Marcelo Mario Nociari, PhD

Assistant Professor
Department of Ophthalmology Cornell University
Medical School New York
New York, USA

Biography

EDUCATIONAL QUALIFICATIONS AND PROFESSIONAL EXPERIENCES

• Bachelor degree, Major in Chemistry. School of Chemistry. Buenos Aires Argentina (1987)
• Master in Science, Major in Biochemistry. University of Biuenos Aires. Argentina (1992)
• PhD Thesis: Molecular Epidemiology of Hospital Infections. University of Biuenos Aires, Argentina (1997)
• Post-doctoral Fellow, Laboratory of Immune senescence. Cornell University, USA (1997-2001)
• Post-doctoral Associate, Innate Immune to intracellular parasites. Cornell University, USA (2001-2005)
• Instructor of Immunology, Innate Immunity to adenovirus. Weill Cornell Medical College, USA (2005-2008)
• Research Assistant Professor, Innate Immunity to AAV vectors. Weill Cornell Medical College, USA (2008-2010)
• Research Assistant Professor, Modulation of Inflammatory response to Lipid Bisretinoids accumulation in RPE
• Assistant Professor, Development of therapeutic interventions in AMD. Weill Cornell, USA (2015-2016)

Research Interest

His research interests include: The study of retinal pathologies that result from the accumulation of lipid bisretinoids (LBs), i.e. dimers of vitamin A that can form spontaneously as subproducts of the visual cycle. LBs accumulate in the Retinal Pigment Epithelium (RPE) and can cause Stargardt Disease, Cone-Rode dystrophy, ABCA4-associated Retinitis Pigmentose and Age-related Macular Degeneration (AMD). He has been developing two complementary approaches to treat retinal diseases caused by LBs: (i) finding drugs that reduce LB deposits; (ii) Identifying drug targets within LB-elicited damaging cascades to prevent RPE dysfunction.

Scientific Activities

AWARDS

• (1989-1992), Graduate student fellowship from the National Research Council (CONICET), of Argentina
• (1992-1996), Research Fellow, Department of Microbiology, School of Medicine, UBA
• (1993), International Fellowship, Brazilian Center for Biotechnology
• (1992-1996), Teaching Assistant, Department of Biochemistry, University of Buenos Aires
• (1993), Advances in Epidemiology of Hospital Infections, Florencio Fiorini Award
• (2014-2016), Tri-Institutional Discovery Institute (TDI) Rodriguez-Boulan and Maxfield (PI), M. Nociari (CoPI)
• (2014-2015), Daedalus Innovator Award, WCMC. Rodriguez-Boulan and Maxfield (PI), Nociari (CoPI). 6/30/14 to 7/1/15
• (2016-2018), BrightFocus Foundation. M. Nociari (PI)
• (2012-2015), Clinical Translational Scientific Center Pilot Award
• (2002-2007), K01 Award, NIH NHLBI, NIH. M. Nociari (PI). E. Falck Pedersen (Mentor) 6/30/02 to 7/1/07

Publications

1. Nociari M, Lehmann G, Perez Bay A, et al. Beta cyclodextrins bind, stabilize and remove lipofuscin bisretinoids from retinal pigment epithelium. Proc Natl Acad Sci USA. 2014; 111(14): E1402-E1408. doi:
2. Nociari M, Ocheretina O, Murphy M, Falck-Pedersen E. Adenovirus induction of IRF3 occurs through a binary trigger targeting Jun N-terminal kinase and TBK1 kinase cascades and type I interferon autocrine signaling. J Virol. 2009; 83(9): 4081-4091. doi: 10.1128/JVI.02591-08
3. Almeida AS, Lago PM, Boechat N, et al. Tuberculosis is associated with a down-modulatory lung immune response that impairs Th1-type immunity. J Immunol. 2009; 183(1): 718-731. doi: 10.4049/jimmunol.0801212
4. Nociari M, Ocheretina O, Schoggins JW, Falck-Pedersen E. Sensing infection by adenovirus: Toll-like receptor-independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator. J Virol. 2007; 81(8): 4145-4157. doi: 10.1128/JVI.02685-06
5. Schoggins JW, Nociari M, Philpott N, Falck-Pedersen E. Influence of fiber detargeting on adenovirus-mediated innate and adaptive immune activation. J Virol. 2005; 79(18): 11627-11637. doi: 10.1128/JVI.79.18.11627-11637.2005
6. Philpott NJ, Nociari M, Elkon KB, Falck-Pedersen E. Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-alpha induction pathway. Proc Natl Acad Sci USA. 2004. 101(16): 6200-6205. doi: 10.1073/pnas.0308368101
7. Moldenhauer A, Nociari M, Lam G, Salama A, Rafii S, Moore MA. Tumor necrosis factor alpha-stimulated endothelium: An inducer of dendritic cell development from hematopoietic progenitors and myeloid leukemic cells. Stem Cells. 2004; 22(2): 144-157. doi: 10.1634/stemcells.22-2-144
8. Moldenhauer A, Nociari MM, Dias S, Lalezari P, Moore MA. Optimized culture conditions for the generation of dendritic cells from peripheral blood monocytes. Vox Sang. 2003. 84(3): 228-236. doi: 10.1046/j.1423-0410.2003.00283.x
9. Fontan PA, Pancholi V, Nociari MM, Fischetti VA. Antibodies to streptococcal surface enolase react with human alpha-enolase: implications in poststreptococcal sequelae. J Infect Dis. 2000; 182(6): 1712-1721. doi: 10.1086/317604
10. Nociari MM, Telford W, Russo C. Postthymic development of CD28-CD8+ T cell subset: Age-associated expansion and shift from memory to naive phenotype. J Immunol. 1999. 162(6): 3327-335. doi:
11. Nociari MM, Shalev A, Benias P, Russo C. A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity. J Immunol Methods. 1998; 213(2): 157-167. doi:
12. Trevani AS, Andonegui G, Giordano M, et al. Neutrophil apoptosis induced by proteolytic enzymes. Lab Invest. 1996; 74(3): 711-721. doi:
13. Nociari MM, Catalano M, Torrero M, Sordelli DO. Pseudomonas aeruginosa ribotyping: stability and interpretation of ribosomal operon restriction patterns. Diagn Microbiol Infect Dis. 1996. 25(1): 27-33. doi: 10.1016/0732-8893(96)00059-4
14. Nociari MM, Catalano M, Centron Garcia D, Copenhaver SC, Vasil ML, Sordelli DO. Comparative usefulness of ribotyping, exotoxin A genotyping, and SalI restriction fragment length polymorphism analysis for Pseudomonas aeruginosa lineage assessment. Diagn Microbiol Infect Dis. 1996; 24(4): 179-190. doi: 10.1016/0732-8893(96)00029-6
15. Garcia DC, Nociari MM, Sordelli DO, Di Martino A, Catalano M. The use of plasmid profile analysis and ribotyping for typing Acinetobacter baumannii isolates. J Hosp Infect. 1996. 34(2): 139-144. doi:
16. Amura CR, Fontan PA, Sanjuan N, Nociari MM, Buzzola FR, Sordelli DO. Tumor necrosis factor alpha plus interleukin 1 beta treatment protects granulocytopenic mice from Pseudomonas aeruginosa lung infection: Role of an unusual inflammatory response. Apmis. 1995; 103(6): 447-459. doi: 10.1111/j.1699-0463.1995.tb01131.x