Ling Chen, BM, MMed, MD


Assistant Professor
Departments of Physiology and Medicine
Director, Physiological Genotyping Core
University of Maryland School of Medicine
685 West Baltimore St, MSTF 816
Baltimore, MD 21201, USA

Biography

Dr. Ling Chen is Assistant Professor of Physiology and Medicine at the University of Maryland School of Medicine. His research is focused on integrative and molecular mechanisms of cardiovascular injury following to intermittent hypoxia, post-infarct remodeling, and salt-sensitive hypertension. He is directing the Physiological Genotyping Core for the School, which provides cutting-edge services focusing on cardiorespiratory models and in vivo measurements.

Research Interest

His research is focused on integrative and molecular mechanisms of cardiovascular injury following to intermittent hypoxia, post-infarct remodeling, and salt-sensitive hypertension; Cardio-respiratory models and in vivo measurements.

Scientific Activities

INSTITUTIONAL SERVICE
Since 2003, he had provided consultations to UMB investigators on development and preparation of Institutional Animal Care and Use protocols in the area of in vivo cardiorespiratory models and measurements. Currently, He is named as a co-investigator in 10 active UMB protocols.

INVITED SPEECHES
1. American Thoracic Society 1997 International Conference. Title: “Role of sympathoadrenal activation in acute hemodynamic response to simulated central apnea in sedated pigs”. 1997, San Francisco, CA
2. Physiology Seminar, Department of Physiology, University of Maryland, Baltimore. April 27, 2006. Title: “Sodium Hydrogen Exchanger-1 and Left Ventricular Function in Chronic Intermittent Hypoxia”
3. New Horizons in Sleep II, University of Maryland School of Medicine. Title: “Cardiac hypertrophy in animal model of sleep apnea”. June 9, 2006
4. Telemetry Educational Symposium, Data Sciences International, Inc and the University of Maryland School of Medicine. Title: “Cardiovascular response to chronic intermittent hypoxia in mice”. May 24, 2006
5. Seminar Series, the Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine. Title: “Na/H exchanger-1 and cardiac function in chronic intermittent hypoxia”. October 18, 2006
6. American Thoracic Society 2006 International Conference. Title: “Chronic intermittent hypoxia upregulates myocardial expression of sodium hydrogen exchanger-1 in rats”. San Diego, CA. May 19-24, 2006
7. Seminar at the Cardiovascular Laboratories, Renmin Hospital, Wuan University School of Medicine, Wuhan, China. Oct 28, 2008. Title: “Cardiac injury of chronic intermittent hypoxia”.
8. Mini-symposium, Changzheng Hospital, Second Military Medical University, Shanghai, China. “Cardiovascular consequence of obstructive sleep apnea”. November 3, 2008
9. Frontier in Heart Research, Second Military Medical University, Shanghai, China. Title: “Na+/H+ exchanger-1 pathway and cardiac injury in chronic intermittent hypoxia”. Aug 3, 2009
10. Physiology Seminar. Department of Physiology, University of Maryland School of Medicine. Title: “Cardiac injury in chronic intermittent hypoxia”, June 10, 2010.
11. Pulmonary Seminar. Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine. Title: “Na+/Ca2+ exchanger-1 and cardiac injury in chronic intermittent hypoxia”. Oct 22, 2010
The High Blood Pressure Research 2013 Scientific Sessions, American Heart Association. Title: “Blood pressure correlates directly with the expression level of high ouabain affinity α2 Na+ pumps in arterial smooth muscle”, Sept 11-14, 2013, New Orleans.
12. The council meeting of University of Maryland School of Medicine. Title: “Cardiovascular effects of chronic intermittent hypoxia”. March 26, 2014

Publications

1. Chen L, Deng K, Ye Y, Luo W, Zhao J, Sheng M. Effects of ipratropium bromide and its combination with salbutamol sulphate on acute asthmatics. Chin J Intern Med. 1989; 28: 657-666.
2. Chen L, Lin B. Neuropeptides in the respiratory system. Trends Nat Foreign Med Sci. 1992; 7: 131-138. doi: 10.1164/ajrccm/144.5.1187
3. Chen L, Luo W. Plasma endothelin-1 and pulmonary hemodynamic at pre- and post-exercise in chronic obstructive pulmonary disease. Chin J Tubercul Respir Dis. 1996; 19: 212-215.
4. Sun R, Luo W, Chen L. Plasma endothelin-1 and its clinical evaluation in asthma. Chin J Tubercul Respir Dis. 1995; 18: 193-195.
5. Scharf SM, Chen L, Slamowitz D, Rao PS. Effects of continuous positive airway pressure on cardiac output and plasma norepinephrine in sedated pigs. J Crit Care. 1996; 11(2): 57-64. doi: 10.1016/S0883-9441(96)90021-0
6. Cohen RI, Chen L, Scharf SM. The effects of high dose NG-nitro-L-arginine-methyl ester on myocardial blood flow and left ventricular function in dogs. J Crit Care. 1996; 11(4): 206-213.
7. Chen L, Scharf SM. Comparative hemodynamic effects of periodic obstructive and simulated central apneas in sedated pigs. J Appl Physiol. 1997; 83(2): 485-494.
8. Tarasiuk A, Chen L, Scharf SM. Effects of periodic obstructive apnoeas on superior and inferior venous return in dogs. Acta Physiol Scand. 1997; 161(2): 187-194. doi: 10.1046/j.1365-201X.1997.00208.x
9. Sofer S, Cohen R, Shapir Y, Chen L, Colon A, Scharf SM. Scorpion venom leads to gastrointestinal ischemia despite increased oxygen delivery in pigs. Crit Care Med. 1997; 25(5): 834-840.
10. Chen L, Sica AL, Greenberg H, Scharf SM. Role of hypoxemia and hypercapnia in acute cardiovascular response to periodic apneas in sedated pigs. Respir Physiol. 1998; 111(3): 257-269. doi: 10.1016/S0034-5687(98)00007-3
11. Chen L, Scharf SM. Systemic and myocardial hemodynamics during periodic obstructive apneas in sedated pigs. J Appl Physiol. 1998; 84(4): 1289-1298.
12. Cohen RI, Shapir Y, Chen L, Scharf SM. Right ventricular overload causes the decrease in cardiac output after nitric oxide synthesis inhibition in endotoxemia. Crit Care Med. 1998; 26(4): 738-747. doi: 10.1097/00003246-199804000-00026
13. Slamowitz D, Chen L, Scharf SM. Effects of vagotomy on cardiovascular response to periodic apneas in sedated pigs. J Appl Physiol. 1999; 86(6): 1890-1896.
14. Chen L, Sica AL, Scharf SM. Mechanisms of acute cardiovascular response to periodic apneas in sedated pigs. J Appl Physiol. 1999; 86(4): 1236-1246.
15. Chen L, Shi Q, Scharf SM. Hemodynamic effects of periodic obstructive apneas in sedated pigs with congestive heart failure. J Appl Physiol. 2000; 88(3): 1051-1060.
16. Chen L, Scharf SM. Effects of aortic nerve on hemodynamic response to obstructive apnea in sedated pigs. J Appl Physiol. 2000; 89(4): 1455-1461.
17. Chen L, Gan XT, Haist JV, et al. Attenuation of compensatory right ventricular hypertrophy and heart failure following monocrotaline-induced pulmonary vascular injury by the Na+-H+ exchange inhibitor cariporide. J Pharmacol Exp Ther. 2001; 298(2): 469-476.
18. Rojas A, Chen L, Bartlett RH, Arenas JD. Assessment of liver function during extracorporeal membrane oxygenation in the non-heart beating donor swine. Transplant Proc. 2004; 36(5): 1268-1270. doi: 10.1016/j.transproceed.2004.05.011
19. Chen L, Chen CX, Gan XT, Beier N, Scholz W, Karmazyn M. Inhibition and reversal of myocardial infarction-induced hypertrophy and heart failure by NHE-1 inhibition. Am J Physiol Heart Circ Physiol. 2004; 286(1): H381-H387. doi: 10.1152/ajpheart.00602.2003
20. Chen L, Einbinder E, Zhang Q, Balke CW, Hasday J, Scharf SM. Oxidative Stress and Left Ventricular Function with Chronic Intermittent Hypoxia in Rats. Am J Respir Crit Care Med. 2005; 172(7): 915-920. doi: 10.1164/rccm.200504-560OC
21. Zhang J, Lee MY, Cavalli M, et al. Sodium pump alpha-2 subunits, arterial myogenic tone and pathogenesis of hypertension. J Physiol. 2005; 569(1): 243-256.
22. Blaustein MP, Zhang J, Chen L, Hamilton BP. How does salt retention raise blood pressure? Am J Physio. Reg Int Comp Physiol. 2006; 290(3): R514-R523. doi: 10.1152/ajpregu.00819.2005
23. Chen-Izu Y, Chen L, Banyasz T, et al. Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development. Am J Physiol Heart Circ Physiol. 2007; 293: H3301-H3310. doi: 10.1152/ajpheart.00259.2007
24. Chen L, Zhang J, Gan T, et al. Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia. J Appl Physiol. 2008; 104: 218-223. doi: 10.1152/japplphysiol.00301.2007
25. Blaustein MP, Zhang J, Chen L, et al. CHBPR: Novartis award for hypertension research – the pump, the exchanger and endogenous ouabain: signaling mechanisms that link salt retention to hypertension. Hypertension. 2009; 53(2): 291-298.
26. Williams AL, Chen L, Scharf SM. Effects of allopurinol on cardiac function and oxidant stress in chronic intermittent hypoxia. Sleep Breath. 2009; 14(1): 51-57. doi: 10.1007/s11325-009-0279-x
27. Zhang J, CY Ren, Chen L, et al. Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current, and lowers blood pressure. Am J Physiol Heart Circ Physiol. 2010; 298(5): H1472-H1483. doi: 10.1152/ajpheart.00964.2009
28. Zhang J, Chen L, Raina H, Blaustein MP, Wier WG. In vivo measurement of arterial pressure, [Ca2+] and MLCK activation in FRET-based biosensor mice. Am J Physiol Heart Circ Physiol. 2010; 299(3): H946-H956.
29. Chen L, J Zhang, Philipson KD, Scharf SM. Cardiac specific Na/Ca exchanger-1 knockout attenuates cardiac injury in chronic intermittent hypoxia. J Appl Physiol. 2010; 109: 1675-1685.
30. Xu KY, Zhu W, Chen L, et al. Mechanistic distinction between activation and inhibition of Na+-K+-ATPase-mediated Ca2+ influx in cardiomyocyte. Biochem Biophys Res Com. 2011; 406(2): 200-203.
31. Yakovlev S, Gao Y, Cao C, et al. Interaction of fibrin with VE-cadherin and anti-inflammatory effect of fibrin-derived fragments. J Thromb Haemost. 2011; 9(9): 1847-1855. doi: 10.1111/j.1538-7836.2011.04438.x
32. Sakoda Y, Anand S, Zhao Y, et al. Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice. J Clin Invest. 2011; 121(12): 4810-4819. doi: 10.1172/JCI57332
33. Blaustein MP, Leenen FH, Chen L, et al. How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension. Am J Physiol Heart Circ Physiol. 2012; 302(5): H1031-H1049. doi: 10.1152/ajpheart.00899.2011
34. Muratoglu SC, Belgrave S, Hampton B, et al. LRP1 protects the vasculature by regulating levels of Connective Tissue Growth Factor and HtrA1. Arterioscl Thromb Vasc Biol. 2013; 33(9): 2137-2146. doi: 10.1161/ATVBAHA.113.301893
35. Wang Y, Chen L, Wier WG, Zhang J. Intravital FRET imaging reveals elevated [Ca2+]i and enhanced sympathetic tone in femoral arteries of angiotensin II-infused hypertensive biosensor mice. J Physiol. 2013; 591(21): 5321-5336. doi: 10.1113/jphysiol.2013.257808