Krzysztof Laudanski, MD

Assistant Professor
Department of Anesthesiology and Critical Care
University of Pennsylvania
Philadelphia, PA 19104, USA

Biography

EDUCATIONAL QUALIFICATIONS

• (06/1998) MD, Medicine, Warsaw Medical University, Warsaw, Poland
• (06/2001) MA, Psychology, Warsaw University, Warsaw, Poland
• (06/2006) PGY-1, Internal Medicine, Griffin Hospital, New Derby, CT, USA
• (06/2009) CA1-CA3, Anesthesiology, University of Florida, Gainesville FL, USA
• (06/2010) Fellowship, Critical Care, Beth Israel Deaconess Hospital, Boston MA, USA
• (10/2012) PhD, Anesthesiology and Immunology, Military Medical Institute, Warsaw, Poland

PROFESSIONAL EXPERIENCES

• (Since 2012) Assistant Professor, Department Anesthesiology and Critical Care, University of Pennsylvania
• (2010-2012) Instructor, Department Anesthesiology and Critical Care, University of Pennsylvania
• (2009-2012) Consultant, Matrix Anesthesia, Brockton Hospital
• (2009-2010) Fellow, Department of Anesthesiology, BIDMC, Harvard Medical School
• (2006-2009) Resident, Department of Anesthesiology, University of Florida
• (2005-2006) Intern, Griffin Hospital, Yale Medical School
• (2003-2005) Instructor, Stress, Trauma and Immune Response Lab, University of Rochester
• (2001-2003) Senior Post-Doc Fellow, Stress, Trauma and Immune Response Lab, University of Rochester
• (1999-2000) Post-Doc Fellow, Department of Surgery, University of Massachusetts Medical School
• (2002) Associate Researcher, Nephrology Department, Teaching Hospital of Polish Army
• (1998-1999) Intern,Teaching Hospital of Polish Army
• (1996-1999) Associate Researcher, Medical University of Warsaw

Research Interest

His sepsis research focuses on the long-term outcome of the severe stress and pathomechanism leading to short and long-term aberrancies of the immune system. More specifically, he focuses on the development of the dendritic cells from monocytes during severe stress and development of T-cell anergy. One of the leading hypothesize is that in some patients the development of naïve monocytes is skewed toward macrophages. This is leading to immunoparalysis due to the depletion of the dendritic cells pool followed by other abnormalities of the immune system cells and end-organ damage. He is also interested in analyzing interaction between immune system components and neuronal system. In his research, he utilizes the animal and humanized models of sepsis as well as sampling of the population of patients. His lab utilizes molecular and translational biology techniques which are firmly established in clinical setting. His research focuses on patient undergoing hip replacement surgery and cardiopulmonary patients as well as ICU patient suffering from sepsis. Additionally, he study the effect of anesthetic on the acquired immunity in vitro. He have strong interest in global health, with the focus on training and education of health care providers in underdeveloped countries. The research in that field involved studying the effect of medical mission on the six axes of competency of US graduates. Finally, he his interested in the outcome of the long-term psychological stress in hosts of medical condition. More specifically, he focus his attention on perception of disease and denial among patient undergoing dialysis.

Scientific Activities

PROFESSIONAL MEMBERSHIPS

• (2012-2017) Critical Care Medicine Question Author for the ABA
• (10/2011) Medical mission. Teaching Hospital. Umthata. South Africa
• (2011-2014) The Shock Society
• (Since 2010) Member of the Editorial Board. Journal of Anesthesia & Clinical Research
• (10/2010) Medical mission. Trauma Teaching Hospital. Ho Chi Minh City, Vietnam
• (Since 2009) International Anesthesiology Research Society
• (Since 2009) The Society for Critical Care Medicine-Member (Since 2009), Chair of In-Training Section (2010-2012)-Member at Large for the In-Training section (Since 2012), Member at Large of Post-Graduate Education Committee (2012-2017)
• (2008-2012) Health Volunteers Overseas
• (Since 2006) American Association of Anesthesiologist
• (2005-2006) American Medical Association
• (Since 2003) American Association of Immunology
• (Since 2000) Worcester Institute for Student Exchange

AWARDS AND HONORS

• (2015) 1st Prize for Best Abstract in Professional Development, Society of Critical Care Medicine
• (2015) 1st Prize/Kosaka Award for Best Abstract, International Anesthesiology Research Society
• (2014) Vision Grant, Society of Critical Care Medicine
• (2013) Society for Critical Care Medicine, Presidential Citation
• (2006) Best Intern Award, Griffin Hospital
• (2004) Travel Award, International Endotoxin Society
• (2003) Travel Award, Society of Leukocyte Biology
• (1999-2001) Scholarship of the Ministry of Education Republic of Poland for Outstanding Students
• (1998) Diploma Doctor of Medicine summa cum laude
• (1998) Award for Research Merit. Students Scientific Society of Medical University of Warsaw
• (1996) Scholarship of the Batory Foundation, the Polish Branch of the Soros Foundation
• (1995-1998) Scholarship of the Polish Ministry of Health for The Leading in Science Students
• (1993-1995) Scholarship of the Medical University of Warsaw

Publications

1. Laudański K, Cudnoch-Jedrzejewska A. Effects of ovariectomy on the regulation of cardiovascular functions in female Wistar rats. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2001; 7(6): 1188-1192.
2. Nowak Z, Laudański K. Calcimimetics as a new chance for effective treatment of calcium metabolism disturbances. Polski merkuriusz lekarski: Organ Polskiego Towarzystwa Lekarskiego. 2002; 13(77): 424-427.
3. Laudański K, Nowak Z, Wańkowicz Z. Mood and illness-related stress in dialysed patients. Polski merkuriusz lekarski: Organ Polskiego Towarzystwa Lekarskiego. 2002; 13(77): 376-379.
4. Laudański K, Nowak Z. Quality of life in dialysed patients–methodological issues. Polski merkuriusz lekarski: Organ Polskiego Towarzystwa Lekarskiego. 2002; 13(77): 421-423.
5. De AK, Laudanski K, Miller-Graziano CL. Failure of monocytes of trauma patients to convert to immature dendritic cells is related to preferential macrophage-colony-stimulating factor-driven macrophage differentiation. Journal of Immunology. 2003; 170(12): 6355-6362. doi:10.4049/jimmunol.170.12.6355
6. Seniow J, Polanowska K, Mandat T, Laudanski K. The cognitive impairments due to the occipito-parietal brain injury after gunshot. A successful neurorehabiliation case study. Brain injury. 2003; 17(8): 701-713. doi:10.1080/0269905031000088621
7. Laudanski K, De A, Brouxhon S, Kyrkanides S, Miller-Graziano C. Abnormal PGE(2) regulation of monocyte TNF-alpha levels in trauma patients parallels development of a more macrophage-like phenotype. Shock. 2004; 22(3): 204-212.
8. Feezor RJ, Baker HV, Mindrinos M, et al. Whole blood and leukocyte RNA isolation for gene expression analyses. Physiological Genomics. 2004; 19(3): 247-254. doi:10.1152/physiolgenomics.00020.2004
9. De AK, Roach SE, De M, et al. Development of a simple method for rapid isolation of polymorphonuclear leukocytes from human blood. Journal of Immunoassay & Immunochemistry. 2005; 26(1): 35-42.
10. Cobb JP, Mindrinos MN, Miller-Graziano C, et al. Application of genome-wide expression analysis to human health and disease. Proceedings of the National Academy of Sciences of the United States of America. 2005; 102(13): 4801-4806. doi:10.1073/pnas.0409768102
11. Laudanski K, Wyczechowska D. Monocyte-related immunopathologies in trauma patients. Archivum Immunologiae et Therapiae Experimentalis. 2005; 53(4): 321-328.
12. De AK, Miller-Graziano CL, Calvano SE, et al. Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation. Journal of Immunology. 2005; 175(9): 6155-6162. doi:10.4049/jimmunol.175.9.6155
13. Laudanski K, De A, Pellegrini J, Miller-Graziano C. Simultaneous aberrations in Mphi and T cell function adversely affect trauma patients clinical outcome: A possible faulty IL-13 feedback loop. Clinical Immunology. 2006; 118(2-3): 332-341.
14. Laudanski K, Wyczechowska D. The distinctive role of small heat shock proteins in oncogenesis. Archivum Immunologiae et Therapiae Experimentalis. 2006; 54(2): 103-111.
15. Laudanski K, Miller-Graziano C, Xiao W, et al. Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103(42): 15564-15569.
16. Bandyopadhyay G, De A, Laudanski K, et al. Negative signaling contributes to T-cell anergy in trauma patients. Critical Care Medicine. 2007; 35(3): 794-801.
17. Laudanski K, De A, Miller-Graziano C. Exogenous heat shock protein 27 uniquely blocks differentiation of monocytes to dendritic cells. European Journal of Immunology. 2007; 37(10): 2812-2824.
18. Miller-Graziano CL, De A, Laudanski K, Herrmann T, Bandyopadhyay S. HSP27: An anti-inflammatory and immunomodulatory stress protein acting to dampen immune function. Novartis Foundation Symposium. 2008; 291:196-208.
19. Laudanski K, Layon AJ. Rapid development of chylothorax in patient with propofol-induced coma. BMJ Case Reports. 2009; 2009.
20. Laudanski K, Ali H, Himmel A, Godula K, Stettmeier M, Calvocoressi L. The relationship between serum ferritin levels and electrocardiogram characteristics in acutely ill patients. Experimental and Clinical Cardiology. 2009; 14(3): 38-41.
21. Laudanski K, Patel SP, Peng YG. Ongoing paradoxical particulate embolism during megaprosthesis placement. Journal of Clinical Anesthesia. 2009; 21(7): 533-537. doi: 10.1016/j.jclinane.2008.10.018.
22. Laudański K, Nowak Z, Wańkowicz Z. Psychological aspects of dialysis: does cognitive appraisal determine the overall outcome? Polskie Archiwum Medycyny Wewnetrznej. 2010; 120(1-2): 49-52.
23. Laudanski K, Schwab WK, Bakuzonis CW, Paulus DA. Thermal damage of the humidified ventilator circuit in the operating room: An analysis of plausible causes. Anesthesia and Analgesia. 2010; 111(6): 1433-1436. doi: 10.1213/ANE.0b013e3181ee8092
24. Laudanski K, Dohlman L. Intensive care in poor-resource settings: Solutions are in the hands at home. Critical Care Medicine. 2011; 39(10): 2385.
25. Laudanski K, Euliano T. Peripartum acute coronary syndrome in an otherwise healthy patient. Journal of Clinical Anesthesia. 2011; 23(8): 661-665. doi:10.1016/j.jclinane.2011.06.006.
26. Laudanski K. Adoptive transfer of naïve dendritic cells in resolving post-sepsis long-term immunosuppression. Medical Hypotheses. 2012; 79(4): 478-480. doi:10.1016/j.mehy.2012.06.028
27. Laudański K, Nowak Z. Aberrant function and differentiation of monocytes in end stage renal disease. Archivum Immunologiae et Therapiae Experimentalis. 2012; 60(6): 453-459. doi:10.1007/s00005-012-0191-0
28. Laudański K, Nowak Z, Niemczyk S. Age-related differences in the quality of life in end-stage renal disease in patients enrolled in hemodialysis or continuous peritoneal dialysis. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 2013; 19: 378-385. doi:10.12659/MSM.883916
29. Pieczynski LM, Laudanski K, Speck RM, McCunn M. Analysis of field reports from anaesthesia volunteers in low- to middle-income countries. Medical Education. 2013; 47(10): 1029-1036. doi:10.1111/medu.12262
30. Nowak Z, Laudański K. The perception of the illness with subsequent outcome measure in more favorable in continuos peritoneal dialysis vs hemodialysis in the framework of appraisal model of stress. International Journal of Medical Sciences. 2014; 11(3): 291-297. doi:10.7150/ijms.5431
31. Patel MB, Laudanski K, Pandharipande PP. An international career development survey of critical care practitioners. Critical Care Medicine. 2014; 42(4): e300-e303. doi:10.1097/CCM.0000000000000137