Lisa Beth Spiryda, MD, PhD

Chair and Professor of the Department of Obstetrics and Gynecology
University of South Alabama, College of Medicine
307 N. University Blvd. #130, Mobile, AL 36688


Dr. Spiryda received a BA in Biochemistry with Honors from Barnard College, Columbia University and a PhD in Cell Biology and Anatomy/Biomedical Sciences and MD from Mount Sinai School of Medicine. She completed her residency in Obstetrics and Gynecology at Brigham and Women’s Hospital/Massachusetts Hospital Integrated Residency Program at Harvard University.
After 3 years of private practice in Rhinebeck, New York, Dr. Spiryda was recruited by University of South Carolina, School of Medicine through the Centenary Program to start-up and direct a translational research program on Biomarkers in Human Papillomavirus, Cervical dysplasia and cancer in 2007. She was an Assistant Professor in Obstetrics and Gynecology and held joint appointments in Women’s Studies Program and Pathology, Microbiology and Immunology departments. Dr. Spiryda served as Director of the Research Division and Resident/Student Research, and Director of Colposcopy.
In August 2013, Dr. Spiryda joined the faculty at University of Florida, College of Medicine in the Department of OB/GYN as an Associate Professor. She serves as Director of Resident Research, Director of Colposcopy, and Chair of the Residency Clinical Competency Committee. Dr. Spiryda directs the Translational Research Program in HPV and cervical dysplasia pursuing biomarkers involved with earlier detection of precancerous lesions and new treatment modalities for premalignant cervical disease. Dr. Spiryda has several ongoing clinical studies involving hysterectomy routes, breastfeeding, health disparities in women’s health including minimally invasive surgery techniques. She is currently a member of the Education Committee for the American Society of Colposcopy and Cervical Pathology (ASCCP).
In addition to her active translational and clinical research programs and teaching responsibilities, Dr. Spiryda has been a Board Certified OB/GYN since 2005 and maintains a large clinical practice encompassing the full spectrum of obstetrics and gynecology. Her special clinical interests include: minimally invasive surgical techniques (da Vinci robotic surgery, advanced laparoscopy and hysteroscopy), abnormal PAP tests, vulvar disease, adolescent gynecology, and family-oriented obstetrics. She belongs to the following professional societies: American College of Obstetrics and Gynecology, American Association of Gynecologic Laparoscopists, American Society of Colposcopy and Cervical Pathology and Association of Professors of Gynecology and Obstetrics.
Dr. Spiryda has published and presented nationally and internationally on a wide variety of topics in Women’s Health including: Trends in routes of Hysterectomy, Health disparities in minimally invasive surgery, HPV /cervical dysplasia/abnormal Pap tests and Health disparities in Breastfeeding, Obesity and Pregnancy outcomes and Graft versus Host disease in female genital organs and vulvar disease. She has mentored over 45 undergraduate, graduate, medical students, and resident physicians.
Dr. Spiryda has received multiple grants and awards for her research from local and national funding sources (USC, NIH, March of Dimes). She is currently the PI for a grant from National Institutes of Health/NCI/Center to Reduce Cancer Health Disparities, and was a co-investigator on a center grant from National Institutes of Health/National Center on Minority Health/ Health Disparities. In 2013, Dr. Spiryda received the American College of Obstetricians and Gynecologists/Hologic Research Fellowship in Cervical Cancer Detection.

Research Interest

Her research interests includes: Trends in Routes of Hysterectomy, Trends in Minimally Invasive Surgery (robotic surgery, hysteroscopy, advanced laparoscopy), Health disparities in Minimally Invasive Surgical techniques for hysterectomy, Molecular biomarkers (cell adhesion proteins, immune markers) and Human Papillomavirus, Cervical dysplasia and cancer, Health disparities in Women’s Health (breastfeeding, birth outcomes).

Scientific Activities


• April 2014 The George C. Trombetta, MD Teaching Award (ASCCP)
• (Mentor: LB Spiryda) Medical Students: Anna Handley (M Gywnne)
• Oral abstract presentation, “Outcomes of the Cervix Project: Increasing
Knowledge, Attitudes, and Practices of University of South Carolina
• Undergraduates Regarding HPV, Screening for HPV, and Vaccination against HPV”
• 2014 Biennial Meeting ASCCP Scottsdale, Arizona
• June 2014 Certificate of Recognition, Participation and Achievement in Medical Student Education for 2013 -2014, UF College of Medicine


• Fellow, American College of Obstetrics and Gynecology
• Member, American Association of Gynecologic Laparoscopists
• Member, Association of Professors of Gynecology and Obstetrics
• Member, American Society for Colposcopy and Cervical Pathology
• Member, International Papillomavirus Society
• Member, Alachua County Medical Society


Original Research Articles

1. Spiryda LB. Do you know Mary? A story of Anorexia Nervosa and Bulimia. Barnard College Health Bulletin. 1989; 1(1): 2-3.
2. Beach MC, Morley J, Spiryda L, Weinstock SB. Effects of liposome encapsulated hemoglobin on the reticuloendothelial system. Biomater Artif Cells Immobilization Biotechnol. 1992; 20(2-4): 771-776.
3. Spiryda LB, Colman DR. Protein zero, a myelin IgCAM, induces physiologically operative tight junctions in nonadhesive carcinoma cells. J Neuro Res. 1998; 54(2): 282-288.
4. Spiryda LB, Colman DR. Suppression of tumorigenicity in an aggressive cervical carcinoma induced by protein zero, a nervous system IgCAM. J Cell Sci. 1998; 111(22): 3253-3560.
5. Spiryda LB. Induction of epithelialization and suppression of tumorigenicity in an aggressive carcinoma by protein zero, a nervous system IgCAM. Doctoral Dissertation MSSM UMI. 1998; 5.
6. Norwitz ER. Xu S, Xu J, et al. Direct binding of AP-1 (Fos/Jun) proteins to a SMAD binding element facilitates both gonadotropin-releasing hormone (GnRH) – and activin-mediated transcriptional activation of the mouse GnRH receptor gene. J Biol Chem. 2002; 277: 37469-37478.
7. Spiryda LB, Laufer MR, Soiffer RJ, Antin JA. Graft-Versus Host Disease of the Vulva and Vagina: Diagnosis and Treatment. Biology of Blood and Marrow Transplantation. 2003; 9(12): 760-766. doi:
8. Spiryda LB, Fuller AF, Goodman A. Aggressive Locally Recurrent Vulva Cancer: review of cases presented to Massachusetts General Hospital 1990 to present. Internl Jl of Gyneologic Oncology . 2005; 15(5): 884-889.
9. Spiryda LB, Brown M, Creek KE, Pirisi L. HSIL PAP test and risk factors predicting acquisition of CIN 2/3 on colposcopy-directed biopsies. J SCMA. 2009; 105(7): 281-289.
10. Wigfall L, Rawls A, Sebastian N, et al. HPV high risk and protective behaviors: The effects of religious affiliation. Journal of Religion and Health. 2011; 1-12. doi: 10.1007/s10943-010-9444-6
11. Boggs EW, Burgis JT, Spiryda LB. Keratinizing squamous dysplasia Pap test: A case for colposcopy. Journal of Lower Genital Tract Disease. 2012; 16(1): 30-33. doi: 10.1097/LGT.0b013e31822d3846
12. Banister CE, Messersmith AR, Chakroborty H, et al. HPV prevalence at enrollment and baseline results from the Carolina Womens Care Study, a longitudinal study of HPV persistence in college-age women. International J Womens Health. 2013; 5: 379-388. doi:
13. Banister C, Messersmith AR, Spiryda LB, Glover S, Pirisi L, Creek KE. Increased risk of persistent human papillomavirus infection and abnormal Pap tests in African American compared to European American women in a college-age cohort. Journal of Infectious Disease. 2014.
14. Lenhard M, Zhang HM, Cao J, Spiryda LB. Factors Influencing the Decision to Breastfeed by Mothers in a Southern Womens Health Clinic. Womens Health, Issues and Care. 2014.
15. Emery J, Marcus BJ, Spiryda LB. Sarcoidosis of the cervix: an unusual case presentation. Genital System & Disorders. 2014.
16. McLeod JB, Cao J, Spiryda LB. Introduction of laparoscopic hysterectomy approach: decreasing the abdominal hysterectomy approach or replacing vaginal hysterectomy. Surg Res Open J. 2015; 2(1): 36-42. doi: 10.17140/SROJ-2-107