Manoj K. Gupta, PhD

Research Scientist
Harvard Medical School
Joslin Diabetes Center
Boston, MA 02215, USA

Biography

Dr. Gupta obtained his PhD from University of Cologne, Germany and presently, he is working as a Research Scientist at Joslin Diabetes Center, Harvard Medical School, Boston. His research focuses on exploring the stem cells in the field of diabetes, obesity and metabolism.

Research Interest

His research interest includes: Growth hormone signaling in development, Diabetes and its related complications, Obesity and metabolism.

Scientific Activities

AWARDS AND HONORS

• (1990-1994) State level scholarships from 6th to 10th Class
• (2001-2003) Scholarship for pursuing Master’s Degree in Biotechnology by the Department of Biotechnology (DBT), Govt. of India
• (2002) Research fellowship from the Council of Industrial and Scientific Research-University Grant Commision (National Eligibility Test for Lectureship), (CSIR-UGC NET/JRF)
• (2003) Qualified for Graduate Aptitude Test in Engineering (GATE-2003) in Life Sciences with 97.87% percentile
• (2009) Best Poster presentation award in 5th International NRW meeting on Stem cell research in Aachen , Germany
• (2010) ISSCR travel grant award
• (2010) 1st Best Poster award in 5th Annual meeting of German Society for Stem Cell Research in Lübeck , Germany
• (2014) Seahorse travel Grant Award

MEMBERSHIPS

• Member, International Society for Stem Cell Research, ISSCR
• Member, German Society for Stem Cell Research, GSZ

Publications

1. Das A, Gupta MK, Saxena RK. Enhanced activation of mouse NK cells by IL-2 in the presence of circulating immune complexes. Curr. Sci. 2004; 87(6): 780-783.
2. Pfannkuche K, Fatima A, Gupta MK, Dieterich R, Hescheler J. Initial colony morphology-based selection for iPS cells derived from adult fibroblasts is substantially improved by temporary UTF1-based selection. PLOS One. 2010; 5(3): e9580. doi:10.1371/journal.pone.0009580
3. Gupta MK, Illich DJ, Gaarz A, et al. Global transcriptional profiles of beating clusters derived from human induced pluripotent stem cells and embryonic stem cells are highly similar. BMC Dev. Biology. 2010, 10: 98. doi:10.1186/1471-213X-10-98
4. Shao K, Koch C, Gupta MK, et al. Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles. Mol Therapy. 2013; 21(1): 240-250. doi:10.1038/mt.2012.207
5. Nguemo F, Fleischmann BK, Gupta MK, et al. The L-type Ca2+ channels blocker nifedipine represses mesodermal fate determination in murine embryonic stem cells. PLOS One. 2013; 8(1): e53407. doi:10.1371/journal.pone.0053407
6. Fatima A, Kaifeng S, Dittmann S, et al. The disease-specific phenotype in cardiomyocytes derived from induced pluripotent stem cells of two long QT syndrome type 3 patients. PLOS One. 2013; 8(12): e83005. doi:10.1371/journal.pone.0083005
7. Gupta MK, Rao TN. Hearty miR-363 controls HAND1 in cardiac cell specification. Stem Cell Res Ther. 2014; 5(4): 89. doi:10.1186/scrt478
8. Rao TN, Marks-Bluth J, Sullivan J, et al. High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice. Stem Cell Research. 2015; 14(3): 307-322. doi:10.1016/j.scr.2015.02.001
9. Gupta MK, Teo AK, Rao TN et al. Excessive Cellular proliferation negatively impacts reprogramming efficiency of human fibroblasts. Stem Cell Trans Med. 2015. doi:10.5966/sctm.2014-0217
10. Bhatt S, Gupta MK, Martinez R, et al. Preserved DNA repair pathway protects from complications in long standing type 1 diabetes. Cell Metabolism. 2015; 22(2): 239-252. doi:10.1016/j.cmet.2015.07.015.

BOOK CHAPTER

1. Šarić T, Frenzel LP, Fatima A, Gupta MK, Hescheler J. Embryonic stem cells, cardiomyoplasty and the risk of teratoma formation. In: Bharavand H, ed. Trends in Stem cell. Biology and Technology. 2009; 229-260.