Mech. 2013; 6: 701-709. doi: 10.1242/dmm.011353.
40. Bangash MN, Patel NS, Benetti E, et al. Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow. Crit Care. 2013; 17(2): R57. doi: 10.1186/cc12585.
41. Khan AI, Coldewey SM, Patel NS, et al. Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the β-common receptor. Dis Model Mech. 2013; 6(4): 1021-1030. doi: 10.1242/dmm.011908.
42. Coldewey SM, Rogazzo M, Collino M, Patel NS, Thiemermann C. Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse. Dis Model Mech. 2013; 6(4): 1031-1042. doi: 10.1242/dmm.012435.
43. Collino M, Pini A, Mugelli N, et al. Beneficial effect of prolonged heme oxygenase 1 activation in a rat model of chronic heart failure.Dis Model Mech. 2013; 6(4): 1012-1020. doi: 10.1242/dmm.011528.
44. Coldewey SM, Khan AI, Kapoor A, et al. Erythropoietin attenuates acute kidney dysfunction in murine experimental sepsis by activation of the β-common receptor. Kidney Int. 2013; 84(3): 482-490. doi: 10.1038/ki.2013.118.
45. Benetti E, Chiazza F, Patel NS, Collino M. The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders. Mediators Inflamm. 2013; 2013: 678627. doi: 10.1155/2013/678627.
46. Benetti E, Mastrocola R, Rogazzo M, et al. High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice: A Protective Role for PPAR- δ Agonism. Mediators Inflamm. 2013; 2013: 509502. doi: 10.1155/2013/509502.
47. Collino M, Rogazzo M, Pini A, et al. Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury. J Cell Mol Med. 2013; 17: 1494-1505. doi: 10.1111/jcmm.12120.
48. Mastrocola R, Collino M, Rogazzo M, et al. Advanced glycation end products promote hepatosteatosis by interfering with SCAP-SREBP pathway in fructose-drinking mice. Am J Physiol Gastrointest Liver Physiol. 2013; 305: G398-G407. doi: 10.1152/ajpgi.00450.2012.
49. Collino M, Rudich A, Konrad D. Mediators of interorgan crosstalk in metabolic inflammation.Mediators Inflamm. 2013; 2013: 609096. doi: 10.1155/2013/646271.