Markandeya Jois, BVSc, MVSc, PhD


Head, Department of Agricultural Sciences and School of Life Sciences
Faculty of Science, Technology and Engineering
La Trobe University, Bundoora, Victoria, 3086
Australia

Biography

Dr. Markandeya Jois graduated B.V.Sc. from the University of Agricultural Sciences, Bangalore, India in 1979 and M.V.Sc. from the same University in 1982. He was awarded a PhD degree from the University of Sydney in 1986 for his work on amino acid metabolism in ruminants. Dr. Jois took up a position as Post-Doctoral Fellow in the Department of Biochemistry, Memorial University of Newfoundland, Canada in 1986 and was appointed Assistant Professor (Research) in the same department in 1989. He spent a year in the University of Melbourne as Research Fellow before joining the teaching staff at La Trobe in 1993. He held the position of Director, Central Animal House from 1997 to 2004. In 2012, he was appointed as the Head, Department of Agricultural Sciences.

Research Interest

His Research interests includes understanding the mechanisms by which diet influences gene expression and dietary interventions for the prevention, treatment and management of obesity, metabolic syndrome and type 2 diabetes.

Scientific Activities

Publications

Full papers published in refereed journals

1. Hafandi A, Begg DP, Premaratna SD, Sinclair AJ, Jois M, Weisinger RS. Dietary repletion with omega-3 fatty acid or with cox inhibition reverses cognitive effects in F3 fatty acid deficient mice. Comparative Medicine. 2014; 64: 106-109.
2. Cichello S, Wesinger RS, Schueijers J, Jois M. 1-Sarcosine-angiotensin II infusion effects on food intake, weight loss, energy expenditure and skeletal muscle UCP3 gene expression in a rat model. Journal of Cachexia Sarcopenia Skeletal Muscle. 2014. doi: 10.1007/s13539-014-0133-2
3. Cichello S, Begg DP, Jois M, Weisinger RS. Prevention of diet-induced obesity in C57BL/BJ mice with addition of 2 % green tea but not with cocoa or coffee to a high fat diet. Mediterr J Nutr Metab. 2013; 6: 233-238. doi: 10.1007/s12349-013-0137-z
4. Cichello S, Liu, Ping-Sheng, Jois M. The anti-obesity effects of EGCG in relation to oxidative stress and air-pollution in China. Nat.Product.Bioprospect. 2013. doi: 10.1007/s13659-013-0060-5
5. Samadi JM, Dunshea FR, Leury BJ. The beta(3)-adrenergic agonist BRL35135A improves feed efficiency and decreases visceral but not subcutaneous fat in lambs. Small Ruminant Research. 2013; 109(2-3): 128-132.
6. Premaratna SD, Manickam E, Begg DP, et al. Angiotensin-converting enzyme inhibition reverses diet-induced obesity, insulin resistance and inflammation in C57BL/6J mice. Int J Obesity. 2013; 36(2): 233-243. doi: 10.1038/ijo.2011.95
7. Samadi, Jois M, Dunshea FR, Leury BJ. The beta(3)-adrenergic agonist (BRL35135A) acutely increases oxygen consumption and plasma intermediate metabolites in sheep. Animal Production Science. 2011; 51 (10): 881-889. doi: http://dx.doi.org/10.1071/AN10019
8. Begg DP, Sinclair AJ, Stahl LA, et al. Hypertension induced by omega-3 polyunsaturated fatty acid deficiency is alleviated by alpha-linolenic acid regardless of dietary source. Hypertens Res. 2010; 33(8): 808-813. doi: 10.1038/hr.2010.84
9. Begg DP, Sinclair AJ, Stahl LA, Garg ML, Jois M, Weisinger RS. Dietary protein level interacts with omega-3 polyunsaturated fatty acid deficiency to induce hypertension. Am J Hypertens. 2010; 23(2): 125-128. doi: 10.1038/ajh.2009.198
10. Jia JJ, Tian YB, Cao ZH, et al. The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes. Mol Biol Rep. 2010; 37(3): 1513-1522. doi: 10.1007/s11033-009-9550-2
11. Chen N, Bezzina R, Hinch E, et al. Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. Nutr Res. 2009; 29(11):784-793. doi: 10.1016/j.nutres.2009.10.003
12. Weisinger RS, Begg DP, Jois M. Antagonists of the renin-angiotensin system and the prevention of obesity. Curr Opin Investig Drugs. 2009; 10(10): 1069-1077.
13. Weisinger RS, Stanley TK, Begg DP, Weisinger HS, Spark KJ, Jois M. Angiotensin converting enzyme inhibition lowers body weight and improves glucose tolerance in C57BL/6J mice maintained on a high fat diet. Physiol Behav. 2009 ; 98(1-2): 192-197. doi: 10.1016/j.physbeh.2009.05.009
14. Jia JJ, Zhang X, Ge CR, Jois M. The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism. obesity and diabetes Obes Rev. 2009; 10(5): 519-526. doi: 10.1111/j.1467-789X.2009.00569.x
15. Jayasooriya AP, Mathai ML, Walker LL, et al. Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance. Proc Natl Acad Sci U S A. 2008; 105(18): 6531-6. doi: 10.1073/pnas.0802690105
16. Weisinger RS, Begg DP, Chen N, Jois M, Mathai ML, Sinclair AJ. The problem of obesity: is there a role for antagonists of the renin-angiotensin system? Asia Pac J Clin Nutr. 2007; 16 Suppl(1): 359-367.
17. Gabler NK, Osrowska E, Imsic M, et al. Dietary onion intake as part of a typical high fat diet improves indices of cardiovascular health using the mixed sex pig model. Plant Foods Hum Nutr. 2006; 61(4): 179-185. doi: 10.1007/s11130-006-0030-8
18. Ostrowska E, Gabler NK, Sterling SJ, et al. Consumption of brown onions (Allium cepa var. cavalier and var. destiny) moderately modulates blood lipids, haematological and haemostatic variables in healthy pigs. Br J Nutr. 2004; 91(2): 211-218. doi: http://dx.doi.org/10.1079/BJN20031036
19. Mohamed Ali, A., Chandler, K, Jois M. Ovine gluconeogenesis from [2-14C]propionate in response to 24 h continuous infusion of glucagon. South African Journal of Animal Science . 1999; 29: 221-222.
20. Mabrouk G.M, Jois M, Brosnan JT. Cell signalling and the hormonal stimulation of hepatic glycine cleavage system by glucagon. Biochemical Journal. 1998; 330: 759-763.
21. Mohamed Ali A, Jois M. Uptake and metabolism of propionate in the liver isolated from sheep treated with glucagon. British Journal of Nutrition. 1997; 77: 783-793. doi: http://dx.doi.org/10.1079/BJN19970075
22. Samadi, Jois M, Dunshea FR, Leury BJ. Effect of a adrenergic agonist (BRL35135A) on growth and body composition of sheep. Proceedings of the Nutrition Society of Australia. 2000; 24: 77.
23. Power GN, Gannon, NJ, Jois M, Dunshea FR. Dietary fibre and protein source affect ileal endogenous flow in pigs fed commercial diets. Proceedings of the Nutrition Society of Australia . 2000; 24: 130.
24. Power GN, Jois M , Dunshea FR, Gannon NJ. Heat damage is not the main reason for low utilization of proteins in cottonseed meal. Proceedings of the Nutrition Society of Australia. 1998; 22: 56 .
25. Mohamed Ali A, Jois M. Transport of propionate in basolateral membrane vesicles of sheep liver. Proceedings of the Nutrition Society of Australia. 1997; 21: 120.
26. Kaicom S, Jois M, Pritchard JE, Wark JD, Leury BJ. Use of DXA for estimating changes in carcass composition of lambs given formaldehyde-treated sunflower meal and clenbuterol. Proceedings of the Nutrition Society of Australia. 1996; 20: 112.
27. Mohamed Ali A, Jois M. Transport and metabolism of propionate in isolated hepatocytes from sheep treated with glucagon. Proceedings of the Nutrition Society of Australia. 1996; 20: 185.
28. Jois M, Hall B, Rowlands K, Brosnan JT. Regulation of hepatic glycine catabolism by glucagon. J. Biol. Chem. 1989; 264: 3347-3351.
29. Jois M, Hall B, Brosnan JT. Stimulation of glycine catabolism in rat liver mitochondria by calcium mobilizing hormones and in isolated rat liver mitochondria by submicromolar concentrations of calcium. J. Biol. Chem. 1990; 265: 1246-8.
30. Jois M, EwartHS, Brosnan JT. Regulation of glycine catabolism in rat liver mitochondria. Biochem. J. 1992; 283: 435-439.
31. Jois M, Hall B ,Collett VM, Brosnan JT. Flux through glycine cleavage system in isolated hepatocytes: effects of glucagon, cAMP, and calcium. Biochem. Cell Biol. 1990; 68: 543-546.
32. Ewart HS , Jois M, Brosnan JT. Glycine cleavage system is stimulated in rat liver mitochondria by high protein diet. Biochem J. 1992; 283: 441-447.
33. Jois M, Brosnan JT. Hormonal regulation of hepatic glycine oxidation. Aust. J. Agric. Res. 1993; 44: 473-8.
34. Jois M, Hall DE, Brosnan JT. Serine synthesis by rat the kidney. Contr. Nephrol. 1988; 63: 136-140.
35. Brosnan, JT, Jois M, Hall B. Hormonal regulation of glycine metabolism. In Amino Acids. Chemistry, Biology and Medicine.ESCOM Publishers B.V. 1990.
36. Jois M, Smithard R, McDowell GH, Annison EF. Effects of growth hormone on amino acid exchanges in muscle tissue of growing calves. Proc. Nutr. Soc. Aust. 1985; 10: 92-95.
37. Jois M, Sampath SR. Utilization of spent ginger in the cattle ration. Indian J. Nutr. Dietetics. 1983; 20: 102-107.
38. Kaicom S, Hosking BJ, Leury BJ, Jois M. Effects of clenbuterol and neostigmine on growth, body composition and blood flow to splanchnic tissues and hindquarters of lambs. Proc. Nutr. Soc. Aust. 1994; 18: 172.
39. Leury BJ, Jois M, Hosking BJ, Egan AR. Portal blood flow and nutrient exchange in lambs maintained by total intragastric infusion. Proc. Nutr. Soc. Aust. 1994; 18: 171.
40. Jois M, Bunnage AP, Egan AR. Non-recirculating perfusion of isolated caudal lobe of sheep liver. XV International Congress of Nutrition, Adelaide. 1994; 147.
41. Jois M, Squires SA, Hall B, Brosnan JT. Hepatic oxidation of glycine in diabetes. XIV International Diabetes Federation Congress Satellite Symposium. 1991; 15.
42. Ewart HS, Jois M, Brosnan JT. Activation of amino acid metabolism following a single high protein meal. FASEB J. 1991; 4: A3124.
43. Jois M, Hall B, Rowlands K, Brosnan JT. Glucagon stimulates the glycine cleavage system in rat liver. FASEB J. 1988; 2: A1723.
44. Jois M, McDowell GH, Annison EF. Metabolism of glycyl-glycine in the hind limb of lambs. XXX meeting. Canadian Federation of Biological Sciences. 1987; PO74.
45. Jois M, McDowell GH, Annison EF. Effects of hormones on amino acids in blood draining leg muscle tissue of sheep. Proc Aust Soc Biochem. 1986; 18: 84.
46. Jois M, Mollah Y, Bryden WL. Effects of dietary protein on plasma amino acids in young chicks. Proc. Nutr. Soc. Aust. 1985; 10: 157.
47. Jois M, Gooden J M, Annison EF, McDowell GH. Effects of growth hormone on amino acid exchanges across muscle and mammary tissues of cattle. Proc XIII Int Congr Nutr. 1985; 27.
48. Leenanuruska D, Smithard R, McDowell GH, Gooden JM, Jois MNP. Effects of growth hormone on nutrient utilization and blood flow in muscle tissue of growing calves. Proc Nutr Soc Aust. 10: 152.
49. Jois M, Annison EF, Gooden JM, McDowell GH. Amino acid exchanges in muscle and mammary tissues of cows. Proc Nutr Soc Aust. 1984; 9: 162.
50. Jois M, McDowell G, Hand AEF. Exchanges of branched chain keto-acids across muscle and mammary tissues of lactating and non-lactating ewes. Proc Nutr Soc Aust. 1984; 9: 162.