Lorna R. Fiedler, PhD

Research Fellow
Program in Cardiovascular and Metabolic Disorders
Duke-NUS Graduate Medical School Singapore
8 College Road
169857, Singapore

Biography

Dr. Fiedler has 12 years experience in the cardiovascular field (specifically in cell biology, therapeutics and protein biochemistry) in both an academic and industrial environment. Following 2 years working for a small biotechnology company in Cambridge (cell signalling and complement therapeutics, 2001-2003) she studied for a PhD in extracellular matrix biology signalling and angiogenesis at Cardiff University (2003-2007). She continued to investigate the molecular and cellular mechanisms underlying cardiovascular disease in an academic environment (Cardiff University, UCL and Imperial College London, with secondments in Cambridge and Germany), which has recently led to initiation of a drug discovery programme in collaboration with industrial partners at MRC-Technology and Domainex. Her international reputation and visibility is increasing through regular selection to present at national, international conferences and internal seminars and is reflected in invitations for conference participation and to serve on editorial boards. Her work has also been recognised by a number of awards (for oral and poster presentations), most recently at the BSCR meeting in Reading this year (best poster prize). In addition, in 2013 she was invited to edit a book (Springer publications) and since 2010, have been listed in Whos Who.

Research Interest

Her research interests include: Exploring the role of STE20 MAP4 kinases in cardiovascular pathology, Molecular basis of cell death, metabolism and autophagy in the heart and Molecular imaging of these processes in situ, using state of the art imaging technologies.
Her research explores the basic signalling mechanisms that underlie cardiovascular disease. Underpinning this, her research uses multiscale of murine and human model systems to provide a firm basis for validation and improved translational potential. Her aim is to identify novel targets for target based drug discovery, or those shared by diverse disease etiologies to utilise existing therapies in alternative indications.

Scientific Activities

PRIZES AND AWARDS

• (2014) First prize, poster at BSCR Autumn Meeting
• (2010-current) Listed in Whos Who
• (2008) Conference Reporter Bursary, British Society for Matrix Biology (BSMB), York, UK (2008, £125)
• (2006) Federation of European Connective Tissue Societies (FECTS), Oulu, Finland (2006)
• (2006) British Society for Matrix Biology (BSMB), Newcastle, UK (2006, £125)
• (2005) British Society for Matrix Biology (BSMB), Manchester, UK (2005, £125)
• (2005) International Association for Dental Research (IADR), Dundee, UK (2005, £150)
• (2005) Cardiff Institute for Tissue Engineering and Repair (CITER), Camarthan, UK (2005, £50)
• (2004) Cardiff Institute for Tissue Engineering and Repair (CITER), Swansea, UK (2004, £50)
• (2001) MAD (Made A Difference) Award, Adprotech (2001, £250)

PROFESSIONAL BODY MEMBERSHIP

• International Society for Heart Research (ISHR)
• European Society Cardiology (ESC) cellular biology of the heart and myocardial function working groups
• British Society for Cardiovascular Research (BSCR)
• Biochemical Society
• Pharmacological Society

Publications

1. Fiedler LR. Methods in Molecular Biology Series: VEGF Signaling, Editor. Springer Protocols, Humana Press, 2015: 1332.
2. Fiedler LR. Cardiovascular research:past, present and future. Heart Res Open J. 2015; 2(2): 70-81.
3. Fiedler LR, Maifoshie E, Schneider MD. Mouse Models of Heart Failure: Cell Signaling and Cell Survival. Mouse models of Developmental Genetic Disease. In: Stewart C, ed. Elsevier. 2014.
4. Stuckey DJ, McSweeney SJ, Thin MZ, et al. T1 Mapping Detects Pharmacological Retardation of Diffuse Cardiac Fibrosis in Mouse Pressure-overload Hypertrophy. CircCardiovasc Imaging. 2014; 7(2): 240-298. doi: 10.1161/CIRCIMAGING.113.000993
5. Fiedler LR, Wojciak-Stothard B. The DDAH/ADMA pathway in the control of endothelial cell migration and angiogenesis. Biochem Soc Trans. 2009; 37(6): 1243-1247.doi: 10.1042/BST0371243
6. Fiedler LR. Rac1 regulates cardiovascular development and postnatal function of endothelium. Cell Adhesion and Migration. 2009; 3(2): 143-145.
7. Fiedler LR. The DDAH/ADMA pathway is a critical regulator of NO signalling in vascular homeostasis. Cell Adhesion and Migration. 2009; 2(3): 149-150.
8. Fiedler LR, Bachetti T, Leiper J, et al. The ADMA/DDAH Pathway Regulates VEGF-mediated Angiogenesis. ArterioScler Thromb Vasc Biol. 2009; 29: 2117-2124. doi: 10.1161/ATVBAHA.109.194035
9. Fiedler LR, Eble JA. Invited Commentary: Decorin Regulates Endothelial Cell-Matrix Interactions During Angiogenesis. Cell Adhesion and Migration. 2009; 3(1): 3-6.
10. Fiedler LR, Schönherr E, Waddington R, et al. Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of α2β1 integrin activity. J Biol Chem. 2008; 283(25): 17406-17415. doi: 10.1074/jbc.M710025200