Lambda Cyhalothrin Elicited Dose Response Toxicity on Haematological, Hepatic, Gonadal and Lipid Metabolic Biomarkers in Rat and Possible Modulatory Role of Taurine.
Elevated ovarian cholesterol and MDA and reduced 3β hydroxy steroid dehydrogenase (HSD) and GSH level were also observed in lambda cyhalothrin exposed female rat at the dose level of 6.29 mg/kg body wt. (1/9th LD50). LCT caused increase in serum triglyceride, cholesterol, low density lipoproteins (LDL), very low density lipoproteins (VLDL) and bilirubin and decrease in serum high density lipoproteins (HDL) in female rat. Taurine pretreatment ameliorated LCT induced altered lipid metabolic biomarkers in female rat.
Hemato-biochemical studies are important for the analysis of the functional status of animals
to suspected toxic agents. It may act as a strong evidence against toxicity of contaminated pyrethroid insecticides. Recent reports have clarified that exposure to pyrethroid leads to a significant modifications in hematological findings. On the other hand the liver is the first organ encountered when toxicants enter into the body.
A large number of man-made chemicals such as pesticides stated to produce liver damage.5
Several investigations also reported that pesticides adversely affect the testicular functions in experimental animals6-9 as well as they are potent endocrine disrupters. Pesticides are responsible for oxidative stress that causes free radicals generation, leading to deoxyribonucleic acid (DNA)
fragmentation.
Taurine, a free intracellular sulfonated beta amino acid, is present in many animal tissues especially muscle, brain, liver, heart, etc. Taurine takes part in bile acid conjugation, detoxification, osmoregulation and modulation of cellular calcium level.
Toxicol Forensic Med Open J. 2016; 1(2): 42-51. doi: 10.17140/TFMOJ-1-107
